CA2222995A1 - Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides - Google Patents
Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptidesInfo
- Publication number
- CA2222995A1 CA2222995A1 CA002222995A CA2222995A CA2222995A1 CA 2222995 A1 CA2222995 A1 CA 2222995A1 CA 002222995 A CA002222995 A CA 002222995A CA 2222995 A CA2222995 A CA 2222995A CA 2222995 A1 CA2222995 A1 CA 2222995A1
- Authority
- CA
- Canada
- Prior art keywords
- deoxy
- polypeptides
- glucose
- poly
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/468,947 | 1995-06-06 | ||
US08/468,947 US5665702A (en) | 1995-06-06 | 1995-06-06 | Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides |
PCT/US1996/007756 WO1996039160A1 (en) | 1995-06-06 | 1996-05-24 | Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2222995A1 true CA2222995A1 (en) | 1996-12-12 |
CA2222995C CA2222995C (en) | 2005-05-10 |
Family
ID=23861854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002222995A Expired - Fee Related CA2222995C (en) | 1995-06-06 | 1996-05-24 | Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides |
Country Status (21)
Country | Link |
---|---|
US (2) | US5665702A (en) |
EP (1) | EP0830137B1 (en) |
JP (1) | JPH11508289A (en) |
KR (1) | KR19990022399A (en) |
CN (1) | CN1192152A (en) |
AT (1) | ATE245031T1 (en) |
AU (1) | AU717188B2 (en) |
BR (1) | BR9609031A (en) |
CA (1) | CA2222995C (en) |
CZ (1) | CZ391697A3 (en) |
DE (1) | DE69629114T2 (en) |
DK (1) | DK0830137T3 (en) |
ES (1) | ES2201188T3 (en) |
HU (1) | HUP9901627A3 (en) |
NZ (1) | NZ308909A (en) |
PL (1) | PL323735A1 (en) |
PT (1) | PT830137E (en) |
RU (1) | RU2172323C2 (en) |
SI (1) | SI9620090A (en) |
SK (1) | SK168397A3 (en) |
WO (1) | WO1996039160A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6479457B2 (en) * | 1995-06-06 | 2002-11-12 | Kinerton Limited | Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides |
US5968895A (en) | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
PL193111B1 (en) * | 1998-01-29 | 2007-01-31 | Poly Med Inc | Absorbable microparticles |
DE69907870T2 (en) | 1998-01-29 | 2004-03-04 | Kinerton Ltd., Blanchardstown | METHOD FOR PRODUCING ABSORBABLE MICROPARTICLES |
CZ303120B6 (en) | 1998-12-07 | 2012-04-11 | Societe De Conseils De Recherches Et Dapplications Scientifiques S. A. | Compound and pharmaceutical composition |
JP4532618B2 (en) * | 1999-02-25 | 2010-08-25 | 株式会社グライコメディクス | Novel sugar primer |
US7037889B2 (en) | 2000-09-13 | 2006-05-02 | Praecis Pharmaceuticals Inc. | Pharmaceutical compositions for sustained drug delivery |
US7122622B2 (en) * | 2002-04-16 | 2006-10-17 | Biosynthema Inc. | Peptide compounds having improved binding affinity to somatostatin receptors |
US7244445B2 (en) | 2002-07-29 | 2007-07-17 | Poly Med, Inc | Conformable, absorbable, solid composite preforms and their use for bone tissue engineering |
CA2504345A1 (en) * | 2002-10-31 | 2004-05-13 | Pfizer Products Inc. | Liquid conjugates of solid pharmaceuticals |
US9221867B2 (en) | 2003-01-06 | 2015-12-29 | Angiochem Inc. | Method for transporting a compound across the blood-brain barrier |
ES2393335T3 (en) | 2003-12-16 | 2012-12-20 | Ipsen Pharma | GLP-1 analogues |
EP1915167A4 (en) | 2005-07-08 | 2010-04-07 | Ipsen Pharma | Melanocortin receptor ligands |
EP2471555A3 (en) | 2005-07-15 | 2012-10-17 | Angiochem Inc. | Use of aprotinin polypeptides as carriers in pharmaceutical conjugates |
US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
EP2650006A1 (en) | 2007-09-07 | 2013-10-16 | Ipsen Pharma S.A.S. | Analogues of exendin-4 and exendin-3 |
AU2008325194B2 (en) | 2007-11-05 | 2012-04-19 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Use melanocortins to treat insulin sensitivity |
US8841440B2 (en) * | 2008-04-01 | 2014-09-23 | Cornell University | Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof |
RU2509809C2 (en) | 2008-07-04 | 2014-03-20 | Транслэшионал Кэнсэр Драгз Фарма, С.Л. | Methods of treating and diagnosing cancer |
AU2009280012B2 (en) | 2008-08-07 | 2012-12-06 | Ipsen Pharma S.A.S. | Truncated analogues of glucose-dependent insulinotropic polypeptide |
WO2010016940A2 (en) | 2008-08-07 | 2010-02-11 | Ipsen Pharma S.A.S. | Analogues of glucose-dependent insulinotropic polypeptide |
CA2733006A1 (en) | 2008-08-07 | 2010-02-11 | Ipsen Pharma S.A.S. | Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal |
US8828925B2 (en) | 2008-10-15 | 2014-09-09 | Angiochem Inc. | Etoposide and doxorubicin conjugates for drug delivery |
EP2346906A4 (en) | 2008-10-15 | 2013-04-24 | Angiochem Inc | Conjugates of glp-1 agonists and uses thereof |
JP5759379B2 (en) | 2008-12-05 | 2015-08-05 | アンジオケム インコーポレーテッド | Neurotensin or neurotensin analog and use thereof |
BRPI0922611A2 (en) | 2008-12-17 | 2018-11-06 | Angiochem Inc | type 1 membrane matrix metalloprotein inhibitors and uses thereof |
US20110293562A1 (en) | 2009-02-12 | 2011-12-01 | Proyecto De Biomedicina Cima, S.L. | Use of cardiotrophin-1 for the treatment of metabolic diseases |
EP2448965A4 (en) | 2009-07-02 | 2015-02-11 | Angiochem Inc | Multimeric peptide conjugates and uses thereof |
US8759299B2 (en) | 2009-07-22 | 2014-06-24 | Ipsen Pharma S.A.S. | Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59 |
US9415012B2 (en) * | 2011-06-14 | 2016-08-16 | Ipsen Pharma S.A.S. | Sustained-release composition containing peptides as active ingredient |
US9962401B2 (en) * | 2011-09-27 | 2018-05-08 | Purdue Research Foundation | Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles |
EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
JPS63258579A (en) * | 1987-04-15 | 1988-10-26 | Fuji Boseki Kk | Production of carrier for immobilization of physiologically active substance |
US5271945A (en) * | 1988-07-05 | 1993-12-21 | Takeda Chemical Industries, Ltd. | Sustained release microcapsule for water soluble drug |
EP0544000B1 (en) * | 1990-08-17 | 1997-05-02 | Drug Delivery System Institute, Ltd. | N-acetylcarboxymethylchitosan derivative and production thereof |
US5298488A (en) * | 1990-10-26 | 1994-03-29 | Fuji Photo Film Co., Ltd. | CM-chitin derivatives and use thereof |
IT1243390B (en) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION. |
US5344644A (en) * | 1991-08-01 | 1994-09-06 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release |
-
1995
- 1995-06-06 US US08/468,947 patent/US5665702A/en not_active Expired - Fee Related
-
1996
- 1996-05-24 ES ES96920510T patent/ES2201188T3/en not_active Expired - Lifetime
- 1996-05-24 AT AT96920510T patent/ATE245031T1/en not_active IP Right Cessation
- 1996-05-24 KR KR1019970708879A patent/KR19990022399A/en not_active Application Discontinuation
- 1996-05-24 PL PL96323735A patent/PL323735A1/en unknown
- 1996-05-24 AU AU58789/96A patent/AU717188B2/en not_active Ceased
- 1996-05-24 RU RU98100091/04A patent/RU2172323C2/en not_active IP Right Cessation
- 1996-05-24 BR BR9609031-6A patent/BR9609031A/en not_active Application Discontinuation
- 1996-05-24 EP EP96920510A patent/EP0830137B1/en not_active Expired - Lifetime
- 1996-05-24 SI SI9620090A patent/SI9620090A/en unknown
- 1996-05-24 CN CN96195836A patent/CN1192152A/en active Pending
- 1996-05-24 WO PCT/US1996/007756 patent/WO1996039160A1/en active IP Right Grant
- 1996-05-24 CA CA002222995A patent/CA2222995C/en not_active Expired - Fee Related
- 1996-05-24 CZ CZ973916A patent/CZ391697A3/en unknown
- 1996-05-24 DE DE69629114T patent/DE69629114T2/en not_active Expired - Fee Related
- 1996-05-24 JP JP9500740A patent/JPH11508289A/en not_active Withdrawn
- 1996-05-24 PT PT96920510T patent/PT830137E/en unknown
- 1996-05-24 DK DK96920510T patent/DK0830137T3/en active
- 1996-05-24 SK SK1683-97A patent/SK168397A3/en unknown
- 1996-05-24 HU HU9901627A patent/HUP9901627A3/en unknown
- 1996-05-24 NZ NZ308909A patent/NZ308909A/en unknown
-
1997
- 1997-09-09 US US08/929,363 patent/US5821221A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2222995C (en) | 2005-05-10 |
DE69629114D1 (en) | 2003-08-21 |
CZ391697A3 (en) | 1998-05-13 |
SI9620090A (en) | 1998-08-31 |
HUP9901627A1 (en) | 1999-09-28 |
EP0830137A1 (en) | 1998-03-25 |
BR9609031A (en) | 1999-12-14 |
EP0830137B1 (en) | 2003-07-16 |
EP0830137A4 (en) | 2002-06-26 |
ATE245031T1 (en) | 2003-08-15 |
JPH11508289A (en) | 1999-07-21 |
WO1996039160A1 (en) | 1996-12-12 |
ES2201188T3 (en) | 2004-03-16 |
AU717188B2 (en) | 2000-03-23 |
PT830137E (en) | 2003-10-31 |
DE69629114T2 (en) | 2004-04-22 |
PL323735A1 (en) | 1998-04-14 |
US5665702A (en) | 1997-09-09 |
NZ308909A (en) | 1999-06-29 |
CN1192152A (en) | 1998-09-02 |
DK0830137T3 (en) | 2003-11-03 |
RU2172323C2 (en) | 2001-08-20 |
KR19990022399A (en) | 1999-03-25 |
HUP9901627A3 (en) | 1999-11-29 |
AU5878996A (en) | 1996-12-24 |
SK168397A3 (en) | 1998-04-08 |
US5821221A (en) | 1998-10-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |