CA2228635A1 - Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods - Google Patents

Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods

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Publication number
CA2228635A1
CA2228635A1 CA002228635A CA2228635A CA2228635A1 CA 2228635 A1 CA2228635 A1 CA 2228635A1 CA 002228635 A CA002228635 A CA 002228635A CA 2228635 A CA2228635 A CA 2228635A CA 2228635 A1 CA2228635 A1 CA 2228635A1
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Canada
Prior art keywords
primers
probes
detection methods
protein gene
gene family
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002228635A
Other languages
French (fr)
Other versions
CA2228635C (en
Inventor
Stephen Baird
Robert G. Korneluk
Peter Liston
Alexander E. Mackenzie
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University of Ottawa
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Individual
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Priority claimed from US08/511,485 external-priority patent/US5919912A/en
Application filed by Individual filed Critical Individual
Priority to CA002403947A priority Critical patent/CA2403947C/en
Publication of CA2228635A1 publication Critical patent/CA2228635A1/en
Application granted granted Critical
Publication of CA2228635C publication Critical patent/CA2228635C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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Abstract

Disclosed is substantially pure DNA encoding mammalian IAP polypeptides;
substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
CA002228635A 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods Expired - Fee Related CA2228635C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002403947A CA2403947C (en) 1995-08-04 1996-08-05 Bir domains of mammalian iap gene family

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/511,485 1995-08-04
US08/511,485 US5919912A (en) 1995-08-04 1995-08-04 Mammalian IAP antibodies and diagnostic kits
US08/576,956 1995-12-22
US08/576,956 US6156535A (en) 1995-08-04 1995-12-22 Mammalian IAP gene family, primers, probes, and detection methods
PCT/IB1996/001022 WO1997006255A2 (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002403947A Division CA2403947C (en) 1995-08-04 1996-08-05 Bir domains of mammalian iap gene family

Publications (2)

Publication Number Publication Date
CA2228635A1 true CA2228635A1 (en) 1997-02-20
CA2228635C CA2228635C (en) 2002-11-26

Family

ID=27057240

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002228635A Expired - Fee Related CA2228635C (en) 1995-08-04 1996-08-05 Mammalian apoptosis inhibitor protein gene family, primers, probes and detection methods

Country Status (8)

Country Link
US (17) US6156535A (en)
EP (2) EP0837939B1 (en)
JP (1) JP4458551B2 (en)
AT (1) ATE310819T1 (en)
CA (1) CA2228635C (en)
DE (1) DE69635482T2 (en)
ES (1) ES2253756T3 (en)
WO (1) WO1997006255A2 (en)

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US8012944B2 (en) * 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
US7342093B2 (en) 2004-07-23 2008-03-11 University Of Massachusetts Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins
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