CA2231481A1 - Pen-type injector drive mechanism - Google Patents

Pen-type injector drive mechanism

Info

Publication number
CA2231481A1
CA2231481A1 CA002231481A CA2231481A CA2231481A1 CA 2231481 A1 CA2231481 A1 CA 2231481A1 CA 002231481 A CA002231481 A CA 002231481A CA 2231481 A CA2231481 A CA 2231481A CA 2231481 A1 CA2231481 A1 CA 2231481A1
Authority
CA
Canada
Prior art keywords
plunger portion
drive
plunger
piston
medication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002231481A
Other languages
French (fr)
Other versions
CA2231481C (en
Inventor
Thomas P. Castellano
Paul H. Kovelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Visionary Medical Products Corp
Original Assignee
Visionary Medical Products Corporation
Thomas P. Castellano
Paul H. Kovelman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visionary Medical Products Corporation, Thomas P. Castellano, Paul H. Kovelman filed Critical Visionary Medical Products Corporation
Publication of CA2231481A1 publication Critical patent/CA2231481A1/en
Application granted granted Critical
Publication of CA2231481C publication Critical patent/CA2231481C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button

Abstract

A medication injection mechanism, for delivering a dosage of medication from a medication cartridge having a piston, includes a two-piece drive shaft, a ratchet mechanism, and a drive mechanism. The two-piece drive shaft includes a plunger portion and a drive portion. The plunger portion has an end that contacts the piston of the medication cartridge, ratchet teeth disposed on the sides of the plunger portion that define a thickness of the plunger portion, and an opening to provide a passage through the plunger portion of the two-piece drive shaft. The drive portion is formed by rails that are coupled together by a connector that passes through the opening in the plunger portion so that the drive portion is coupled to the plunger portion, and can move relative to the plunger portion. Each of the rails forming the drive portion has threads on a surface that extend beyond the defined thickness of the plunger portion. The ratchet mechanism engages with the ratchet teeth of the plunger portion to permit the movement of the plunger portion toward the piston of the medication cartridge and to inhibit movement of the plunger portion away from the piston of the medication cartridge. Also, the drive mechanism engages with the threads on the rails of the drive portion, but is free of contact with the ratchet teeth on the plunger portion to adjust the position of the drive portion relative to the plunger portion so that the drive portion can be moved toward the piston of the medication cartridge a fixed distance and the plunger portion is moved a distance that is less than or equal to the fixed distance.
CA002231481A 1995-09-08 1996-09-06 Pen-type injector drive mechanism Expired - Lifetime CA2231481C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US340995P 1995-09-08 1995-09-08
US08/706,609 US5820602A (en) 1995-09-08 1996-09-05 Pen-type injector drive mechanism
US08/706,609 1996-09-05
US60/003,409 1996-09-05
PCT/US1996/014266 WO1997009080A1 (en) 1995-09-08 1996-09-06 Pen-type injector drive mechanism

Publications (2)

Publication Number Publication Date
CA2231481A1 true CA2231481A1 (en) 1997-03-13
CA2231481C CA2231481C (en) 2008-01-22

Family

ID=26671719

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002231481A Expired - Lifetime CA2231481C (en) 1995-09-08 1996-09-06 Pen-type injector drive mechanism

Country Status (10)

Country Link
US (1) US5820602A (en)
EP (1) EP0850079B1 (en)
JP (1) JP3835817B2 (en)
AT (1) ATE193215T1 (en)
AU (1) AU1860697A (en)
CA (1) CA2231481C (en)
DE (1) DE69608567T2 (en)
DK (1) DK0850079T3 (en)
ES (1) ES2149499T3 (en)
WO (1) WO1997009080A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11554215B2 (en) 2017-06-08 2023-01-17 Novartis Ag Injection device and injection solution transferring system

Families Citing this family (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US6248095B1 (en) * 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
DE19819409A1 (en) * 1998-04-30 1999-11-11 Schering Ag Injection device
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
JP4399752B2 (en) * 1999-07-06 2010-01-20 日本ケミカルリサーチ株式会社 Syringe with drug dissolution mechanism
US6277099B1 (en) * 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
US6585698B1 (en) * 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
US20020173752A1 (en) * 2000-02-16 2002-11-21 Polzin U1F Method for reconstituting an injection liquid and an injection appliance for carrying out such a method
US6607508B2 (en) 2000-04-27 2003-08-19 Invivotech, Inc. Vial injector device
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
US6986760B2 (en) * 2000-08-02 2006-01-17 Becton, Dickinson And Company Pen needle and safety shield system
EP3138598B1 (en) * 2000-08-02 2019-10-23 Becton, Dickinson and Company Pen needle and safety shield system
WO2002024257A1 (en) * 2000-09-22 2002-03-28 Novo Nordisk A/S A medication delivery device
US6387078B1 (en) * 2000-12-21 2002-05-14 Gillespie, Iii Richard D. Automatic mixing and injecting apparatus
IL156245A0 (en) * 2000-12-22 2004-01-04 Dca Design Int Ltd Drive mechanism for an injection device
US6899699B2 (en) * 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
WO2002064196A1 (en) * 2001-02-14 2002-08-22 Novo Nordisk A/S Electronically controlled injection or infusion device
CA2440983A1 (en) 2001-03-14 2002-09-26 Penjet Corporation System and method for removing dissolved gas from a solution
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
WO2002087663A2 (en) 2001-04-27 2002-11-07 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
EP1776975B1 (en) * 2001-05-16 2011-06-22 Eli Lilly & Company Medication injector apparatus with drive assembly that facilitates reset
AU2012200045B2 (en) * 2001-05-16 2013-10-10 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
EP1409046B1 (en) * 2001-07-16 2005-03-02 Eli Lilly And Company Medication dispensing apparatus configured for rotate to prime and pull/push to inject functionality
DE10163327A1 (en) 2001-07-30 2003-02-27 Disetronic Licensing Ag Reservoir module with piston rod
DE10163328B4 (en) * 2001-07-30 2005-08-11 Tecpharma Licensing Ag Administration device with anti-rotation device
DE10137408A1 (en) * 2001-07-31 2003-03-13 W J Huk Syringe utilizes a conventional pressure operated snap mechanim of a ball-point pen to audibly and touchably indicate that a predetermined pressure limit during injection has been exceeded
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
GB0201686D0 (en) * 2002-01-25 2002-03-13 Dca Design Consultants Ltd Improvements in and relating to a medicament delivery device
EP1476210B1 (en) 2002-02-11 2008-09-24 Antares Pharma, Inc. Intradermal injector
US6979316B1 (en) 2002-05-23 2005-12-27 Seedlings Life Science Ventures Llc Apparatus and method for rapid auto-injection of medication
EP1391794A1 (en) * 2002-07-23 2004-02-25 Novo Nordisk A/S Device with time indicating means
DE10237258B4 (en) * 2002-08-14 2006-09-21 Tecpharma Licensing Ag injection device
US20040039337A1 (en) * 2002-08-21 2004-02-26 Letzing Michael Alexander Portable safety auto-injector
US7081109B2 (en) * 2002-08-22 2006-07-25 Baxa Corporation Sterile docking apparatus and method
DE10250629A1 (en) * 2002-10-30 2004-05-19 Tecpharma Licensing Ag Method and device for indicating and dosing when administering a product
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
DE10351732B4 (en) * 2003-07-10 2010-10-21 Tecpharma Licensing Ag Configuration of an injection device
US8932264B2 (en) 2003-08-11 2015-01-13 Becton, Dickinson And Company Medication delivery pen assembly with needle locking safety shield
PT1656170T (en) 2003-08-12 2019-05-31 Lilly Co Eli Medication dispensing apparatus with triple screw threads for mechanical advantage
IL157981A (en) 2003-09-17 2014-01-30 Elcam Medical Agricultural Cooperative Ass Ltd Auto-injector
ES2739529T3 (en) 2003-11-06 2020-01-31 Lifescan Inc Drug administration pen with event notification means
IL160891A0 (en) 2004-03-16 2004-08-31 Auto-mix needle
DK1799287T3 (en) 2004-10-04 2013-09-02 Sanofi Aventis Deutschland Drive mechanism for a drug delivery device
WO2006045526A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Dial-down mechanism for wind-up pen
JP5185620B2 (en) 2004-10-21 2013-04-17 ノボ・ノルデイスク・エー／エス Injection device with torsion spring and rotary indicator
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
DE102004063664A1 (en) * 2004-12-31 2006-07-20 Tecpharma Licensing Ag Real-time display of a device for metered administration of a product
DE102004063648A1 (en) * 2004-12-31 2006-07-20 Tecpharma Licensing Ag Injection or infusion device with life-determining device
CA2594764C (en) 2005-01-21 2014-01-14 Novo Nordisk A/S An automatic injection device with a top release mechanism
JP5216328B2 (en) 2005-01-24 2013-06-19 アンタレス ファーマ インコーポレイテッド Pre-filled needle assist syringe jet injector
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
ES2396745T3 (en) 2005-02-01 2013-02-25 Intelliject, Inc. Devices for medication administration
US8231573B2 (en) * 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
WO2006114396A1 (en) 2005-04-24 2006-11-02 Novo Nordisk A/S Injection device
US7611505B2 (en) * 2005-05-10 2009-11-03 Baxa Corporation Sterile docking apparatus and method
CN101400394B (en) * 2006-03-10 2012-07-04 诺沃-诺迪斯克有限公司 An injection device having a gearing arrangement
CN101400393B (en) * 2006-03-10 2011-09-14 诺沃-诺迪斯克有限公司 An injection device and a method of changing a cartridge in the device
WO2007107561A2 (en) 2006-03-20 2007-09-27 Novo Nordisk A/S Determination of position of injection needle
US8251947B2 (en) 2006-05-03 2012-08-28 Antares Pharma, Inc. Two-stage reconstituting injector
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
ATE458517T1 (en) 2006-05-16 2010-03-15 Novo Nordisk As TRANSMISSION MECHANISM FOR AN INJECTION DEVICE
JP5253387B2 (en) 2006-05-18 2013-07-31 ノボ・ノルデイスク・エー／エス Injection device with mode locking means
US7673819B2 (en) * 2006-06-26 2010-03-09 Battelle Memorial Institute Handheld sprayer with removable cartridge and method of using same
WO2008002556A1 (en) * 2006-06-26 2008-01-03 Battelle Memorial Institute Cartridge having self-actuating seal for a wetted lead screw
PL2051753T3 (en) * 2006-08-18 2017-01-31 Shl Medical Ab Device for delivering medicament encompassing a pressure release mechanism
DK2073871T3 (en) * 2006-09-29 2013-06-10 Novo Nordisk As Injection device with electronic detection means
FR2908753B1 (en) * 2006-11-16 2011-11-11 Becton Dickinson France DEVICE FOR AUTOMATICALLY DELIVERING SUCCESSIVE PRODUCT DOSES
AU2008231897B2 (en) 2007-03-23 2012-11-29 Novo Nordisk A/S An injection device comprising a locking nut
US20080249477A1 (en) * 2007-04-05 2008-10-09 West Pharmaceutical Services, Inc. Pen injector having a needle shield
DE102007018696A1 (en) 2007-04-18 2008-10-23 Sanofi-Aventis Deutschland Gmbh Injection device for dispensing a medicament
US7817498B1 (en) * 2007-05-11 2010-10-19 Michael R. Schramm Medical apparatus having elapsed time indicated and method of use
WO2009024562A1 (en) 2007-08-17 2009-02-26 Novo Nordisk A/S Medical device with value sensor
US7883033B2 (en) * 2007-12-10 2011-02-08 Battelle Memorial Institute Lead screw locking device
US8708957B2 (en) * 2007-12-31 2014-04-29 Novo Nordisk A/S Electronically monitored injection device
US20090182582A1 (en) * 2008-01-15 2009-07-16 Hawkeye Production Llc System and portable apparatus for securely dispensing and maintaining accurate inventory of controlled substances in a hospital setting
EP2268342B1 (en) 2008-03-10 2015-09-16 Antares Pharma, Inc. Injector safety device
MX2010011251A (en) 2008-05-02 2010-11-12 Sanofi Aventis Deutschland Medication delivery device.
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
ES2738539T3 (en) 2008-08-05 2020-01-23 Antares Pharma Inc Multi dose injector
WO2010033770A2 (en) 2008-09-18 2010-03-25 Becton, Dickinson And Company Medical injector with ratcheting plunger
DE102008049638A1 (en) * 2008-09-30 2010-04-15 Tecpharma Licensing Ag Injection device with exactly ascertainable piston rod
CA2740331C (en) 2008-10-13 2017-08-01 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method of manufacturing a drug delivery device
ES2567715T3 (en) * 2008-11-17 2016-04-26 Becton Dickinson And Company Additional force device for medication delivery pen for intradermal medication injection
US8366680B2 (en) 2008-12-12 2013-02-05 Sanofi-Aventis Deutschland Gmbh Resettable drive mechanism for a medication delivery device and medication delivery device
US9375529B2 (en) 2009-09-02 2016-06-28 Becton, Dickinson And Company Extended use medical device
EP3677293A1 (en) 2009-01-12 2020-07-08 Becton, Dickinson and Company In-dwelling rigid catheter with flexible features
EP3593844A1 (en) 2009-02-27 2020-01-15 Lifescan, Inc. Medical module for drug delivery pen
WO2010108116A1 (en) 2009-03-20 2010-09-23 Antares Pharma, Inc. Hazardous agent injection system
BRPI1012730A2 (en) 2009-03-31 2016-05-03 Sanofi Aventis Deutschland drug delivery device
DK2414012T3 (en) 2009-03-31 2015-04-27 Sanofi Aventis Deutschland Pen cap
JP5898612B2 (en) 2009-03-31 2016-04-06 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Dosing button for drug delivery device and method of manufacturing the dosing button
WO2010115820A1 (en) 2009-03-31 2010-10-14 Sanofi-Aventis Deutschland Gmbh Method for manufacturing a drug delivery device body using an adhesive and drug delivery device body
MX2011011298A (en) 2009-04-30 2011-11-18 Sanofi Aventis Deutschland Axially adjustable connection of piston rod to piston for drive mechanism of a drug delivery device.
US9623187B2 (en) * 2009-06-01 2017-04-18 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
US10034982B2 (en) 2009-06-01 2018-07-31 Sanofi-Aventis Deutschland Gmbh Spindle for a drug delivery device
US9199040B2 (en) * 2009-06-01 2015-12-01 Sanofi-Aventis Deutschland Gmbh Drug delivery device last dose lock-out mechanism
US8257319B2 (en) 2009-06-01 2012-09-04 Sanofi-Aventis Deutschland Gmbh Drug delivery device inner housing having helical spline
US8585656B2 (en) 2009-06-01 2013-11-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US8672896B2 (en) * 2009-06-01 2014-03-18 Sanofi-Aventis Deutschland Gmbh Inner housing for a drug delivery device
US9457150B2 (en) * 2009-06-01 2016-10-04 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a drug delivery device
US9950116B2 (en) 2009-06-01 2018-04-24 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US8728043B2 (en) * 2009-06-01 2014-05-20 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
US9108007B2 (en) * 2009-06-01 2015-08-18 Sanofi-Aventis Deutschland Gmbh Spindle and bearing combination and drug delivery device
US9345840B2 (en) * 2009-06-01 2016-05-24 Sanofi-Aventis Deutschland Gmbh Drug delivery dose setting mechanism with variable maximum dose
US9238106B2 (en) * 2009-06-01 2016-01-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US9463283B2 (en) * 2009-06-01 2016-10-11 Sanofi-Aventis Deutschland Gmbh Dosing mechanism for a drug deliver device
US20110015576A1 (en) * 2009-06-01 2011-01-20 Sanofi-Aventis Deutschland Gmbh Medicament identification system for multi-dose injection devices
US9125994B2 (en) * 2009-06-01 2015-09-08 Sanofi—Aventis Deutschland GmbH Drug delivery device with dose dial sleeve rotational stop
US8974423B2 (en) * 2009-06-01 2015-03-10 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
TWI530306B (en) 2009-06-02 2016-04-21 賽諾菲阿凡提斯德意志有限公司 Assembly for a drug delivery device and drug delivery device
US8939928B2 (en) 2009-07-23 2015-01-27 Becton, Dickinson And Company Medical device having capacitive coupling communication and energy harvesting
US10092691B2 (en) 2009-09-02 2018-10-09 Becton, Dickinson And Company Flexible and conformal patch pump
JP5805092B2 (en) 2009-09-30 2015-11-04 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Injection device
CN102695531B (en) 2009-11-03 2014-10-15 赛诺菲-安万特德国有限公司 Assembly for a drug delivery device and drug delivery device
EP2579922B1 (en) * 2010-06-11 2016-11-16 Sanofi-Aventis Deutschland GmbH Drive mechanism for a drug delivery device and drug delivery device
CA2807080A1 (en) 2010-08-06 2012-02-09 Sanofi-Aventis Deutschland Gmbh Cartridge holder and method for assembling a cartridge unit for a drug delivery device
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
US8814831B2 (en) 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
US9950109B2 (en) 2010-11-30 2018-04-24 Becton, Dickinson And Company Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US11577029B2 (en) 2012-03-15 2023-02-14 Becton, Dickinson And Company Multiple use disposable injection pen
RU2653780C1 (en) 2011-03-16 2018-05-14 Бектон, Дикинсон Энд Компани Disposable syringe-pen for several doses
AR086257A1 (en) 2011-05-06 2013-11-27 Sanofi Aventis Deutschland FARMACOS ADMINISTRATION DEVICE AND CARTRIDGE SUPPORT FOR A FARMACOS ADMINISTRATION DEVICE
US9623188B2 (en) 2011-07-07 2017-04-18 Novo Nordisk A/S Drug delivery injection pen with add-on dose capturing and display module
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
JP6165786B2 (en) 2012-03-06 2017-07-19 アンタレス・ファーマ・インコーポレーテッド Filling syringe with release force feature
KR102124660B1 (en) 2012-04-05 2020-06-18 사노피-아벤티스 도이칠란트 게엠베하 Pen-type injector with window element
KR20150011346A (en) 2012-04-06 2015-01-30 안타레스 팔마, 인코퍼레이티드 Needle assisted jet injection administration of testosterone compositions
US10065000B2 (en) 2012-04-19 2018-09-04 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device and drug delivery device
WO2013169800A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Injection device with cammed ram assembly
CN108815645A (en) 2012-05-30 2018-11-16 赛诺菲-安万特德国有限公司 Bearing, piston rod assembly and the piston rod main body of piston rod main body for medicine delivery device
CN104797282B (en) * 2012-08-03 2017-09-12 赛诺菲-安万特德国有限公司 Pen-type drug injection device and the additional monitoring module of electronics for monitoring and recording dosage setting and the daily record being administered
US20150165122A1 (en) 2012-08-08 2015-06-18 Sanofi-Aventis Deutschland Gmbh Drug delivery device with tamper-evident closure
EP3669913A1 (en) 2012-08-31 2020-06-24 Sanofi-Aventis Deutschland GmbH Drug delivery device
EP3639872B1 (en) 2012-08-31 2023-01-25 Sanofi-Aventis Deutschland GmbH Drug delivery device
JP2015531258A (en) 2012-09-11 2015-11-02 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Drive mechanism for drug delivery device and drug delivery device
CN104768593B (en) * 2012-10-03 2017-08-15 卡贝欧洲有限公司 Medicament delivery device
RU2598809C1 (en) * 2012-10-05 2016-09-27 Кэрбей Юроп Лтд Device for drug delivery
CA2886304C (en) 2012-10-05 2017-06-13 Carebay Europe Ltd Medicament delivery device
WO2014106096A1 (en) 2012-12-27 2014-07-03 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
CA2900672C (en) 2013-02-11 2018-03-27 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US20140253519A1 (en) * 2013-03-08 2014-09-11 Michael David Expandable diameter stylus
JP6030803B2 (en) 2013-03-11 2016-11-24 アンタレス・ファーマ・インコーポレーテッド Dose syringe with pinion system
TWI653069B (en) 2013-03-11 2019-03-11 德商賽諾菲阿凡提斯德意志有限公司 "piston rod and drug delivery device comprising the piston rod"
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
US10406293B2 (en) 2013-03-13 2019-09-10 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device comprising a feedback feature
US10471217B2 (en) 2013-03-13 2019-11-12 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device comprising a feedback feature
US10232118B2 (en) 2013-04-10 2019-03-19 Sanofi Drive assembly for a drug delivery device
US10369291B2 (en) 2013-05-16 2019-08-06 Sanofi-Aventis Deutschland Gmbh Mechanism for a drug delivery device
WO2014191190A1 (en) 2013-05-27 2014-12-04 Sanofi-Aventis Deutschland Gmbh Drive assembly for a drug delivery device and drug delivery device
EP3038678B1 (en) 2013-08-29 2020-01-01 Sanofi-Aventis Deutschland GmbH Cap for a drug delivery device
MX2016002588A (en) 2013-08-29 2016-06-14 Sanofi Aventis Deutschland Housing and cap for an injection device made of an outer metal part and an inner plastic part.
CN105492049B (en) 2013-08-29 2019-11-08 赛诺菲-安万特德国有限公司 Cap assemblies and medicine delivery device for medicine delivery device
DK3041538T3 (en) 2013-09-03 2020-08-24 Sanofi Sa DRIVE MECHANISM AND INJECTION DEVICE THEREFORE
EP3049131B1 (en) 2013-09-23 2020-10-21 Sanofi-Aventis Deutschland GmbH Assembly for a drug delivery device and drug delivery device
EP3071268B1 (en) 2013-11-22 2019-04-03 Sanofi-Aventis Deutschland GmbH Assembly for a drug delivery device
WO2015091763A1 (en) 2013-12-20 2015-06-25 Sanofi-Aventis Deutschland Gmbh Assembly for a drug delivery device and drug delivery device
US10004845B2 (en) 2014-04-18 2018-06-26 Becton, Dickinson And Company Split piston metering pump
US10159797B2 (en) 2014-06-06 2018-12-25 Novo Nordisk A/S Logging device for drug delivery device
JP6568112B2 (en) 2014-06-06 2019-08-28 ノボ・ノルデイスク・エー／エス Recording device actuated by a drug delivery device
USD770038S1 (en) 2014-06-26 2016-10-25 Eli Lilly And Company Medication injection device
US9416775B2 (en) 2014-07-02 2016-08-16 Becton, Dickinson And Company Internal cam metering pump
US10971260B2 (en) 2014-09-14 2021-04-06 Becton, Dickinson And Company System and method for capturing dose information
US10704944B2 (en) 2014-09-14 2020-07-07 Becton, Dickinson And Company System and method for capturing dose information
US10556067B2 (en) * 2014-10-12 2020-02-11 Min Wei Automatic injection device for multiple dosing
US9532743B2 (en) * 2014-11-06 2017-01-03 Southern Taiwan University Of Science And Technology Apparatus for detecting tissue hardness of living body
US9629550B2 (en) * 2014-11-11 2017-04-25 Southern Taiwan University Of Science And Technology Spring type firing mechanism applied to endoscope accessory
US9686976B2 (en) * 2015-03-02 2017-06-27 Bayer Cropscience Lp Variable metered airless applicator with cartridge
BR112017020163B1 (en) 2015-03-23 2022-09-06 Sanofi-Aventis Deutschland Gmbh ACCOMMODATION FOR AN INJECTION DEVICE AND INJECTION DEVICE
MX2018003983A (en) 2015-09-30 2018-11-09 Rhythm Pharmaceuticals Inc Method of treating melanocortin-4 receptor pathway-associated disorders.
JP6543775B2 (en) 2016-03-25 2019-07-10 イーライ リリー アンド カンパニー Determination of set and delivered dose in drug delivery device
WO2017184401A1 (en) 2016-04-19 2017-10-26 Eli Lilly And Company Determination of a dose in a medication delivery device using two moving arrays with teeth and a sensor
US11471607B2 (en) 2016-08-12 2022-10-18 Eli Lilly And Company Dose sensing mechanism in a medication delivery device
CA3044858C (en) 2016-12-15 2022-04-26 Eli Lilly And Company Medication delivery device with sensing system
CA3050752C (en) 2017-02-28 2022-09-06 Eli Lilly And Company Dose detection and drug identification for a medication delivery device
EP3399214B1 (en) * 2017-05-05 2020-07-15 Eppendorf AG Electronic dosing drive
US20220088316A1 (en) 2017-09-22 2022-03-24 Novo Nordisk A/S Accessory device for drug delivery device
US11918794B2 (en) * 2017-11-02 2024-03-05 Sanofi Button and button assembly for a drug delivery device
WO2019110494A1 (en) 2017-12-04 2019-06-13 Novo Nordisk A/S Drug delivery system with multipolar magnet and sensor system
KR102510636B1 (en) 2018-02-22 2023-03-17 일라이 릴리 앤드 캄파니 Dose detection system module for medication delivery device

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1997129A (en) * 1933-10-27 1935-04-09 Alfred C Taylor Lubricating device
US2221739A (en) * 1939-10-16 1940-11-12 Reiter David Hypodermic syringe
DE730971C (en) * 1940-06-02 1943-01-29 Hauptner Fa H Injection syringe, especially for veterinary use
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
US2718299A (en) * 1950-06-01 1955-09-20 Verne L Atwater Medicinal dispenser
CH293302A (en) * 1951-08-21 1953-09-15 Eisenhut Arnold Injection syringe.
US2632445A (en) * 1951-10-20 1953-03-24 Sr John L Kas Dosing hypodermic syringe
US2695023A (en) * 1952-01-04 1954-11-23 Pfizer & Co C Hypodermic syringe
FR1149735A (en) * 1956-05-09 1957-12-31 Large capacity syringe
FR1170312A (en) * 1957-03-25 1959-01-13 Syringe Order
DE1070784B (en) * 1957-05-10 1959-12-10 Bad Neuenahr Dr. iwed. Dr. phil. Erich Both Injection syringe
US3110310A (en) * 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3141583A (en) * 1962-03-23 1964-07-21 William L Brickson Injection gun
US3293749A (en) * 1964-02-03 1966-12-27 Connecticut Scient Ct Inc Amalgam gun
US3348545A (en) * 1964-10-22 1967-10-24 Sarnoff Latched cartridge
FR1445659A (en) * 1965-06-02 1966-07-15 Adjustable dose pistol-shaped syringe
GB1225495A (en) * 1967-06-15 1971-03-17
US3517668A (en) * 1967-10-16 1970-06-30 Bio Neering Inc Multiple dosage veterinary injection gun
US3481510A (en) * 1968-05-22 1969-12-02 Robert Edward Allen Jr Twin unit gun-type dispenser for extrudable material in disposable cartridges
CA873458A (en) * 1968-09-03 1971-06-15 F. Ritsky Anthony Self-aspirating syringe
AR205787A1 (en) * 1972-08-10 1976-06-07 Merck & Co Inc A MULTIPLE DOSE PASTE DISPENSER GUN FOR USE IN CONJUNCTION WITH DISPOSABLE CARTRIDGES
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4284077A (en) * 1974-11-19 1981-08-18 Wolfgang Wagner Suction injector having an adjustable dosing device
US4600403A (en) * 1974-11-19 1986-07-15 Wolfgang Wagner Suction injector II
US4114619A (en) * 1975-11-21 1978-09-19 Wolfgang Wagner Automatic injecting apparatus
GB1517289A (en) * 1975-05-30 1978-07-12 Wolfgang Wagner Liquid medicine dispensers for oral and injection therapy
US4573970A (en) * 1974-11-19 1986-03-04 Wolfgang Wagner Suction injector
US4393870A (en) * 1974-11-19 1983-07-19 Wolfgang Wagner Suction injector
US3977574A (en) * 1975-05-29 1976-08-31 Bradley Scott Thomas Dispensing pipette actuator system
US4139008A (en) * 1975-11-21 1979-02-13 Wolfgang Wagner Controlled-dose injection apparatus
US4022207A (en) * 1976-03-25 1977-05-10 Indicon Inc. Actuator for a syringe
US4099548A (en) * 1976-08-25 1978-07-11 Oxford Laboratories Inc. Hand-held pipette for repetitively dispensing precise volumes of liquid
CA1103314A (en) * 1978-02-21 1981-06-16 Ryuzo Kawamori Artificial beta cell for controlling a quantity of insulin infusion
DE2807367A1 (en) * 1978-02-21 1979-08-30 Nikkiso Co Ltd ARTIFICIAL BETA CELL
US4457712A (en) * 1979-11-13 1984-07-03 Dragan William B Dental syringe
DE3163728D1 (en) * 1980-04-08 1984-06-28 Greater Glasgow Health Board Dispensing device
US4333458A (en) * 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating syringe with positively engaged locking collet
IE52621B1 (en) * 1981-02-12 1988-01-06 Turner Robert Charles Dose metering plunger devices for use with syringes
US4395921A (en) * 1981-06-26 1983-08-02 Scientific Manufacturing Industries, Inc. Adjustable volume liquid dispenser
JPS5874891A (en) * 1981-10-28 1983-05-06 Matsushita Electric Ind Co Ltd Compressor
ATE19203T1 (en) * 1981-11-12 1986-05-15 John Joseph Jacklich DENTAL SYRINGE.
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
US4415101A (en) * 1982-01-22 1983-11-15 Shapiro Justin J Incremental liquid dispensing device
DE3204178C2 (en) * 1982-02-06 1986-03-20 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Pipetting device
US4425121A (en) * 1982-02-22 1984-01-10 American Cyanamid Company Adjustable feeding device for the administration of dosages of gels and pastes to farm animals
DE3208436C2 (en) * 1982-02-22 1985-09-26 Glasgerätebau Hirschmann, 7101 Eberstadt Bottle dispenser
US4435173A (en) * 1982-03-05 1984-03-06 Delta Medical Industries Variable rate syringe pump for insulin delivery
US4475905A (en) * 1982-09-30 1984-10-09 Himmelstrup Anders B Injection device
EP0109913A3 (en) * 1982-11-03 1984-09-12 Micro-Mega Dental syringe for intra-ligament injections
US4710178A (en) * 1982-11-03 1987-12-01 Micro-Mega S.A. Precision injection system and method for intraligmental anesthesia
US4538616A (en) * 1983-07-25 1985-09-03 Robert Rogoff Blood sugar level sensing and monitoring transducer
DE3468173D1 (en) * 1983-09-07 1988-02-04 Disetronic Ag Portable infusion apparatus
US4664128A (en) * 1983-12-16 1987-05-12 Peter F. Lee, Inc Single-hand controlled aspiration device
DD230730A3 (en) * 1984-01-02 1985-12-11 Zentralinstitut Fuer Diabetes DEVICE FOR THE PROSPECTIVE AUTOMATIC DETERMINATION OF INDIVIDUAL-SPECIFIC GLUCOSE REGULATION PARAMETERS
US4592745A (en) * 1984-02-29 1986-06-03 Novo Industri A/S Dispenser
AU5560486A (en) * 1984-09-07 1987-10-08 Wolfgang Wagner Measuring metabolism during liquid injection
US4613328A (en) * 1984-10-22 1986-09-23 Cecil Boyd Bio-medical injector apparatus
US5279294A (en) * 1985-04-08 1994-01-18 Cascade Medical, Inc. Medical diagnostic system
DE3670768D1 (en) * 1985-11-08 1990-06-07 Disetronic Ag INJECTION DEVICE.
US4659327A (en) * 1985-11-26 1987-04-21 Dentsply Research & Development Corp. Multiple dosage syringe
FR2596278B2 (en) * 1986-03-27 1989-07-13 Micro Mega Sa DENTAL SYRINGE FOR INTRA-LIGAMENTARY INJECTIONS
US5180371A (en) * 1986-05-30 1993-01-19 Spintech, Inc. Hypodermic anesthetic injection apparatus and method
DE3645245C2 (en) * 1986-11-14 1994-01-27 Haselmeier Wilhelm Fa Injection appliance
US4710172A (en) * 1986-11-24 1987-12-01 John Jacklich High pressure syringe with pressure indicator
DE3715258C2 (en) * 1987-05-08 1996-10-31 Haselmeier Wilhelm Fa Injection device
NL8701091A (en) * 1987-05-08 1988-12-01 Spruyt Hillen Bv INJECTION PEN.
GB8713810D0 (en) * 1987-06-12 1987-07-15 Hypoguard Uk Ltd Measured dose dispensing device
EP0396536B1 (en) * 1988-01-07 1994-08-31 HAZON, Bernard Syringe-pushing device for ambulant administration of parenteral injections, with flow rate governed by the contents of the syringe and method of control thereof
CH675078A5 (en) * 1988-01-22 1990-08-31 Nosta Ag
DK166948B1 (en) * 1988-02-10 1993-08-09 Dcp Af 1988 As DOSING UNIT FOR DOSING A NUMBER OF MEASURED QUANTITIES OF A FLUID, SUCH AS INSULIN, FROM A GLASS STUBLE
GB8809115D0 (en) * 1988-04-18 1988-05-18 Turner R C Syringes
US4959056A (en) * 1988-06-14 1990-09-25 Wayne State University Digital dispenser
US4998570A (en) * 1988-06-27 1991-03-12 Pavel Jordan & Associates Filling device with sound indicator for filling injection syringe
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
US4995402A (en) * 1988-10-12 1991-02-26 Thorne, Smith, Astill Technologies, Inc. Medical droplet whole blood and like monitoring
US5244465A (en) * 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
DE8813905U1 (en) * 1988-11-07 1989-12-07 Nothdurft, Klaus, 7000 Stuttgart, De
GB2229497B (en) * 1989-03-10 1992-06-03 Graseby Medical Ltd Infusion pump
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5085642A (en) * 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5102393A (en) * 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
FR2651314A1 (en) * 1989-08-25 1991-03-01 Taddei Andre PORTABLE DEVICE FOR PERFORMING MULTIPLE ASSAYS OF A LIQUID OR PASTY PRODUCT.
US5050612A (en) * 1989-09-12 1991-09-24 Matsumura Kenneth N Device for computer-assisted monitoring of the body
GB9001635D0 (en) * 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
US5226896A (en) * 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
US5249584A (en) * 1990-05-18 1993-10-05 Karkar Maurice N Syringe for hematocrit and oxygen saturation blood analyzer
US5069668A (en) * 1990-07-12 1991-12-03 Boydman Scott A Patient controlled analgesia system
US5230884A (en) * 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
US5256157A (en) * 1991-01-31 1993-10-26 Baxter International Inc. Automated infusion pump with replaceable memory cartridges
US5425716A (en) * 1991-08-09 1995-06-20 Atom Kabushiki Kaisha Infusion apparatus
DK194291D0 (en) * 1991-11-29 1991-11-29 Novo Nordisk As SPRAY FOR AUTOMATIC INJECTION.
US5279586A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
FR2690622B1 (en) * 1992-04-29 1995-01-20 Chronotec Programmable ambulatory infusion pump system.
US5383865A (en) * 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5540664A (en) * 1993-05-27 1996-07-30 Washington Biotech Corporation Reloadable automatic or manual emergency injection system
US5536249A (en) * 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11554215B2 (en) 2017-06-08 2023-01-17 Novartis Ag Injection device and injection solution transferring system

Also Published As

Publication number Publication date
AU1860697A (en) 1997-07-28
ES2149499T3 (en) 2000-11-01
EP0850079A1 (en) 1998-07-01
DE69608567D1 (en) 2000-06-29
CA2231481C (en) 2008-01-22
DK0850079T3 (en) 2000-11-20
DE69608567T2 (en) 2001-02-01
JP3835817B2 (en) 2006-10-18
US5820602A (en) 1998-10-13
WO1997009080A1 (en) 1997-03-13
EP0850079B1 (en) 2000-05-24
ATE193215T1 (en) 2000-06-15
JPH11512303A (en) 1999-10-26

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