CA2232986A1 - Bone grafting matrix - Google Patents

Bone grafting matrix

Info

Publication number
CA2232986A1
CA2232986A1 CA002232986A CA2232986A CA2232986A1 CA 2232986 A1 CA2232986 A1 CA 2232986A1 CA 002232986 A CA002232986 A CA 002232986A CA 2232986 A CA2232986 A CA 2232986A CA 2232986 A1 CA2232986 A1 CA 2232986A1
Authority
CA
Canada
Prior art keywords
matrix
bone grafting
grafting matrix
biodegradable
microns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002232986A
Other languages
French (fr)
Other versions
CA2232986C (en
Inventor
Michael K. Kwan
Stephen D. Pacetti
Ronald K. Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Spine LLC
Original Assignee
Orquest, Inc.
Michael K. Kwan
Stephen D. Pacetti
Ronald K. Yamamoto
Depuy Acromed, Inc.
Depuy Spine, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orquest, Inc., Michael K. Kwan, Stephen D. Pacetti, Ronald K. Yamamoto, Depuy Acromed, Inc., Depuy Spine, Inc. filed Critical Orquest, Inc.
Publication of CA2232986A1 publication Critical patent/CA2232986A1/en
Application granted granted Critical
Publication of CA2232986C publication Critical patent/CA2232986C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30092—Properties of materials and coating materials using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A61F2310/00383—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

A porous three-dimensional bone grafting matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix and having a particle size of 5 microns or less.
CA002232986A 1995-10-16 1996-10-15 Bone grafting matrix Expired - Fee Related CA2232986C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US552395P 1995-10-16 1995-10-16
US60/005,523 1995-10-16
US08/633,554 1996-04-17
US08/633,554 US5776193A (en) 1995-10-16 1996-04-17 Bone grafting matrix
PCT/US1996/016496 WO1997014376A1 (en) 1995-10-16 1996-10-15 Bone grafting matrix
US10/086,225 US6764517B2 (en) 1995-10-16 2002-02-22 Tissue repair matrix

Publications (2)

Publication Number Publication Date
CA2232986A1 true CA2232986A1 (en) 1997-04-24
CA2232986C CA2232986C (en) 2008-11-25

Family

ID=28046145

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002232986A Expired - Fee Related CA2232986C (en) 1995-10-16 1996-10-15 Bone grafting matrix
CA2476929A Expired - Fee Related CA2476929C (en) 1995-10-16 2003-02-21 Tissue repair matrix

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2476929A Expired - Fee Related CA2476929C (en) 1995-10-16 2003-02-21 Tissue repair matrix

Country Status (13)

Country Link
US (4) US5776193A (en)
EP (2) EP0855884B1 (en)
JP (2) JP4275732B2 (en)
CN (2) CN1172724C (en)
AT (2) ATE270078T1 (en)
AU (2) AU705303B2 (en)
CA (2) CA2232986C (en)
DE (1) DE69632829T2 (en)
DK (1) DK0855884T3 (en)
ES (1) ES2224182T3 (en)
NZ (2) NZ321756A (en)
PT (1) PT855884E (en)
WO (2) WO1997014376A1 (en)

Families Citing this family (255)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6132674A (en) * 1995-10-12 2000-10-17 Bristol-Myers Squibb Company Method of making an orthopaedic implant having a porous surface
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
IT1282207B1 (en) * 1995-11-20 1998-03-16 Fidia Advanced Biopolymers Srl HUMAN BONE MARROW STEM CELL CULTURE SYSTEMS IN THREE-DIMENSIONAL MATRIXES CONSISTING OF HYALURONIC ACID ESTERS
US20110207666A1 (en) * 1996-03-05 2011-08-25 Depuy Spine, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US6221854B1 (en) * 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US20020098222A1 (en) * 1997-03-13 2002-07-25 John F. Wironen Bone paste
AU738334B2 (en) * 1997-05-30 2001-09-13 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US7524335B2 (en) * 1997-05-30 2009-04-28 Smith & Nephew, Inc. Fiber-reinforced, porous, biodegradable implant device
DE19726412A1 (en) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implant material with a carrier-drug combination
US6241771B1 (en) * 1997-08-13 2001-06-05 Cambridge Scientific, Inc. Resorbable interbody spinal fusion devices
US6296667B1 (en) * 1997-10-01 2001-10-02 Phillips-Origen Ceramic Technology, Llc Bone substitutes
US6977095B1 (en) * 1997-10-01 2005-12-20 Wright Medical Technology Inc. Process for producing rigid reticulated articles
US20040081704A1 (en) * 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US20030147860A1 (en) 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
DE19855890A1 (en) * 1998-12-03 2000-06-08 Nerlich Michael Porous composite matrix, its production and use
US6224629B1 (en) * 1998-12-09 2001-05-01 Purzer Pharmaceuticals Co. Ltd. Bone substitute composition and process of preparation thereof
IT1302534B1 (en) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl INJECTABLE, BIOCOMPATIBLE AND BIODEGRADABLE COMPOSITIONS INCLUDING AT LEAST A DERIVATIVE OF HYALURONIC ACID, CHONDROGENIC CELLS, FOR
DE19962090B4 (en) * 1998-12-22 2014-07-17 Karl Weis Process for the production of moldings
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
WO2000045870A1 (en) * 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Osteogenic paste compositions and uses thereof
AU772682B2 (en) * 1999-02-04 2004-05-06 Warsaw Orthopedic, Inc. Highly-mineralized osteogenic sponge compositions, and uses thereof
JP4472804B2 (en) * 1999-05-18 2010-06-02 学校法人松本歯科大学 Bone filler and method for producing the same
WO2001000792A1 (en) 1999-06-29 2001-01-04 Marchosky J Alexander Compositions and methods for forming and strengthening bone
CA2379683A1 (en) * 1999-07-20 2001-01-25 University Of Southern California Identification of pluripotent pre-mesenchymal, pre-hematopoietic progenitor cell
US6458162B1 (en) * 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US6162258A (en) * 1999-08-25 2000-12-19 Osteotech, Inc. Lyophilized monolithic bone implant and method for treating bone
DE19956503A1 (en) * 1999-11-24 2001-06-21 Universitaetsklinikum Freiburg Sprayable bone replacement material
KR100331608B1 (en) * 1999-11-25 2002-04-09 김정근 Process for manufacturing of bone graft materials using animal bones
WO2001082828A2 (en) * 2000-04-28 2001-11-08 Anthony Atala Tissue engineered testicular prosthesis and use thereof
EP1284756B1 (en) * 2000-05-31 2004-09-15 Mnemoscience GmbH Shape memory thermoplastics and polymer networks for tissue engineering
DE10028975B4 (en) * 2000-06-16 2005-06-30 Henkel Kgaa Compositions for the treatment of tooth and / or bone tissue
DE10029520A1 (en) * 2000-06-21 2002-01-17 Merck Patent Gmbh Coating for metallic implant materials
US7726319B1 (en) 2000-08-24 2010-06-01 Osteotech, Inc. Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization
AU2002225862B2 (en) * 2000-10-24 2005-05-12 Warsaw Orthopedic, Inc. Spinal fusion methods and devices
AU1185002A (en) * 2000-10-31 2002-05-15 Orquest Inc Mineralized collagen-polysaccharide matrix for bone and cartilage repair
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
WO2002059395A2 (en) * 2000-12-28 2002-08-01 The Board Of Regents Of The University Of Nebraska Electrolytic deposition of coatings for prosthetic metals and alloys
US6558709B2 (en) * 2001-01-05 2003-05-06 Howmedica Osteonics Corp. Calcium phosphate composition and method of preparing same
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US7763769B2 (en) * 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) * 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US20020115742A1 (en) * 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
JP4790917B2 (en) * 2001-02-23 2011-10-12 独立行政法人科学技術振興機構 Artificial vertebral body
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
GB0115320D0 (en) * 2001-06-22 2001-08-15 Univ Nottingham Matrix
IL144446A0 (en) * 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
JP2003180820A (en) * 2001-10-09 2003-07-02 Techno Network Shikoku Co Ltd Biological material, drug, food, medical instrument, cell culture instrument and process of producing tissue- inducible material
JP4403268B2 (en) * 2001-10-21 2010-01-27 独立行政法人産業技術総合研究所 Method for producing calcium phosphate porous sintered body and method for producing artificial bone using the same
JP2003169845A (en) * 2001-12-07 2003-06-17 Japan Science & Technology Corp Sponge-like porous apatite-collagen composite, sponge-like superporous apatite-collagen composite and method of manufacturing the same
ES2354871T3 (en) * 2002-02-22 2011-03-18 Depuy Spine, Inc. TISSULAR REPAIR MATRIX.
TW200400062A (en) * 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
US7247288B2 (en) * 2002-04-18 2007-07-24 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
US7776600B2 (en) 2002-04-18 2010-08-17 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
EP1523342B1 (en) 2002-04-29 2009-07-22 Biomet Deutschland GmbH Structured composites as a matrix (scaffold) for the tissue engineering of bones
JP3727059B2 (en) * 2002-05-01 2005-12-14 独立行政法人科学技術振興機構 Method for producing porous composite material
US20030225347A1 (en) * 2002-06-03 2003-12-04 Argenta Louis C. Directed tissue growth employing reduced pressure
US7166133B2 (en) * 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
GB0224986D0 (en) 2002-10-28 2002-12-04 Smith & Nephew Apparatus
KR100872079B1 (en) * 2002-11-06 2008-12-05 도쿠리츠교세이호징 붓시쯔 자이료 겐큐키코 Apatite/collagen crosslinked porous material containing self-organized apatite/collagen composite and process for producing the same
ITMI20030186A1 (en) * 2003-02-05 2004-08-06 Consiglio Nazionale Ricerche ARTIFICIAL BONE TISSUE SYNTHESIS PROCEDURE,
GB0307011D0 (en) * 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
JP4680771B2 (en) * 2003-05-26 2011-05-11 Ｈｏｙａ株式会社 Calcium phosphate-containing composite porous body and method for producing the same
WO2005000483A1 (en) * 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
DE10328892A1 (en) * 2003-06-26 2005-05-12 Curasan Ag Bone building agent and manufacturing process
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
JP4699902B2 (en) * 2003-10-27 2011-06-15 Ｈｏｙａ株式会社 Calcium phosphate ceramic porous body and method for producing the same
JP4671596B2 (en) * 2003-11-26 2011-04-20 京セラ株式会社 Porous bone repair material and method for producing the same
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
EP1701729B1 (en) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Improved bone matrix compositions and methods
US7189263B2 (en) * 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
JP4643166B2 (en) * 2004-03-30 2011-03-02 独立行政法人物質・材料研究機構 Method for controlling average pore diameter of porous material containing apatite / collagen composite fiber
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US10058642B2 (en) 2004-04-05 2018-08-28 Bluesky Medical Group Incorporated Reduced pressure treatment system
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
GB0409446D0 (en) 2004-04-28 2004-06-02 Smith & Nephew Apparatus
US20070009606A1 (en) * 2004-05-12 2007-01-11 Serdy James G Manufacturing process, such as three dimensional printing, including binding of water-soluble material followed by softening and flowing and forming films of organic-solvent-soluble material
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US20090012625A1 (en) * 2004-09-14 2009-01-08 Ying Jackie Y Porous biomaterial-filler composite and method for making the same
US7722895B1 (en) * 2004-09-20 2010-05-25 Warsaw Orthopedic, Inc. Osteogenic implants with combined implant materials, and materials and methods for same
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
KR101153785B1 (en) 2004-10-25 2012-07-09 셀로노바 바이오사이언시스 저머니 게엠베하 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US7732573B2 (en) * 2004-10-28 2010-06-08 National Institute For Materials Science Method for producing porous body comprising apatite/collagen composite fibers
DE102005016443A1 (en) * 2004-11-23 2006-05-24 Ossacur Ag Bioabsorbable and mineralized material, useful for filling of bone defects, comprises a collagen matrix from aggregated collagen chains, where only the surface of the aggregated collagen chain is mineralized
EP1819371A2 (en) * 2004-11-23 2007-08-22 Ossacur AG Bioresorbable, surface-mineralised material for filling osseous defects
WO2006062518A2 (en) 2004-12-08 2006-06-15 Interpore Spine Ltd. Continuous phase composite for musculoskeletal repair
US20070038303A1 (en) * 2006-08-15 2007-02-15 Ebi, L.P. Foot/ankle implant and associated method
US8535357B2 (en) * 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
DE102005034420A1 (en) * 2004-12-23 2006-07-06 Ossacur Ag Gel-like material for filling bone and / or cartilage defects
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US7740794B1 (en) 2005-04-18 2010-06-22 Biomet Sports Medicine, Llc Methods of making a polymer and ceramic composite
US8506646B2 (en) * 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
US7857853B2 (en) 2005-04-29 2010-12-28 Sdgi Holdings, Inc Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture
US20060251628A1 (en) * 2005-05-06 2006-11-09 Mohamed Attawia Defatted, dewatered bone marrow
US8518436B2 (en) * 2005-05-16 2013-08-27 Purdue Research Foundation Engineered extracellular matrices
GB0517499D0 (en) 2005-08-26 2005-10-05 West Hertfordshire Hospitals N Surgical scaffold
CA2620663A1 (en) * 2005-09-02 2007-03-08 Colbar Lifescience Ltd. Cross-linked polysaccharide and protein matrices and methods for their preparation
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US9005646B2 (en) 2005-10-12 2015-04-14 Lifenet Health Compositions for repair of defects in tissues, and methods of making the same
US9132208B2 (en) * 2008-08-07 2015-09-15 Lifenet Health Composition for a tissue repair implant and methods of making the same
AU2006308534B2 (en) * 2005-11-01 2013-02-07 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
EP1951331A4 (en) * 2005-11-14 2010-03-24 Seoul Nat Univ Ind Foundation Method for producing collagen/apatite composite membrane for guided bone regeneration
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
AU2007207429A1 (en) 2006-01-19 2007-07-26 Warsaw Orthopedic, Inc. Injectable and moldable bone substitute materials
US20070173949A1 (en) * 2006-01-25 2007-07-26 Sharps Lewis S Bonding system for orthopedic implants
US7939092B2 (en) * 2006-02-01 2011-05-10 Warsaw Orthopedic, Inc. Cohesive osteogenic putty and materials therefor
DE102006011211A1 (en) * 2006-03-02 2007-09-06 Ossacur Ag Material for the treatment of bone and / or cartilage defects
EP2007317A2 (en) * 2006-04-05 2008-12-31 University Of Nebraska Bioresorbable polymer reconstituted bone and methods of formation thereof
US20070269476A1 (en) 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
CA2656050C (en) 2006-06-29 2015-02-03 Orthovita, Inc. Kit for bone graft comprising collagen,calcium phosphate,and bioactive glass
CN101505689B (en) 2006-08-22 2012-08-29 三菱电机株式会社 Laser processing apparatus, method of bone junction, implant member, process for producing implant member, and implant member production apparatus
JP2008061897A (en) * 2006-09-08 2008-03-21 Saga Univ Living body implant
WO2008036393A1 (en) 2006-09-21 2008-03-27 Purdue Research Foundation Collagen preparation and method of isolation
DE102006048833A1 (en) * 2006-10-16 2008-04-17 Universität Rostock Combination for preparing medicine product for treatment of osteoporosis, prophylaxis or bone fractures, or for anchorage of implants, comprises calcium-containing substance and cross linking agent
AU2007333425B2 (en) * 2006-11-03 2014-03-27 Biomimetic Therapeutics, Llc Compositions and methods for arthrodetic procedures
US7931651B2 (en) 2006-11-17 2011-04-26 Wake Lake University Health Sciences External fixation assembly and method of use
US7381224B1 (en) 2006-12-08 2008-06-03 Collagen Matrix, Inc. Bone implant composite
US7544212B2 (en) * 2006-12-08 2009-06-09 Collagen Matrix, Inc. Bone implant composite
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US8048857B2 (en) * 2006-12-19 2011-11-01 Warsaw Orthopedic, Inc. Flowable carrier compositions and methods of use
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8377016B2 (en) 2007-01-10 2013-02-19 Wake Forest University Health Sciences Apparatus and method for wound treatment employing periodic sub-atmospheric pressure
EP1964583A1 (en) 2007-02-09 2008-09-03 Royal College of Surgeons in Ireland Process for producing a collagen/hydroxyapatite composite scaffold
US8431148B2 (en) * 2007-03-08 2013-04-30 Warsaw Orthopedic, Inc. Bone void filler
AU2008265852B2 (en) 2007-06-15 2014-04-17 Warsaw Orthopedic, Inc. Method of treating tissue
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
EP2167147B1 (en) 2007-06-15 2017-03-29 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
ITMI20071298A1 (en) * 2007-06-29 2008-12-30 Univ Bologna Alma Mater POROUS COMPOSITE MATERIAL, RELATED PREPARATION PROCESS AND ITS USE FOR THE DEVELOPMENT OF DEVICES FOR TISSUE ENGINEERING
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
CA2695697A1 (en) 2007-08-07 2009-02-12 Advanced Technologies And Regenerative Medicine, Llc Protein formulations comprising gdf-5 in aqueous acidic solution
EP2214641A1 (en) * 2007-10-08 2010-08-11 Sureshan Sivanthan A scalable matrix for the in vivo cultivation of bone and cartilage
BRPI0817544A2 (en) 2007-10-10 2017-05-02 Univ Wake Forest Health Sciences apparatus for treating damaged spinal cord tissue
US8202539B2 (en) * 2007-10-19 2012-06-19 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
US7998499B2 (en) * 2007-10-25 2011-08-16 Collagen Matrix, Inc. Calcium-containing bone implants
JP2009132601A (en) * 2007-11-01 2009-06-18 Hoya Corp Porous body comprising apatite/collagen composite fiber and its production method
WO2009061887A2 (en) * 2007-11-06 2009-05-14 University Of Connecticut Ceramic/structural protein composites and method of preparation thereof
US9149563B2 (en) * 2007-11-06 2015-10-06 The University Of Connecticut Calcium phosphate/structural protein composites and method of preparation thereof
US20090131867A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system with cavity creation element
US20090131886A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system
US9510885B2 (en) 2007-11-16 2016-12-06 Osseon Llc Steerable and curvable cavity creation system
GB0722820D0 (en) 2007-11-21 2008-01-02 Smith & Nephew Vacuum assisted wound dressing
EP3254650B1 (en) 2007-11-21 2020-01-08 Smith & Nephew plc Wound dressing
EP2217298B1 (en) 2007-11-21 2015-11-11 T.J. Smith & Nephew Limited Suction device and dressing
GB0723875D0 (en) 2007-12-06 2008-01-16 Smith & Nephew Wound management
US11253399B2 (en) 2007-12-06 2022-02-22 Smith & Nephew Plc Wound filling apparatuses and methods
US9867905B2 (en) 2007-12-10 2018-01-16 Purdue Research Foundation Collagen-based matrices with stem cells
CA2711847C (en) * 2008-01-09 2018-05-08 Innovative Health Technologies, Llc Implant pellets and methods for performing bone augmentation and preservation
WO2009089435A1 (en) 2008-01-09 2009-07-16 Wake Forest University Health Sciences Device and method for treating central nervous system pathology
US20110008460A1 (en) * 2008-01-11 2011-01-13 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite composite materials and methods for the preparation thereof
GB0803564D0 (en) 2008-02-27 2008-04-02 Smith & Nephew Fluid collection
US20140031944A1 (en) * 2008-03-18 2014-01-30 Yoh Sawatari Cylindrical graft and method for preparing a recipient site and implanting a cylindrical graft into alveolar jaw bone
JP5458237B2 (en) * 2008-04-02 2014-04-02 ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 Expandable porous body comprising apatite / collagen composite and method for producing the same
US7947649B2 (en) * 2008-04-14 2011-05-24 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
US9616153B2 (en) 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
US20090263507A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use
ES2565185T3 (en) 2008-04-18 2016-04-01 Collplant Ltd. Methods of generation and use of procollagen
US20090263458A1 (en) * 2008-04-21 2009-10-22 Lasse Daniel Efskind Material for surgical use in traumatology
WO2009132229A2 (en) * 2008-04-24 2009-10-29 Medtronic, Inc. Cold ionizing radiation sterilization
JP2009268685A (en) * 2008-05-07 2009-11-19 Hoya Corp Artificial bone formed by covering it with apatite/collagen complex and its production method
KR20100007180A (en) * 2008-07-11 2010-01-22 세원셀론텍(주) Method manufacture of bone recovery collagen gel composition
RU2544093C2 (en) 2008-07-18 2015-03-10 Уэйк Форест Юниверсити Хелс Сайенсиз Device and method for cardiac tissue modulation by local application of pressure below atmospheric for minimising cell death and injury
KR100932945B1 (en) 2009-01-16 2009-12-21 원광대학교산학협력단 Solid scaffold formed with bone powder and fibrin glue
US9220598B2 (en) 2009-02-12 2015-12-29 Warsaw Orthopedic, Inc. Delivery systems, tools, and methods of use
US10806833B1 (en) 2009-05-11 2020-10-20 Integra Lifesciences Corporation Adherent resorbable matrix
US20100298832A1 (en) 2009-05-20 2010-11-25 Osseon Therapeutics, Inc. Steerable curvable vertebroplasty drill
EP3718579A1 (en) * 2009-07-23 2020-10-07 NuVasive Netherlands B.V. Injectable and moldable osteoinductive ceramic materials
ES2606042T3 (en) * 2009-10-29 2017-03-17 Prosidyan, Inc. Dynamic bioactive bone graft material and methods for handling
ES2672590T3 (en) 2009-10-29 2018-06-15 Prosidyan, Inc. Dynamic bioactive bone graft material that has a designed porosity
US8758791B2 (en) 2010-01-26 2014-06-24 Warsaw Orthopedic, Inc. Highly compression resistant matrix with porous skeleton
WO2015147923A1 (en) 2010-03-03 2015-10-01 Novabone Products, Llc Kit for delivering bone grafting materials
US8795702B2 (en) * 2010-03-03 2014-08-05 Novabone Products, Llc Devices and methods for the regeneration of bony defects
US9144629B2 (en) 2010-03-03 2015-09-29 Novabone Products, Llc Ionically crosslinked materials and methods for production
CN101791438B (en) * 2010-03-16 2013-02-27 浙江大学 Method for preparing bioactive poly(lactic-co-glycolic acid)/collagen/hydroxyapatite composite fiber membrane for bone repair
US9492590B2 (en) 2010-04-16 2016-11-15 Apatech Limited Biomaterial
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
EP2563233B1 (en) 2010-04-29 2020-04-01 Dfine, Inc. System for use in treatment of vertebral fractures
US9295695B2 (en) * 2010-04-30 2016-03-29 Skeletal Kinetics, Llc Temperature-insensitive calcium phosphate cements
AU2011250934B2 (en) 2010-05-11 2016-02-25 Howmedica Osteonics Corp., Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
US8858577B2 (en) 2010-05-19 2014-10-14 University Of Utah Research Foundation Tissue stabilization system
GB201011173D0 (en) 2010-07-02 2010-08-18 Smith & Nephew Provision of wound filler
US8877220B2 (en) * 2010-08-05 2014-11-04 Collagen Matrix, Inc. Self-expandable biopolymer-mineral composite
US9339387B2 (en) 2010-10-13 2016-05-17 Cibor, Inc. Synthetic bone grafts constructed from carbon foam materials
US8926710B2 (en) 2010-10-25 2015-01-06 Warsaw Orthopedic, Inc. Osteoinductive bone graft injectable cement
WO2012068135A1 (en) 2010-11-15 2012-05-24 Zimmer Orthobiologics, Inc. Bone void fillers
GB201020005D0 (en) 2010-11-25 2011-01-12 Smith & Nephew Composition 1-1
MX337627B (en) 2010-11-25 2016-03-10 Smith & Nephew Composition i-ii and products and uses thereof.
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US9119728B2 (en) 2011-01-17 2015-09-01 Cibor, Inc. Reinforced carbon fiber/carbon foam intervertebral spine fusion device
US8852214B2 (en) 2011-02-04 2014-10-07 University Of Utah Research Foundation System for tissue fixation to bone
CN103476440B (en) * 2011-02-25 2016-10-19 新特斯有限责任公司 Promote implant and the method for induction of bone growth of skeletonization
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
EP2529764A1 (en) 2011-05-31 2012-12-05 Curasan AG Biodegradable composite material
US20150159066A1 (en) 2011-11-25 2015-06-11 Smith & Nephew Plc Composition, apparatus, kit and method and uses thereof
WO2013142763A1 (en) 2012-03-22 2013-09-26 University Of Connecticut Biomimetic scaffold for bone regeneration
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
CN102805881B (en) * 2012-06-18 2014-02-19 浙江星月生物科技股份有限公司 Collagen basal bone cartilage three-layer compound and preparation method thereof
US20130345826A1 (en) 2012-06-22 2013-12-26 Collagen Matrix, Inc. Implants for Bone and Cartilage Repair
US11944531B2 (en) 2012-07-30 2024-04-02 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9629632B2 (en) 2012-07-30 2017-04-25 Conextions, Inc. Soft tissue repair devices, systems, and methods
US11253252B2 (en) 2012-07-30 2022-02-22 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9427309B2 (en) 2012-07-30 2016-08-30 Conextions, Inc. Soft tissue repair devices, systems, and methods
US11957334B2 (en) 2012-07-30 2024-04-16 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10390935B2 (en) 2012-07-30 2019-08-27 Conextions, Inc. Soft tissue to bone repair devices, systems, and methods
US10219804B2 (en) 2012-07-30 2019-03-05 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10835241B2 (en) 2012-07-30 2020-11-17 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9066853B2 (en) * 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
US9381274B2 (en) 2013-03-14 2016-07-05 Prosidyan, Inc. Bone graft implants containing allograft
US8889178B2 (en) 2013-03-14 2014-11-18 Prosidyan, Inc Bioactive porous bone graft compositions in synthetic containment
US8883195B2 (en) 2013-03-14 2014-11-11 Prosidyan, Inc. Bioactive porous bone graft implants
US20160120706A1 (en) 2013-03-15 2016-05-05 Smith & Nephew Plc Wound dressing sealant and use thereof
RU2563621C2 (en) * 2013-09-16 2015-09-20 Федеральное государственное бюджетное учреждение науки Институт физики полупроводников им. А.В. Ржанова Сибирского отделения Российской академии наук (ИФП СО РАН) Bioresorbable polymer cell matrix
CN103536965B (en) * 2013-09-24 2014-11-05 北京大学口腔医学院 Preparation method for three-dimensional mineralized collagen bracket with strict grade structure as well as product and application of three-dimensional mineralized collagen bracket
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) * 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
US11583384B2 (en) 2014-03-12 2023-02-21 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9895354B2 (en) 2014-04-04 2018-02-20 University Of Kentucky Research Foundation Bilayered calcium sulfate/calcium phosphate space-making composites with multiple drug delivery capabilities
US9539363B2 (en) * 2014-04-24 2017-01-10 Warsaw Orthopedic, Inc. Collagen matrix
CN104147641B (en) * 2014-07-11 2016-08-31 深圳职业技术学院 A kind of for personalized bone renovating material and its preparation method
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
US11919941B2 (en) 2015-04-21 2024-03-05 Purdue Research Foundation Cell-collagen-silica composites and methods of making and using the same
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US9580543B1 (en) * 2016-02-05 2017-02-28 Xerox Corporation Method of making branched polyester resin with a target glass transition temperature
FI127762B (en) * 2016-09-19 2019-02-15 Tty Saeaetioe Method for producing porous composite material
US11696822B2 (en) 2016-09-28 2023-07-11 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
CN109862834B (en) 2016-10-27 2022-05-24 Dfine有限公司 Bendable osteotome with cement delivery channel
CN110368531A (en) * 2016-10-31 2019-10-25 北京奥精医药科技有限公司 Mineralized collagen base alveolar bone repairing material and preparation method thereof
JP7256119B2 (en) 2016-11-28 2023-04-11 ディファイン インコーポレイテッド Tumor resection device and related method
CN110035704B (en) 2016-12-09 2022-09-06 Dfine有限公司 Medical device for treating hard tissue and related methods
WO2018129180A1 (en) 2017-01-06 2018-07-12 Dfine, Inc. Osteotome with a distal portion for simultaneous advancement and articulation
CN106798949B (en) * 2017-02-22 2019-09-20 福建吉特瑞生物科技有限公司 A kind of porous hydroxyapatite bone renovating material and preparation method thereof
CA3061428A1 (en) 2017-04-25 2018-11-01 Purdue Research Foundation 3-dimensional (3d) tissue-engineered muscle for tissue restoration
US11547397B2 (en) 2017-12-20 2023-01-10 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10973509B2 (en) 2017-12-20 2021-04-13 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11116647B2 (en) 2018-04-13 2021-09-14 Surgentec, Llc Bone graft delivery system and method for using same
US10687828B2 (en) 2018-04-13 2020-06-23 Surgentec, Llc Bone graft delivery system and method for using same
EP3876856A4 (en) 2018-11-08 2022-10-12 Dfine, Inc. Tumor ablation device and related systems and methods
WO2021111172A1 (en) 2019-12-04 2021-06-10 Datum Dental Ltd. A collagen-hydroxyapatite device for non-surgical periodontal treatment
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same
CN112494463B (en) * 2020-11-23 2022-10-18 潍坊医学院 Berberine/mineralized collagen composite membrane as well as preparation method and application thereof
CN114425104B (en) * 2021-12-21 2023-03-03 中国人民解放军空军军医大学 Medicine-carrying bone guiding/inducing composite structure and preparation method and application thereof
WO2023150739A2 (en) * 2022-02-07 2023-08-10 Moskovitz Martin J Cryo-surgical device and materials and method of use thereof

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1271763A (en) * 1969-05-12 1972-04-26 Fmc Corp New or improved structures for example, prstuetic structures, and a method of preparing them
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4789663A (en) * 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
US4888366A (en) * 1984-10-24 1989-12-19 Collagen Corporation Inductive collagen-based bone repair preparations
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US5246457A (en) * 1985-03-28 1993-09-21 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
CA1260391A (en) * 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
US4780450A (en) * 1985-12-20 1988-10-25 The University Of Maryland At Baltimore Physically stable composition and method of use thereof for osseous repair
US4698326A (en) * 1985-12-20 1987-10-06 Regents Of The University Of Minnesota Composition and method for osseous repair
US5133755A (en) * 1986-01-28 1992-07-28 Thm Biomedical, Inc. Method and apparatus for diodegradable, osteogenic, bone graft substitute device
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
CA1339083C (en) * 1987-11-13 1997-07-29 Steven R. Jefferies Bone repair material and delayed drug delivery system
US4863732A (en) * 1987-12-16 1989-09-05 Collagen Corporation Injectable composition for inductive bone repair
GB2215209B (en) 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
GB8819755D0 (en) * 1988-08-19 1988-09-21 Geistlich Soehne Ag Chemical compound
US5264214A (en) * 1988-11-21 1993-11-23 Collagen Corporation Composition for bone repair
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5092883A (en) * 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
DE3907663A1 (en) * 1989-03-09 1990-09-13 Espe Stiftung BONE REPLACEMENT FROM GLASIONOMIC CEMENT
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5071655A (en) * 1990-01-12 1991-12-10 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5219998A (en) * 1990-06-04 1993-06-15 Levin Robert H Yeast-derived epidermal growth factor
DE69120177T2 (en) * 1990-09-10 1996-10-10 Synthes Ag Bone regeneration membrane
US5231169A (en) * 1990-10-17 1993-07-27 Norian Corporation Mineralized collagen
JP3356775B2 (en) * 1990-11-30 2002-12-16 セルトリックス ファーマシューティカルズ， インコーポレイテッド Use of osteogenic proteins for bone repair by co-combination with TGF-β
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
JP3064470B2 (en) * 1991-04-19 2000-07-12 杉郎 大谷 Artificial prosthetic materials
CA2102808A1 (en) * 1991-05-10 1992-11-11 Hanne Bentz Targeted delivery of bone growth factors
DE4120325A1 (en) * 1991-06-20 1992-12-24 Merck Patent Gmbh IMPLANT MATERIAL
DE4121043A1 (en) * 1991-06-26 1993-01-07 Merck Patent Gmbh BONE REPLACEMENT MATERIAL WITH FGF
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5306303A (en) * 1991-11-19 1994-04-26 The Medical College Of Wisconsin, Inc. Bone induction method
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
CA2117379C (en) * 1992-02-14 1999-11-16 Kypriacos A. Athanasiou Multi-phase bioerodible implant/carrier and method of manufacturing and using same
DE69302680D1 (en) * 1992-02-21 1996-06-20 Ici Plc OXIDATION CATALYSTS
US5532217A (en) * 1992-04-24 1996-07-02 Silver; Frederick H. Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone
IL106159A0 (en) * 1992-06-30 1993-10-20 Dow Chemical Co Targeted delivery of growth factors for bone regeneration
WO1994001483A1 (en) 1992-07-02 1994-01-20 Collagen Corporation Biocompatible polymer conjugates
EP0679097B1 (en) * 1993-01-12 1997-05-28 Genentech, Inc. Tgf-beta formulation for inducing bone growth
US5531794A (en) * 1993-09-13 1996-07-02 Asahi Kogaku Kogyo Kabushiki Kaisha Ceramic device providing an environment for the promotion and formation of new bone
JP3061732B2 (en) * 1993-09-13 2000-07-10 旭光学工業株式会社 Ceramics functional material providing a place for osteoinduction and bone formation, and method for producing the same
WO1995008304A1 (en) * 1993-09-21 1995-03-30 The Penn State Research Foundation Bone substitute composition comprising hydroxyapatite and a method of production therefor
JP3410195B2 (en) * 1994-02-28 2003-05-26 テルモ株式会社 Composite material of bioabsorbable plastic and collagen
US5577792A (en) * 1995-02-21 1996-11-26 Prince Corporation Multiple visor system with aligned pivot axes
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6902584B2 (en) * 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix

Also Published As

Publication number Publication date
CA2232986C (en) 2008-11-25
US6187047B1 (en) 2001-02-13
DE69632829D1 (en) 2004-08-05
US5776193A (en) 1998-07-07
EP0855884B1 (en) 2004-06-30
ATE490744T1 (en) 2010-12-15
ES2224182T3 (en) 2005-03-01
EP1482872A1 (en) 2004-12-08
EP1482872A4 (en) 2006-02-15
AU2003213235B2 (en) 2008-09-11
JPH11513590A (en) 1999-11-24
CN1646070A (en) 2005-07-27
US20040220680A1 (en) 2004-11-04
JP2007007452A (en) 2007-01-18
CA2476929C (en) 2011-06-21
CA2476929A1 (en) 2003-09-04
DE69632829T2 (en) 2005-04-14
US6764517B2 (en) 2004-07-20
WO1997014376A1 (en) 1997-04-24
JP4526525B2 (en) 2010-08-18
WO2003071991A1 (en) 2003-09-04
US7842097B2 (en) 2010-11-30
AU2003213235A1 (en) 2003-09-09
EP1482872B1 (en) 2010-12-08
NZ321756A (en) 1999-11-29
EP0855884A4 (en) 2001-08-08
AU7516796A (en) 1997-05-07
PT855884E (en) 2004-09-30
NZ535466A (en) 2005-08-26
JP4275732B2 (en) 2009-06-10
CN1646070B (en) 2012-06-13
US20020183855A1 (en) 2002-12-05
DK0855884T3 (en) 2004-08-16
AU705303B2 (en) 1999-05-20
CN1172724C (en) 2004-10-27
ATE270078T1 (en) 2004-07-15
CN1204245A (en) 1999-01-06
EP0855884A1 (en) 1998-08-05

Similar Documents

Publication Publication Date Title
CA2232986A1 (en) Bone grafting matrix
EP0838430A4 (en) Fine particles of petaloid porous hydroxyapatite and process for producing the same
AU2759397A (en) Resorbable implant biomaterial made of condensed calcium phosphate particles
AU6946198A (en) Calcium phosphate microcarriers and microspheres
HUP9901130A3 (en) Reactive amorphous calcium phosphate, method of its manufacture and use of the same
EP0846666A4 (en) Calcium silicate plate and process for producing the plate
HUP9900239A3 (en) Modified avidin and streptavidin molecules and use thereof
PL327057A1 (en) Method of obtaining fine calcium carbonate particles
AU7436096A (en) Purifying highly impure calcium hydroxide and producing high-value precipitated calcium carbonate and other calcium products
AU691136B2 (en) Process for producing ultrafine particles of colloidal calcium carbonate
AU9283798A (en) Artificial dura mater and process for producing dura mater
AU2938897A (en) Hollow bone mineral-like calcium phosphate particles
AU7887698A (en) Novel water-in-oil microencapsulation process and microcapsules produced thereby
AU1505297A (en) Calcium silicate board and method of manufacture therefor
EP0778304A3 (en) Hydrophobic resorbable polyesters and their use
AU3461597A (en) Water-insoluble porous particles of biocompatible substances and process for producing the same
AU6109196A (en) Modified avidin and streptavidin and methods of use thereof
AU8273398A (en) Method for producing high solids aqueous acid-resistant calcium carbonate suspensions and product thereof
AUPN244895A0 (en) Railway plate and method of manufacture
AU5162596A (en) Composition containing readily absorbable calcium and proces s for producing the same
AU5320496A (en) Hydroxyapatite forming dry particulate agglomerate and methods therefor
AU6872796A (en) Polyisocyanate particles of controlled particle size and particle size distribution
AU1462697A (en) Polyester particles
AU6138996A (en) Calcium silicate board and method of manufacturing same
AU6766494A (en) Microfluidization of calcium/oxyanion-containing particles

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20131015