CA2234233A1 - Retrievable bioartificial implants - Google Patents
Retrievable bioartificial implantsInfo
- Publication number
- CA2234233A1 CA2234233A1 CA002234233A CA2234233A CA2234233A1 CA 2234233 A1 CA2234233 A1 CA 2234233A1 CA 002234233 A CA002234233 A CA 002234233A CA 2234233 A CA2234233 A CA 2234233A CA 2234233 A1 CA2234233 A1 CA 2234233A1
- Authority
- CA
- Canada
- Prior art keywords
- bioartificial
- implants
- retrievable
- thin sheets
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
Bioartificial implant and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology.
Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/542506 | 1995-10-13 | ||
US08/542,506 US5855613A (en) | 1995-10-13 | 1995-10-13 | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
PCT/US1996/016499 WO1997013474A1 (en) | 1995-10-13 | 1996-10-15 | Retrievable bioartificial implants |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2234233A1 true CA2234233A1 (en) | 1997-04-17 |
CA2234233C CA2234233C (en) | 2007-01-16 |
Family
ID=24164114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002234233A Expired - Fee Related CA2234233C (en) | 1995-10-13 | 1996-10-15 | Retrievable bioartificial implants |
Country Status (7)
Country | Link |
---|---|
US (3) | US5855613A (en) |
EP (1) | EP0862391B1 (en) |
AT (1) | ATE297169T1 (en) |
AU (1) | AU725104B2 (en) |
CA (1) | CA2234233C (en) |
DE (1) | DE69634828T2 (en) |
WO (1) | WO1997013474A1 (en) |
Families Citing this family (161)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7018419B2 (en) * | 1994-05-20 | 2006-03-28 | Spielberg Theodore E | Microporous encapsulated endocrine cell disks, biconcave disks and multidimpled chambers for hormonal replacement |
US5855613A (en) * | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
US7657297B2 (en) * | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
US6872387B1 (en) | 1998-02-24 | 2005-03-29 | The Regents Of The University Of Michigan | Three-dimensional hydrogel/cell system |
DE60018571T8 (en) * | 1999-07-28 | 2006-04-27 | Davol Inc. | HERNIENPROTHESE |
US6264695B1 (en) * | 1999-09-30 | 2001-07-24 | Replication Medical, Inc. | Spinal nucleus implant |
US20020151055A1 (en) * | 1999-11-02 | 2002-10-17 | Stegemann Jan Philip | Novel artificial pancreas |
US8012500B2 (en) * | 2000-01-01 | 2011-09-06 | Beta-O2 Technologies Ltd. | Implantable device |
IL134009A (en) * | 2000-01-12 | 2011-07-31 | Bo2 Technologies Ltd | Implantable device |
US6468301B1 (en) | 2000-03-27 | 2002-10-22 | Aga Medical Corporation | Repositionable and recapturable vascular stent/graft |
US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US6638312B2 (en) | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
US7404819B1 (en) | 2000-09-14 | 2008-07-29 | C.R. Bard, Inc. | Implantable prosthesis |
CA2421036A1 (en) | 2000-09-20 | 2002-03-28 | Islet Sheet Medical Llc | Fabrication of thin sheet bio-artificial organs |
WO2003007788A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Unitary surgical device and method |
AU2002316694B2 (en) * | 2001-07-16 | 2007-09-06 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US8025896B2 (en) * | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US7201917B2 (en) * | 2001-07-16 | 2007-04-10 | Depuy Products, Inc. | Porous delivery scaffold and method |
WO2003007839A2 (en) * | 2001-07-16 | 2003-01-30 | Depuy Products, Inc. | Devices form naturally occurring biologically derived |
EP1416878A4 (en) * | 2001-07-16 | 2007-04-18 | Depuy Products Inc | Hybrid biologic-synthetic bioabsorbable scaffolds |
US8092529B2 (en) | 2001-07-16 | 2012-01-10 | Depuy Products, Inc. | Meniscus regeneration device |
US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
DE60239342D1 (en) * | 2001-07-16 | 2011-04-14 | Depuy Products Inc | DEVICE FOR THE REPAIR OF CARTILING MATERIAL |
JP4197157B2 (en) | 2001-07-16 | 2008-12-17 | デピュイ・プロダクツ・インコーポレイテッド | Cartilage repair and reproduction apparatus and method |
US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
WO2003040692A2 (en) * | 2001-11-08 | 2003-05-15 | Vanderbilt University | Method for modeling signal transduction in cells |
US7182961B2 (en) * | 2001-11-20 | 2007-02-27 | Advanced Inhalation Research, Inc. | Particulate compositions for pulmonary delivery |
US6790213B2 (en) | 2002-01-07 | 2004-09-14 | C.R. Bard, Inc. | Implantable prosthesis |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US20030213007A1 (en) * | 2002-03-27 | 2003-11-13 | Slattery Charles Wilbur | Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof |
US20060258761A1 (en) * | 2002-05-22 | 2006-11-16 | Robert Boock | Silicone based membranes for use in implantable glucose sensors |
US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
US20030220696A1 (en) * | 2002-05-23 | 2003-11-27 | Levine David Jerome | Implantable porous metal |
EP2662211A1 (en) | 2002-06-24 | 2013-11-13 | Tufts University | Silk biomaterials and methods of use thereof |
US20040166169A1 (en) * | 2002-07-15 | 2004-08-26 | Prasanna Malaviya | Porous extracellular matrix scaffold and method |
US20040034275A1 (en) * | 2002-07-29 | 2004-02-19 | Peter Forsell | Multi-material incontinence treatment constriction device |
US7025982B2 (en) * | 2002-09-19 | 2006-04-11 | Medtronic, Inc. | Medical assembly suitable for long-term implantation and method for fabricating the same |
US7025791B2 (en) | 2002-12-02 | 2006-04-11 | Gi Dynamics, Inc. | Bariatric sleeve |
WO2004075855A2 (en) * | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
US7134999B2 (en) | 2003-04-04 | 2006-11-14 | Dexcom, Inc. | Optimized sensor geometry for an implantable glucose sensor |
WO2005012606A2 (en) | 2003-04-10 | 2005-02-10 | Tufts University | Concentrated aqueous silk fibroin solution and use thereof |
US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US8282549B2 (en) | 2003-12-09 | 2012-10-09 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
WO2005012871A2 (en) * | 2003-07-25 | 2005-02-10 | Dexcom, Inc. | Increasing bias for oxygen production in an electrode system |
WO2005011520A2 (en) * | 2003-07-25 | 2005-02-10 | Dexcom, Inc. | Oxygen enhancing membrane systems for implantable devices |
US20050176136A1 (en) * | 2003-11-19 | 2005-08-11 | Dexcom, Inc. | Afinity domain for analyte sensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US8257963B2 (en) * | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
US7927599B2 (en) * | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
US7897384B2 (en) * | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
SE526959C2 (en) * | 2003-10-02 | 2005-11-29 | Tikomed Ab | Bioartificial implant comprising a semipermeable barrier and a method for reducing the risk of connective tissue formation in the implant after implantation by providing the barrier with a permeable coating of bioactive metal |
EP1558215A4 (en) * | 2003-10-14 | 2007-09-12 | Wockhardt Ltd | Sterile gelling agents |
US20050090607A1 (en) * | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
WO2005057173A2 (en) * | 2003-12-08 | 2005-06-23 | Dexcom, Inc. | Systems and methods for improving electrochemical analyte sensors |
US20050182451A1 (en) * | 2004-01-12 | 2005-08-18 | Adam Griffin | Implantable device with improved radio frequency capabilities |
US7364592B2 (en) * | 2004-02-12 | 2008-04-29 | Dexcom, Inc. | Biointerface membrane with macro-and micro-architecture |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
WO2009048462A1 (en) | 2007-10-09 | 2009-04-16 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
US20050245799A1 (en) * | 2004-05-03 | 2005-11-03 | Dexcom, Inc. | Implantable analyte sensor |
US20050249772A1 (en) * | 2004-05-04 | 2005-11-10 | Prasanna Malaviya | Hybrid biologic-synthetic bioabsorbable scaffolds |
US7569233B2 (en) * | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
JP5175092B2 (en) | 2004-06-01 | 2013-04-03 | クワラタ トレーディング リミティド | In vitro technology using stem cells |
US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
US8170803B2 (en) | 2004-07-13 | 2012-05-01 | Dexcom, Inc. | Transcutaneous analyte sensor |
WO2006006166A2 (en) | 2004-07-14 | 2006-01-19 | Glusense, Ltd. | Implantable power sources and sensors |
US20060067917A1 (en) * | 2004-09-20 | 2006-03-30 | Athanassios Sambanis | Insulin delivery system |
US7513866B2 (en) * | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
US9788978B2 (en) * | 2004-12-20 | 2017-10-17 | Nicholas A. Rojo | Implantable systems and stents containing cells for therapeutic uses |
US7354627B2 (en) * | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
US9427496B2 (en) | 2005-02-18 | 2016-08-30 | Drexel University | Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering |
US20060246111A1 (en) * | 2005-04-19 | 2006-11-02 | Smith Larry L | Polysaccharides as ultrasound transmission media |
US20060292690A1 (en) * | 2005-06-22 | 2006-12-28 | Cesco Bioengineering Co., Ltd. | Method of making cell growth surface |
US9005654B2 (en) * | 2005-07-27 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Systems and methods for manufacturing liposomes |
WO2007065118A2 (en) * | 2005-12-01 | 2007-06-07 | Innograft, Llc | Method for ionically cross-linking polysaccharide material for thin film applications and products produced therefrom |
TW200734462A (en) * | 2006-03-08 | 2007-09-16 | In Motion Invest Ltd | Regulating stem cells |
WO2007120381A2 (en) | 2006-04-14 | 2007-10-25 | Dexcom, Inc. | Analyte sensor |
EP2029727B1 (en) * | 2006-06-16 | 2012-04-11 | FMC Biopolymer AS | Alginate coated, collagen matrix cellular device, preparative methods, and uses thereof. |
US7758649B2 (en) * | 2006-08-04 | 2010-07-20 | Integrity Intellect Inc. | Reversibly deformable implant |
CN101528166B (en) * | 2006-08-29 | 2014-05-07 | 阿克伦大学 | Implantable devices for producing insulin |
US20100028451A1 (en) | 2006-09-26 | 2010-02-04 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
WO2008062417A2 (en) * | 2006-11-22 | 2008-05-29 | Beta O2 Technologies Ltd. | Protecting algae from body fluids |
ES2659988T3 (en) * | 2006-11-28 | 2018-03-20 | Beta O2 Technologies Ltd. | Oxygen supply for cell transplantation and vascularization |
US7871440B2 (en) * | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
US20100121446A1 (en) * | 2007-02-19 | 2010-05-13 | Ticapex Ab | Implant assembly |
EP2129772B1 (en) | 2007-02-27 | 2016-07-27 | Trustees Of Tufts College | Tissue-engineered silk organs |
US20200037875A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
AU2008262018A1 (en) | 2007-06-08 | 2008-12-18 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US20090010983A1 (en) * | 2007-06-13 | 2009-01-08 | Fmc Corporation | Alginate Coated, Polysaccharide Gel-Containing Foam Composite, Preparative Methods, and Uses Thereof |
US9808557B2 (en) | 2007-08-10 | 2017-11-07 | Trustees Of Tufts College | Tubular silk compositions and methods of use thereof |
WO2009029958A2 (en) * | 2007-08-30 | 2009-03-05 | Sunstorm Research Corporation | Implantable delivery device |
US8821431B2 (en) * | 2007-09-07 | 2014-09-02 | Beta O2 Technologies Ltd. | Air gap for supporting cells |
WO2009108760A2 (en) * | 2008-02-26 | 2009-09-03 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
US9446168B2 (en) | 2010-06-07 | 2016-09-20 | Beta-O2 Technologies Ltd. | Multiple-layer immune barrier for donor cells |
WO2010032242A1 (en) * | 2008-09-17 | 2010-03-25 | Beta O2 Technologies Ltd. | Optimization of alginate encapsulation of islets for transplantation |
EP2344049B1 (en) | 2008-10-03 | 2021-01-27 | C.R.Bard, Inc. | Implantable prosthesis |
US8043271B2 (en) * | 2008-11-26 | 2011-10-25 | Beta 02 Technologies Ltd. | Apparatus for transportation of oxygen to implanted cells |
US20100160749A1 (en) * | 2008-12-24 | 2010-06-24 | Glusense Ltd. | Implantable optical glucose sensing |
AU2010206374B2 (en) | 2009-01-23 | 2013-01-17 | Gloriana Therapeutics Sarl | Improved cell lines and their use in encapsulated cell biodelivery |
US9277999B2 (en) | 2009-02-27 | 2016-03-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Joint bioscaffolds |
EP2475309A4 (en) | 2009-09-08 | 2015-07-29 | Atrium Medical Corp | Hernia patch |
WO2011106369A1 (en) * | 2010-02-25 | 2011-09-01 | Orteq B.V. | Meniscus repair assembly and method |
FR2962898B1 (en) * | 2010-07-22 | 2012-08-17 | Statice Sante | POCKET TO FORM AN IMPLANTABLE ARTIFICIAL BODY |
EP2621403B1 (en) | 2010-09-27 | 2015-03-18 | NsGene A/S | Implantable cell device with supportive and radial diffusive scaffolding |
US8946194B2 (en) | 2010-10-08 | 2015-02-03 | Board Of Regents, University Of Texas System | One-step processing of hydrogels for mechanically robust and chemically desired features |
JP6042815B2 (en) | 2010-10-08 | 2016-12-14 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム | Anti-adhesion barrier membranes using alginate and hyaluronic acid for biomedical applications |
US9725689B2 (en) | 2010-10-08 | 2017-08-08 | Terumo Bct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
DK3575796T3 (en) | 2011-04-15 | 2021-01-18 | Dexcom Inc | ADVANCED ANALYZE SENSOR CALIBRATION AND ERROR DETECTION |
US10335519B2 (en) | 2011-04-20 | 2019-07-02 | Trustees Of Tufts College | Dynamic silk coatings for implantable devices |
US9037205B2 (en) | 2011-06-30 | 2015-05-19 | Glusense, Ltd | Implantable optical glucose sensing |
WO2013142119A1 (en) | 2012-03-20 | 2013-09-26 | Trustees Of Tufts College | Silk reservoirs for drug delivery |
JP2015512944A (en) | 2012-04-13 | 2015-04-30 | トラスティーズ・オブ・タフツ・カレッジTrustees Of Tufts College | Methods and compositions for preparing silk microspheres |
US10034945B2 (en) | 2012-07-13 | 2018-07-31 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
KR101766679B1 (en) | 2012-12-11 | 2017-08-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | Hydrogel membrane for adhesion prevention |
US11565027B2 (en) | 2012-12-11 | 2023-01-31 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
ES2896354T3 (en) | 2012-12-21 | 2022-02-24 | Astellas Inst For Regenerative Medicine | Methods for the production of platelets from pluripotent stem cells |
US11505587B2 (en) * | 2013-01-18 | 2022-11-22 | Nanyang Technological University | Method of preparing a keratin-based biomaterial and keratin-based biomaterial formed thereof |
KR102457668B1 (en) | 2013-03-15 | 2022-10-21 | 트러스티즈 오브 터프츠 칼리지 | Low molecular weight silk compositions and stabilizing silk compositions |
US11376329B2 (en) | 2013-03-15 | 2022-07-05 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
US10285702B2 (en) | 2013-04-24 | 2019-05-14 | Trustees Of Tufts College | Bioresorbable biopolymer anastomosis devices |
CN105992816B (en) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | Cell amplification in bioreactor |
EP3122866B1 (en) | 2014-03-25 | 2019-11-20 | Terumo BCT, Inc. | Passive replacement of media |
CN107073176B (en) * | 2014-06-09 | 2021-02-19 | 康奈尔大学 | Implantable therapy delivery system and method thereof |
EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
WO2016059635A1 (en) | 2014-10-13 | 2016-04-21 | Glusense Ltd. | Analyte-sensing device |
US10758645B2 (en) | 2014-12-17 | 2020-09-01 | Tufts University | Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
EP3324907B1 (en) | 2015-07-20 | 2021-09-22 | Tufts University | Biodegradable silk ear tubes |
WO2017183030A1 (en) | 2016-04-20 | 2017-10-26 | Glusense Ltd. | Fret-based glucose-detection molecules |
US10864299B2 (en) | 2016-04-29 | 2020-12-15 | Trustees Of Tufts College | Artificial silk based innervated cornea |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
WO2018006037A1 (en) | 2016-07-01 | 2018-01-04 | Trustees Of Tufts College | Innervated artificial skin |
US11248313B2 (en) | 2016-08-01 | 2022-02-15 | Trustees Of Tufts College | Biomimetic mechanical tension driven fabrication of nanofibrillar architecture |
WO2018136754A1 (en) | 2017-01-20 | 2018-07-26 | Massachusetts Institute Of Technology | Injectable polymer micro-depots for controlled local drug delivery |
US11702634B2 (en) | 2017-03-31 | 2023-07-18 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
EP3409239A1 (en) | 2017-05-29 | 2018-12-05 | University College Dublin, National University of Ireland, Dublin | An implantable active agent encapsulating device |
CN209606445U (en) | 2017-10-24 | 2019-11-08 | 德克斯康公司 | Pre-connection analyte sensor |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
WO2019089567A1 (en) | 2017-10-30 | 2019-05-09 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
US20210236644A1 (en) | 2017-11-10 | 2021-08-05 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
CA3142608A1 (en) | 2019-06-04 | 2020-12-10 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
KR20220070474A (en) | 2019-09-27 | 2022-05-31 | 이슬라 테크놀로지스, 인크. | bioprosthetic pancreas |
EP4125963A1 (en) * | 2020-04-03 | 2023-02-08 | The Brigham and Women's Hospital, Inc. | Implantable cell macroencapsulation device and method of manufacture and use |
IL305016A (en) | 2021-02-19 | 2023-10-01 | Hoffmann La Roche | Means and methods for implanting cells secreting a therapeutic compound |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3093831A (en) * | 1959-10-22 | 1963-06-18 | Jordan Gerhard Paul Wilhelm | Artificial gland |
US5141581A (en) * | 1972-10-08 | 1992-08-25 | Markham Harold A | Implants with a cover which resists formation of firm spherical encapsulation |
US4282317A (en) * | 1979-01-15 | 1981-08-04 | Roth Jonathan N | Pectin culture media and method |
US4241187A (en) * | 1979-03-27 | 1980-12-23 | United States Of America | Method and apparatus for cell and tissue culture |
US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
US4424132A (en) * | 1981-02-05 | 1984-01-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus and method for separating blood components |
US4322298A (en) * | 1981-06-01 | 1982-03-30 | Advanced Blood Component Technology, Inc. | Centrifugal cell separator, and method of use thereof |
US4378016A (en) * | 1981-07-15 | 1983-03-29 | Biotek, Inc. | Artificial endocrine gland containing hormone-producing cells |
US4402694A (en) * | 1981-07-16 | 1983-09-06 | Biotek, Inc. | Body cavity access device containing a hormone source |
US4686098A (en) * | 1984-05-14 | 1987-08-11 | Merck & Co., Inc. | Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo |
NO166836C (en) * | 1985-03-14 | 1991-09-11 | Univ California | PROCEDURE FOR TREATMENT OF AN ORGAN TRANSPLANT. |
US4699141A (en) * | 1986-01-16 | 1987-10-13 | Rhode Island Hospital | Neovascularization |
US5158881A (en) * | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
US5182111A (en) * | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
US5283187A (en) * | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
US5156844A (en) * | 1987-11-17 | 1992-10-20 | Brown University Research Foundation | Neurological therapy system |
US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US5015476A (en) * | 1989-08-11 | 1991-05-14 | Paravax, Inc. | Immunization implant and method |
US5116494A (en) * | 1989-08-25 | 1992-05-26 | W. R. Grace & Co.-Conn. | Artificial pancreatic perfusion device with temperature sensitive matrix |
US5459054A (en) | 1989-12-05 | 1995-10-17 | Neocrin Company | Cells encapsulated in alginate containing a high content of a- l- guluronic acid |
US5270192A (en) * | 1991-02-07 | 1993-12-14 | Monsanto Company | Biological artificial liver |
JPH06505186A (en) * | 1991-02-11 | 1994-06-16 | オマーヤ,アユブ ケー. | Spinal fluid-powered prosthesis |
US5222982A (en) * | 1991-02-11 | 1993-06-29 | Ommaya Ayub K | Spinal fluid driven artificial organ |
US5370681A (en) * | 1991-09-16 | 1994-12-06 | Atrium Medical Corporation | Polyumenal implantable organ |
JPH07503943A (en) | 1991-10-29 | 1995-04-27 | クローバー コンソリデイテッド,リミテッド | Cross-linked polysaccharides, polycations and lipids useful for encapsulation and drug release |
US5545423A (en) | 1991-11-25 | 1996-08-13 | Vivorx, Inc. | Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials |
US5260002A (en) * | 1991-12-23 | 1993-11-09 | Vanderbilt University | Method and apparatus for producing uniform polymeric spheres |
ES2153378T3 (en) | 1992-02-28 | 2001-03-01 | Univ Texas | PHOTOPOLIMERIZABLE BIODEGRADABLE HYDROGELS AS FABRIC CONTACT MATERIALS AND CONTROLLED DISCHARGE CARRIER. |
US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
US5521079A (en) | 1994-01-24 | 1996-05-28 | The Regents Of The University Of California | Microcapsule generating system containing an air knife and method of encapsulating |
US5578314A (en) | 1992-05-29 | 1996-11-26 | The Regents Of The University Of California | Multiple layer alginate coatings of biological tissue for transplantation |
US5429821A (en) * | 1992-05-29 | 1995-07-04 | The Regents Of The University Of California | Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use |
WO1994013266A1 (en) | 1992-05-29 | 1994-06-23 | The Regents Of The University Of California | Novel electrostatic process for manufacturing coated transplants and products |
US5387237A (en) * | 1992-07-30 | 1995-02-07 | The University Of Toledo | Bioartificial pancreas |
US5425764A (en) | 1992-07-30 | 1995-06-20 | The University Of Toledo | Bioartificial pancreas |
DE4229526B4 (en) * | 1992-09-07 | 2006-02-16 | Schrezenmeir, Jürgen, Dr. | Device for receiving and introducing biologically active tissues or cells into the human body |
US5387327A (en) * | 1992-10-19 | 1995-02-07 | Duquesne University Of The Holy Ghost | Implantable non-enzymatic electrochemical glucose sensor |
JP3338119B2 (en) * | 1993-04-14 | 2002-10-28 | 呉羽化学工業株式会社 | Antidiabetic agent |
EP0938893B1 (en) | 1993-08-10 | 2004-08-25 | W.L. Gore & Associates, Inc. | Cell encapsulating device |
AU7568094A (en) * | 1993-08-12 | 1995-03-14 | Cytotherapeutics, Inc. | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
EP1174156A2 (en) * | 1994-01-11 | 2002-01-23 | Baxter International Inc. | Ported tissue implant systems and methods of using same |
US5876742A (en) | 1994-01-24 | 1999-03-02 | The Regents Of The University Of California | Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof |
US5620883A (en) | 1994-04-01 | 1997-04-15 | The Johns Hopkins University | Living cells microencapsulated in a polymeric membrane having two layers |
US5651980A (en) | 1994-04-15 | 1997-07-29 | Biohybrid Technologies, Inc. | Methods of use of uncoated gel particles |
US5550050A (en) | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
US6392118B1 (en) | 1994-07-20 | 2002-05-21 | Neurotech S.A. | Mx-1 conditionally immortalized cells |
US5935849A (en) | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US5510102A (en) * | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
US5916790A (en) | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
WO1997010807A1 (en) | 1995-09-22 | 1997-03-27 | Gore Hybrid Technologies, Inc. | Improved cell encapsulation device |
US5855613A (en) * | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
-
1995
- 1995-10-13 US US08/542,506 patent/US5855613A/en not_active Expired - Lifetime
-
1996
- 1996-10-15 DE DE69634828T patent/DE69634828T2/en not_active Expired - Lifetime
- 1996-10-15 WO PCT/US1996/016499 patent/WO1997013474A1/en active IP Right Grant
- 1996-10-15 AT AT96936512T patent/ATE297169T1/en not_active IP Right Cessation
- 1996-10-15 EP EP96936512A patent/EP0862391B1/en not_active Expired - Lifetime
- 1996-10-15 AU AU74327/96A patent/AU725104B2/en not_active Ceased
- 1996-10-15 CA CA002234233A patent/CA2234233C/en not_active Expired - Fee Related
-
1998
- 1998-08-03 US US09/128,188 patent/US6165225A/en not_active Expired - Lifetime
-
2000
- 2000-08-25 US US09/648,050 patent/US6372244B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU7432796A (en) | 1997-04-30 |
EP0862391B1 (en) | 2005-06-08 |
US6372244B1 (en) | 2002-04-16 |
EP0862391A1 (en) | 1998-09-09 |
ATE297169T1 (en) | 2005-06-15 |
DE69634828D1 (en) | 2005-07-14 |
US5855613A (en) | 1999-01-05 |
EP0862391A4 (en) | 1999-09-01 |
WO1997013474A1 (en) | 1997-04-17 |
US6165225A (en) | 2000-12-26 |
DE69634828T2 (en) | 2006-03-23 |
CA2234233C (en) | 2007-01-16 |
AU725104B2 (en) | 2000-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2234233A1 (en) | Retrievable bioartificial implants | |
Kuroyanagi et al. | Tissue‐engineered product: allogeneic cultured dermal substitute composed of spongy collagen with fibroblasts | |
WO2001055212A3 (en) | Delivery of therapeutic biological from implantable tissue matrices | |
CA2207286A1 (en) | Localized delivery of factors enhancing survival of transplanted cells | |
WO2001036589A3 (en) | Human ex vivo immune system | |
WO2002018441A3 (en) | Electroprocessed fibrin-based matrices and tissues | |
DE69530086D1 (en) | INCORPORATION OF BIOLOGICALLY ACTIVE MOLECULES IN BIOACTIVE GLASS | |
CA2166074A1 (en) | Implantable system for cell growth control | |
WO1994007432A3 (en) | Porous vascular implants | |
WO1999046366A8 (en) | Uses for humane non-autologous mesenchymal stem cells | |
BR9612051A (en) | Medical implant | |
DE69221484D1 (en) | IMPLANTABLE, BIOCOMPATIBLE IMMUNISOLATOR SUPPORT SUBSTANCE FOR DELIVERING SELECTED THERAPEUTIC PRODUCTS | |
WO1995005452A3 (en) | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules | |
EP1143935A3 (en) | Controlled-release biocompatible ocular drug delivery implant devices and methods | |
AU5647996A (en) | Artificial skin containing as support biocompatible materials based on hyaluronic acid derivatives | |
WO2007030512A3 (en) | Graft implant containing drug crystals | |
IT1307829B1 (en) | DENTAL PROSTHESIS WITH MEANS FOR THE RELEASE OF DRUGS OR SPECIFIC FACTORS TO PREVENT THE ONset OF INFECTIONS AND / OR PROMOTE | |
WO2005120549A3 (en) | Local delivery of growth factors for stem cell transplantation | |
KR20090115773A (en) | Tissue equivalant for transplantation and process for producing the same | |
HK1095542A1 (en) | Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation | |
WO2002007749A3 (en) | Device providing regulated growth factor delivery for the regeneration of peripheral nerves | |
WO2003099230A3 (en) | Electroprocessed collagen and tissue engineering | |
HK1023599A1 (en) | Cells for preventing graft rejection in transplantation and their uses. | |
CA2250880A1 (en) | Implantable agarose-collagen beads containing cells which produce a diffusible biological product, and uses thereof | |
DE60313356D1 (en) | USE OF DEXTRANSULFATE FOR THE TREATMENT OF IBMIR |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20141015 |