CA2234233A1 - Retrievable bioartificial implants - Google Patents

Retrievable bioartificial implants

Info

Publication number
CA2234233A1
CA2234233A1 CA002234233A CA2234233A CA2234233A1 CA 2234233 A1 CA2234233 A1 CA 2234233A1 CA 002234233 A CA002234233 A CA 002234233A CA 2234233 A CA2234233 A CA 2234233A CA 2234233 A1 CA2234233 A1 CA 2234233A1
Authority
CA
Canada
Prior art keywords
bioartificial
implants
retrievable
thin sheets
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002234233A
Other languages
French (fr)
Other versions
CA2234233C (en
Inventor
Richard D. Antanovich
Randel Dorian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Islet Sheet Medical Inc
Original Assignee
Islet Sheet Medical, Inc.
Richard D. Antanovich
Randel Dorian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Islet Sheet Medical, Inc., Richard D. Antanovich, Randel Dorian filed Critical Islet Sheet Medical, Inc.
Publication of CA2234233A1 publication Critical patent/CA2234233A1/en
Application granted granted Critical
Publication of CA2234233C publication Critical patent/CA2234233C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Bioartificial implant and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology.
Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
CA002234233A 1995-10-13 1996-10-15 Retrievable bioartificial implants Expired - Fee Related CA2234233C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/542506 1995-10-13
US08/542,506 US5855613A (en) 1995-10-13 1995-10-13 Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
PCT/US1996/016499 WO1997013474A1 (en) 1995-10-13 1996-10-15 Retrievable bioartificial implants

Publications (2)

Publication Number Publication Date
CA2234233A1 true CA2234233A1 (en) 1997-04-17
CA2234233C CA2234233C (en) 2007-01-16

Family

ID=24164114

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002234233A Expired - Fee Related CA2234233C (en) 1995-10-13 1996-10-15 Retrievable bioartificial implants

Country Status (7)

Country Link
US (3) US5855613A (en)
EP (1) EP0862391B1 (en)
AT (1) ATE297169T1 (en)
AU (1) AU725104B2 (en)
CA (1) CA2234233C (en)
DE (1) DE69634828T2 (en)
WO (1) WO1997013474A1 (en)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7018419B2 (en) * 1994-05-20 2006-03-28 Spielberg Theodore E Microporous encapsulated endocrine cell disks, biconcave disks and multidimpled chambers for hormonal replacement
US5855613A (en) * 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US7192450B2 (en) * 2003-05-21 2007-03-20 Dexcom, Inc. Porous membranes for use with implantable devices
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US20050033132A1 (en) 1997-03-04 2005-02-10 Shults Mark C. Analyte measuring device
US7657297B2 (en) * 2004-05-03 2010-02-02 Dexcom, Inc. Implantable analyte sensor
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US6872387B1 (en) 1998-02-24 2005-03-29 The Regents Of The University Of Michigan Three-dimensional hydrogel/cell system
US6497650B1 (en) * 1999-07-28 2002-12-24 C. R. Bard, Inc. Hernia prosthesis
US6264695B1 (en) * 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
US20020151055A1 (en) * 1999-11-02 2002-10-17 Stegemann Jan Philip Novel artificial pancreas
IL134009A (en) 2000-01-12 2011-07-31 Bo2 Technologies Ltd Implantable device
US8012500B2 (en) * 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
US6468301B1 (en) 2000-03-27 2002-10-22 Aga Medical Corporation Repositionable and recapturable vascular stent/graft
US8366787B2 (en) * 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US6638312B2 (en) * 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
US7404819B1 (en) 2000-09-14 2008-07-29 C.R. Bard, Inc. Implantable prosthesis
WO2002024107A2 (en) 2000-09-20 2002-03-28 Islet Sheet Medical Llc Fabrication of thin sheet bio-artificial organs
US20040191246A1 (en) * 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
WO2003007784A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Meniscus regeneration device and method
US7163563B2 (en) * 2001-07-16 2007-01-16 Depuy Products, Inc. Unitary surgical device and method
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
WO2003007839A2 (en) * 2001-07-16 2003-01-30 Depuy Products, Inc. Devices form naturally occurring biologically derived
WO2003007790A2 (en) * 2001-07-16 2003-01-30 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
US7201917B2 (en) * 2001-07-16 2007-04-10 Depuy Products, Inc. Porous delivery scaffold and method
WO2003007847A1 (en) * 2001-07-16 2003-01-30 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorable scaffolds
US7361195B2 (en) * 2001-07-16 2008-04-22 Depuy Products, Inc. Cartilage repair apparatus and method
US8025896B2 (en) * 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
JP4197157B2 (en) 2001-07-16 2008-12-17 デピュイ・プロダクツ・インコーポレイテッド Cartilage repair and reproduction apparatus and method
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US7113898B2 (en) * 2001-11-08 2006-09-26 Vanderbilt University Method for modeling signal transduction in cells
DK1455755T3 (en) * 2001-11-20 2013-07-15 Civitas Therapeutics Inc Improved particle composition for delivery in lung
US6790213B2 (en) * 2002-01-07 2004-09-14 C.R. Bard, Inc. Implantable prosthesis
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US20030213007A1 (en) * 2002-03-27 2003-11-13 Slattery Charles Wilbur Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US20060258761A1 (en) * 2002-05-22 2006-11-16 Robert Boock Silicone based membranes for use in implantable glucose sensors
US20030220696A1 (en) * 2002-05-23 2003-11-27 Levine David Jerome Implantable porous metal
EP3351376B1 (en) 2002-06-24 2023-04-12 Tufts University Silk biomaterials and methods of use thereof
US20040166169A1 (en) * 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US20040034275A1 (en) * 2002-07-29 2004-02-19 Peter Forsell Multi-material incontinence treatment constriction device
US7025982B2 (en) * 2002-09-19 2006-04-11 Medtronic, Inc. Medical assembly suitable for long-term implantation and method for fabricating the same
US7025791B2 (en) * 2002-12-02 2006-04-11 Gi Dynamics, Inc. Bariatric sleeve
US7134999B2 (en) 2003-04-04 2006-11-14 Dexcom, Inc. Optimized sensor geometry for an implantable glucose sensor
JP4698596B2 (en) 2003-04-10 2011-06-08 タフツ ユニバーシティー Concentrated aqueous silk fibroin solutions and their use
US7875293B2 (en) 2003-05-21 2011-01-25 Dexcom, Inc. Biointerface membranes incorporating bioactive agents
US20050056552A1 (en) * 2003-07-25 2005-03-17 Simpson Peter C. Increasing bias for oxygen production in an electrode system
US20050176136A1 (en) * 2003-11-19 2005-08-11 Dexcom, Inc. Afinity domain for analyte sensor
JP4708342B2 (en) 2003-07-25 2011-06-22 デックスコム・インコーポレーテッド Oxygen augmentation membrane system for use in implantable devices
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US8257963B2 (en) * 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US7927599B2 (en) * 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
SE526959C2 (en) * 2003-10-02 2005-11-29 Tikomed Ab Bioartificial implant comprising a semipermeable barrier and a method for reducing the risk of connective tissue formation in the implant after implantation by providing the barrier with a permeable coating of bioactive metal
EP1558215A4 (en) * 2003-10-14 2007-09-12 Wockhardt Ltd Sterile gelling agents
US20050090607A1 (en) * 2003-10-28 2005-04-28 Dexcom, Inc. Silicone composition for biocompatible membrane
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
ES2646312T3 (en) * 2003-12-08 2017-12-13 Dexcom, Inc. Systems and methods to improve electromechanical analyte sensors
WO2005057175A2 (en) 2003-12-09 2005-06-23 Dexcom, Inc. Signal processing for continuous analyte sensor
US20050182451A1 (en) * 2004-01-12 2005-08-18 Adam Griffin Implantable device with improved radio frequency capabilities
US7364592B2 (en) * 2004-02-12 2008-04-29 Dexcom, Inc. Biointerface membrane with macro-and micro-architecture
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US20050245799A1 (en) * 2004-05-03 2005-11-03 Dexcom, Inc. Implantable analyte sensor
US7569233B2 (en) * 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US20050249772A1 (en) * 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds
SI1759536T1 (en) 2004-06-01 2011-09-30 Kwalata Trading Ltd In vitro techniques for use with stem cells
EP1786834B1 (en) 2004-07-14 2016-02-17 Glusense Ltd. Implantable power sources and sensors
US20060067917A1 (en) * 2004-09-20 2006-03-30 Athanassios Sambanis Insulin delivery system
US7513866B2 (en) * 2004-10-29 2009-04-07 Depuy Products, Inc. Intestine processing device and associated method
US9788978B2 (en) * 2004-12-20 2017-10-17 Nicholas A. Rojo Implantable systems and stents containing cells for therapeutic uses
US7354627B2 (en) * 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
US9427496B2 (en) 2005-02-18 2016-08-30 Drexel University Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
US20060246111A1 (en) * 2005-04-19 2006-11-02 Smith Larry L Polysaccharides as ultrasound transmission media
US20060292690A1 (en) * 2005-06-22 2006-12-28 Cesco Bioengineering Co., Ltd. Method of making cell growth surface
CN101267805A (en) * 2005-07-27 2008-09-17 普洛体维生物治疗公司 Systems and methods for manufacturing liposomes
EP1954327A4 (en) * 2005-12-01 2012-03-28 Innograft Llc Method for ionically cross-linking polysaccharide material for thin film applications and products produced therefrom
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
WO2007120381A2 (en) 2006-04-14 2007-10-25 Dexcom, Inc. Analyte sensor
EP2029727B1 (en) * 2006-06-16 2012-04-11 FMC Biopolymer AS Alginate coated, collagen matrix cellular device, preparative methods, and uses thereof.
US7758649B2 (en) * 2006-08-04 2010-07-20 Integrity Intellect Inc. Reversibly deformable implant
EP2056759B1 (en) * 2006-08-29 2015-01-14 The University of Akron Implantable devices for producing insulin
WO2008118133A2 (en) 2006-09-26 2008-10-02 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
WO2008062417A2 (en) * 2006-11-22 2008-05-29 Beta O2 Technologies Ltd. Protecting algae from body fluids
EP2104492B1 (en) * 2006-11-28 2017-11-22 Beta O2 Technologies Ltd. Oxygen supply for cell transplant and vascularization
US7871440B2 (en) * 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US20100121446A1 (en) * 2007-02-19 2010-05-13 Ticapex Ab Implant assembly
JP2010522583A (en) 2007-02-27 2010-07-08 トラスティーズ オブ タフツ カレッジ Silk organs made by tissue engineering
US20200037875A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
CA2688184A1 (en) 2007-06-08 2008-12-18 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
JP5328780B2 (en) * 2007-06-13 2013-10-30 エフ エム シー コーポレーション Alginate-coated polysaccharide gel-containing foam composite, its production and use
WO2009023615A1 (en) 2007-08-10 2009-02-19 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
US8303536B2 (en) * 2007-08-30 2012-11-06 Sunstorm Research Corp. Implantable delivery device
US8821431B2 (en) 2007-09-07 2014-09-02 Beta O2 Technologies Ltd. Air gap for supporting cells
US9452258B2 (en) 2007-10-09 2016-09-27 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8668863B2 (en) * 2008-02-26 2014-03-11 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
WO2010032242A1 (en) * 2008-09-17 2010-03-25 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
US9072586B2 (en) 2008-10-03 2015-07-07 C.R. Bard, Inc. Implantable prosthesis
US9801575B2 (en) 2011-04-15 2017-10-31 Dexcom, Inc. Advanced analyte sensor calibration and error detection
US8043271B2 (en) * 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
US20100160749A1 (en) * 2008-12-24 2010-06-24 Glusense Ltd. Implantable optical glucose sensing
AU2010206374B2 (en) 2009-01-23 2013-01-17 Gloriana Therapeutics Sarl Improved cell lines and their use in encapsulated cell biodelivery
US9277999B2 (en) * 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
US20110144667A1 (en) 2009-09-08 2011-06-16 Anthony Richard Horton Hernia patch
EP2538985A1 (en) * 2010-02-25 2013-01-02 Orteq B.V. Meniscus repair assembly and method
WO2011154941A2 (en) * 2010-06-07 2011-12-15 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
FR2962898B1 (en) 2010-07-22 2012-08-17 Statice Sante POCKET TO FORM AN IMPLANTABLE ARTIFICIAL BODY
WO2012041320A1 (en) * 2010-09-27 2012-04-05 Nsgene A/S Implantable cell device with supportive and radial diffusive scaffolding
EP2625264B1 (en) 2010-10-08 2022-12-07 Terumo BCT, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
EP2624874A4 (en) 2010-10-08 2014-04-02 Univ Texas Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
WO2012048283A1 (en) 2010-10-08 2012-04-12 Board Of Regents, The University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
US10335519B2 (en) 2011-04-20 2019-07-02 Trustees Of Tufts College Dynamic silk coatings for implantable devices
US9037205B2 (en) 2011-06-30 2015-05-19 Glusense, Ltd Implantable optical glucose sensing
CA2867464A1 (en) 2012-03-20 2013-09-26 Trustees Of Tufts College Silk reservoirs for drug delivery
AU2013245785A1 (en) 2012-04-13 2014-10-23 Trustees Of Tufts College Methods and compositions for preparing a silk microsphere
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
US11565027B2 (en) 2012-12-11 2023-01-31 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
US9662424B2 (en) 2012-12-11 2017-05-30 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
US11505587B2 (en) * 2013-01-18 2022-11-22 Nanyang Technological University Method of preparing a keratin-based biomaterial and keratin-based biomaterial formed thereof
KR20210149207A (en) 2013-03-15 2021-12-08 트러스티즈 오브 터프츠 칼리지 Low molecular weight silk compositions and stabilizing silk compositions
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
WO2014176458A2 (en) 2013-04-24 2014-10-30 Trustees Of Tufts College Bioresorbable biopolymer anastomosis devices
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
US10493107B2 (en) 2014-06-09 2019-12-03 Cornell University Implantable therapeutic delivery system and methods thereof
US20160090569A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled Feed
CN106999118B (en) 2014-10-13 2020-07-17 葡萄糖传感器公司 Analyte sensing device
US10758645B2 (en) 2014-12-17 2020-09-01 Tufts University Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CA2995233C (en) 2015-07-20 2024-01-02 Tufts University Biodegradable silk ear tubes
EP3445872A1 (en) 2016-04-20 2019-02-27 Glusense Ltd. Fret-based glucose-detection molecules
WO2017189832A1 (en) 2016-04-29 2017-11-02 Trustees Of Tufts College An artificial silk based innervated cornea
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2018006037A1 (en) 2016-07-01 2018-01-04 Trustees Of Tufts College Innervated artificial skin
WO2018026853A1 (en) 2016-08-01 2018-02-08 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
US20200000713A1 (en) 2017-01-20 2020-01-02 Massachusetts Institute Of Technology Injectable polymer micro-depots for controlled local drug delivery
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3409239A1 (en) 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin An implantable active agent encapsulating device
US20190120785A1 (en) 2017-10-24 2019-04-25 Dexcom, Inc. Pre-connected analyte sensors
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
WO2019094702A1 (en) 2017-11-10 2019-05-16 Cocoon Biotech Inc. Ocular applications of silk-based products
AU2020288624A1 (en) 2019-06-04 2022-02-03 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
EP4034174A4 (en) 2019-09-27 2023-11-01 Isla Technologies, Inc. Bioartificial pancreas
WO2021202975A1 (en) * 2020-04-03 2021-10-07 The Brigham And Women's Hospital, Inc. Implantable cell macroencapsulation device and method of manufacture and use
EP4294472A1 (en) 2021-02-19 2023-12-27 F. Hoffmann-La Roche AG Means and methods for implanting cells secreting a therapeutic compound

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3093831A (en) * 1959-10-22 1963-06-18 Jordan Gerhard Paul Wilhelm Artificial gland
US5141581A (en) * 1972-10-08 1992-08-25 Markham Harold A Implants with a cover which resists formation of firm spherical encapsulation
US4282317A (en) * 1979-01-15 1981-08-04 Roth Jonathan N Pectin culture media and method
US4241187A (en) * 1979-03-27 1980-12-23 United States Of America Method and apparatus for cell and tissue culture
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4424132A (en) * 1981-02-05 1984-01-03 Asahi Kasei Kogyo Kabushiki Kaisha Apparatus and method for separating blood components
US4322298A (en) * 1981-06-01 1982-03-30 Advanced Blood Component Technology, Inc. Centrifugal cell separator, and method of use thereof
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4402694A (en) * 1981-07-16 1983-09-06 Biotek, Inc. Body cavity access device containing a hormone source
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
NO166836C (en) * 1985-03-14 1991-09-11 Univ California PROCEDURE FOR TREATMENT OF AN ORGAN TRANSPLANT.
US4699141A (en) * 1986-01-16 1987-10-13 Rhode Island Hospital Neovascularization
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5156844A (en) * 1987-11-17 1992-10-20 Brown University Research Foundation Neurological therapy system
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5015476A (en) * 1989-08-11 1991-05-14 Paravax, Inc. Immunization implant and method
US5116494A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with temperature sensitive matrix
US5459054A (en) 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
US5270192A (en) * 1991-02-07 1993-12-14 Monsanto Company Biological artificial liver
US5222982A (en) * 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
WO1992013501A1 (en) * 1991-02-11 1992-08-20 Ommaya Ayub K Spinal fluid driven artificial organ
US5370681A (en) * 1991-09-16 1994-12-06 Atrium Medical Corporation Polyumenal implantable organ
EP0610441A4 (en) 1991-10-29 1996-01-10 Clover Cons Ltd Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release.
US5545423A (en) 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5260002A (en) * 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
DK0627911T3 (en) 1992-02-28 2000-11-20 Univ Texas Photopolymerizable biodegradable hydrogels as tissue contact materials and controlled release carriers
US5578314A (en) 1992-05-29 1996-11-26 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
AU4396893A (en) 1992-05-29 1994-07-04 Regents Of The University Of California, The Novel electrostatic process for manufacturing coated transplants and products
US5521079A (en) 1994-01-24 1996-05-28 The Regents Of The University Of California Microcapsule generating system containing an air knife and method of encapsulating
US5429821A (en) * 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
US5387237A (en) * 1992-07-30 1995-02-07 The University Of Toledo Bioartificial pancreas
US5425764A (en) 1992-07-30 1995-06-20 The University Of Toledo Bioartificial pancreas
DE4229526B4 (en) * 1992-09-07 2006-02-16 Schrezenmeir, Jürgen, Dr. Device for receiving and introducing biologically active tissues or cells into the human body
US5387327A (en) * 1992-10-19 1995-02-07 Duquesne University Of The Holy Ghost Implantable non-enzymatic electrochemical glucose sensor
JP3338119B2 (en) * 1993-04-14 2002-10-28 呉羽化学工業株式会社 Antidiabetic agent
DE938893T1 (en) 1993-08-10 2000-03-09 Gore & Ass Cell encapsulation device
CA2169292C (en) * 1993-08-12 2010-11-23 E. Edward Baetge Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
EP0688196B1 (en) * 1994-01-11 2002-04-17 Baxter International Inc. Ported tissue implant systems
US5876742A (en) 1994-01-24 1999-03-02 The Regents Of The University Of California Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
US5620883A (en) 1994-04-01 1997-04-15 The Johns Hopkins University Living cells microencapsulated in a polymeric membrane having two layers
US5651980A (en) 1994-04-15 1997-07-29 Biohybrid Technologies, Inc. Methods of use of uncoated gel particles
US5550050A (en) 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US5935849A (en) 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5776747A (en) 1994-07-20 1998-07-07 Cytotherapeutics, Inc. Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer
US5510102A (en) * 1995-01-23 1996-04-23 The Regents Of The University Of California Plasma and polymer containing surgical hemostatic adhesives
US5916790A (en) 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
US5837234A (en) 1995-06-07 1998-11-17 Cytotherapeutics, Inc. Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
WO1997010807A1 (en) 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US5855613A (en) * 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change

Also Published As

Publication number Publication date
WO1997013474A1 (en) 1997-04-17
DE69634828T2 (en) 2006-03-23
AU7432796A (en) 1997-04-30
EP0862391B1 (en) 2005-06-08
US5855613A (en) 1999-01-05
DE69634828D1 (en) 2005-07-14
US6165225A (en) 2000-12-26
AU725104B2 (en) 2000-10-05
EP0862391A4 (en) 1999-09-01
US6372244B1 (en) 2002-04-16
CA2234233C (en) 2007-01-16
EP0862391A1 (en) 1998-09-09
ATE297169T1 (en) 2005-06-15

Similar Documents

Publication Publication Date Title
CA2234233A1 (en) Retrievable bioartificial implants
Kuroyanagi et al. Tissue‐engineered product: allogeneic cultured dermal substitute composed of spongy collagen with fibroblasts
WO2001055212A3 (en) Delivery of therapeutic biological from implantable tissue matrices
CA2207286A1 (en) Localized delivery of factors enhancing survival of transplanted cells
WO2002018441A3 (en) Electroprocessed fibrin-based matrices and tissues
DE69530086D1 (en) INCORPORATION OF BIOLOGICALLY ACTIVE MOLECULES IN BIOACTIVE GLASS
CA2166074A1 (en) Implantable system for cell growth control
WO1994007432A3 (en) Porous vascular implants
ATE237285T1 (en) MEDICAL IMPLANT
WO1999046366A8 (en) Uses for humane non-autologous mesenchymal stem cells
WO1995005452A3 (en) Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
EP1143935A3 (en) Controlled-release biocompatible ocular drug delivery implant devices and methods
EP0127989A3 (en) Microencapsulation of living tissue and cells
WO2007030512A3 (en) Graft implant containing drug crystals
IT1307829B1 (en) DENTAL PROSTHESIS WITH MEANS FOR THE RELEASE OF DRUGS OR SPECIFIC FACTORS TO PREVENT THE ONset OF INFECTIONS AND / OR PROMOTE
WO2005120549A3 (en) Local delivery of growth factors for stem cell transplantation
KR20090115773A (en) Tissue equivalant for transplantation and process for producing the same
HK1087042A1 (en) New use of dextran sulfate
HK1095542A1 (en) Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation
NO309124B1 (en) Artificial biological devices for the release of hormones
WO2002007749A3 (en) Device providing regulated growth factor delivery for the regeneration of peripheral nerves
WO2003099230A3 (en) Electroprocessed collagen and tissue engineering
HK1023599A1 (en) Cells for preventing graft rejection in transplantation and their uses.
CA2250880A1 (en) Implantable agarose-collagen beads containing cells which produce a diffusible biological product, and uses thereof
CA2073453A1 (en) Methods of enhancing wound healing and tissue repair

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20141015