CA2248140A1 - Assay and reagents for quantifying hbnp - Google Patents

Assay and reagents for quantifying hbnp

Info

Publication number
CA2248140A1
CA2248140A1 CA002248140A CA2248140A CA2248140A1 CA 2248140 A1 CA2248140 A1 CA 2248140A1 CA 002248140 A CA002248140 A CA 002248140A CA 2248140 A CA2248140 A CA 2248140A CA 2248140 A1 CA2248140 A1 CA 2248140A1
Authority
CA
Canada
Prior art keywords
hbnp
reagents
assay
assays
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002248140A
Other languages
French (fr)
Other versions
CA2248140C (en
Inventor
Ronald P. Mischak
Garrett A. Lim
Jan Marian Scardina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scios LLC
Original Assignee
Ronald P. Mischak
Garrett A. Lim
Jan Marian Scardina
Scios Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ronald P. Mischak, Garrett A. Lim, Jan Marian Scardina, Scios Inc. filed Critical Ronald P. Mischak
Publication of CA2248140A1 publication Critical patent/CA2248140A1/en
Application granted granted Critical
Publication of CA2248140C publication Critical patent/CA2248140C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/841—Muscles; heart

Abstract

The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes comprising the amino acid sequences 5-13, 1-10 and 15-25 of hBNP.
These antibodies, and peptide fragments containing these sequences, can be employed in the assays of the invention, which may be carried out in a sandwich format or a competition format.
CA002248140A 1996-03-04 1997-03-04 Assay and reagents for quantifying hbnp Expired - Lifetime CA2248140C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61017296A 1996-03-04 1996-03-04
US08/610,172 1996-03-04
PCT/US1997/003163 WO1997032900A1 (en) 1996-03-04 1997-03-04 ASSAY AND REAGENTS FOR QUANTIFYING hBNP

Publications (2)

Publication Number Publication Date
CA2248140A1 true CA2248140A1 (en) 1997-09-12
CA2248140C CA2248140C (en) 2005-02-01

Family

ID=24443982

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002248140A Expired - Lifetime CA2248140C (en) 1996-03-04 1997-03-04 Assay and reagents for quantifying hbnp

Country Status (13)

Country Link
US (3) US6162902A (en)
EP (3) EP1557431B1 (en)
JP (3) JP4049816B2 (en)
AT (1) ATE297950T1 (en)
AU (1) AU1981597A (en)
CA (1) CA2248140C (en)
DE (1) DE69733560T2 (en)
DK (2) DK0914344T3 (en)
ES (1) ES2243979T3 (en)
HK (1) HK1078096A1 (en)
PT (2) PT2292662E (en)
WO (1) WO1997032900A1 (en)
ZA (1) ZA971864B (en)

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US7291501B2 (en) * 2003-07-16 2007-11-06 Abbott Laboratories Stable compositions for measuring human natriuretic peptides
US7445933B2 (en) * 2003-07-16 2008-11-04 Abbott Laboratories, Inc. Stable calibrators or controls for measuring human natriuretic peptides
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US7731965B2 (en) 2005-02-17 2010-06-08 Abbott Lab Human ring specific BNP antibodies
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US7939069B2 (en) * 2005-11-09 2011-05-10 Abbott Laboratories Human BNP immunospecific antibodies
US7795221B2 (en) * 2006-03-30 2010-09-14 Palatin Technologies, Inc. Linear natriuretic peptide constructs
US8580746B2 (en) * 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
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Also Published As

Publication number Publication date
HK1078096A1 (en) 2006-03-03
EP0914344B1 (en) 2005-06-15
DK0914344T3 (en) 2005-08-29
JP2011102318A (en) 2011-05-26
US6124430A (en) 2000-09-26
AU1981597A (en) 1997-09-22
EP0914344B8 (en) 2005-08-10
US6376207B1 (en) 2002-04-23
EP2292662B1 (en) 2014-04-23
DE69733560T2 (en) 2006-05-11
JP2007169293A (en) 2007-07-05
ATE297950T1 (en) 2005-07-15
US6162902A (en) 2000-12-19
ZA971864B (en) 1997-12-18
JP4049816B2 (en) 2008-02-20
EP2292662A3 (en) 2011-07-13
EP2292662A2 (en) 2011-03-09
WO1997032900A1 (en) 1997-09-12
EP1557431A1 (en) 2005-07-27
ES2243979T3 (en) 2005-12-01
CA2248140C (en) 2005-02-01
PT2292662E (en) 2014-07-16
EP0914344A1 (en) 1999-05-12
EP1557431B1 (en) 2012-08-15
DE69733560D1 (en) 2005-07-21
JP2000507094A (en) 2000-06-13
DK2292662T3 (en) 2014-05-05
PT914344E (en) 2005-10-31

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Effective date: 20170306