CA2254954A1 - Morphogen treatment for chronic renal failure - Google Patents

Morphogen treatment for chronic renal failure

Info

Publication number
CA2254954A1
CA2254954A1 CA002254954A CA2254954A CA2254954A1 CA 2254954 A1 CA2254954 A1 CA 2254954A1 CA 002254954 A CA002254954 A CA 002254954A CA 2254954 A CA2254954 A CA 2254954A CA 2254954 A1 CA2254954 A1 CA 2254954A1
Authority
CA
Canada
Prior art keywords
mammal
renal
therapeutic agent
gfr
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002254954A
Other languages
French (fr)
Other versions
CA2254954C (en
Inventor
Kuber T. Sampath
Charles M. Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARIEL THERAPEUTICS Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2254954A1 publication Critical patent/CA2254954A1/en
Application granted granted Critical
Publication of CA2254954C publication Critical patent/CA2254954C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of, chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certain proteins of, or based upon, the osteogenic protein/bone morphogenetic protein (OP/BMP) family of the TGF.beta. superfamily of proteins, or the administration of certain morphogens, inducers of those morphogens, agonists of the corresponding morphogen receptors, or implantation of renal cells induced with those morphogens. The morphogens useful in the invention are also members of, or based upon, the OP/BMP family of proteins.

Claims (60)

1. A method of treatment for a mammal in, or at risk of, chronic renal failure comprising administering to said mammal a therapeutically effective amount of an OP/BMP renal therapeutic agent or morphogen.
2. A method of treatment for a mammal in, or at risk of, chronic renal failure comprising administering to said mammal a therapeutically effective amount of an inducer ofendogenous OP/BMP renal therapeutic agent or morphogen expression.
3. A method of treatment for a mammal in, or at risk of, chronic renal failure comprising administering to said mammal a therapeutically effective amount of an agonist of an OP/BMP renal therapeutic agent or morphogen receptor.
4. A method of treatment for a mammal in, or at risk of, chronic renal failure comprising introducing within the kidney of said mammal a therapeutically effective amount of renal mesenchymal progenitor cells.
5. A method as in claim 4 comprising the additional step of inducing metanephric differentiation of said cells by contacting said cells with an OP/BMP
renal therapeutic agent or morphogen.
6. A method as in claim 4 comprising the additional step of inducing metanephric differentiation of said cells by contacting said cells with an inducer of an OP/BMP renal therapeutic agent or morphogen.
7. A method as in claim 4 comprising the additional step of inducing metanephric differentiation of said cells by contacting said cells with an agonist of an OP/BMP renal therapeutic agent or morphogen receptor.
8. A method of treatment to delay the need for, or reduce the frequency of, chronic dialysis treatments comprising administering to a mammal a therapeutically effective amount of an OP/BMP renal therapeutic agent or morphogen.
9. A method of treatment to delay the need for, or reduce the frequency of, chronic dialysis treatments comprising administering to said mammal a therapeutically effective amount of an inducer ofendogenous OP/BMP renal therapeutic agent or morphogen expression.
10. A method of treatment to delay the need for, or reduce the frequency of, chronic dialysis treatments comprising administering to said mammal a therapeutically effective amount of an agonist of an OP/BMP renal therapeutic agent or morphogen receptor.
11. A method as in any one of claims 1-10 wherein said mammal is afflicted with a condition selected from the group consisting of chronic renal failure, end-stage renal disease, chronic diabetic nephropathy, diabetic glomerulopathy, diabetic renal hypertrophy, hypertensive nephrosclerosis, hypertensive glomerulosclerosis, chronic glomerulonephritis, hereditary nephritis, and renal dysplasia.
12. A method as in any one of claims 1 - 10 wherein examination of a renal biopsy of said mammal indicates that said mammal is afflicted with a condition selected from the group consisting of glomerular hypertrophy, tubular hypertrophy, glomerulosclerosis, and tubulointerstitial sclerosis.
13. A method as in any one of claims 1-10 wherein examination of said mammal indicates renal fibrosis.
14. A method as in claim 13 wherein said examination is an ultrasound, MRI or CAT scan of said mammal.
15. A method as in any one of claims 1- 1 0 wherein said mammal possesses a number of functional nephron units which is less than about 50%
of a number of functional nephron units present in a mammal having intact healthy kidneys.
16. A method as in any one of claims 1-10 wherein said mammal possesses a number of functional nephron units which is less than about 40%
of a number of functional nephron units present in a mammal having intact healthy kidneys.
17. A method as in any one of claims 1-10 wherein said mammal possesses a number of functional nephron units which is less than about 30%
of a number of functional nephron units present in a mammal having intact healthy kidneys.
18. A method as in any one of claims 1-10 wherein said mammal possesses a number of functional nephron units which is less than about 20%
of a number of functional nephron units present in a mammal having intact healthy kidneys.
19. A method as in any one of claims 1-10 wherein said mammal is a kidney transplant recipient.
20. A method as in any one of claims 1-10 wherein said mammal possesses only one kidney.
21. A method as in any one of claims 1 -10 wherein examination of a urinary sediment of said mammal indicates a presence of broad casts.
22. A method as in any one of claims 1 - 10 wherein said mammal has a GFR which is chronically less than about 50% of a GFR exp for said mammal.
23. A method as in claim 22 wherein said mammal has a GFR which is chronically less than about 40% of a GFR exp for said mammal.
24. A method as in claim 22 wherein said mammal has a GFR which is chronically less than about 30% of a GFR exp for said mammal.
25. A method as in claim 22 wherein said mammal has a GFR which is chronically less than about 20% of a GFR exp for said mammal.
26. A method as in any one of claims 1-10 wherein said mammal is a human male weighing at least about 50 kg and has a GFR which ischronically less than about 50 ml/min.
27. A method as in claim 26 wherein said mammal is a human male weighing at least about 50 kg and has a GFR which ischronically less than about 40 ml/min.
28. A method as in claim 26 wherein said mammal is a human male weighing at least about 50 kg and has a GFR which ischronically less than about 30 ml/min.
29. A method as in claim 26 wherein said mammal is a human male weighing at least about 50 kg and has a GFR which ischronically less than about 20 ml/min.
30 A method as in any one of claims 1-10 wherein said mammal is a human female weighing at least about 40 kg and has a GFR which is chronically less than about 40 ml/min.
31. A method as in claim 30 wherein said mammal is a human female weighing at least about 40 kg and has a GFR which is chronically less than about 30 ml/min.
32. A method as in claim 30 wherein said mammal is a human female weighing at least about 40 kg and has a GFR which is chronically less than about 20 ml/min.
33. A method as in claim 30 wherein said mammal is a human female weighing at least about 40 kg and has a GFR which is chronically less than about 10 ml/min.
34. A method as in any one of claims 1 - 10 wherein said treatment reduces serum creatinine levels in said mammal by at least about 5% over 3 months.
35. A method as in any one of claims 1-10 wherein prior to said treatment said mammal presented a chronic decline in a clinical indicator of renal function; and after at least about 3 months of said treatment, said indicator stabilizes.
36. A method as in any one of claims 1-3 wherein said administration is oral.
37. A method as in any one of claims 1-3 wherein said administration is parenteral.
38. A method as in claim 37 wherein said administration is intravenous.
39. A method as in claim 37 wherein said administration is intraperitoneal.
40. A method as in claim 37 wherein said administration is into the renal capsule.
41. A method as in claim 37 wherein a stent has been implanted into said mammal for said administration.
42. A method as in claim 41 wherein said stent is an intravenous stent.
43. A method as in claim 41 wherein said stent is an intraperitoneal stent.
44. A method as in claim 41 wherein said stent is a renal intracapsular stent.
45. A method as in claim 37 wherein said administration is by an implanted device.
46. A method as in any one of claims 1-3 wherein said administration is at least once a week for a period of at least about one month.
47. A method as in any one of claims 1-3 wherein said administration is at least once a month for a period of at least about one year.
48. A method as in claim 1 wherein said OP/BMP renal therapeutic agent or morphogen is administered at a dosage of about 0.01-1000 µg/kg body weight of said mammal.
49. A method as in claim 48 wherein said OP/BMP renal therapeutic agent or morphogen is administered at a dosage of about 10-300 µg/kg body weight of said mammal.
50. A method of promoting metanephric differentiation of renal mesenchymal progenitor cells comprising the step of contacting said cells with an OP/BMP renal therapeutic agent or morphogen in an amount effective to induce said differentiation.
51. A method as in claim 1 wherein said renal therapeutic agent comprises a polypeptide consisting of at least a C-terminal cysteine domain of a protein selected from the group consisting of a pro form, a mature form, and a soluble form of a polypeptide selected from the group consisting of OP-1, OP-2, OP-3, BMP2, BMP3, BMP4, BMP5, BMP6, and BMP9.
52. A method as in claim 51 wherein said renal therapeutic agent comprises a polypeptide consisting of at least a C-terminal cysteine domain of a protein selected from the group consisting of a pro form, a mature form, and a soluble form of human OP-1.
53. A method as in claim 1 wherein said renal therapeutic agent comprises a polypeptide having at least 70% homology with an amino acid sequence of a C-terminal seven-cysteine domain of human OP-1.
54. A method as in claim 53 wherein said polypeptide has at least 75% homology with an amino acid sequence of a C-terminal seven-cysteine domain of human OP-1.
55. A method as in claim 53 wherein said polypeptide has at least 80% homology with an amino acid sequence of a C-terminal seven-cysteine domain of human OP-1.
56. A method as in claim 53 wherein said polypeptide has at least 60% identity with an amino acid sequence of a C-terminal seven-cysteine domain of human OP-1.
57 A method as in claim 53 wherein said polypeptide has at least 65% identity with an amino acid sequence of a C-terminal seven-cysteine domain of human OP-1.
58. A method as in claim 53 wherein said polypeptide has at least 70% identity with an amino acid sequence of a C-terminal seven-cysteine domain of human OP-1.
59. A method as in any one of claims 51-58 wherein said renal therapeutic agent (a) induces chondrogenesis in an ectopic bone assay;
(b) prevents, inhibits, delays or alleviates loss of renal function in an animal model of chronic renal failure; or (c) causes a clinically significant improvement in a standard marker of renal function when administered to a mammal in, or at risk of, chronic renal failure.
60. A method as in claim 1 wherein said renal therapeutic agent is selected from the group consisting of human osteogenic proteins and human bone morphogenetic proteins.
CA002254954A 1996-05-06 1997-05-06 Morphogen treatment for chronic renal failure Expired - Fee Related CA2254954C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/643,321 1996-05-06
US08/643,321 US6498142B1 (en) 1996-05-06 1996-05-06 Morphogen treatment for chronic renal failure
PCT/US1997/007816 WO1997041881A1 (en) 1996-05-06 1997-05-06 Morphogen treatment for chronic renal failure

Publications (2)

Publication Number Publication Date
CA2254954A1 true CA2254954A1 (en) 1997-11-13
CA2254954C CA2254954C (en) 2010-01-12

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CA002254953A Expired - Fee Related CA2254953C (en) 1996-05-06 1997-05-06 Therapies for chronic renal failure
CA002254954A Expired - Fee Related CA2254954C (en) 1996-05-06 1997-05-06 Morphogen treatment for chronic renal failure

Family Applications Before (1)

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Country Status (11)

Country Link
US (5) US6498142B1 (en)
EP (2) EP0910400B1 (en)
JP (4) JP2000510835A (en)
AT (2) ATE245997T1 (en)
AU (2) AU2933997A (en)
CA (2) CA2254953C (en)
DE (2) DE69730966T2 (en)
DK (2) DK0914146T3 (en)
ES (2) ES2203803T3 (en)
PT (2) PT910400E (en)
WO (2) WO1997041880A1 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2363965C (en) * 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US20030167492A1 (en) 1994-07-08 2003-09-04 Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
US6498142B1 (en) * 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
ATE278414T1 (en) * 1997-05-05 2004-10-15 Curis Inc THERAPIES FOR THE TREATMENT OF ACUTE KIDNEY FAILURE
AU7473098A (en) * 1997-05-07 1998-11-27 Biogen, Inc. Novel therapies for cystic kidney disease
ATE220564T1 (en) 1997-08-14 2002-08-15 Sulzer Innotec Ag COMPOSITION AND DEVICE FOR REPAIRING CARTILAGE TISSUE IN VIVO CONSISTING OF NANOCAPSULES WITH OSTEOINDUCTIVE AND/OR CHONDROINDUCTIVE FACTORS
US6203788B1 (en) * 1997-09-29 2001-03-20 Adherex Inc. Compounds and methods for regulating cell adhesion
AU1706499A (en) * 1997-12-04 1999-06-16 Curis, Inc. Maintenance of smooth muscle integrity by morphogenic proteins
NZ509609A (en) * 1998-07-28 2003-11-28 Univ Johns Hopkins Med Disrupting growth differentiation factor-11 (GDF-11) to increase the muscle and bone tissue in animals
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
US6992066B2 (en) * 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
DE60027907T2 (en) * 1999-09-14 2007-01-04 Biogen Idec Ma Inc., Cambridge THERAPIES FOR CHRONIC KIDNEY INUFFICIENCY USING ONE OR MORE INTEGRINANT AGONIST (DE)
US20020173453A1 (en) * 2000-12-15 2002-11-21 Rama Akella Method of treating renal injury
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7232802B2 (en) * 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
CA2497048A1 (en) * 2002-08-28 2004-03-11 Curis, Inc. Conjoint administration of morphogens and ace inhibitors in treatment of chronic renal failure
DK1677735T3 (en) 2003-10-17 2014-10-27 Joslin Diabetes Center Inc METHODS AND COMPOSITIONS FOR MODULATING ADIPOCYTE FUNCTION
US7844367B2 (en) 2003-12-23 2010-11-30 Rain Bird Corporation Code replacement for irrigation controllers
CA2557999C (en) * 2004-03-30 2013-11-12 Ilypsa, Inc. Methods and compositions for treatment of ion imbalances
CA2561809A1 (en) * 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
US20100150885A1 (en) 2005-06-01 2010-06-17 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
US7771995B2 (en) * 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
CA2629522A1 (en) 2005-11-14 2007-05-18 Merial Limited Gene therapy for renal failure
US20070196810A1 (en) 2006-01-24 2007-08-23 Northfield Laboratories Inc. Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US20080090765A1 (en) * 2006-05-25 2008-04-17 The Trustees Of Columbia University In The City Of New York Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage
ES2379603T3 (en) 2006-05-30 2012-04-27 Antibodyshop A/S Methods for rapid assessment of the severity of trauma
US7722665B2 (en) 2006-07-07 2010-05-25 Graft Technologies, Inc. System and method for providing a graft in a vascular environment
EP2574625B1 (en) 2006-07-21 2015-02-25 HuBit genomix, Inc. Remedy for renal disease
WO2008075173A2 (en) * 2006-12-15 2008-06-26 Ruprecht-Karls-Universität Heidelberg Methods for treating podocyte-related disorders
US20080268016A1 (en) * 2007-04-24 2008-10-30 Fang Carrie H Engineered Renal Tissue
DE102007034580B4 (en) * 2007-07-13 2012-11-08 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Biomaterial based on a hydrophilic polymeric carrier
US20090155245A1 (en) * 2007-12-18 2009-06-18 Fang Carrie H Treatment for Organ Regeneration with Combination of Drug and Biologics
CN102083969A (en) * 2008-05-06 2011-06-01 乔斯林糖尿病中心股份有限公司 Methods and compositions for inducing brown adipogenesis
JP5485885B2 (en) * 2008-06-24 2014-05-07 株式会社根本杏林堂 Chemical injection device, fluoroscopic imaging system having this chemical injection device, computer program of chemical injection device, and data processing method
EP2743702B1 (en) * 2008-08-28 2017-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN105021826A (en) * 2008-08-29 2015-11-04 阿斯图特医药公司 Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2347260A4 (en) * 2008-10-21 2012-09-26 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3246707B1 (en) 2008-10-21 2020-09-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2913676A1 (en) 2008-11-10 2015-09-02 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ592552A (en) * 2008-11-22 2013-12-20 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BRPI1007917A2 (en) * 2009-02-06 2019-09-24 Astute Medical Inc method for assessing renal status in an individual, and use of one or more markers of renal injury
CA2752157A1 (en) * 2009-02-12 2010-08-19 Stryker Corporation Peripheral administration of proteins including tgf-.beta. superfamily members for systemic treatment of disorders and disease
CN102369017A (en) * 2009-02-12 2012-03-07 史赛克公司 Compositions and methods for minimally invasive systemic delivery of proteins comprising TGF-beta superfamily members
US8828937B2 (en) * 2009-03-12 2014-09-09 Haase Investments Ug Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
EP2462440B1 (en) 2009-08-07 2017-05-17 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2774024A1 (en) 2009-09-17 2011-03-24 Stryker Corporation Buffers for controlling the ph of bone morphogenetic proteins
MX340078B (en) 2009-11-07 2016-06-24 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure.
NZ600828A (en) 2009-12-20 2014-09-26 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2013514811A (en) 2009-12-22 2013-05-02 ストライカー コーポレイション BMP-7 mutant with reduced immunogenicity
SI2666872T1 (en) 2010-02-05 2016-08-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011269847A1 (en) 2010-02-26 2013-01-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2011220413B2 (en) 2010-02-26 2015-07-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2576587B1 (en) 2010-05-24 2018-03-21 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
WO2011162821A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR101767860B1 (en) 2010-08-20 2017-08-14 와이어쓰 엘엘씨 Designer osteogenic proteins
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
WO2013086359A1 (en) 2011-12-08 2013-06-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BR112015007749A2 (en) 2012-10-08 2017-07-04 Relypsa Inc methods for treating hypertension, hyperkalaemia, and chronic kidney disease.
EP2925337B1 (en) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
WO2014113558A1 (en) 2013-01-17 2014-07-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
EP2784083A1 (en) 2013-03-28 2014-10-01 Charité - Universitätsmedizin Berlin Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity
JP2016536588A (en) * 2013-11-11 2016-11-24 ゼネラル・エレクトリック・カンパニイ A method for reducing errors in rotor speed measurement.
EP2944326B1 (en) 2014-05-16 2018-11-21 Cyanagen Srl Tricarbocyanine-cyclodextrin-conjugates and their use for the diagnosis of kidney diseases
JP7199809B2 (en) 2015-02-13 2023-01-06 ファクター バイオサイエンス インコーポレイテッド Nucleic acid product and its administration method
US11243217B2 (en) 2016-06-06 2022-02-08 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
IL264439B1 (en) 2016-08-17 2024-04-01 Factor Bioscience Inc non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment
JP2019039673A (en) * 2017-08-22 2019-03-14 セイコーエプソン株式会社 Time digital conversion circuit, circuit device, physical quantity measuring device, electronic apparatus, and mobile entity

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156741B (en) * 1978-05-15 1987-02-04 Sigma Tau Ind Farmaceuti THERAPEUTIC APPLICATION OF CARNITINE AND SOME ACYLATED DERIVATIVES OF CARNITINE IN HEMODIALYSIS
US4342828A (en) 1979-07-20 1982-08-03 Morinaga Milk Industry Co., Ltd. Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
US4627839A (en) 1985-11-21 1986-12-09 American Hospital Supply Corporation Patient controlled analgesia conversion
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5045452A (en) 1988-09-02 1991-09-03 Brigham And Women's Hospital Method for evaluating nephrotoxicity
ATE162223T1 (en) 1989-03-28 1998-01-15 Genetics Inst OSTEOINDUCTIVE COMPOSITIONS
ES2168091T3 (en) 1990-05-16 2002-06-01 Genetics Inst OSEA AND CARTILAGINOUS INDUCTION PROTEINS.
JPH0426624A (en) * 1990-05-18 1992-01-29 Tsumura & Co Remedy for chronic renal failure
DK0533840T3 (en) 1990-06-22 1996-12-30 Du Pont Treatment of chronic renal failure with imidazole-angiotensin II receptor antagonists
US6194376B1 (en) 1991-03-11 2001-02-27 Creative Biomolecules, Inc. Method for modulating inflammatory response comprising administering morphogen
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
ATE203166T1 (en) 1991-03-11 2001-08-15 Curis Inc PROTEIN-INDUCING MORPHOGENESIS
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
ATE197611T1 (en) 1991-08-30 2000-12-15 Creative Biomolecules Inc SCREENING METHOD OF MORPHOGENIC PROTEINS
EP0601135B1 (en) 1991-08-30 2005-11-02 Curis, Inc. Osteogenic proteins in the treatment of metabolic bone diseases
EP0601106B2 (en) 1991-08-30 2003-11-05 Curis, Inc. Morphogen-induced modulation of inflammatory response
US6120760A (en) * 1992-02-12 2000-09-19 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Growth/differentiation factors of the TGF-β family
EP0661933B1 (en) 1992-07-31 1998-04-22 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
CA2141554C (en) 1992-07-31 2003-02-11 David C. Rueger Morphogen-induced nerve regeneration and repair
DE69333745T2 (en) 1992-07-31 2005-12-29 Stryker Corp., Kalamazoo SOLUBLE COMPLEX OF MORPHOGENIC PROTEINS AND COMPOSITIONS THEREOF
ES2114073T3 (en) 1992-09-16 1998-05-16 Creative Biomolecules Inc REGENERATION OF THE LIVER INDUCED BY MORPHOGEN.
WO1994010203A2 (en) 1992-11-03 1994-05-11 Creative Biomolecules, Inc. Op-3-induced morphogenesis
US5372335A (en) 1992-12-18 1994-12-13 Scott H. Yenzer Aerial marker ball and method of placement
DE69434914T2 (en) 1993-03-04 2007-10-31 Stryker Corp., Kalamazoo METHOD AND COMPOSITIONS FOR PREPARING RECOMBINANT OSTEOGENIC PROTEIN
US5631159A (en) 1993-09-22 1997-05-20 Creative Biomolecules, Inc. Lipid-modified serum free media
US5585237A (en) 1993-10-25 1996-12-17 Creative Biomolecules, Inc. Methods and compositions for high protein production from recombinant DNA
CA2176709A1 (en) * 1993-11-15 1995-05-26 Howard R. Higley Method of treating renal disease by administering igf-i and igfbp-3
US5525621A (en) * 1994-05-20 1996-06-11 Cytos Pharmaceuticals Llc Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses
US5714511A (en) 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
US5723411A (en) * 1995-10-31 1998-03-03 E. I. Du Pont De Nemours And Company Herbicidal pyridazinones
WO1997034618A1 (en) 1996-03-22 1997-09-25 The General Hospital Corporation Administration of polypeptide growth factors following central nervous system ischemia or trauma
US5820589A (en) 1996-04-30 1998-10-13 Medtronic, Inc. Implantable non-invasive rate-adjustable pump
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
US5879908A (en) * 1997-04-30 1999-03-09 Smithkline Beecham Corporation CRFG-1a, a target and marker for chronic renal failure
US7147839B2 (en) * 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity

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