CA2255476C - Stent fabrication - Google Patents

Stent fabrication Download PDF

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Publication number
CA2255476C
CA2255476C CA002255476A CA2255476A CA2255476C CA 2255476 C CA2255476 C CA 2255476C CA 002255476 A CA002255476 A CA 002255476A CA 2255476 A CA2255476 A CA 2255476A CA 2255476 C CA2255476 C CA 2255476C
Authority
CA
Canada
Prior art keywords
stent
tube
wall
covering layer
discontinuous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002255476A
Other languages
French (fr)
Other versions
CA2255476A1 (en
Inventor
Goran Lukic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schneider Europe GmbH
Original Assignee
Schneider Europe GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8212838&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2255476(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schneider Europe GmbH filed Critical Schneider Europe GmbH
Publication of CA2255476A1 publication Critical patent/CA2255476A1/en
Application granted granted Critical
Publication of CA2255476C publication Critical patent/CA2255476C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable

Abstract

A stent is covered with a discontinuous expandable wall by the steps of radially contracting the stent and inserting at least a portion of the contracted stent into a tube, the inner surface of which has been previously done over with a lifting medium. The stent is allowed to radially expand in the tube, and the assembly tube plus stent is wetted with an elastomeric polymerisable composition dissolved in a sufficient amount of solvent to permit wet forming.
After evaporation of the solvent, the elastomeric composition in the tube is polymerised and the layer covered portion of the stent is taken out of the tube.

Description

CA 022~476 1998-12-17 This is a division of our co-pending Canadian Patent Application No. 2,114,891 filed February 3, 1994.
This invention relates to the making of a stent with a discontinuous expandable wall comprising on at least a portion of its length a continuous covering layer of elastic material with an outer surface surrounding the discontinuous wall.
The discontinuous walls of stents, such as for instance the macroporous walls formed by a deformable wire mesh allowing diametral retraction for introduction of the stent into air cr food pipes and expansion therein for dilatation, or repair, or bridging of said pipes, have the disadvantage that they permit ingrowth of tumors and other rapid growth cells through the wire mesh or discontinuous wall, with the resulting risk of stent occlusion.
For preventing ingrowth of cells through the stent, the document DE-3918736-Al describes an expandable metallic stent with an inner teflon tube affixed to the stent by suture or pressure, or an inner tube and an outer tube, both of teflon, connected pouch like to each other. At least in case of degradation of the inner tube, there will be a strong risk of having flaps from the inner tube occluding the vessel, or migration of the inner tube with respect to the stent and a further risk of occlusion of the vessel. Furthermore, the absence of resiliency of teflon does not allow constriction and expansion of the stent without additional place consuming measures such as zig-zag folds of the teflon tubes.

CA 022~476 1998-12-17 The document "Endoscopy 1992 : 416-420" also describes an expandable metalllc stent for preventlng lngrowth of mallgnant structures. This stent, formed by an expandable wlre mesh, is covered by a slllcone membrane or sklrt whlch surrounds a portlon of lts length. Thls membrane or sklrt ls secured around the stent by suture of lts ends to the wlre mesh, and, in sltu, the membrane is thus radlally held in place between the stent wall and vessel wall. To have the membrane or sklrt posltloned between the stent wall and vessel wall ls advantageous ln case of degradatlon of the membrane.
However, such a coverage of the stent ls far from belng effortless and mostly wlll have to be done by hand, which requlres skill. In addition, it is limited to certain types of materlals and may prove fraglle, it being possible for the membrane or skirt to loosen from the wire mesh, which may allow relative movement between the membrane and the stent, with the resulting risk of occluding the vessel.
The lnventlon provldes a method for applylng a coverlng layer ln a stent with a discontinuous expandable wall comprlslng on at least a portlon of lts length a contlnuous covering layer of elastic material with an outer surface surrounding the discontlnuous wall, whereln the continuous covering layer of elastic material is adhered to the said portlon of the discontinuous wall of the stent being thereby intimately united with said wall portion, comprising the steps of forming a tube of predetermlned length wlth an elastomerlc polymerlsable composltlon, radially contracting CA 022~476 1998-12-17 - 2a -the stent, insertlng lnto the tube a portlon of the stent correspondlng to sald predetermlned length of the tube, allowlng the stent to radlally expand ln the tube, and weldlng the surfaces of contact between the stent and the tube.
In this way, the tube ls closely bound to the dlscontlnuous structure whlch lt covers and there ls definately no rlsk of separatlon therebetween. And even ln the case of a strong degradatlon of the coverlng layer tube ln course of tlme, there cannot by any mlgratlon of the coverlng layer wlth respect to the dlscontlnuous wall of the stent because of the aforesald lntlmal lnterconnection.
Furthermore, the llalson of the coverlng layer wlth the dlscontlnuous wall of the stent ellmlnates any need for dellcate, time and sklll consumlng efforts and allows coating of any klnd of dlscontlnuous expandable stent wall.
The lnventlon wlll now be descrlbed more partlcularly wlth reference to the accompanylng drawlngs whlch CA 022~476 1998-12-17 - show, by way of example only, one embodiment of the invention.

In the drawings :
Figure 1 is a perspective view of a quarter cut along the longitudlnal axis of the ~xemplified embodiment;

Figure 2 is an enlarged view of an axial cut of a 10 portion of its wall during a procedure for applying the covering layer.

The stent shown in Figure 1 is an expandable stent of which the wall (1), for instance cylindrical, is 15 formed by meshed wires (2) of stainless steel, plastics or hybrid materials such as plastics and carbon fiber.

The wall (1) comprises, on a portion of its length, a covering layer (3) made of an elastomeric biocompati-20 ble composition such as, for instance, the elastomericpolymerisable composition described in US Patent N~
5,112,900. The outer face (4) of layer (3) forms a surrounding surface, and layer (3) extends around and inside the discontinuous structure of ~he stent 25 in order to totally embrace and intimately unite with any material part of the meshed wires (2) which constitu-te said discontinuous structure.

On Figure 1, the left front face (5) of the covering 30 layer (3) is shown in an area of wall (1) where the wires (2) do not cross each other; on the contrary, the quarter cut along the longitudinal axis is shown in an area where the wires (2) cross and overlap each other.
A portion of the stent wall (1) is shown on Figure
2 with its covering layer (3), the stent wall (1) CA 022~476 1998-12-17 , being shown in an area where its wires (2) overlap each other, and the stent being inserted in a tube (6) the inner surface of which is coated with a lifting medium (7) as described in detail hereafter in connec-5 tion with a procedure for applying the covering layerto the stent.

In order to apply the covering layer (3) on the stent, the deformable wall (1) of the stent is radially con-10 tracted and the portion thereof which has to be coatedis inserted into the tube (6) the inner surface of which has been previously done over with a lifting medium (7) such as for instance "teflon" in order to avoid adherence to the elastomeric composition 15 forming the covering layer (3). The contracted stent is allowed to expand radially in the tube (6) and the assembly of the tube and stent is wetted with the elastomeric polymerisable composition dissolved in a sufficient amount of solvent to permit wet forming 20 of a continuous covering layer around the totality of the discontinuous wall of the stent formed by the wire mesh inside the tube (6). The solvent is evaporated and the elastomeric composition is then polymerised in the tube and the layer covered stent portion is 25 taken out of the tube.

In that way, the shaping and liaison of the covering layer with the discontinuous wall of the stent is obtained automatically by mass polymerisation of the 30 elastomeric composition wholly surrounding the structure of such a wall inside the tube moulding its outer surface.

Of course, the discontinuous wall of the stent may 35 also be covered with the continuous covering layer all over its length, in which case the stent will be fully inserted into the tube for the dip forming CA 022~476 1998-12-17 !.

- process. In addition, the invention is not limited to the embodiment shown, being applicable to any kind of expandable stent having a discontinuous wall.

5 The thickness of the covering layer may be advantageous-ly selected as a function of the quantity of solvent added to the elastomeric com~osition, before polymerisa-tion and within the limits of a fluidity sufficient to allow wetting.

As a variant, it is also possible to obtain a greater thickness of the portions of the covering layer which are located at the outside of the discontinuous wall of the stent and between the mesh or elements thereof.
15 To this effect, the tube (6) done over with the lifting medium is first wetted alone with the elastomeric compo-sition previously added with an appropriate amount of solvent. The solvent is evaporated and the stent is then radially contracted for insertion into the tube 20 and the procedure follows as outlined hereinbefore.

According to a variant, not shown, the covering layer of elastic material needs not to integrally embrace the discontinuous structure of the stent, being suffi-25 cient that only a part of the thickness of the structurebe covered by the elastic material, in case of the example shown in Figure 1, only a radial portion of the wires (2).

30 According to further variants, also not shown, the elastic covering may be achieved by surface adhesion forces or through use of a binder.

Accordingly, a variant method provides for doing over 35 a roll on surface with a lifting medium and coating said roll on surface with an elastomeric polymerisable composition dissolved in a sufficient amount of solvent CA 022~476 1998-12-17 .' ~'' to permit contact forming, such an elastomeric composi-tion being, for instance, the composition described in US Patent N~ 5,112,900. An appropriate portion of the stent in expanded condition'is then rolled on said coated roll on surface; the stent is then withdrawn from the roll on surface, the solvent is allowed to evaporate, and the elastomeric composition adhered to the stent is polymerised.

A further variant method provides for using a covering layer formed of a tube made of an elastomeric polymerisa-ble composition, inserting the contracted stent into the tube, allowing the contracted stent to expand in the tube and vulcanising or similarly welding the surface of contact between the stent and the tube.

Still a further variant method also provides for using a covering layer formed of a tube made of an elastomeric polymerisable composition, coating the inside of the tube with an adhesive medium, inserting the contracted stent into the tube, and allowing the stent to expand radially in the so coated tube and the adhesive medium to cure, to thereby achieve adhesion of the assembly of stent and tube.
As a variant of this method, the inside of the tube may be coated with an elastomeric polymerisable composi-tion dissolved in an amount of solvent permitting contact forming, whereby after expansion of the stent, the solvent is allowed to evaporate and the elastomeric coating adhered by contact to the tube and to the stent is polymerised.

In a further variant the covering layer of elastic material may be adhered to the stent by radial pressure of the stent against the covering layer. In that case, the covering layer may be, for instance, formed of CA 022~476 1998-12-17 a tube made of an elastomeric composition stretched over the stent in order to allow contraction and ex-pansion thereof. Adhesion of the covering layer to the stent will be achieved by surface adhesion forces 5 with additionnal interpenetration between the covering layer and the stent.

In another variant, also-not shown, the covering layer may have a structured surface towards the wall of the stent, whereby adhesion of the covering layer to the stent will be achieved by some engagement of said structured surface into the discontinuous structure of the stent.

Of course, in all these variants, the discontinuous wall of the stent may be covered with the continuous covering layer all over its length or only over a portion thereof.

Claims

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A method for applying a covering layer in a stent with a discontinuous expandable wall comprising on at least a portion of its length a continuous covering layer of elastic material with an outer surface surrounding the discontinuous wall, wherein the continuous covering layer of elastic material is adhered to the said portion of the discontinuous wall of the stent being thereby intimately united with said wall portion, comprising the steps of:
forming a tube of predetermined length with an elastomeric polymerisable composition, radially contracting the stent, inserting into the tube a portion of the stent corresponding to said predetermined length of the tube, allowing the stent to radially expand in the tube, and welding the surfaces of contact between the stent and the tube.
CA002255476A 1993-04-23 1994-02-03 Stent fabrication Expired - Fee Related CA2255476C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP93106646A EP0621015B1 (en) 1993-04-23 1993-04-23 Stent with a covering layer of elastic material and method for applying the layer on the stent
EP93106646.8 1993-04-23
CA002114891A CA2114891C (en) 1993-04-23 1994-02-03 Stent with a covering layer of elastic material and methods for applying the layer on the stent

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002114891A Division CA2114891C (en) 1993-04-23 1994-02-03 Stent with a covering layer of elastic material and methods for applying the layer on the stent

Publications (2)

Publication Number Publication Date
CA2255476A1 CA2255476A1 (en) 1994-10-24
CA2255476C true CA2255476C (en) 2000-07-18

Family

ID=8212838

Family Applications (5)

Application Number Title Priority Date Filing Date
CA002206712A Expired - Fee Related CA2206712C (en) 1993-04-23 1994-02-03 Stent fabrication
CA002255476A Expired - Fee Related CA2255476C (en) 1993-04-23 1994-02-03 Stent fabrication
CA002114891A Expired - Fee Related CA2114891C (en) 1993-04-23 1994-02-03 Stent with a covering layer of elastic material and methods for applying the layer on the stent
CA002206709A Expired - Fee Related CA2206709C (en) 1993-04-23 1994-02-03 Stent fabrication
CA002205533A Expired - Fee Related CA2205533C (en) 1993-04-23 1994-02-03 Stent fabrication

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002206712A Expired - Fee Related CA2206712C (en) 1993-04-23 1994-02-03 Stent fabrication

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA002114891A Expired - Fee Related CA2114891C (en) 1993-04-23 1994-02-03 Stent with a covering layer of elastic material and methods for applying the layer on the stent
CA002206709A Expired - Fee Related CA2206709C (en) 1993-04-23 1994-02-03 Stent fabrication
CA002205533A Expired - Fee Related CA2205533C (en) 1993-04-23 1994-02-03 Stent fabrication

Country Status (8)

Country Link
US (3) US5534287A (en)
EP (1) EP0621015B1 (en)
JP (1) JP2914420B2 (en)
AT (1) ATE164056T1 (en)
CA (5) CA2206712C (en)
DE (1) DE69317548T2 (en)
DK (1) DK0621015T3 (en)
ES (1) ES2114964T3 (en)

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CA2205533A1 (en) 1994-10-24
DK0621015T3 (en) 1998-12-21
CA2206709A1 (en) 1994-10-24
EP0621015A1 (en) 1994-10-26
US6375787B1 (en) 2002-04-23
US20020096252A1 (en) 2002-07-25
DE69317548T2 (en) 1998-08-13
CA2205533C (en) 2000-05-16
CA2206712A1 (en) 1994-10-24
DE69317548D1 (en) 1998-04-23
JPH07529A (en) 1995-01-06
JP2914420B2 (en) 1999-06-28
EP0621015B1 (en) 1998-03-18
CA2206709C (en) 1999-09-14
CA2255476A1 (en) 1994-10-24
US5534287A (en) 1996-07-09
CA2114891A1 (en) 1994-10-24
CA2206712C (en) 1999-08-10
CA2114891C (en) 1999-01-05
ES2114964T3 (en) 1998-06-16
ATE164056T1 (en) 1998-04-15

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