CA2257749A1 - Device for the intraocular transfer of active products by iontophoresis - Google Patents

Device for the intraocular transfer of active products by iontophoresis Download PDF

Info

Publication number
CA2257749A1
CA2257749A1 CA002257749A CA2257749A CA2257749A1 CA 2257749 A1 CA2257749 A1 CA 2257749A1 CA 002257749 A CA002257749 A CA 002257749A CA 2257749 A CA2257749 A CA 2257749A CA 2257749 A1 CA2257749 A1 CA 2257749A1
Authority
CA
Canada
Prior art keywords
iontophoresis
active products
reservoir
patient
intraocular transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002257749A
Other languages
French (fr)
Other versions
CA2257749C (en
Inventor
Jean-Marie Parel
Francine Behar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EyeGate Pharma SAS
Original Assignee
Jean-Marie Parel
Francine Behar
Optisinvest N.V.
Optis Bv
Optis France
Eyegate Pharma S.A.
Eyegate Pharma Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jean-Marie Parel, Francine Behar, Optisinvest N.V., Optis Bv, Optis France, Eyegate Pharma S.A., Eyegate Pharma Sas filed Critical Jean-Marie Parel
Publication of CA2257749A1 publication Critical patent/CA2257749A1/en
Application granted granted Critical
Publication of CA2257749C publication Critical patent/CA2257749C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

Abstract

The invention relates to a device for transferring at least one active product, in particular a medicament, into the eyeball by iontophoresis, comprising a reservoir of active product, which can- be applied to a patient's eye. The reservoir has at least one active surface electrode arranged facing an eye tissue lying at the periphery of the cornea a return electrode and a current generator. The return electrode is preferably in contact with the patient's partly closed eyelids
CA002257749A 1998-01-05 1999-01-04 Device for the intraocular transfer of active products by iontophoresis Expired - Lifetime CA2257749C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9800009 1998-01-05
FR9800009A FR2773320B1 (en) 1998-01-05 1998-01-05 DEVICE FOR INTRAOCULAR TRANSFER OF ACTIVE PRODUCTS BY IONTOPHORESIS

Publications (2)

Publication Number Publication Date
CA2257749A1 true CA2257749A1 (en) 1999-07-05
CA2257749C CA2257749C (en) 2009-03-24

Family

ID=9521510

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002257749A Expired - Lifetime CA2257749C (en) 1998-01-05 1999-01-04 Device for the intraocular transfer of active products by iontophoresis

Country Status (13)

Country Link
US (1) US6154671A (en)
EP (2) EP1452203B1 (en)
JP (1) JP4308353B2 (en)
KR (1) KR100551706B1 (en)
AT (2) ATE292493T1 (en)
BR (1) BR9900009A (en)
CA (1) CA2257749C (en)
DE (2) DE69841028D1 (en)
DK (1) DK0927560T3 (en)
ES (2) ES2327636T3 (en)
FR (1) FR2773320B1 (en)
IL (1) IL127711A (en)
PT (1) PT927560E (en)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6101411A (en) * 1998-09-24 2000-08-08 Newsome; David A. Dilation enhancer
US7346389B1 (en) * 1998-09-24 2008-03-18 Newsome David A Dilation enhancer with pre-medicated contact lenses
US6728573B1 (en) * 2000-02-23 2004-04-27 Iomed, Inc. Ocular iontophoretic apparatus handle
US6319240B1 (en) * 1999-05-25 2001-11-20 Iomed, Inc. Methods and apparatus for ocular iontophoresis
US7252655B2 (en) 1999-05-25 2007-08-07 Iomed, Inc. Ocular iontophoretic apparatus handle
US6539251B2 (en) 1999-05-25 2003-03-25 Iomed, Inc. Ocular iontophoretic apparatus
US6546283B1 (en) * 2000-10-18 2003-04-08 Iomed, Inc. High current density iontophoretic device and method of use thereof
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
US7031776B2 (en) * 2001-06-29 2006-04-18 Optobionics Methods for improving damaged retinal cell function
US20050004625A1 (en) * 2001-06-29 2005-01-06 Chow Alan Y. Treatment of degenerative retinal disease via electrical stimulation of surface structures
US20040106965A1 (en) * 2001-06-29 2004-06-03 Chow Alan Y. Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation
US20050033202A1 (en) * 2001-06-29 2005-02-10 Chow Alan Y. Mechanically activated objects for treatment of degenerative retinal disease
EP1443931B1 (en) * 2001-07-20 2007-03-28 Iomed, Inc. Ocular iontophoretic device for delivering methotrexate based medicaments and use thereof to treat neoplastic, angiogenic, fibroplastic, and/or immunosuppresive ocular irregularities
JP2004535462A (en) * 2001-07-20 2004-11-25 イオメド インコーポレイテッド Use of 5-fluorouracil delivered by iontophoresis as an inhibitor of cell proliferation of the eye, bulbar conjunctiva, eyelid conjunctiva, eyelid, periorbital soft tissue and skin.
FR2830767B1 (en) * 2001-10-12 2004-03-12 Optis France Sa DEVICE FOR DELIVERING DRUGS BY IONTOPHORESIS OR INTROCULAR ELECTROPORATION
FR2830766B1 (en) * 2001-10-12 2004-03-12 Optis France Sa DEVICE   OF   ISSUE   OF   DRUGS   THROUGH   IONTOPHORESIS   TRANSPALPEBRALE
FR2836832B1 (en) 2002-03-08 2005-02-04 Optis France Sa CONNECTION ASSEMBLY FOR MEDICAL USE FOR THE TRANSFER OF FLUIDS
MXPA04011416A (en) 2002-05-17 2005-09-30 Othera Pharmaceuticals Inc Amelioration of the development of cataracts and other opthalmic diseases.
FR2851912B1 (en) 2003-03-03 2005-05-13 Optis France Sa UNIFORM POWER CONNECTOR FOR DELIVERY DEVICES OF ACTIVE PRINCIPLES
US7589107B2 (en) 2003-05-19 2009-09-15 Othera Holding, Inc. Amelioration of vitrectomy-induced cataracts
US7825134B2 (en) * 2003-05-19 2010-11-02 Othera Holding, Inc. Amelioration of cataracts, macular degeneration and other ophthalmic diseases
FR2855761B1 (en) * 2003-06-03 2006-02-24 Optis France Sa OCULAR DEVICE FOR VARIABLE DELIVERY OF ACTIVE PRINCIPLES BY IONTOPHORESIS
ZA200604403B (en) * 2003-11-20 2007-09-26 Othera Pharmaceuticals Inc Amelioration of macular degeneration and other ophthalmic diseases
US7251528B2 (en) * 2004-02-06 2007-07-31 Scyfix, Llc Treatment of vision disorders using electrical, light, and/or sound energy
EP1758598B1 (en) 2004-04-30 2016-04-13 Eyegate Pharma SAS Irritation-reducing ocular iontophoretic device
FR2869531B1 (en) 2004-04-30 2006-07-14 Optis France Sa Sa OCULAR IONTOPHORESIS DEVICE REDUCING IRRITATION
JP2008500359A (en) * 2004-05-25 2008-01-10 オセラ・フアーマシユーチカルズ・インコーポレーテツド Ocularselective drugs and prodrugs
US8246949B2 (en) * 2004-10-27 2012-08-21 Aciont, Inc. Methods and devices for sustained in-vivo release of an active agent
US8262715B2 (en) * 2004-11-23 2012-09-11 Eye Delivery System, Llc Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy
ATE501684T1 (en) * 2004-11-23 2011-04-15 Edward Wong MEDICAL DEVICE FOR TEMPERATURE CONTROL AND TREATMENT OF THE EYE AND SURROUNDING TISSUE
US20070282282A1 (en) * 2004-11-23 2007-12-06 Wong Edward K Jr Medical device and method for temperature control and treatment of the eye and surrounding tissues
WO2006072887A1 (en) * 2005-01-05 2006-07-13 Eyegate Pharma Sa Ocular iontophoresis device for delivering sirna and aptamers
EP2266656B1 (en) * 2005-04-18 2020-10-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Devices for delivering a biologically active agent to the ocular sphere of a subject
WO2006127592A2 (en) * 2005-05-26 2006-11-30 Othera Pharmaceuticals, Inc. Use of hydroxylamine derivates for inhibiting vitrectomy-induced cataracts
US8755880B2 (en) * 2005-10-24 2014-06-17 Aciont, Inc. Intraocular iontophoretic device and associated methods
US20070260171A1 (en) * 2005-09-27 2007-11-08 Higuchi John W Intraocular iontophoretic device and associated methods
US8634907B2 (en) 2005-10-24 2014-01-21 Aciont, Inc. Intraocular iontophoretic device and associated methods
WO2007050645A2 (en) * 2005-10-24 2007-05-03 Aciont, Inc. Intraocular iontophoretic device and associated methods
US8099162B2 (en) * 2005-11-29 2012-01-17 Eyegate Pharma, S.A.S. Ocular iontophoresis device
FR2893852B1 (en) * 2005-11-29 2010-09-03 Eyegate Pharma Sa OCULAR IONTOPHORESIS DEVICE
US20070203190A1 (en) * 2006-02-22 2007-08-30 Ghanshyam Patil Hydroxylamines and derivatives for the inhibition of complement activation
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
JPWO2007123142A1 (en) * 2006-04-20 2009-09-03 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
US20070299386A1 (en) * 2006-06-23 2007-12-27 Minu, L.L.C. Delivery of an ocular agent using iontophoresis
US20080027371A1 (en) * 2006-07-26 2008-01-31 Higuchi John W Method and device for minimally invasive site specific ocular drug delivery
US8923961B2 (en) 2006-10-18 2014-12-30 The Cleveland Clinic Foundation Electrode assembly for delivering a therapeutic agent into ocular tissue
CN101687786B (en) 2007-02-22 2013-05-22 奥特拉控股公司 Hydroxylamine compounds and methods of their use
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8480638B2 (en) * 2007-10-04 2013-07-09 Aciont, Inc. Intraocular iontophoretic device and associated methods
WO2009076220A1 (en) * 2007-12-05 2009-06-18 Eyegate Pharma S.A.S. Methods for delivering sirna via iontophoresis
CA2716390C (en) 2008-02-25 2016-08-23 Eyegate Pharma S.A.S. Enhanced delivery of a therapeutic to ocular tissues through iontophoresis
FR2928536B1 (en) 2008-03-14 2012-04-27 Inst Nat Sante Rech Med INJECTION DEVICE IN THE EYE
MX2011006925A (en) * 2008-12-31 2011-07-28 Eyegate Pharma S A S System and method for ocular iontophoresis with buffering.
WO2010093873A2 (en) 2009-02-12 2010-08-19 Incept, Llc Drug delivery through hydrogel plugs
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
EP2555751B8 (en) 2010-04-03 2018-02-14 Praful Doshi Methods of coating a contact lens
AU2011270754B2 (en) 2010-06-25 2015-04-23 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Methods of treatment using sterculic acid
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
EP2648663B1 (en) * 2011-01-12 2015-03-25 Sooft Italia Spa Device for corneal delivery of riboflavin by iontophoresis for the treatment of keratoconus
WO2012162459A1 (en) * 2011-05-26 2012-11-29 Pepose Jay Device and method for administering eye medications
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
CA2940513C (en) 2013-03-11 2023-08-15 University Of Florida Research Foundation, Inc. Delivery of card protein as therapy for ocular inflammation
WO2014179698A2 (en) 2013-05-03 2014-11-06 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
ITVE20130043A1 (en) * 2013-07-31 2015-02-01 I A C E R S R L OPHTHALMOLOGICAL PERFECT DEVICE FOR THE TREATMENT OF CORNEAL DISEASES SUCH AS THE KERATOCONO.
EP2898922B1 (en) * 2014-01-27 2017-05-24 OPIA Technologies Ocular iontophoresis device
JP5828535B1 (en) * 2014-10-10 2015-12-09 石根 三井 Contact lenses for straightening corneal cross-linking
CN104353183B (en) * 2014-10-31 2016-12-07 厦门微科格瑞生物科技有限公司 The wearable intellectual drug guiding structure that electrolyte position is fixing
AU2016209028A1 (en) 2015-01-22 2017-05-11 Eyegate Pharmaceuticals, Inc. Iontophoretic contact lens
US10206814B2 (en) * 2016-01-06 2019-02-19 David R. Hardten System and method for the delivery of medications or fluids to the eye
JP2019514581A (en) * 2016-05-02 2019-06-06 クリアサイド バイオメディカル，インコーポレイテッド Systems and methods for ocular drug delivery
JP2020513983A (en) 2017-03-23 2020-05-21 ドヘニー アイ インスティテュート Multiplex en-face angiographic averaging system, method and apparatus for optical coherence tomography
AU2019352954B2 (en) 2018-10-01 2022-03-10 Biovisics Medical, Inc. System and methods for controlled electrical modulation for vision therapy
EP3886974A2 (en) 2018-11-30 2021-10-06 Biovisics Medical, Inc. Head worn apparatuses for vision therapy
CA3126135A1 (en) 2019-01-09 2020-07-16 Twenty Twenty Therapeutics Llc Eye mounted device for therapeutic agent release
US11464674B2 (en) 2019-01-09 2022-10-11 Twenty Twenty Therapeutics Llc Programmable therapeutic agent delivery from eye mounted device
WO2020210471A1 (en) 2019-04-10 2020-10-15 Biovisics Medical, Inc. Systems and interfaces for ocular therapy
WO2020252278A1 (en) 2019-06-14 2020-12-17 Biovisics Medical, Inc. Wearable medical device
CN110547907A (en) * 2019-08-15 2019-12-10 中南大学湘雅二医院 Double-ring iris expander for intraocular operation
WO2024009535A1 (en) * 2022-07-08 2024-01-11 テルモ株式会社 Intraocular drug administration device, agent reservoir, and method for operating intraocular drug administration device

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US551880A (en) * 1895-12-24 Theodore b
US2525381A (en) * 1947-09-25 1950-10-10 Tower Paul Contact-type electrode holder
US3122137A (en) * 1961-10-30 1964-02-25 Erlanger Gustav Device for facilitating iontophoresis treatment of eyes
SU995783A1 (en) 1980-07-21 1983-02-15 Омский Государственный Ордена Трудового Красного Знамени Медицинский Институт Им.М.И.Калинина Device for electrophoresis of medicinal substances into eye tissues
US4678466A (en) * 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
US4564016A (en) 1982-05-24 1986-01-14 The Board Of Trustees Of The Leland Stanford Junior University Apparatus for introducing ionized drugs into the posterior segment of the eye and method
US5053000A (en) * 1985-11-13 1991-10-01 Imperial Chemical Industries Plc Ocular treatment
IL86076A (en) * 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
US4955378A (en) * 1988-05-02 1990-09-11 University Of South Florida Apparatus and methods for performing electrofusion at specific anatomical sites
AU5354190A (en) * 1989-03-17 1990-10-22 Candela Laser Corporation Non-invasive sclerostomy laser apparatus and method
US5174304A (en) * 1990-02-16 1992-12-29 Latina Mark A Electrocycloablation apparatus and method
US5472436A (en) * 1994-07-26 1995-12-05 Fremstad; Daria A. Ocular appliance for delivering medication
US5522864A (en) * 1994-10-25 1996-06-04 Wallace; Larry B. Apparatus and method for ocular treatment
AUPM982694A0 (en) * 1994-12-02 1995-01-05 University Of Queensland, The Iontophoresis method and apparatus
US5676648A (en) * 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use

Also Published As

Publication number Publication date
FR2773320B1 (en) 2000-03-03
DK0927560T3 (en) 2005-08-15
DE69829637D1 (en) 2005-05-12
FR2773320A1 (en) 1999-07-09
BR9900009A (en) 2001-03-20
CA2257749C (en) 2009-03-24
EP1452203A3 (en) 2004-09-08
EP1452203A2 (en) 2004-09-01
EP0927560A1 (en) 1999-07-07
DE69841028D1 (en) 2009-09-10
IL127711A0 (en) 1999-10-28
JPH11244323A (en) 1999-09-14
PT927560E (en) 2005-07-29
EP0927560B1 (en) 2005-04-06
JP4308353B2 (en) 2009-08-05
ES2327636T3 (en) 2009-11-02
KR100551706B1 (en) 2006-07-06
EP1452203B1 (en) 2009-07-29
IL127711A (en) 2004-06-20
ATE292493T1 (en) 2005-04-15
DE69829637T2 (en) 2006-03-09
KR19990066875A (en) 1999-08-16
ATE437672T1 (en) 2009-08-15
US6154671A (en) 2000-11-28
ES2236880T3 (en) 2005-07-16

Similar Documents

Publication Publication Date Title
CA2257749A1 (en) Device for the intraocular transfer of active products by iontophoresis
CA2317232C (en) Apparatus for electrical stimulation of the body
US6101411A (en) Dilation enhancer
US9192512B2 (en) Device for delivering medicines by transpalpebral electrophoresis
CA2307283A1 (en) Dual shock atrial defibrillation apparatus
US9220885B2 (en) Placement devices that enable patients to accurately position medical patches at target locations and methods therefor
EP1754453A3 (en) Improved scleral prosthesis for treatment of presbyopia and other eye disorders
WO2001041685A3 (en) Treatment of ocular disease
CA2294927A1 (en) Circumferential ablation device assembly and method
EP2158937A3 (en) Artificial retina device
WO2005000398A3 (en) Intravascular electrophysiological system and methods
US6083250A (en) Apparatus and method for inhibiting lesion formation by selectively treating the prodromal stage of the lesion with a pulsatile electrical stimulation
CA2231803A1 (en) Lipid extract having anti-inflammatory activity
CA2129635A1 (en) Method of Ophthalmic Drug Delivery
IL125629A (en) Device for application of endermic electrotherapeutic treatments to a human body
JP2006500139A (en) Tactile stimulator
Shwaluk Initiation of reflex activity from the temporomandibular joint of the cat
EP0403360A3 (en) Use of phenylethanolamines for the preparation of a medicament for treating ophthalmologic disorders
WO2003028598A3 (en) An ophthalmic delivery device
WO2000015120A8 (en) Iontophoretic drug delivery electrodes
AU643772B2 (en) Use of hexetidine or its derivatives or salts for the preparation of a pharmaceutical composition for ophthalmological use
CN2288718Y (en) Medicine supply cleaning therapentic equipment for ophthalmopathy
WO2023107404A3 (en) Garment features for therapy electrode pressure and/or stabilization in a wearable medical device
IT1258756B (en) Device to stimulate tissues of the human body
RU93009013A (en) METHOD OF CALLING FRIENDLY SPECIAL REFLEX ON THE LIGHT

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20190104