CA2258829A1 - Electroporation-mediated intravascular delivery - Google Patents

Electroporation-mediated intravascular delivery

Info

Publication number
CA2258829A1
CA2258829A1 CA002258829A CA2258829A CA2258829A1 CA 2258829 A1 CA2258829 A1 CA 2258829A1 CA 002258829 A CA002258829 A CA 002258829A CA 2258829 A CA2258829 A CA 2258829A CA 2258829 A1 CA2258829 A1 CA 2258829A1
Authority
CA
Canada
Prior art keywords
electroporation
intravascular delivery
mediated intravascular
delivery
mediated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002258829A
Other languages
French (fr)
Other versions
CA2258829C (en
Inventor
Sukhendu B. Dev
Nagendu B. Dev
Gunter A. Hofmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetronics Inc
Original Assignee
Genetronics, Inc.
Sukhendu B. Dev
Nagendu B. Dev
Gunter A. Hofmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics, Inc., Sukhendu B. Dev, Nagendu B. Dev, Gunter A. Hofmann filed Critical Genetronics, Inc.
Publication of CA2258829A1 publication Critical patent/CA2258829A1/en
Application granted granted Critical
Publication of CA2258829C publication Critical patent/CA2258829C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Abstract

A method for sustained intravascular delivery via electroporation is provided.
The method is useful for delivery of therapeutic compositions such as antithrombotic and anticoagulant agents. The invention also provides a catheter apparatus for introducing a composition into at least one cell in a vessel in a subject.
CA002258829A 1996-06-24 1997-06-23 Electroporation-mediated intravascular delivery Expired - Fee Related CA2258829C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/668,725 US5944710A (en) 1996-06-24 1996-06-24 Electroporation-mediated intravascular delivery
US08/668,725 1996-06-24
PCT/US1997/010975 WO1997049450A1 (en) 1996-06-24 1997-06-23 Electroporation-mediated intravascular delivery

Publications (2)

Publication Number Publication Date
CA2258829A1 true CA2258829A1 (en) 1997-12-31
CA2258829C CA2258829C (en) 2007-12-18

Family

ID=24683482

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002258829A Expired - Fee Related CA2258829C (en) 1996-06-24 1997-06-23 Electroporation-mediated intravascular delivery

Country Status (6)

Country Link
US (2) US5944710A (en)
EP (1) EP0915721B1 (en)
JP (1) JP4126095B2 (en)
CA (1) CA2258829C (en)
DE (1) DE69735763T2 (en)
WO (1) WO1997049450A1 (en)

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