CA2259437A1 - Multiple mechanical microporation of skin or mucosa - Google Patents

Multiple mechanical microporation of skin or mucosa

Info

Publication number
CA2259437A1
CA2259437A1 CA002259437A CA2259437A CA2259437A1 CA 2259437 A1 CA2259437 A1 CA 2259437A1 CA 002259437 A CA002259437 A CA 002259437A CA 2259437 A CA2259437 A CA 2259437A CA 2259437 A1 CA2259437 A1 CA 2259437A1
Authority
CA
Canada
Prior art keywords
drug
mucosa
skin
multiple mechanical
microporation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002259437A
Other languages
French (fr)
Other versions
CA2259437C (en
Inventor
Jonathan A. Eppstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
Original Assignee
Altea Technologies, Inc.
Spectrx, Inc.
Jonathan A. Eppstein
Altea Development Corp.
Altea Therapeutics Corporation
Guided Therapeutics, Inc.
Midcap Funding Iii, Llc
Nitto Denko Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altea Technologies, Inc., Spectrx, Inc., Jonathan A. Eppstein, Altea Development Corp., Altea Therapeutics Corporation, Guided Therapeutics, Inc., Midcap Funding Iii, Llc, Nitto Denko Corporation filed Critical Altea Technologies, Inc.
Publication of CA2259437A1 publication Critical patent/CA2259437A1/en
Application granted granted Critical
Publication of CA2259437C publication Critical patent/CA2259437C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Abstract

A device and methods of use for delivering a drug to the body, or monitoring an analyze found in the body, are described. The device (10) comprises a base (14), a plurality of puncturing members (18) extending therefrom, a plurality of holes (26) extending through the base for the passage of drug or the analyze therethrough, and a network of channels (66) for distributing the drug or collecting the analyte.
Methods of trans-dermal or trans-mucous delivering a drug or monitoring an analyte are also disclosed.
CA002259437A 1996-07-03 1997-07-03 Multiple mechanical microporation of skin or mucosa Expired - Lifetime CA2259437C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2121296P 1996-07-03 1996-07-03
US60/021,212 1996-07-03
PCT/US1997/011670 WO1998000193A1 (en) 1996-07-03 1997-07-03 Multiple mechanical microporation of skin or mucosa

Publications (2)

Publication Number Publication Date
CA2259437A1 true CA2259437A1 (en) 1998-01-08
CA2259437C CA2259437C (en) 2006-12-05

Family

ID=21802981

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002259437A Expired - Lifetime CA2259437C (en) 1996-07-03 1997-07-03 Multiple mechanical microporation of skin or mucosa

Country Status (10)

Country Link
US (2) US6183434B1 (en)
EP (1) EP0921840B1 (en)
JP (1) JP3942640B2 (en)
AT (1) ATE241405T1 (en)
AU (1) AU3880697A (en)
CA (1) CA2259437C (en)
DE (1) DE69722414T2 (en)
DK (1) DK0921840T3 (en)
ES (1) ES2200187T3 (en)
WO (1) WO1998000193A1 (en)

Families Citing this family (276)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060240381A1 (en) * 1995-08-31 2006-10-26 Biolase Technology, Inc. Fluid conditioning system
US20090143775A1 (en) * 1995-08-31 2009-06-04 Rizoiu Ioana M Medical laser having controlled-temperature and sterilized fluid output
EP1579814A3 (en) * 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
US20020010406A1 (en) 1996-05-17 2002-01-24 Douglas Joel S. Methods and apparatus for expressing body fluid from an incision
US7828749B2 (en) * 1996-05-17 2010-11-09 Roche Diagnostics Operations, Inc. Blood and interstitial fluid sampling device
US7235056B2 (en) * 1996-05-17 2007-06-26 Amira Medical Body fluid sampling device and methods of use
EP0914178B1 (en) 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
CA2265906C (en) * 1996-09-17 2003-11-11 Deka Products Limited Partnership System for delivery of drugs by transport
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US20060002959A1 (en) * 1996-11-14 2006-01-05 Government Of The United States Skin-sctive adjuvants for transcutaneous immuization
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US8182473B2 (en) * 1999-01-08 2012-05-22 Palomar Medical Technologies Cooling system for a photocosmetic device
US20060149343A1 (en) * 1996-12-02 2006-07-06 Palomar Medical Technologies, Inc. Cooling system for a photocosmetic device
WO1998029134A2 (en) * 1996-12-31 1998-07-09 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
AU7568698A (en) 1997-05-15 1998-12-08 General Hospital Corporation, The Method and apparatus for dermatology treatment
US20040258703A1 (en) * 1997-11-14 2004-12-23 The Government Of The Us, As Represented By The Secretary Of The Army Skin-active adjuvants for transcutaneous immunization
US6706000B2 (en) * 1997-11-21 2004-03-16 Amira Medical Methods and apparatus for expressing body fluid from an incision
DE19800416C2 (en) * 1998-01-08 2002-09-19 Storz Karl Gmbh & Co Kg Device for the treatment of body tissue, in particular soft tissue close to the surface, by means of ultrasound
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
DE69938100D1 (en) * 1998-03-06 2008-03-20 Spectrx Inc INTEGRATED PORATION, COLLECTION AND ANALYSIS DEVICE AND METHOD THEREFOR
DE69926348T2 (en) 1998-03-12 2006-06-01 Palomar Medical Technologies, Inc., Burlington SYSTEM FOR THE ELECTROMAGNETIC IRRADIATION OF THE SKIN
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
EP1090301B1 (en) 1998-06-24 2002-07-31 Transderm Technologies LLC Non-invasive transdermal detection of analytes
EP1189281B1 (en) * 1998-06-30 2007-08-22 Micronas GmbH Chip-arrangement
WO2000003758A1 (en) 1998-07-14 2000-01-27 Spectrx, Inc. Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport
US7384396B2 (en) 1998-07-21 2008-06-10 Spectrx Inc. System and method for continuous analyte monitoring
US7037277B1 (en) 1998-07-21 2006-05-02 Spectrx, Inc. System and method for fluid management in a continuous fluid collection and sensor device
CA2343762A1 (en) 1998-09-10 2000-03-23 Spectrx, Inc. Attribute compensation for analyte detection and/or continuous monitoring
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6708060B1 (en) * 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6597946B2 (en) * 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
JP4932086B2 (en) * 1999-04-08 2012-05-16 インターセル ユーエスエイ、インコーポレイテッド Dry formulation for transcutaneous immunization
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
CA2376128C (en) * 1999-06-04 2009-01-06 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
ES2260021T3 (en) * 1999-06-08 2006-11-01 Altea Therapeutics Corporation APPARATUS FOR THE MICROPORATION OF BIOLOGICAL MEMBRANES USING DEVICES OF TEXTLE FILM FABRIC INTERFACE, AND ITS METHOD.
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
AU5482000A (en) 1999-06-11 2001-01-02 Altea Therapeutics Corporation Integrated alignment devices, systems, and methods for efficient fluid extraction, substance delivery and other applications
US6925317B1 (en) 1999-06-11 2005-08-02 Spectrx, Inc. Integrated alignment devices, system, and methods for efficient fluid extraction, substance delivery and other applications
WO2000078212A1 (en) * 1999-06-18 2000-12-28 University Of Virginia Patent Foundation An apparatus for fluid transport and related method thereof
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
DE60024312T2 (en) 1999-12-10 2006-08-17 Alza Corp., Mountain View Transdermal drug delivery of macromolecular agents and device therefor
CA2398238A1 (en) * 2000-01-25 2001-08-02 Palomar Medical Technologies, Inc. Method and apparatus for medical treatment utilizing long duration electromagnetic radiation
WO2001066065A2 (en) * 2000-03-09 2001-09-13 Nanopass Ltd. Systems and methods for fluid transport through dermal barriers
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
AU8857501A (en) 2000-09-08 2002-03-22 Insulet Corp Devices, systems and methods for patient infusion
DE60129585T2 (en) 2000-09-08 2008-04-17 Alza Corp., Mountain View TRANSDERMALE DEVICE
JP2002085561A (en) * 2000-09-14 2002-03-26 Terumo Corp Liquid injection needle
WO2002030506A2 (en) * 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
CA2425537C (en) 2000-10-13 2009-09-08 Alza Corporation Microblade array impact applicator
ES2317940T3 (en) 2000-10-13 2009-05-01 Alza Corporation RETAINING DEVICE FOR A MICROSALIENT ELEMENT FOR IMPACT APPLICATOR.
US6882884B1 (en) 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
KR20030068136A (en) 2000-10-13 2003-08-19 알자 코포레이션 Apparatus and method for piercing skin with microprotrusions
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
CN1239212C (en) 2000-10-26 2006-02-01 阿尔扎公司 Device for percutaneous transdermal delivery having coated micro-protrusions
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US7027478B2 (en) 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US20060020309A1 (en) * 2004-04-09 2006-01-26 Palomar Medical Technologies, Inc. Methods and products for producing lattices of EMR-treated islets in tissues, and uses therefor
US20080214988A1 (en) * 2000-12-28 2008-09-04 Palomar Medical Technologies, Inc. Methods And Devices For Fractional Ablation Of Tissue
US6805926B2 (en) 2001-02-23 2004-10-19 Technical Graphics Security Products, Llc Security label having security element and method of making same
US6888319B2 (en) * 2001-03-01 2005-05-03 Palomar Medical Technologies, Inc. Flashlamp drive circuit
CN1872363A (en) * 2001-03-02 2006-12-06 帕洛玛医疗技术公司 Apparatus and method for photocosmetic and photodermatological treatment
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6855372B2 (en) 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
CN101129327A (en) 2001-04-20 2008-02-27 阿尔扎公司 Micro-projection array having a beneficial agent containing coating
EP3251722B1 (en) 2001-04-20 2020-06-17 ALZA Corporation Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US7186235B2 (en) * 2001-06-08 2007-03-06 Becton, Dickinson And Company Device for manipulating a needle or abrader array and method of use
US20020188223A1 (en) 2001-06-08 2002-12-12 Edward Perez Devices and methods for the expression of bodily fluids from an incision
US6721586B2 (en) 2001-06-12 2004-04-13 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US6875613B2 (en) 2001-06-12 2005-04-05 Lifescan, Inc. Biological fluid constituent sampling and measurement devices and methods
US6793632B2 (en) 2001-06-12 2004-09-21 Lifescan, Inc. Percutaneous biological fluid constituent sampling and measurement devices and methods
US6501976B1 (en) 2001-06-12 2002-12-31 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US6837988B2 (en) 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
US20030028125A1 (en) * 2001-08-06 2003-02-06 Yuzhakov Vadim V. Physiological sample collection devices and methods of using the same
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024518A2 (en) * 2001-09-14 2003-03-27 The Procter & Gamble Company Microstructures for delivering a composition cutaneously to skin using rotatable structures
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2002327675A1 (en) 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
DE60239229D1 (en) 2001-09-21 2011-03-31 Valeritas Inc GAS PRESSURE-OPERATED MICRONADEL ARRANGEMENTS AND ASSOCIATED SYSTEMS AND METHODS THEREOF
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
ATE420676T1 (en) * 2001-10-29 2009-01-15 Becton Dickinson Co DEVICE FOR DELIVERING A SUBSTANCE
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US20040147984A1 (en) * 2001-11-29 2004-07-29 Palomar Medical Technologies, Inc. Methods and apparatus for delivering low power optical treatments
US6952604B2 (en) * 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
WO2003057059A1 (en) * 2001-12-27 2003-07-17 Palomar Medical Technologies, Inc. Method and apparatus for improved vascular related treatment
US20040073175A1 (en) * 2002-01-07 2004-04-15 Jacobson James D. Infusion system
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
WO2003066126A2 (en) * 2002-02-04 2003-08-14 Becton, Dickinson And Company Dermal access member
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
EP3061492B1 (en) 2002-03-11 2018-09-19 Nitto Denko Corporation Transdermal drug delivery patch system
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
EP1499255B1 (en) 2002-04-19 2015-07-22 Syneron Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US7060192B2 (en) 2002-05-09 2006-06-13 Lifescan, Inc. Methods of fabricating physiological sample collection devices
US20070239142A1 (en) * 2006-03-10 2007-10-11 Palomar Medical Technologies, Inc. Photocosmetic device
BR0311901A (en) * 2002-06-19 2005-04-05 Gen Hospital Corp Process and apparatus for photothermal deep tissue treatment
JP2005535370A (en) 2002-06-19 2005-11-24 パロマー・メディカル・テクノロジーズ・インコーポレイテッド Method and apparatus for treating skin and subcutaneous conditions
BR0312671A (en) * 2002-07-19 2005-04-26 3M Innovative Properties Co Micro-needle device, method for using a micro-needle device, and method for applying a micro-needle device
ES2537171T3 (en) * 2002-08-29 2015-06-03 Becton Dickinson And Company Micro-scraper with controlled scraping characteristics
WO2004033021A1 (en) 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
US20070219604A1 (en) * 2006-03-20 2007-09-20 Palomar Medical Technologies, Inc. Treatment of tissue with radiant energy
EP1555948A2 (en) * 2002-10-23 2005-07-27 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
US20040225339A1 (en) * 2002-12-20 2004-11-11 Palomar Medical Technologies Inc. Light treatments for acne and other disorders of follicles
AU2004213047A1 (en) * 2003-02-19 2004-09-02 Palomar Medical Technologies, Inc. Method and apparatus for treating pseudofolliculitis barbae
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20080149524A1 (en) * 2003-03-27 2008-06-26 Rademaker William B Food containers including dental cleaning devices and other personal care items
EP3572106A1 (en) 2003-04-23 2019-11-27 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
JP2004343275A (en) * 2003-05-14 2004-12-02 Murata Mach Ltd Image processing system and scanner
BRPI0412029A (en) 2003-06-30 2006-09-05 Alza Corp formulations for coated microprojections containing nonvolatile counterions
US20050059166A1 (en) * 2003-09-11 2005-03-17 Robert Markes Sampling instrument
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
AU2004285484A1 (en) 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
WO2005044139A2 (en) 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
CN100571643C (en) 2003-10-31 2009-12-23 阿尔扎公司 The self-driven applicator that is used for microprotrusion array
AU2004292953A1 (en) * 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
CN1886171A (en) * 2003-11-28 2006-12-27 艾克若克斯Dds有限公司 Method and system for rapid transdermal administration
US7220254B2 (en) * 2003-12-31 2007-05-22 Palomar Medical Technologies, Inc. Dermatological treatment with visualization
US20100151406A1 (en) * 2004-01-08 2010-06-17 Dmitri Boutoussov Fluid conditioning system
KR20060134050A (en) * 2004-01-09 2006-12-27 알자 코포레이션 Frequency assisted transdermal agent delivery method and system
CA2557966C (en) 2004-03-06 2012-07-10 F. Hoffmann-La Roche Ag Body fluid sampling device
US7819822B2 (en) * 2004-03-06 2010-10-26 Roche Diagnostics Operations, Inc. Body fluid sampling device
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
EP1742588B1 (en) 2004-04-01 2016-10-19 The General Hospital Corporation Apparatus for dermatological treatment and tissue reshaping
US8882717B2 (en) * 2004-04-12 2014-11-11 Allergan, Inc. Multi-site injection system
US7315758B2 (en) 2004-06-03 2008-01-01 Lynntech, Inc. Transdermal delivery of therapeutic agent
US9089636B2 (en) * 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
WO2006047290A2 (en) * 2004-10-21 2006-05-04 Bayer Healthcare Llc Method of determining the concentration of an analyte in a body fluid and system therefor
JP2008529746A (en) * 2005-02-18 2008-08-07 パロマー・メディカル・テクノロジーズ・インコーポレイテッド Dermatological treatment device
US20060253176A1 (en) * 2005-02-18 2006-11-09 Palomar Medical Technologies, Inc. Dermatological treatment device with deflector optic
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
BRPI0611186A2 (en) 2005-06-03 2010-08-24 Biolase Tech Inc Tissue treatment device and method
CA2610757A1 (en) * 2005-06-10 2006-12-14 Transpharma Medical, Ltd. Patch for transdermal drug delivery
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
TWI419717B (en) * 2005-06-17 2013-12-21 Altea Therapeutics Corp Permeant delivery system and methods for use thereof
KR101070165B1 (en) * 2005-06-24 2011-10-05 바이오레이즈 테크놀로지, 인크. Visual feedback implements for electromagnetic energy output devices
BRPI0616167A2 (en) 2005-09-15 2011-06-07 Palomar Medical Tech Inc optical skin characterization device
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
EP3461406A1 (en) 2005-09-30 2019-04-03 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US20070194717A1 (en) * 2006-02-17 2007-08-23 Palomar Medical Technologies, Inc. Lamp for use in a tissue treatment device
CA2646324C (en) 2006-03-30 2016-06-07 Valeritas, Llc Multi-cartridge fluid delivery device
WO2007117580A2 (en) * 2006-04-06 2007-10-18 Palomar Medical Technologies, Inc. Apparatus and method for skin treatment with compression and decompression
US7662177B2 (en) * 2006-04-12 2010-02-16 Bacoustics, Llc Apparatus and methods for pain relief using ultrasound waves in combination with cryogenic energy
EP2010276B1 (en) * 2006-04-26 2014-01-22 Covidien LP Multi-stage microporation device
EP2036586B1 (en) * 2006-07-04 2015-09-09 Toppan Printing Co., Ltd. Method for manufacturing microneedle
US10208158B2 (en) 2006-07-10 2019-02-19 Medipacs, Inc. Super elastic epoxy hydrogel
EP2047882B1 (en) * 2006-07-27 2014-09-10 Toppan Printing Co., Ltd. Microneedle and method for producing microneedle
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
US20080152592A1 (en) * 2006-12-21 2008-06-26 Bayer Healthcare Llc Method of therapeutic drug monitoring
CA2676221C (en) * 2007-01-22 2016-12-20 Corium International, Inc. Applicators for microneedles
US9101377B2 (en) * 2007-01-25 2015-08-11 Biolase, Inc. Electromagnetic energy output system
US7695469B2 (en) * 2007-01-25 2010-04-13 Biolase Technology, Inc. Electromagnetic energy output system
US7815630B2 (en) * 2007-01-25 2010-10-19 Biolase Technology, Inc. Target-close electromagnetic energy emitting device
US20080186591A1 (en) * 2007-02-01 2008-08-07 Palomar Medical Technologies, Inc. Dermatological device having a zoom lens system
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
US20090225060A1 (en) * 2007-05-03 2009-09-10 Rizoiu Ioana M Wrist-mounted laser with animated, page-based graphical user-interface
US8143034B2 (en) * 2007-08-21 2012-03-27 Polytechnic Institute Of New York University Method for preparing long-chain hydroxyacids, diacids and oligomers and polymers thereof
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
US9037229B2 (en) * 2007-10-09 2015-05-19 Syneron Medical Ltd Magnetic patch coupling
JP5178132B2 (en) * 2007-10-11 2013-04-10 キヤノン株式会社 Image processing system and image processing method
EP2205967B1 (en) * 2007-10-17 2013-05-01 Syneron Medical Ltd. Dissolution rate verification
CA2704164A1 (en) * 2007-10-29 2009-05-07 Transpharma Medical Ltd. Vertical patch drying
US9995295B2 (en) 2007-12-03 2018-06-12 Medipacs, Inc. Fluid metering device
JP2011505899A (en) 2007-12-05 2011-03-03 シネロン メディカル リミテッド Disposable electromagnetic energy applicator and method of using the same
WO2009079589A2 (en) 2007-12-17 2009-06-25 New World Pharmaceuticals, Llc Integrated intra-dermal delivery, diagnostic and communication system
EP2280645B1 (en) * 2008-05-02 2015-03-18 Covidien LP Skin preparation device and biopotential sensor
JP5816080B2 (en) 2008-05-30 2015-11-17 インテュイティ メディカル インコーポレイテッド Body fluid collection device and collection site interface
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
ES2907152T3 (en) 2008-06-06 2022-04-22 Intuity Medical Inc Blood glucose meter and method of operation
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
KR101013581B1 (en) * 2008-08-06 2011-02-14 라종주 Electric Skin Treatment Device
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
TW201027393A (en) 2009-01-06 2010-07-16 Pixart Imaging Inc Electronic apparatus with virtual data input device
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
ES2634667T3 (en) * 2009-04-24 2017-09-28 Corium International, Inc. Methods for manufacturing microprojection assemblies
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US9238102B2 (en) 2009-09-10 2016-01-19 Medipacs, Inc. Low profile actuator and improved method of caregiver controlled administration of therapeutics
US9017310B2 (en) * 2009-10-08 2015-04-28 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including microneedles
US8882748B2 (en) 2009-10-08 2014-11-11 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including chemical permeation enhancers
US9014799B2 (en) * 2009-10-08 2015-04-21 Palo Alto Research Center Incorporated Transmucosal drug delivery device and method including electrically-actuated permeation enhancement
EP3106871B1 (en) 2009-11-30 2021-10-27 Intuity Medical, Inc. A method of verifying the accuracy of the operation of an analyte monitoring device
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
BR112012021805A2 (en) * 2010-03-01 2016-05-17 Inovio Pharmaceuticals Inc tolerable and minimally invasive skin electroporation device
JP6327852B2 (en) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド Methods and devices for transdermal delivery of parathyroid hormone using microprojection arrays
EP2584964B1 (en) 2010-06-25 2021-08-04 Intuity Medical, Inc. Analyte monitoring devices
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
WO2013066427A1 (en) * 2011-06-28 2013-05-10 Inovio Pharmaceuticals, Inc. A miniminally invasive dermal electroporation device
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
EP2847249A4 (en) 2012-03-14 2016-12-28 Medipacs Inc Smart polymer materials with excess reactive molecules
WO2013149186A1 (en) 2012-03-30 2013-10-03 Insulet Corporation Fluid delivery device with transcutaneous access tool, insertion mechansim and blood glucose monitoring for use therewith
KR102183581B1 (en) 2012-04-18 2020-11-27 싸이노슈어, 엘엘씨 Picosecond laser apparatus and methods for treating target tissues with same
JP2015523876A (en) * 2012-05-30 2015-08-20 スコット マクナルティ System, method, and apparatus for electromagnetic detection and analysis of biometric information
KR101372403B1 (en) * 2012-06-21 2014-03-25 주식회사 파나시 Pressure Sensitive Automatic Injection System
US9999720B2 (en) 2012-09-27 2018-06-19 Palo Alto Research Center Incorporated Drug reconstitution and delivery device and methods
US9005108B2 (en) 2012-09-27 2015-04-14 Palo Alto Research Center Incorporated Multiple reservoir drug delivery device and methods
WO2014073531A1 (en) 2012-11-09 2014-05-15 凸版印刷株式会社 Needle-like structure and method for manufacturing same
JP6865524B2 (en) 2012-12-21 2021-04-28 コリウム， インコーポレイテッド Microarrays and usages for delivering therapeutic agents
US9744341B2 (en) 2013-01-15 2017-08-29 Palo Alto Research Center Incorporated Devices and methods for intraluminal retention and drug delivery
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
EP3751684A1 (en) 2013-03-15 2020-12-16 Cynosure, Inc. Picosecond optical radiation systems and methods of use
CN105246458B (en) 2013-03-15 2020-09-15 考里安公司 Microarrays for therapeutic agent delivery and methods of use thereof
CA2903583C (en) 2013-03-15 2021-12-28 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP2968751B1 (en) 2013-03-15 2022-11-30 Corium, Inc. Multiple impact microprojection applicators
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
WO2014205412A1 (en) 2013-06-21 2014-12-24 Intuity Medical, Inc. Analyte monitoring system with audible feedback
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
US9297083B2 (en) 2013-12-16 2016-03-29 Palo Alto Research Center Incorporated Electrolytic gas generating devices, actuators, and methods
GB2523989B (en) 2014-01-30 2020-07-29 Insulet Netherlands B V Therapeutic product delivery system and method of pairing
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
JP6565906B2 (en) 2014-05-20 2019-08-28 凸版印刷株式会社 Needle-like body manufacturing method and needle-like body
US9801660B2 (en) 2014-07-31 2017-10-31 Palo Alto Research Center Incorporated Implantable fluid delivery devices, systems, and methods
US10278675B2 (en) 2014-07-31 2019-05-07 Palo Alto Research Center Incorporated Implantable estrus detection devices, systems, and methods
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
WO2016072350A1 (en) * 2014-11-07 2016-05-12 凸版印刷株式会社 Needle assembly for transdermal administration and method for manufacturing same
WO2016134137A1 (en) 2015-02-18 2016-08-25 Insulet Corporation Fluid delivery and infusion devices, and methods of use thereof
CN107530490B (en) 2015-03-10 2021-06-25 爱力根销售有限责任公司 Multi-needle syringe
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017091624A1 (en) 2015-11-24 2017-06-01 Insulet Corporation Wearable automated medication delivery system
WO2017091584A1 (en) 2015-11-25 2017-06-01 Insulet Corporation Wearable medication delivery device
US10275573B2 (en) 2016-01-13 2019-04-30 Bigfoot Biomedical, Inc. User interface for diabetes management system
CN112933333B (en) 2016-01-14 2023-03-28 比格福特生物医药公司 Adjusting insulin delivery rate
WO2017136268A1 (en) 2016-02-04 2017-08-10 Insulet Corporation Anti-inflammatory cannula
AU2017246114B2 (en) 2016-04-08 2022-03-17 Allergan, Inc. Aspiration and injection device
WO2018058041A1 (en) 2016-09-23 2018-03-29 Insulet Corporation Fluid delivery device with sensor
WO2018080923A1 (en) * 2016-10-28 2018-05-03 Georgetown University Non-invasive passive interstitial fluid collector
WO2018144506A1 (en) 2017-01-31 2018-08-09 Georgetown University Harvesting cell-free non-coding rnas (cfncrs) from interstitial fluid for sensitive biomarkers
US11045603B2 (en) 2017-02-22 2021-06-29 Insulet Corporation Needle insertion mechanisms for drug containers
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
US10898656B2 (en) 2017-09-26 2021-01-26 Insulet Corporation Needle mechanism module for drug delivery device
US11147931B2 (en) 2017-11-17 2021-10-19 Insulet Corporation Drug delivery device with air and backflow elimination
WO2019165426A1 (en) 2018-02-26 2019-08-29 Cynosure, Inc. Q-switched cavity dumped sub-nanosecond laser
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
AU2019263490A1 (en) 2018-05-04 2020-11-26 Insulet Corporation Safety constraints for a control algorithm-based drug delivery system
AU2019347755B2 (en) 2018-09-28 2023-02-02 Insulet Corporation Activity mode for artificial pancreas system
US11565039B2 (en) 2018-10-11 2023-01-31 Insulet Corporation Event detection for drug delivery system
US11801344B2 (en) 2019-09-13 2023-10-31 Insulet Corporation Blood glucose rate of change modulation of meal and correction insulin bolus quantity
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
WO2021113647A1 (en) 2019-12-06 2021-06-10 Insulet Corporation Techniques and devices providing adaptivity and personalization in diabetes treatment
US11833329B2 (en) 2019-12-20 2023-12-05 Insulet Corporation Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns
US11551802B2 (en) 2020-02-11 2023-01-10 Insulet Corporation Early meal detection and calorie intake detection
US11547800B2 (en) 2020-02-12 2023-01-10 Insulet Corporation User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system
US11324889B2 (en) 2020-02-14 2022-05-10 Insulet Corporation Compensation for missing readings from a glucose monitor in an automated insulin delivery system
US11607493B2 (en) 2020-04-06 2023-03-21 Insulet Corporation Initial total daily insulin setting for user onboarding
US11684716B2 (en) 2020-07-31 2023-06-27 Insulet Corporation Techniques to reduce risk of occlusions in drug delivery systems
US11904140B2 (en) 2021-03-10 2024-02-20 Insulet Corporation Adaptable asymmetric medicament cost component in a control system for medicament delivery
CN117295535A (en) * 2021-06-09 2023-12-26 花王株式会社 injection needle
WO2023049900A1 (en) 2021-09-27 2023-03-30 Insulet Corporation Techniques enabling adaptation of parameters in aid systems by user input
US11439754B1 (en) 2021-12-01 2022-09-13 Insulet Corporation Optimizing embedded formulations for drug delivery

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4340048A (en) * 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US4522622A (en) 1982-12-23 1985-06-11 Alza Corporation Multiple fluid pulse dispenser
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
US5169389A (en) 1989-06-16 1992-12-08 Science, Inc. Fluid delivery apparatus
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5115805A (en) 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5223219A (en) 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5421816A (en) 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
US5582184A (en) * 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
AU4256496A (en) 1994-12-09 1996-06-26 Novartis Ag Transdermal system
TR199800347T1 (en) * 1995-08-29 1998-05-21 Spectrx, Inc. Micro-poring of human skin for drug application and monitoring applications.
US5801057A (en) 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
JP2828064B2 (en) * 1996-09-20 1998-11-25 日本電気株式会社 Suction leachate collection method and device
US6027459A (en) 1996-12-06 2000-02-22 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
WO1998029134A2 (en) * 1996-12-31 1998-07-09 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6155992A (en) 1997-12-02 2000-12-05 Abbott Laboratories Method and apparatus for obtaining interstitial fluid for diagnostic tests
ES2253876T3 (en) 1998-02-17 2006-06-01 Abbott Laboratories DEVICE FOR COLLECTION AND CONTROL OF INTERSTITIAL LIQUID.
US6022316A (en) * 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications

Also Published As

Publication number Publication date
DE69722414D1 (en) 2003-07-03
EP0921840A1 (en) 1999-06-16
EP0921840B1 (en) 2003-05-28
WO1998000193A1 (en) 1998-01-08
DK0921840T3 (en) 2003-09-22
EP0921840A4 (en) 2000-04-12
CA2259437C (en) 2006-12-05
ATE241405T1 (en) 2003-06-15
AU3880697A (en) 1998-01-21
US20020010412A1 (en) 2002-01-24
JP2000513971A (en) 2000-10-24
JP3942640B2 (en) 2007-07-11
ES2200187T3 (en) 2004-03-01
DE69722414T2 (en) 2004-05-19
US6183434B1 (en) 2001-02-06

Similar Documents

Publication Publication Date Title
CA2259437A1 (en) Multiple mechanical microporation of skin or mucosa
CA2271167A1 (en) Device and method for enhancing transdermal agent flux
DE69925506D1 (en) IMPLANTABLE MEDICAL DEVICE, MONITORING PROCESS AND SYSTEM
AU6953698A (en) Minimally invasive detecting device
WO2002078592A3 (en) Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses
AU8920291A (en) Disposable skin perforator and blood testing device
GB9822117D0 (en) Computerized optometer and medical office management system
HU9802422D0 (en) Substituted isoquinoline-3-carboxamide derivatives, process for producing them and their medical use
WO1988006440A3 (en) Liposome-incorporated nystatin
FR2739031B1 (en) TRANSDERMAL MATRIX SYSTEM FOR ADMINISTRATION OF AN ESTROGEN AND / OR A PROGESTIVE BASED ON STYRENE-ISOPRENE-STYRENE COPOLYMER, PREPARATION METHOD AND THERAPEUTIC USE
DE59702560D1 (en) Spunbonded nonwoven and device for its production
SI0825178T1 (en) Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or in diagnostic agents and drugs containing them
CA2200174A1 (en) Central station waveform display having dedicated user message areas
IT8620102A0 (en) PROCEDURE AND DEVICE FOR PREPARING CROISSANTS, PREFERABLY CROISSANTS.
AU2910397A (en) Cytokine production inhibitors, formulations thereof and their use in medicine, and methods for their identification
FR2793688B1 (en) GASTROPROTEGED MICROGRANULES, PROCESS FOR OBTAINING AND PHARMACEUTICAL PREPARATIONS
AU1138699A (en) Dna demethylase, therapeutic and diagnostic uses thereof
PT81782A (en) PREFERRED EXTRACTION METHODS METHOD FOR THE PRODUCTION THEREOF AND CORRESPONDING AGENTS FOR HUMAN AND VETERINARY MEDICINAL USE
ZA200007111B (en) Methods and devices for providing prolonged drug therapy.
EP0897988A4 (en) Physiologically active substances tkr1785's, process for the preparation thereof, and microbe
DE69713586D1 (en) DOSAGE FORMS AND THEIR USE
AU7003096A (en) Semi-finished product for producing drug bases, bases obtained using the same and variants, and drugs obtained using these bases and variants
林道红 et al. Experimental Research on the Cryopreserved Human Fetal Brain Tissue in Culture
NL191276B (en) Radio, comprising a broadcast channel indicating device and a broadcasting channel indicating device for use in a radio.
HUP9901870A3 (en) 5alfa-reductase inhibitory preparation for oral administration, process for producing the same, and use thereof

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170704