CA2259984A1 - Precise efficacy assay methods for active agents including chemotherapeutic agents - Google Patents
Precise efficacy assay methods for active agents including chemotherapeutic agentsInfo
- Publication number
- CA2259984A1 CA2259984A1 CA002259984A CA2259984A CA2259984A1 CA 2259984 A1 CA2259984 A1 CA 2259984A1 CA 002259984 A CA002259984 A CA 002259984A CA 2259984 A CA2259984 A CA 2259984A CA 2259984 A1 CA2259984 A1 CA 2259984A1
- Authority
- CA
- Canada
- Prior art keywords
- tissue sample
- patient
- preparation
- agents
- active agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficay as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best treatment or agent for the particular patient. Specific method innovations such as tissue sample preparation techniques render this method practically as well as theoretically useful. One particularly important tissue sample preparation technique is the initial preparation of cohesive multicellular particulates of the tissue sample, rather than enzymatically dissociated cell suspensions or preparations, for initial tissue culture monolayer preparation. By subjecting uniform samples of cells to a wide variety of active agents (and concentrations thereof), the most promising agent and concentration for treatment of a particular patient can be determined.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/679,056 US5728541A (en) | 1996-07-12 | 1996-07-12 | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
US08/679,056 | 1996-07-12 | ||
PCT/US1997/011595 WO1998002038A1 (en) | 1996-07-12 | 1997-07-10 | Precise efficacy assay methods for active agents including chemotherapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2259984A1 true CA2259984A1 (en) | 1998-01-22 |
CA2259984C CA2259984C (en) | 2008-10-07 |
Family
ID=24725407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002259984A Expired - Lifetime CA2259984C (en) | 1996-07-12 | 1997-07-10 | Precise efficacy assay methods for active agents including chemotherapeutic agents |
Country Status (13)
Country | Link |
---|---|
US (13) | US5728541A (en) |
EP (1) | EP0912085B1 (en) |
JP (1) | JP4108128B2 (en) |
CN (1) | CN1143618C (en) |
AT (1) | ATE360989T1 (en) |
AU (1) | AU712302B2 (en) |
BR (1) | BR9710348A (en) |
CA (1) | CA2259984C (en) |
DE (1) | DE69737684T2 (en) |
ES (1) | ES2283022T3 (en) |
IL (1) | IL127964A (en) |
NZ (1) | NZ333830A (en) |
WO (1) | WO1998002038A1 (en) |
Families Citing this family (70)
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US5728541A (en) * | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
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US6416967B2 (en) * | 1996-07-12 | 2002-07-09 | Precision Therapeutics, Inc. | Method of using multicellular particulates to analyze malignant or hyperproliferative tissue |
US20040023375A1 (en) * | 2002-07-30 | 2004-02-05 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays |
US6171780B1 (en) | 1997-06-02 | 2001-01-09 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
US6517781B1 (en) * | 1997-06-02 | 2003-02-11 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
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-
1996
- 1996-07-12 US US08/679,056 patent/US5728541A/en not_active Expired - Lifetime
-
1997
- 1997-07-10 AU AU36493/97A patent/AU712302B2/en not_active Ceased
- 1997-07-10 BR BR9710348-9A patent/BR9710348A/en not_active Application Discontinuation
- 1997-07-10 ES ES97933267T patent/ES2283022T3/en not_active Expired - Lifetime
- 1997-07-10 DE DE69737684T patent/DE69737684T2/en not_active Expired - Lifetime
- 1997-07-10 NZ NZ333830A patent/NZ333830A/en unknown
- 1997-07-10 CN CNB971961433A patent/CN1143618C/en not_active Expired - Fee Related
- 1997-07-10 IL IL12796497A patent/IL127964A/en not_active IP Right Cessation
- 1997-07-10 WO PCT/US1997/011595 patent/WO1998002038A1/en active IP Right Grant
- 1997-07-10 AT AT97933267T patent/ATE360989T1/en not_active IP Right Cessation
- 1997-07-10 CA CA002259984A patent/CA2259984C/en not_active Expired - Lifetime
- 1997-07-10 EP EP97933267A patent/EP0912085B1/en not_active Expired - Lifetime
- 1997-07-10 JP JP50606998A patent/JP4108128B2/en not_active Expired - Fee Related
-
1998
- 1998-03-16 US US09/039,957 patent/US6933129B1/en not_active Expired - Lifetime
- 1998-03-17 US US09/040,161 patent/US6900027B1/en not_active Expired - Lifetime
-
2002
- 2002-07-26 US US10/205,887 patent/US6887680B2/en not_active Expired - Lifetime
-
2005
- 2005-03-08 US US11/073,931 patent/US7112415B2/en not_active Expired - Lifetime
- 2005-03-17 US US11/081,827 patent/US7314731B2/en not_active Expired - Fee Related
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2006
- 2006-08-15 US US11/504,098 patent/US7563593B2/en not_active Expired - Fee Related
-
2007
- 2007-11-26 US US11/944,884 patent/US7501260B2/en not_active Expired - Fee Related
-
2008
- 2008-09-10 US US12/208,076 patent/US7678552B2/en not_active Expired - Fee Related
- 2008-10-02 US US12/244,463 patent/US7771963B2/en not_active Expired - Fee Related
-
2010
- 2010-01-20 US US12/690,529 patent/US8183009B2/en not_active Expired - Fee Related
- 2010-07-01 US US12/828,665 patent/US8058025B2/en not_active Expired - Fee Related
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2011
- 2011-10-06 US US13/267,581 patent/US20120088264A1/en not_active Abandoned
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