CA2264647A1 - Fragmented polymeric hydrogels for adhesion prevention and their preparation - Google Patents

Fragmented polymeric hydrogels for adhesion prevention and their preparation

Info

Publication number
CA2264647A1
CA2264647A1 CA002264647A CA2264647A CA2264647A1 CA 2264647 A1 CA2264647 A1 CA 2264647A1 CA 002264647 A CA002264647 A CA 002264647A CA 2264647 A CA2264647 A CA 2264647A CA 2264647 A1 CA2264647 A1 CA 2264647A1
Authority
CA
Canada
Prior art keywords
composition
cross
tissue
linked
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002264647A
Other languages
French (fr)
Other versions
CA2264647C (en
Inventor
Donald G. Wallace
Cary J. Reich
Narinder S. Shargill
Felix Vega
A. Edward Osawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107390&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2264647(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2264647A1 publication Critical patent/CA2264647A1/en
Application granted granted Critical
Publication of CA2264647C publication Critical patent/CA2264647C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents

Abstract

Molecular cross-linked gels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such molecular gels may be applied to target sites in a patient's body by extruding the gel through an orifice at the target site. Alternatively, the gels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for inhibiting postsurgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.

Claims (44)

1. A fragmented polymeric composition comprising a biocompatible cross-linked hydrogel having:
a subunit size when fully hydrated in the range from 0.05 mm to 5 mm;
an equilibrium swell from 400% to 1300%; and an in vivo degradation time in a moist tissue environment in the range from 1 day to 1 year.
2. A composition as in claim 1, comprising a dry powder having a particle size in the range from 0.01 mm to 1.5 mm and a moisture content below 20% by weight.
3. A composition as in claim 1, comprising a partially hydrated hydrogel having a degree of hydration in the range from 50% to 95% of the hydration at equilibrium swell.
4. A composition as in claim 1, comprising a fully hydrated hydrogel having a degree of hydration above 95%.
5. A composition as in any one of claims 1-4, wherein the hydrogel has been disrupted after cross-linking.
6. A composition as in any one of claims 1-4, wherein the hydrogel has been disrupted before cross-linking.
7. A composition as in any one of claims 1-4, further comprising a plasticizer selected from the group consisting of polyethylene glycol, sorbitol, and glycerol.
8. A composition as in claim 7, wherein the plasticizer is present at from 0.1% by weight to 30% by weight of the composition of the polymeric component.
9. A composition as in any one of claims 1-4, further comprising an active agent.
10. A composition as in claim 9, wherein the active agent is a hemostatic agent.
11. A composition as in claim 10, wherein the active agent is thrombin.
12. A composition as in any one of claims 1-4, wherein the molecular cross-linked gel comprises a cross-linked protein hydrogel.
13. A composition as in claim 12, wherein the protein is selected from the group consisting of gelatin, soluble collagen, albumin, hemoglobin, fibrogen, fibrin, casein, fibronectin, elastin, keratin, laminin, and derivatives and combinations thereof.
14. A composition as in any one of claims 1-4, wherein the molecular cross-linked gel comprises a cross-linked polysaccharide.
15. A composition as in claim 14, wherein the polysaccharide is selected from the group consisting of glycosaminoglycans, starch derivatives, cellulose derivatives, hemicellulose derivatives, xylan, agarose, alginate, and chitosan, and derivatives and combinations thereof.
16. A composition as in any one of claims 1-4, wherein the molecular cross-linked gel comprises a cross-linked non-biologic polymer.
17. A composition as in claim 16, wherein the polymer selected from the group consisting of polyacrylates, polymethacrylates, polyacrylamides, polyvinyl resins, polylactide-glycolides, polcaprolactones, polyoxyethlenes, and derivatives and combinations thereof.
18. A composition as in any one of claims 1-4, wherein the resorbable molecular cross-linked hydrogel comprises at least two components selected from the group consisting of cross-linked proteins, cross-linked polysaccharides, and cross-linked non-biologic polymers.
19. A composition as in any one of claims 1-4, wherein the molecular cross-linked hydrogel comprises a polymer and a cross-linking agent, wherein the polymer and cross-linking agent have been reacted under conditions which yield cross-linking of polymer molecules.
20. A composition as in any one of claims 1-4, wherein the molecular cross-linked hydrogel has been produced by irradiation of the polymer under conditions which yield cross-linking of polymer molecules.
21. A composition as in any one of claims 1-4, wherein the molecular cross-linked hydrogel has been produced by reaction of monounsaturated and polyunsaturated monomers under conditions which yield cross-linking of polymer molecules.
22. A method for making a polymeric composition, said method comprising:
providing a biocompatible resorbable polymer;
combining the polymer with an aqueous buffer to form a gel;
cross-linking the gel; and disrupting the cross-linked gel.
23. A method for making a polymeric composition, said method comprising:
providing a biocompatible resorbable polymer;
disrupting the polymer;
cross-linking the disrupted polymer; and combining the cross-linked disrupted polymer with an aqueous buffer.
24. A method as in claim 22 or 23, wherein the cross-linking step comprises exposing the polymer to radiation.
25. A method as in claim 24, further comprising combining the cross-linked composition with an amount of a stabilizer effective to inhibit modification of the polymer when exposed to the sterilizing radiation.
26. A method as in claim 25, wherein the stabilizer is ascorbic acid, sodium ascorbate, other salts of ascorbic acid, or an antioxidant.
27. A method for sealing a tissue tract, said method comprising at least partly filling a tissue tract with a composition according to claim 1.
28. A method for inhibiting bleeding at a target site in a patient's body, said method comprising delivering the composition of claim 1 to the target site in an amount sufficient to inhibit bleeding.
29. A method for delivering a bioactive substance to a target site in a patient's body, said method comprising delivering the composition of claim 1 in combination with the bioactive substance to the target site.
30. A method for delivering a swellable composition to a target site in tissue, said method comprising providing a composition according to claim 1, said composition being hydrated at less than its equilibrium swell and applying the composition to the target site, wherein it swells to an equilibrium swell value.
31. A kit comprising:
a composition comprising a sterile biocompatible resorbable molecular cross-linked gel;
written instructions to apply the gel onto a target site on tissue; and a container holding the composition and the written instructions.
32. A kit as in claim 31, wherein the gel is dehydrated.
33. A kit as in claim 31, wherein the gel is hydrated.
34. A method for applying a polymeric composition at a target site in a patient's body, said method comprising:
providing a biocompatible resorbable molecular cross-linked hydrogel; and extruding the gel through an orifice at the target site.
35. A method as in any of claim 1, wherein the extrusion step comprises manually dispensing the hydrogel through a syringe having an orifice size in the range from 0.01 mm to 5.0 mm.
36. A method as in any of claim 1, wherein the hydrogel has been disrupted prior to the extrusion step.
37. A method as in claim 34, wherein the target site is in tissue selected from the group consisting of muscle, skin, epithelial tissue, connective or supporting tissue, nerve tissue, ophthalmic and other sense organ tissue, vascular and cardiac tissue, gastrointestinal organs and tissue, pleura and other pulmonary tissue, kidney, endocrine glands, male and female reproductive organs, adipose tissue, liver, pancreas, lymph, cartilage, bone, oral tissue, and mucosal tissue, and spleen and other abdominal organs.
38. A method as in claim 37, wherein the target site is a void region within the selected tissue.
39. A method as in claim 38, wherein the void region is selected from the group consisting of tissue divots, tissue tracts, intravertebral spaces, and body cavities.
40. A method as in claim 38, further comprising immobilizing a barrier layer over the void after the gel has been extruded.
41. A method as in claim 33, wherein the extrusion step causes the hydrogel to fracture into sub-units having a size in the range from 0.05 mm to 3.0 mm.
42. An applicator containing a molecular cross-linked hydrogel, said applicator comprising:
an applicator body having an internal receptacle volume and an extrusion orifice; and a quantity of the biocompatible resorbable molecular cross-linked hydrogel in the internal receptacle.
43. An applicator as in claim 42, wherein the applicator body is a syringe having an orifice size in the range from 0.01 mm to 5.0 mm.
44. A sterile package comprising:
a container having a sealed interior; and an applicator as in either of claims 42 or 43, wherein the applicator is maintained in a sterile condition within the container.
CA002264647A 1996-08-27 1997-08-14 Fragmented polymeric hydrogels for adhesion prevention and their preparation Expired - Lifetime CA2264647C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US70485296A 1996-08-27 1996-08-27
US08/704,852 1996-08-27
US08/903,674 US6063061A (en) 1996-08-27 1997-07-31 Fragmented polymeric compositions and methods for their use
US08/903,674 1997-07-31
PCT/US1997/015262 WO1998008550A1 (en) 1996-08-27 1997-08-14 Fragmented polymeric hydrogels for adhesion prevention and their preparation

Publications (2)

Publication Number Publication Date
CA2264647A1 true CA2264647A1 (en) 1998-03-05
CA2264647C CA2264647C (en) 2009-11-24

Family

ID=27107390

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002264647A Expired - Lifetime CA2264647C (en) 1996-08-27 1997-08-14 Fragmented polymeric hydrogels for adhesion prevention and their preparation

Country Status (10)

Country Link
US (1) US6063061A (en)
EP (1) EP0927053B1 (en)
JP (3) JP4418535B2 (en)
AU (1) AU719534B2 (en)
BR (1) BR9711241B8 (en)
CA (1) CA2264647C (en)
DE (1) DE69720479T2 (en)
IL (1) IL128496A (en)
RU (1) RU2207882C2 (en)
WO (1) WO1998008550A1 (en)

Families Citing this family (235)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071300A (en) * 1995-09-15 2000-06-06 Sub-Q Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US6183497B1 (en) * 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US7871637B2 (en) * 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US8603511B2 (en) * 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
AT407117B (en) * 1997-09-19 2000-12-27 Immuno Ag FIBRINE SPONGE
US6315753B1 (en) * 1998-05-01 2001-11-13 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US20010045575A1 (en) * 1998-05-01 2001-11-29 Mark Ashby Device and method for facilitating hemostasis of a biopsy tract
JP2003521270A (en) * 1998-08-04 2003-07-15 フュージョン メディカル テクノロジーズ， インコーポレイテッド Percutaneous tissue tract occlusion assemblies and methods
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US7790192B2 (en) 1998-08-14 2010-09-07 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
GB9826658D0 (en) * 1998-12-03 1999-01-27 Univ London Tissue repair
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6679870B1 (en) * 1999-07-23 2004-01-20 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6685694B2 (en) * 1999-07-23 2004-02-03 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6371984B1 (en) * 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6984219B2 (en) * 1999-09-23 2006-01-10 Mark Ashby Depth and puncture control for blood vessel hemostasis system
AU778318B2 (en) * 2000-02-03 2004-11-25 Tissuemed Limited Device for the closure of a surgical puncture
GB0011169D0 (en) * 2000-05-10 2000-06-28 Reckitt & Colmann Prod Ltd Improvements in or relating to medicinal compositions
US20040049187A1 (en) * 2000-10-23 2004-03-11 Stuart Burnett Self-adhesive hydratable matrix for topical therapeutic use
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US8187625B2 (en) * 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
FI20010540A0 (en) * 2001-03-16 2001-03-16 Yli Urpo Antti Composite for the correction of defects in soft and hard tissue and the use of said composite
US20020193812A1 (en) * 2001-05-04 2002-12-19 Concentric Medical Hydrogel vaso-occlusive device
US7008440B2 (en) * 2001-11-08 2006-03-07 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US6592608B2 (en) * 2001-12-07 2003-07-15 Biopsy Sciences, Llc Bioabsorbable sealant
WO2003035722A1 (en) 2001-09-25 2003-05-01 Southwest Research Institute Methods for controlling peptide solubility, chemically modified peptides, and stable solvent systems for producing same
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
CA2474723A1 (en) 2002-01-28 2003-08-07 Keraplast Technologies, Ltd. Bioactive keratin peptides
US7001987B2 (en) 2002-04-22 2006-02-21 Keraplast Technologies, Ltd. Hydrogel with controllable mechanical, chemical, and biological properties and method for making same
US6989437B2 (en) 2002-04-10 2006-01-24 Keraplast Technologies, Ltd. Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks
US6914126B2 (en) 2002-04-10 2005-07-05 Keraplast Technologies, Ltd. Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
PL377477A1 (en) * 2002-12-11 2006-02-06 Ferrosan A/S Gelatine-based materials as swabs
WO2004064811A1 (en) * 2003-01-24 2004-08-05 Magle Holding Ab A composition material for transmucosal delivery
SE0302947D0 (en) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
DE602004025217D1 (en) * 2003-04-04 2010-03-11 Tissuemed Ltd
US9289195B2 (en) 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
US7331979B2 (en) * 2003-06-04 2008-02-19 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US20070020314A1 (en) * 2003-06-30 2007-01-25 Hirotaka Haro Adhesion inhibiting material for vertebral/spinal operation
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
US20060019868A1 (en) * 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US8440225B2 (en) * 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20050036955A1 (en) * 2003-08-13 2005-02-17 Degould Michael D. Bioresorbable tooth extraction socket dressing
US20050148512A1 (en) * 2003-11-10 2005-07-07 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US7875043B1 (en) 2003-12-09 2011-01-25 Sub-Q, Inc. Cinching loop
CA2554994C (en) * 2004-01-30 2015-05-19 Ferrosan A/S Haemostatic sprays and compositions
US7109163B2 (en) * 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
US7879604B2 (en) * 2004-02-20 2011-02-01 Isto Technoliges, Inc. Intervertebral disk repair, methods and devices therefor
US20060275273A1 (en) * 2004-02-20 2006-12-07 Seyedin Mitchell S Intervertebral Disc Repair, Methods and Devices Therefor
US20050187429A1 (en) * 2004-02-23 2005-08-25 Poppas Dix P. Vaginal rejuvenation
US20050226936A1 (en) 2004-04-08 2005-10-13 Q-Med Ab Method of soft tissue augmentation
US8119160B2 (en) * 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
US8021684B2 (en) * 2004-07-09 2011-09-20 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
MX2007001554A (en) * 2004-08-03 2007-04-10 Tissuemed Ltd Tissue-adhesive materials.
US7439012B2 (en) 2004-08-17 2008-10-21 Wake Forest University Health Sciences Ambient stored blood plasma expanders containing keratose
US8348971B2 (en) 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
DE102004047115B9 (en) * 2004-09-27 2007-10-31 Universität Hamburg Method for producing a wound dressing
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
KR101153785B1 (en) 2004-10-25 2012-07-09 셀로노바 바이오사이언시스 저머니 게엠베하 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US8262693B2 (en) * 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US8663225B2 (en) 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
US7530578B2 (en) * 2004-11-17 2009-05-12 Continental Commercial Products, Llc Step-on receptacle with tip prevention
US8017139B2 (en) 2005-02-23 2011-09-13 Zimmer Technology, Inc. Blend hydrogels and methods of making
US7857856B2 (en) * 2005-03-15 2010-12-28 Warsaw Ortho Pedic, Inc. Composite spinal nucleus implant with water absorption and swelling capabilities
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US8257438B2 (en) * 2005-04-12 2012-09-04 Warsaw Orthopedic, Inc. Methods and devices for preserving motion in an articulating prosthetic disc
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
WO2007002362A2 (en) 2005-06-24 2007-01-04 Duke University A direct drug delivery system based on thermally responsive biopolymers
DK1940439T3 (en) 2005-08-11 2011-02-14 Univ Saskatchewan Reduction of postoperative adhesion formation with intraperitoneal glutamine
US20070074980A1 (en) * 2005-09-02 2007-04-05 Bankoski Brian R Implant rehydration packages and methods of use
US8920827B2 (en) 2005-10-21 2014-12-30 Wake Forest University Health Sciences Keratin bioceramic compositions
JP2009513286A (en) * 2005-10-28 2009-04-02 バクスター・インターナショナル・インコーポレイテッド Applicator and method of use
US9101742B2 (en) * 2005-10-28 2015-08-11 Baxter International Inc. Gastrointestinal applicator and method of using same
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
WO2007067697A2 (en) 2005-12-07 2007-06-14 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
CA2634034A1 (en) 2005-12-20 2007-06-28 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) * 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US8178495B2 (en) 2008-06-27 2012-05-15 Duke University Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide
EP1801135B1 (en) 2005-12-22 2010-09-29 Zimmer Inc. Perfluorocyclobutane crosslinked hydrogels
JP2007177074A (en) * 2005-12-28 2007-07-12 Tohoku Univ Composition and its manufacturing method
CA2640629A1 (en) 2006-02-03 2007-08-09 Tissuemed Limited Tissue-adhesive materials
EP1991253B1 (en) 2006-02-10 2013-07-31 Wake Forest University Health Sciences Nerve regeneration employing keratin biomaterials
WO2007098053A2 (en) 2006-02-17 2007-08-30 Wake Forest University Health Sciences Coatings and biomedical implants formed from keratin biomaterials
US8273702B2 (en) 2006-02-17 2012-09-25 Wake Forest University Health Sciences Wound healing compositions containing keratin biomaterials
US20090018575A1 (en) * 2006-03-01 2009-01-15 Tissuemed Limited Tissue-adhesive formulations
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US8795709B2 (en) * 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US7597882B2 (en) * 2006-04-24 2009-10-06 Incept Llc Protein crosslinkers, crosslinking methods and applications thereof
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7872068B2 (en) 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
AU2007267338B2 (en) * 2006-05-31 2013-04-04 Baxter Healthcare S.A. Method for directed cell in-growth and controlled tissue regeneration in spinal surgery
US8167847B2 (en) 2006-06-22 2012-05-01 Excelsior Medical Corporation Antiseptic cap and antiseptic cap equipped plunger and syringe barrel assembly
TWI436793B (en) 2006-08-02 2014-05-11 Baxter Int Rapidly acting dry sealant and methods for use and manufacture
US7671014B2 (en) 2006-08-14 2010-03-02 Warsaw Orthopedic, Inc. Flowable carrier matrix and methods for delivering to a patient
CA2662169C (en) * 2006-09-08 2018-03-20 Symphony Medical, Inc. Intramyocardial patterning for global cardiac resizing and reshaping
EP2077765A2 (en) * 2006-09-13 2009-07-15 Accessclosure, Inc. Apparatus for sealing a vascular puncture
FR2909285A1 (en) * 2006-12-01 2008-06-06 Anteis Sa Use of an injectable or implantable antiadhesive antifibrotic gel based on a crosslinked natural or synthetic polymer for treating glaucoma or surgical wounds
CN102552967B (en) 2006-12-15 2015-08-12 生命连结有限公司 Gelatin-transglutaminase hemostatic dressings and encapsulant
US8088095B2 (en) * 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
CA2578647A1 (en) * 2007-02-15 2008-08-15 University Of Saskatchewan Reducing post-operative adhesion formation with intraperitoneal glutamine
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
EP2146667A2 (en) * 2007-04-11 2010-01-27 Henry Ford Health System Cardiac repair, resizing and reshaping using the venous system of the heart
WO2008154033A2 (en) * 2007-06-11 2008-12-18 Symphony Medical, Inc. Cardiac patterning for improving diastolic function
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
DE102007038125A1 (en) * 2007-08-03 2009-02-05 Aesculap Ag Combination for bonding biological tissues
CN101485897B (en) * 2008-01-14 2015-05-20 纪欣 Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
US9068162B2 (en) 2007-08-17 2015-06-30 Wake Forest University Health Sciences Keratin biomaterials for cell culture and methods of use
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7993367B2 (en) * 2007-09-28 2011-08-09 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
JP2011500237A (en) 2007-10-30 2011-01-06 バクスター・インターナショナル・インコーポレイテッド Use of regenerative biofunctional collagen biomatrix to treat visceral or cavity wall defects
EP2209426A4 (en) * 2007-11-02 2015-04-22 Incept Llc Apparatus and methods for sealing a vascular puncture
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8299316B2 (en) * 2007-12-18 2012-10-30 Ethicon, Inc. Hemostatic device
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US8642831B2 (en) * 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
EP2265728A4 (en) * 2008-04-03 2012-08-01 Zymogenetics Inc Hemostatic microspheres
US9364206B2 (en) 2008-04-04 2016-06-14 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8029533B2 (en) * 2008-04-04 2011-10-04 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US20090259210A1 (en) * 2008-04-10 2009-10-15 Sabbah Hani N Method, apparatus and kits for forming structural members within the cardiac venous system
US8801665B2 (en) * 2008-04-10 2014-08-12 Henry Ford Health System Apparatus and method for controlled depth of injection into myocardial tissue
ES2759373T3 (en) 2008-06-12 2020-05-08 Medtronic Xomed Inc Product for the treatment of chronic wounds with an extracellular system of solvation of polymeric substances
WO2009153751A2 (en) * 2008-06-18 2009-12-23 Lifebond Ltd A method for enzymatic cross-linking of a protein
CN104031393B (en) 2008-06-18 2017-08-01 生命连结有限公司 Improved cross-linked composition
WO2009153748A2 (en) * 2008-06-18 2009-12-23 Lifebond Ltd Methods and devices for use with sealants
WO2010027693A2 (en) 2008-08-26 2010-03-11 Killion Douglas P Method and system for sealing percutaneous punctures
JP5702723B2 (en) 2008-09-04 2015-04-15 ザ ジェネラル ホスピタル コーポレイション Hydrogels for strengthening and repairing vocal cords and soft tissues
US20100086576A1 (en) 2008-10-06 2010-04-08 Myntti Matthew F Antimicrobial composition and methods of making and using same
EP2364112B1 (en) 2008-11-12 2016-03-09 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
AU2010246115A1 (en) 2009-05-04 2011-12-08 Incept. Llc Biomaterials for track and puncture closure
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
MX2011013795A (en) * 2009-06-16 2012-04-30 Baxter Int Hemostatic sponge.
JP2011025013A (en) * 2009-06-25 2011-02-10 Doshisha Antiadhesive material and method for manufacturing the same
HUE032703T2 (en) 2009-08-14 2017-10-30 Phasebio Pharmaceuticals Inc Modified vasoactive intestinal peptides
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
EP2498764B1 (en) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmented hydrogels
WO2011060390A2 (en) 2009-11-13 2011-05-19 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
IN2012DN05177A (en) 2009-12-15 2015-10-23 Incept Llc
JP2013514093A (en) 2009-12-16 2013-04-25 バクスター・インターナショナル・インコーポレイテッド Hemostatic sponge
WO2011077388A1 (en) 2009-12-22 2011-06-30 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
WO2011109730A2 (en) 2010-03-04 2011-09-09 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
CA2791386C (en) 2010-03-05 2023-10-31 Wake Forest University Health Sciences Keratin gel composition for controlled delivery of a compound
US8545893B2 (en) 2010-03-08 2013-10-01 Wake Forest University Health Sciences Keratin biomaterials for treatment of ischemia
SA111320355B1 (en) 2010-04-07 2015-01-08 Baxter Heathcare S A Hemostatic sponge
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
ES2682302T3 (en) 2010-06-01 2018-09-19 Baxter International Inc Process for the production of dry and stable hemostatic compositions
KR101967085B1 (en) 2010-06-01 2019-04-08 백스터 인터내셔널 인코포레이티드 Process for making dry and stable hemostatic compositions
BR112012030463B1 (en) 2010-06-01 2021-08-24 Baxter International Inc. PROCESS TO MANUFACTURE A DRY AND STABLE HEMOSTATIC COMPOSITION, FINAL FINISHED CONTAINER, KIT TO MANAGE A HEMOSTATIC COMPOSITION, AND, THROMBINE COATED GRANULES
EP2600910B1 (en) 2010-08-05 2016-01-20 Lifebond Ltd Dry composition wound dressings and adhesives
JP5721379B2 (en) * 2010-09-21 2015-05-20 学校法人同志社 Suture reinforcement material for automatic suturing device containing hydrophilic polymer
AU2011329839B2 (en) 2010-11-17 2016-12-08 Wake Forest University Health Sciences Keratin compositions for treatment of bone deficiency or injury
KR101272484B1 (en) * 2011-01-19 2013-06-10 세원셀론텍(주) A radiation crosslinked collagen gel, its manufacture and its usage method
ES2870965T3 (en) 2011-01-19 2021-10-28 Access Closure Inc Procedures to seal a vascular puncture
US9820728B2 (en) 2011-01-19 2017-11-21 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
EP2484387A1 (en) 2011-02-03 2012-08-08 Q-Med AB Hyaluronic acid composition
WO2012122044A2 (en) 2011-03-04 2012-09-13 Orthovita, Inc. Flowable collagen-based hemostat and methods of use
EP3460064B8 (en) 2011-04-03 2024-03-20 The General Hospital Corporation d/b/a Massachusetts General Hospital Efficient protein expression in vivo using modified rna (mod-rna)
CA2835211C (en) 2011-05-10 2019-09-24 Next Science, Llc Antimicrobial solid and methods of making and using same
US9386968B2 (en) 2011-05-11 2016-07-12 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9561262B2 (en) 2011-06-06 2017-02-07 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
US9149511B2 (en) 2011-06-30 2015-10-06 Ethicon, Inc. Procoagulant peptides and their derivatives and uses therefor
JP5779249B2 (en) * 2011-08-02 2015-09-16 大日精化工業株式会社 Anti-adhesion medical material and method for producing the same
EP2766060B1 (en) 2011-10-11 2022-11-23 Baxter International Inc. Hemostatic composition
KR102102002B1 (en) 2011-10-11 2020-04-20 백스터 인터내셔널 인코포레이티드 Hemostatic compositions
MX346958B (en) 2011-10-11 2017-04-06 Baxter Int Hemostatic compositions.
US20130096082A1 (en) 2011-10-11 2013-04-18 Baxter Healthcare S.A. Hemostatic compositions
US20130108671A1 (en) * 2011-10-27 2013-05-02 Baxter Healthcare S.A. Hemostatic compositions
US20130129710A1 (en) 2011-10-27 2013-05-23 Baxter Healthcare S.A. Hemostatic compositions
KR20190090048A (en) 2011-12-05 2019-07-31 인셉트, 엘엘씨 Medical organogel processes and compositions
US20130202656A1 (en) 2012-02-03 2013-08-08 Dynasil Biomedical Corporation Systems and kits for the fabrication of tissue patches
WO2013131520A2 (en) 2012-03-06 2013-09-12 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
US9757105B2 (en) 2012-03-23 2017-09-12 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US8721680B2 (en) 2012-03-23 2014-05-13 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
KR20130134447A (en) * 2012-05-31 2013-12-10 리젠프라임 주식회사 New nanofiber membrane and manufacturing method thereof
RU2636240C2 (en) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Dry haemostatic composition
US9616088B2 (en) 2013-03-13 2017-04-11 Gel-E, Inc. Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
JP6390873B2 (en) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー／エス Dry composition expanded under reduced pressure and syringe for holding the same
RU2678592C1 (en) 2013-12-11 2019-01-30 Ферросан Медикал Дивайсиз А/С Dry composition comprising extrusion enhancer
WO2015172046A1 (en) 2014-05-08 2015-11-12 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
KR102614915B1 (en) 2014-07-17 2023-12-19 더 리전트 오브 더 유니버시티 오브 캘리포니아 Controllable self-annealing microgel particles for biomedical applications
BR112017007466B1 (en) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S method for preparing a dry composition, method for reconstituting the dry composition, paste, dry composition, container, homeostatic kit, and, using a dry composition
JP6747650B2 (en) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス Syringe for holding and mixing the first substance and the second substance
RU2606990C2 (en) * 2014-12-26 2017-01-10 Общество с ограниченной ответственностью "Проект Экопак" Biodegradable substance based on renewable raw material
CA2976038A1 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
CN104861179B (en) * 2015-06-03 2017-09-12 西北师范大学 The preparation and the application as pharmaceutical carrier of a kind of feather keratin sodium alginate composite high-molecular sensitive hydrogel
CN104892864B (en) * 2015-06-03 2017-09-22 西北师范大学 The preparation and the application as pharmaceutical carrier of a kind of composite microporous gel of keratin sodium alginate
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
EP3331577A4 (en) 2015-08-07 2019-07-17 Xcede Technologies, Inc. Adhesive compositions and related methods
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
WO2017037178A1 (en) 2015-09-01 2017-03-09 Trauma Care Consult Traumatologische Forschung Gemeinnützige Gesellschaft Mbh Hemostatic material
US11931480B2 (en) 2016-02-16 2024-03-19 The Regents Of The University Of California Microporous annealed particle gels and methods of use
WO2017149584A1 (en) * 2016-02-29 2017-09-08 川澄化学工業株式会社 Adhesion prevention material
RU2628809C1 (en) * 2016-06-30 2017-08-22 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения Российской Федерации (ФГБУ ГНЦ Минздрава России) Hemostatic sponge and method of its production
WO2018136205A1 (en) 2016-12-29 2018-07-26 Tempo Therapeutics, Inc. Methods and systems for treating a site of a medical implant
US11679177B2 (en) 2017-08-08 2023-06-20 Baxter International Inc. Polymeric compositions, delivery devices, and methods
BR112020007148A2 (en) 2017-11-03 2020-09-24 Baxter International Inc. polymeric compositions, application devices and methods
EP3731885A1 (en) 2017-12-29 2020-11-04 Baxter International Inc. Spray-dried thrombin and methods of using and making spray-dried thrombin
PL3731807T3 (en) * 2017-12-29 2022-05-09 Matex Lab S.P.A. Method to prepare a filler with a hyaluronic acid base comprising a neutralization step
CN108314790A (en) * 2018-03-16 2018-07-24 东华大学 A kind of photo-crosslinking thio chitosan-polyethylene glycol methacrylate-styrene polymer hydrogel and preparation method thereof for tissue adhesive
CN108498871A (en) * 2018-03-23 2018-09-07 中南大学湘雅二医院 A kind of preparation of autologous organisms protein hydrogel and its application in ophthalmology
CN108853598A (en) * 2018-03-23 2018-11-23 中南大学湘雅二医院 A kind of preparation of autologous organisms protein hydrogel and its application in operation on retina
KR20210008479A (en) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 How to prepare a hemostatic composition
JP7043369B2 (en) * 2018-08-24 2022-03-29 日立Ｇｅニュークリア・エナジー株式会社 Radiation-resistant hydrogel material and its manufacturing method
JP7042730B2 (en) 2018-10-31 2022-03-28 株式会社ハイレックスコーポレーション In vivo non-degradable adhesion inhibitor
CN109529098A (en) * 2018-12-03 2019-03-29 广州润虹医药科技股份有限公司 A kind of surgery adhesive of medical
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
KR102441137B1 (en) * 2022-02-07 2022-09-06 김환철 A biocompatible polymer hydrogel comprising an ether group capable of controlling the degradation rate

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013078A (en) * 1974-11-25 1977-03-22 Feild James Rodney Intervertebral protector means
DE3036033A1 (en) * 1980-09-24 1982-05-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen POWDERED WOUND TREATMENT AND METHOD FOR THE PRODUCTION THEREOF
DE3105624A1 (en) * 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München MATERIAL FOR SEALING AND HEALING Wounds
JPS60222045A (en) * 1984-04-20 1985-11-06 日立化成工業株式会社 Blood vessel closure agent
SE456346B (en) * 1984-07-23 1988-09-26 Pharmacia Ab GEL TO PREVENT ADHESION BETWEEN BODY TISSUE AND SET FOR ITS PREPARATION
GB8422950D0 (en) * 1984-09-11 1984-10-17 Warne K J Hydrogel
JPS61122222A (en) * 1984-11-19 1986-06-10 Koken:Kk Hemostatic agent composed of collagen or gelatin and protamine
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US5007916A (en) * 1985-08-22 1991-04-16 Johnson & Johnson Medical, Inc. Method and material for prevention of surgical adhesions
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5350573A (en) * 1988-05-31 1994-09-27 University Of Florida Research Foundation, Inc. Method and composition for preventing surgical adhesions
US5140016A (en) * 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
US5196185A (en) * 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5134229A (en) * 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
JPH0813750B2 (en) * 1990-03-01 1996-02-14 持田製薬株式会社 Oral thrombin formulation
US5634943A (en) * 1990-07-12 1997-06-03 University Of Miami Injectable polyethylene oxide gel implant and method for production
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5129882A (en) * 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
NL9101051A (en) * 1991-06-18 1993-01-18 Ashridge Ag CLOSING DEVICE FOR A VESSEL OR THE LIKE.
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
AU3665693A (en) * 1992-02-28 1993-09-13 Collagen Corporation High concentration homogenized collagen compositions
JPH07504106A (en) * 1992-02-28 1995-05-11 コラーゲン　コーポレイション Injectable ceramic compositions and methods for their manufacture and use
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
WO1993021844A1 (en) * 1992-04-23 1993-11-11 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5413571A (en) * 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
ATE206602T1 (en) * 1992-11-12 2001-10-15 Neville Alleyne DEVICE FOR PROTECTING THE HEART
WO1994027630A1 (en) * 1993-05-31 1994-12-08 Kaken Pharmaceutical Co., Ltd. Cross-linked gelatin gel preparation containing basic fibroblast growth factor
FR2715309B1 (en) * 1994-01-24 1996-08-02 Imedex Adhesive composition, for surgical use, based on collagen modified by oxidative cutting and not crosslinked.
US5531759A (en) * 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5599735A (en) * 1994-08-01 1997-02-04 Texas Instruments Incorporated Method for doped shallow junction formation using direct gas-phase doping
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5677284A (en) * 1995-06-06 1997-10-14 Regen Biologics, Inc. Charged collagen particle-based delivery matrix
US5902832A (en) * 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use

Also Published As

Publication number Publication date
DE69720479D1 (en) 2003-05-08
EP0927053A1 (en) 1999-07-07
AU719534B2 (en) 2000-05-11
JP4842713B2 (en) 2011-12-21
CA2264647C (en) 2009-11-24
EP0927053B1 (en) 2003-04-02
JP2002515086A (en) 2002-05-21
JP4843079B2 (en) 2011-12-21
RU2207882C2 (en) 2003-07-10
JP2006231090A (en) 2006-09-07
BR9711241B8 (en) 2021-06-22
IL128496A0 (en) 2000-01-31
JP2009256391A (en) 2009-11-05
US6063061A (en) 2000-05-16
DE69720479T2 (en) 2004-03-04
WO1998008550A1 (en) 1998-03-05
JP4418535B2 (en) 2010-02-17
IL128496A (en) 2004-06-20
AU4241297A (en) 1998-03-19
BR9711241A (en) 1999-08-17
BRPI9711241B1 (en) 2016-12-20

Similar Documents

Publication Publication Date Title
CA2264647A1 (en) Fragmented polymeric hydrogels for adhesion prevention and their preparation
US10159742B2 (en) Hydrogel compositions
RU99106523A (en) GRINDED POLYMER HYDROGELS FOR EXCLUSION OF THE FORMATION OF ADHESIVES AND METHODS OF PRODUCING THEM
US9700650B2 (en) Polysaccharide based hydrogels
ES2383550T3 (en) Quick-acting dry sealant material and methods for use and processing
EP1185288B1 (en) Hemoactive compositions and methods for their manufacture and use
JP2009545405A5 (en)
WO2009029049A1 (en) A bone and/or dental cement composition and uses thereof
KR20020011955A (en) A conglutination inhibitor
CN1538006A (en) Biopaper
JP2011046749A (en) Fragmented polymeric hydrogel for adhesion prevention, and preparation thereof

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170814

MKEX Expiry

Effective date: 20170814