CA2268026A1 - Method and apparatus for using electroporation mediated delivery of drugs and genes - Google Patents

Method and apparatus for using electroporation mediated delivery of drugs and genes

Info

Publication number
CA2268026A1
CA2268026A1 CA002268026A CA2268026A CA2268026A1 CA 2268026 A1 CA2268026 A1 CA 2268026A1 CA 002268026 A CA002268026 A CA 002268026A CA 2268026 A CA2268026 A CA 2268026A CA 2268026 A1 CA2268026 A1 CA 2268026A1
Authority
CA
Canada
Prior art keywords
electroporation
ept
therapy
vivo
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002268026A
Other languages
French (fr)
Other versions
CA2268026C (en
Inventor
Gunter A. Hofmann
Sukhendu B. Dev
Steven C. Dimmer
Jeffrey I. Levatter
Gurvinder S. Nanda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetronics Inc
Original Assignee
Genetronics, Inc.
Gunter A. Hofmann
Sukhendu B. Dev
Steven C. Dimmer
Jeffrey I. Levatter
Gurvinder S. Nanda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics, Inc., Gunter A. Hofmann, Sukhendu B. Dev, Steven C. Dimmer, Jeffrey I. Levatter, Gurvinder S. Nanda filed Critical Genetronics, Inc.
Publication of CA2268026A1 publication Critical patent/CA2268026A1/en
Application granted granted Critical
Publication of CA2268026C publication Critical patent/CA2268026C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502Skin piercing electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

This invention is a method, and apparatus (100) for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus (100) of the invention, and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage, and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode (114) having a "keying" element that determines the set point of the therapy voltage pulse, and/or selective array switching patterns. A number of electrode applicator designs permit access to, and treatment of a variety of tissue sites. Another embodiment provides a laparascopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
CA002268026A 1997-08-01 1998-07-31 Method and apparatus for using electroporation mediated delivery of drugs and genes Expired - Lifetime CA2268026C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/905,240 1997-08-01
US08/905,240 US6055453A (en) 1997-08-01 1997-08-01 Apparatus for addressing needle array electrodes for electroporation therapy
PCT/US1998/016042 WO1999006101A1 (en) 1997-08-01 1998-07-31 Method and apparatus for using electroporation mediated delivery of drugs and genes

Publications (2)

Publication Number Publication Date
CA2268026A1 true CA2268026A1 (en) 1999-02-11
CA2268026C CA2268026C (en) 2003-07-29

Family

ID=25420478

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268026A Expired - Lifetime CA2268026C (en) 1997-08-01 1998-07-31 Method and apparatus for using electroporation mediated delivery of drugs and genes

Country Status (14)

Country Link
US (5) US6055453A (en)
EP (1) EP0999867B1 (en)
JP (2) JP2000503586A (en)
KR (1) KR100756252B1 (en)
CN (2) CN1768873B (en)
AT (1) ATE480294T1 (en)
AU (1) AU734343B2 (en)
BR (1) BR9806069A (en)
CA (1) CA2268026C (en)
DE (1) DE69841888D1 (en)
HK (1) HK1027049A1 (en)
RU (1) RU2195332C2 (en)
TW (1) TW396043B (en)
WO (1) WO1999006101A1 (en)

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