CA2272308A1 - Use of low molecular weight amino alcohols in ophthalmic compositions - Google Patents

Use of low molecular weight amino alcohols in ophthalmic compositions Download PDF

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Publication number
CA2272308A1
CA2272308A1 CA002272308A CA2272308A CA2272308A1 CA 2272308 A1 CA2272308 A1 CA 2272308A1 CA 002272308 A CA002272308 A CA 002272308A CA 2272308 A CA2272308 A CA 2272308A CA 2272308 A1 CA2272308 A1 CA 2272308A1
Authority
CA
Canada
Prior art keywords
amino
ophthalmic compositions
molecular weight
low molecular
amino alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002272308A
Other languages
French (fr)
Other versions
CA2272308C (en
Inventor
Bahram Asgharian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2272308A1 publication Critical patent/CA2272308A1/en
Application granted granted Critical
Publication of CA2272308C publication Critical patent/CA2272308C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/147—Alcohols or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

Abstract

The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.
CA002272308A 1996-12-13 1997-11-17 Use of low molecular weight amino alcohols in ophthalmic compositions Expired - Lifetime CA2272308C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3307996P 1996-12-13 1996-12-13
US60/033,079 1996-12-13
PCT/US1997/020826 WO1998025649A1 (en) 1996-12-13 1997-11-17 Use of low molecular weight amino alcohols in ophthalmic compositions

Publications (2)

Publication Number Publication Date
CA2272308A1 true CA2272308A1 (en) 1998-06-18
CA2272308C CA2272308C (en) 2007-01-16

Family

ID=21868442

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002272308A Expired - Lifetime CA2272308C (en) 1996-12-13 1997-11-17 Use of low molecular weight amino alcohols in ophthalmic compositions

Country Status (15)

Country Link
US (5) US6319464B1 (en)
EP (1) EP0948357B1 (en)
JP (2) JP3724813B2 (en)
KR (1) KR100366676B1 (en)
CN (1) CN1157227C (en)
AT (2) ATE218887T1 (en)
AU (1) AU718199B2 (en)
CA (1) CA2272308C (en)
DE (2) DE69735963T2 (en)
DK (1) DK0948357T3 (en)
ES (2) ES2262603T3 (en)
HK (1) HK1022089A1 (en)
NZ (1) NZ336031A (en)
PT (2) PT1190718E (en)
WO (1) WO1998025649A1 (en)

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Also Published As

Publication number Publication date
US20060264516A1 (en) 2006-11-23
US8563011B2 (en) 2013-10-22
JP3724813B2 (en) 2005-12-07
US7045095B2 (en) 2006-05-16
ES2178786T3 (en) 2003-01-01
US20020106304A1 (en) 2002-08-08
ES2262603T3 (en) 2006-12-01
US20140056997A1 (en) 2014-02-27
CA2272308C (en) 2007-01-16
US6949218B2 (en) 2005-09-27
PT1190718E (en) 2006-08-31
DE69735963T2 (en) 2007-01-25
JP4276139B2 (en) 2009-06-10
HK1022089A1 (en) 2000-07-28
ATE326983T1 (en) 2006-06-15
PT948357E (en) 2002-10-31
DE69735963D1 (en) 2006-06-29
ATE218887T1 (en) 2002-06-15
JP2004262948A (en) 2004-09-24
NZ336031A (en) 2000-05-26
WO1998025649A1 (en) 1998-06-18
AU718199B2 (en) 2000-04-06
US6319464B1 (en) 2001-11-20
DE69713388D1 (en) 2002-07-18
US20050239900A1 (en) 2005-10-27
KR20000057524A (en) 2000-09-25
EP0948357B1 (en) 2002-06-12
JP2000513001A (en) 2000-10-03
KR100366676B1 (en) 2003-01-14
CN1157227C (en) 2004-07-14
DE69713388T2 (en) 2002-10-31
DK0948357T3 (en) 2002-07-15
EP0948357A1 (en) 1999-10-13
AU5257898A (en) 1998-07-03
CN1240361A (en) 2000-01-05
US8865776B2 (en) 2014-10-21

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Effective date: 20171117