CA2272308A1 - Use of low molecular weight amino alcohols in ophthalmic compositions - Google Patents
Use of low molecular weight amino alcohols in ophthalmic compositions Download PDFInfo
- Publication number
- CA2272308A1 CA2272308A1 CA002272308A CA2272308A CA2272308A1 CA 2272308 A1 CA2272308 A1 CA 2272308A1 CA 002272308 A CA002272308 A CA 002272308A CA 2272308 A CA2272308 A CA 2272308A CA 2272308 A1 CA2272308 A1 CA 2272308A1
- Authority
- CA
- Canada
- Prior art keywords
- amino
- ophthalmic compositions
- molecular weight
- low molecular
- amino alcohols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/147—Alcohols or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
Abstract
The use of low molecular weight amino alcohols in ophthalmic compositions is described. These compounds have been found to enhance the efficacy of anti-microbial preservatives. Particularly preferred amino alcohols are 2-amino-2-methyl-1-propanol (AMP), 2-dimethylamino-2-methyl-1-propanediol (DMAMP), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-1-butanol (AB). The ophthalmic compositions further optionally comprise a borate/polyol buffer system and an alkylamine.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3307996P | 1996-12-13 | 1996-12-13 | |
US60/033,079 | 1996-12-13 | ||
PCT/US1997/020826 WO1998025649A1 (en) | 1996-12-13 | 1997-11-17 | Use of low molecular weight amino alcohols in ophthalmic compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2272308A1 true CA2272308A1 (en) | 1998-06-18 |
CA2272308C CA2272308C (en) | 2007-01-16 |
Family
ID=21868442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002272308A Expired - Lifetime CA2272308C (en) | 1996-12-13 | 1997-11-17 | Use of low molecular weight amino alcohols in ophthalmic compositions |
Country Status (15)
Country | Link |
---|---|
US (5) | US6319464B1 (en) |
EP (1) | EP0948357B1 (en) |
JP (2) | JP3724813B2 (en) |
KR (1) | KR100366676B1 (en) |
CN (1) | CN1157227C (en) |
AT (2) | ATE218887T1 (en) |
AU (1) | AU718199B2 (en) |
CA (1) | CA2272308C (en) |
DE (2) | DE69735963T2 (en) |
DK (1) | DK0948357T3 (en) |
ES (2) | ES2262603T3 (en) |
HK (1) | HK1022089A1 (en) |
NZ (1) | NZ336031A (en) |
PT (2) | PT948357E (en) |
WO (1) | WO1998025649A1 (en) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT948357E (en) * | 1996-12-13 | 2002-10-31 | Alcon Lab Inc | USE OF ALCOHOLS OF LOW MOLECULAR WEIGHT IN OPHTHALMIC COMPOSITIONS |
US6730065B1 (en) * | 2000-09-15 | 2004-05-04 | Ocularis Pharma, Inc. | Night vision composition |
US8889112B2 (en) * | 1999-09-16 | 2014-11-18 | Ocularis Pharma, Llc | Ophthalmic formulations including selective alpha 1 antagonists |
US20020082288A1 (en) * | 1999-09-16 | 2002-06-27 | Gerald Horn | Ophthalmic formulations comprising an imidazoline |
US20020039975A1 (en) * | 2000-07-31 | 2002-04-04 | Stone Ralph P. | Simplified process for cleaning and disinfecting contact lenses with a single solution |
US20060211753A1 (en) * | 2000-11-03 | 2006-09-21 | Ocularis Pharma, Inc. | Method and composition which reduces stimulation of muscles which dilate the eye |
DE10106230A1 (en) * | 2001-02-10 | 2002-08-14 | Creavis Tech & Innovation Gmbh | Process for the production of microbicidal surfaces by immobilization of amino alcohols |
PL211494B1 (en) | 2001-12-21 | 2012-05-31 | Alcon | Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs |
WO2003059193A2 (en) * | 2001-12-21 | 2003-07-24 | Alcon, Inc. | Use of nanoparticles as carriers for biocides in ophthalmic compositions |
WO2003059263A2 (en) * | 2001-12-21 | 2003-07-24 | Alcon, Inc. | Inorganic nanoparticles to modify the viscosity and physical properties of ophthalmic and otic compositions. |
US7928147B2 (en) * | 2002-04-11 | 2011-04-19 | Teva Animal Health, Inc. | Antimicrobial wash and carrier solutions, and uses thereof |
US20040115160A1 (en) * | 2002-12-13 | 2004-06-17 | Salamone Joseph C. | Quaternary ammonium esters for disinfection and preservation |
TWI322828B (en) * | 2002-12-23 | 2010-04-01 | Alcon Inc | Use of multifunctional surface active agents to clean contact lenses |
US20040185028A1 (en) * | 2003-03-19 | 2004-09-23 | Zhenze Hu | Antimicrobial compositions containing ethanolamine buffer and biguanide disinfectant |
PT1656955E (en) * | 2003-08-20 | 2007-12-10 | Menicon Co Ltd | Liquid preparation for contact lens |
US6936640B2 (en) * | 2003-12-04 | 2005-08-30 | Alcon, Inc. | Biguanide/quaternary ammonium containing copolymeric biocides and use thereof in pharmaceutical compositions |
ES2323132T3 (en) * | 2003-12-09 | 2009-07-07 | Alcon, Inc. | USE OF BIS-AMINAS TO INCREASE ANTIMICROBIAL ACTIVITY OF WATER COMPOSITIONS. |
EP1691798A1 (en) * | 2003-12-09 | 2006-08-23 | Alcon, Inc. | Use of organic buffering agents to enhance the antimicrobial activity of pharmaceutical compositions |
US7022740B2 (en) * | 2004-04-29 | 2006-04-04 | Leonard Mackles | Lubricious ophthalmic solutions |
US20060047005A1 (en) * | 2004-08-26 | 2006-03-02 | Salamone Joseph C | Compositions containing N,N,N',N'-tetrakis(hydroxyalkyl)diamine-or N,N,N',N'-tetrakis(hydroxyalkoxy)diamine-based buffers |
US7629386B2 (en) * | 2004-08-26 | 2009-12-08 | Bausch + Lomb Incorporated | Compositions containing trialkanolamine alkoxylate buffer |
US20060141059A1 (en) * | 2004-12-27 | 2006-06-29 | Alcon, Inc. | Self-preserved ophthalmic pharmaceutical compositions containing tobramycin |
JP5108234B2 (en) * | 2005-02-07 | 2012-12-26 | 日本特殊陶業株式会社 | Micro heater and sensor |
US20060229219A1 (en) * | 2005-04-11 | 2006-10-12 | Advanced Medical Optics, Inc. | Borate-polyol mixtures as a buffering system |
US20070053948A1 (en) * | 2005-09-08 | 2007-03-08 | Bausch & Lomb Incorporated | Lens care solution demonstration kit |
US8071345B2 (en) * | 2006-03-31 | 2011-12-06 | Novozymes A/S | Stabilized subtilisin composition |
US20070287752A1 (en) * | 2006-06-08 | 2007-12-13 | Burke Susan E | Ophthalmic Compositions Comprising A Branched, Glycerol Compound |
TWI394564B (en) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | Self-preserved aqueous pharmaceutical compositions |
US20100021561A1 (en) * | 2006-09-21 | 2010-01-28 | Chowhan Masood A | Self-preserved aqueous pharmaceutical compositions |
KR101421519B1 (en) | 2006-09-28 | 2014-07-30 | 알콘 리서치, 리미티드 | Self-preserved aqueous pharmaceutical compositions |
US20080095863A1 (en) * | 2006-10-24 | 2008-04-24 | Alcon Manufacturing Ltd. | 2-pyrrolidone derivatives for preservation of ophthalmic, otic and nasal compositions |
TWI434926B (en) * | 2006-12-11 | 2014-04-21 | Alcon Res Ltd | Use of peo-pbo block copolymers in ophthalmic compositions |
MX2010009336A (en) * | 2008-03-17 | 2010-09-24 | Alcon Res Ltd | Aqueous pharmaceutical compositions containing borate-polyol complexes. |
TWI544927B (en) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | Pharmaceutical compositions having low concentration of surfactants for promoting bioavailability of therapeutic agents |
US8163684B2 (en) * | 2008-03-26 | 2012-04-24 | Abbott Medical Optics Inc. | Antimicrobials having polyquaternary ammoniums and alcohol-bearing amidoamines and methods for their use |
TWI495469B (en) | 2008-06-09 | 2015-08-11 | Alcon Res Ltd | Improved pharmaceutical compositions containing a fluoroquinolone antibiotic drug |
US8093352B2 (en) * | 2008-08-05 | 2012-01-10 | Alcon Research, Ltd. | Polyalkylene oxide polyquaternary ammonium biocides |
TW201023912A (en) | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
US8431751B1 (en) | 2008-12-24 | 2013-04-30 | Alcon Research, Ltd. | Polymeric quaternary ammonium compounds with vicinal hydroxy groups |
US8912236B2 (en) | 2009-03-03 | 2014-12-16 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye |
TWI489997B (en) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | Aqueous pharmaceutical compositions containing borate-polyol complexes |
TWI547522B (en) * | 2009-07-07 | 2016-09-01 | 愛爾康研究有限公司 | Ethyleneoxide butyleneoxide block copolymer compositions |
WO2011153349A1 (en) | 2010-06-02 | 2011-12-08 | Alcon Research, Ltd. | Ophthalmic compositions comprising pbo-peo-pbo block copolymers |
KR101381903B1 (en) * | 2011-03-10 | 2014-04-10 | 주식회사 엘지생활건강 | Antibacterial or preservative composition containing 3-butoxy-1,2-propanediol |
JP5989365B2 (en) * | 2012-03-19 | 2016-09-07 | ロート製薬株式会社 | Contact lens ophthalmic composition |
JP6592527B2 (en) * | 2015-11-30 | 2019-10-16 | ロート製薬株式会社 | Ophthalmic composition |
CN113056199A (en) | 2018-11-08 | 2021-06-29 | 陈煌兴 | Trisubstituted biguanide compounds and uses thereof |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3966905A (en) * | 1973-05-29 | 1976-06-29 | Barnes-Hind Pharmaceuticals, Inc. | Stabilized catechol amine solutions |
US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
AU565948B2 (en) * | 1982-02-03 | 1987-10-01 | Baremek Pty. Ltd. | Electrophoretic cleaner and sterilizer |
FR2521856A1 (en) | 1982-02-19 | 1983-08-26 | Pos Lab | OPHTHALMIC MEDICAMENT FOR THE TREATMENT OF GLAUCOMES, BASED ON ETHERS-OXIDES OR ETHER-OXIMES OF ALKYLAMINE DERIVATIVES |
ZA837627B (en) * | 1982-10-15 | 1984-06-27 | Procter & Gamble | Storage stable topical pharmaceutical composition containing low dielectric solvents |
US4758595A (en) * | 1984-12-11 | 1988-07-19 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
US4620979A (en) * | 1985-08-02 | 1986-11-04 | Schachar Ronald A | Ophthalmological irrigating solution containing ascorbate |
US4904359A (en) * | 1985-10-31 | 1990-02-27 | The Procter & Gamble Company | Liquid detergent composition containing polymeric surfactant |
DE3612537C1 (en) | 1986-04-14 | 1987-07-16 | Dispersa Ag | Medicines used to treat inflammation in the eye |
DE3612538A1 (en) * | 1986-04-14 | 1987-10-15 | Dispersa Ag | STABILIZATION OF MERCURY-CONTAINING PRESERVATIVES IN EYE DROPS |
PH25150A (en) | 1986-06-05 | 1991-03-13 | Ciba Geigy Ag | Novel pharmaceutical preparation for topical application |
US4734475A (en) * | 1986-12-15 | 1988-03-29 | Ciba-Geigy Corporation | Wettable surface modified contact lens fabricated from an oxirane containing hydrophobic polymer |
JPH0662417B2 (en) * | 1987-12-25 | 1994-08-17 | 参天製薬株式会社 | Anti-allergic eye drops |
CA2009118C (en) * | 1989-02-21 | 1996-02-27 | Mary F. Mowrey-Mckee | Method and composition for cleaning and disinfecting contact lenses |
US5290774A (en) * | 1989-08-03 | 1994-03-01 | Eisai Co., Ltd. | Photostabilizing method for ophthalmic solutions and the resulting ophthalmic solutions therefrom |
US5171526A (en) * | 1990-01-05 | 1992-12-15 | Allergan, Inc. | Ophthalmic compositions and methods for preserving and using same |
HU209538B (en) | 1990-05-09 | 1994-07-28 | Vepex Contractor Ltd | Set and cleaning composition for treating contactlenses |
JP3058656B2 (en) * | 1990-06-18 | 2000-07-04 | トーメー産業株式会社 | Contact lens solution composition and method for cleaning or storing contact lenses using the same |
US5540864A (en) * | 1990-12-21 | 1996-07-30 | The Procter & Gamble Company | Liquid hard surfce detergent compositions containing zwitterionic detergent surfactant and monoethanolamine and/or beta-aminoalkanol |
UA26334A (en) | 1990-12-27 | 1999-08-30 | Еллергаh Іhк. | METHOD OF DISACTIFICATION OF COATS AND LOSS AND COMPOSITION FOR DISINFECTION OF COATS |
JPH0775620B2 (en) * | 1991-04-08 | 1995-08-16 | トーメー産業株式会社 | Liquid formulation for hydrous contact lens and method for washing hydrous contact lens |
JPH0558967A (en) | 1991-08-27 | 1993-03-09 | Otsuka Pharmaceut Co Ltd | Amino alcohol compound salt and disinfectant |
JP3337218B2 (en) * | 1992-05-06 | 2002-10-21 | アルコン ラボラトリーズ,インコーポレイテッド | Use of a borate-polyol complex in ophthalmic compositions |
US5505953A (en) | 1992-05-06 | 1996-04-09 | Alcon Laboratories, Inc. | Use of borate-polyol complexes in ophthalmic compositions |
TW203128B (en) | 1992-06-17 | 1993-04-01 | Ciba Geigy Ag | The protection method for hard and soft contact lens |
US5260021A (en) * | 1992-06-29 | 1993-11-09 | Allergan, Inc. | Hydrogen peroxide-containing gels and contact lens disinfecting using same |
US5356555A (en) * | 1992-09-14 | 1994-10-18 | Allergan, Inc. | Non-oxidative method and composition for simultaneously cleaning and disinfecting contact lenses using a protease with a disinfectant |
WO1994019027A1 (en) | 1993-02-26 | 1994-09-01 | Wesley-Jessen Corporation | Method and composition for disinfecting contact lenses |
JPH0776700A (en) | 1993-07-14 | 1995-03-20 | Senju Pharmaceut Co Ltd | Stabilization of agent for contact lens |
US5573726A (en) | 1993-09-22 | 1996-11-12 | Alcon Laboratories, Inc. | Use of amidoamines in ophthalmic compositions |
US5393491A (en) * | 1993-09-22 | 1995-02-28 | Alcon Laboratories, Inc. | Use of amidoamines in ophthalmic compositions |
US5631005A (en) | 1994-09-21 | 1997-05-20 | Alcon Laboratories, Inc. | Use of amidoamines in ophthalmic compositions |
WO1995009905A1 (en) | 1993-10-06 | 1995-04-13 | Allergan, Inc. | Compositions and methods for inhibiting and reducing lysozyme deposition on hydrophilic contact lenses |
US5451237A (en) | 1993-11-10 | 1995-09-19 | Vehige; Joseph G. | Compositions and methods for inhibiting and reducing lysozyme deposition on hydrophilic contact lenses using biocompatible colored compounds |
FR2717075B1 (en) * | 1994-03-14 | 1996-04-05 | Oreal | Aqueous organopolysiloxane makeup gel. |
AU2277495A (en) | 1994-04-05 | 1995-10-23 | Allergan, Inc. | Disposable disinfectant system for contact lenses |
WO1996000275A1 (en) | 1994-06-23 | 1996-01-04 | Allergan | Contact lens cleaning compositions with solubilized polymers |
WO1996002624A1 (en) | 1994-07-13 | 1996-02-01 | So-Safe Specialty Products Pty. Ltd. | A cleaning kit and a cleaning composition and methods of use |
WO1996003158A1 (en) * | 1994-07-22 | 1996-02-08 | Alcon Laboratories, Inc. | Use of low molecular weight amino acids in ophthalmic compositions |
IT1273742B (en) | 1994-08-01 | 1997-07-09 | Lifegroup Spa | HIGH BIO ADHESIVE AND MUCO ADHESIVE COMPOSITIONS USEFUL FOR THE TREATMENT OF EPITALS AND MUCOSES |
US5820695A (en) * | 1994-09-06 | 1998-10-13 | S. C. Johnson & Son, Inc. | Single-phase soap compositions |
US5603929A (en) | 1994-11-16 | 1997-02-18 | Alcon Laboratories, Inc. | Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds |
JPH08194192A (en) | 1995-01-13 | 1996-07-30 | Senju Pharmaceut Co Ltd | Production of freeze-dried material containing proteolytic enzyme |
US5558876A (en) * | 1995-03-29 | 1996-09-24 | Alcon Laboratories, Inc. | Topical ophthalmic acidic drug formulations |
JPH0930966A (en) | 1995-07-24 | 1997-02-04 | Gakuzo Tamura | New pharmaceutical preparation for eye |
EP0888780B2 (en) | 1996-11-13 | 2009-08-19 | Menicon Co., Ltd. | Treatment composition for contact lenses and method for treating contact lenses with the same |
PT948357E (en) * | 1996-12-13 | 2002-10-31 | Alcon Lab Inc | USE OF ALCOHOLS OF LOW MOLECULAR WEIGHT IN OPHTHALMIC COMPOSITIONS |
US6331513B1 (en) * | 1999-04-28 | 2001-12-18 | Jacam Chemicals L.L.C. | Compositions for dissolving metal sulfates |
ES2323132T3 (en) * | 2003-12-09 | 2009-07-07 | Alcon, Inc. | USE OF BIS-AMINAS TO INCREASE ANTIMICROBIAL ACTIVITY OF WATER COMPOSITIONS. |
-
1997
- 1997-11-17 PT PT97947519T patent/PT948357E/en unknown
- 1997-11-17 JP JP52667098A patent/JP3724813B2/en not_active Expired - Lifetime
- 1997-11-17 DE DE69735963T patent/DE69735963T2/en not_active Expired - Lifetime
- 1997-11-17 DK DK97947519T patent/DK0948357T3/en active
- 1997-11-17 ES ES01204124T patent/ES2262603T3/en not_active Expired - Lifetime
- 1997-11-17 DE DE69713388T patent/DE69713388T2/en not_active Expired - Lifetime
- 1997-11-17 NZ NZ336031A patent/NZ336031A/en not_active IP Right Cessation
- 1997-11-17 WO PCT/US1997/020826 patent/WO1998025649A1/en active IP Right Grant
- 1997-11-17 CA CA002272308A patent/CA2272308C/en not_active Expired - Lifetime
- 1997-11-17 US US09/308,456 patent/US6319464B1/en not_active Expired - Lifetime
- 1997-11-17 EP EP97947519A patent/EP0948357B1/en not_active Expired - Lifetime
- 1997-11-17 ES ES97947519T patent/ES2178786T3/en not_active Expired - Lifetime
- 1997-11-17 AU AU52578/98A patent/AU718199B2/en not_active Expired
- 1997-11-17 CN CNB971805768A patent/CN1157227C/en not_active Expired - Lifetime
- 1997-11-17 AT AT97947519T patent/ATE218887T1/en active
- 1997-11-17 AT AT01204124T patent/ATE326983T1/en active
- 1997-11-17 KR KR10-1999-7005231A patent/KR100366676B1/en not_active IP Right Cessation
- 1997-11-17 PT PT01204124T patent/PT1190718E/en unknown
-
2000
- 2000-01-18 HK HK00100308A patent/HK1022089A1/en not_active IP Right Cessation
-
2001
- 2001-10-22 US US10/007,423 patent/US6949218B2/en not_active Expired - Lifetime
-
2004
- 2004-06-24 JP JP2004186117A patent/JP4276139B2/en not_active Expired - Lifetime
-
2005
- 2005-06-28 US US11/168,788 patent/US7045095B2/en not_active Expired - Lifetime
-
2006
- 2006-01-30 US US11/343,068 patent/US8563011B2/en not_active Expired - Fee Related
-
2013
- 2013-09-18 US US14/030,388 patent/US8865776B2/en not_active Expired - Fee Related
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