CA2274565A1 - Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents - Google Patents

Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents Download PDF

Info

Publication number
CA2274565A1
CA2274565A1 CA002274565A CA2274565A CA2274565A1 CA 2274565 A1 CA2274565 A1 CA 2274565A1 CA 002274565 A CA002274565 A CA 002274565A CA 2274565 A CA2274565 A CA 2274565A CA 2274565 A1 CA2274565 A1 CA 2274565A1
Authority
CA
Canada
Prior art keywords
pharmaceutical agents
transdermal penetration
hydroalcoholic compositions
pharmaceutical agent
hydroalcoholic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002274565A
Other languages
French (fr)
Other versions
CA2274565C (en
Inventor
Matthew T. Scholz
Robert A. Asmus
John C. Hedenstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Co
Original Assignee
Minnesota Mining And Manufacturing Company
Matthew T. Scholz
Robert A. Asmus
John C. Hedenstrom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining And Manufacturing Company, Matthew T. Scholz, Robert A. Asmus, John C. Hedenstrom filed Critical Minnesota Mining And Manufacturing Company
Publication of CA2274565A1 publication Critical patent/CA2274565A1/en
Application granted granted Critical
Publication of CA2274565C publication Critical patent/CA2274565C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Abstract

Hydroalcoholic compositions useful for the enhancement of the transdermal delivery of a pharmaceutical agent, methods of preparation, transdermal delivery systems, and methods of delivering the pharmaceutical agent are provided. The composition includes a lower alcohol and water in a weight ratio of at least about 20:80, a pharmaceutical agent, and an emulsifier system.
CA002274565A 1997-01-09 1997-12-23 Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents Expired - Fee Related CA2274565C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/781097 1997-01-09
US08/781,097 US6019997A (en) 1997-01-09 1997-01-09 Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents
PCT/US1997/023483 WO1998030244A1 (en) 1997-01-09 1997-12-23 Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents

Publications (2)

Publication Number Publication Date
CA2274565A1 true CA2274565A1 (en) 1998-07-16
CA2274565C CA2274565C (en) 2008-04-08

Family

ID=25121692

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002274565A Expired - Fee Related CA2274565C (en) 1997-01-09 1997-12-23 Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents

Country Status (8)

Country Link
US (1) US6019997A (en)
EP (1) EP0957939B1 (en)
JP (1) JP2001508062A (en)
AU (1) AU738444B2 (en)
CA (1) CA2274565C (en)
DE (1) DE69738200T2 (en)
ES (1) ES2293667T3 (en)
WO (1) WO1998030244A1 (en)

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Also Published As

Publication number Publication date
JP2001508062A (en) 2001-06-19
WO1998030244A1 (en) 1998-07-16
US6019997A (en) 2000-02-01
CA2274565C (en) 2008-04-08
EP0957939A1 (en) 1999-11-24
ES2293667T3 (en) 2008-03-16
DE69738200D1 (en) 2007-11-22
DE69738200T2 (en) 2008-07-10
AU5709898A (en) 1998-08-03
AU738444B2 (en) 2001-09-20
EP0957939B1 (en) 2007-10-10

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