CA2276170A1 - Sustained analgesia achieved with buprenorphine - Google Patents

Sustained analgesia achieved with buprenorphine Download PDF

Info

Publication number
CA2276170A1
CA2276170A1 CA002276170A CA2276170A CA2276170A1 CA 2276170 A1 CA2276170 A1 CA 2276170A1 CA 002276170 A CA002276170 A CA 002276170A CA 2276170 A CA2276170 A CA 2276170A CA 2276170 A1 CA2276170 A1 CA 2276170A1
Authority
CA
Canada
Prior art keywords
buprenorphine
dosing interval
day
additional
manner indicative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002276170A
Other languages
French (fr)
Other versions
CA2276170C (en
Inventor
Robert F. Reder
Paul D. Goldenheim
Robert F. Kaiko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro-Celtique, S.A.
Robert F. Reder
Paul D. Goldenheim
Robert F. Kaiko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26715643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2276170(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro-Celtique, S.A., Robert F. Reder, Paul D. Goldenheim, Robert F. Kaiko filed Critical Euro-Celtique, S.A.
Publication of CA2276170A1 publication Critical patent/CA2276170A1/en
Application granted granted Critical
Publication of CA2276170C publication Critical patent/CA2276170C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)

Abstract

The use of buprenorphine in the preparation of a medicament for a method of effectively treating pain in humans is achieved by administering buprenorphine in a manner indicative of first order pharmacokinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in a manner indicative of zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.
CA002276170A 1997-02-24 1998-02-24 Sustained analgesia achieved with buprenorphine Expired - Lifetime CA2276170C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3891997P 1997-02-24 1997-02-24
US60/038,919 1997-02-24
US08/939,068 1997-09-29
US08/939,068 US5968547A (en) 1997-02-24 1997-09-29 Method of providing sustained analgesia with buprenorphine
PCT/US1998/003584 WO1998036728A2 (en) 1997-02-24 1998-02-24 Sustained analgesia achieved with buprenorphine

Publications (2)

Publication Number Publication Date
CA2276170A1 true CA2276170A1 (en) 1998-08-27
CA2276170C CA2276170C (en) 2007-12-04

Family

ID=26715643

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002276170A Expired - Lifetime CA2276170C (en) 1997-02-24 1998-02-24 Sustained analgesia achieved with buprenorphine

Country Status (22)

Country Link
US (15) US5968547A (en)
EP (9) EP2305192A1 (en)
JP (1) JP2000511936A (en)
KR (1) KR100703101B1 (en)
CN (2) CN1827107B (en)
AT (3) ATE336212T1 (en)
AU (2) AU2004218685B2 (en)
BR (1) BR9815439A (en)
CA (1) CA2276170C (en)
CZ (2) CZ299414B6 (en)
DE (2) DE05011213T1 (en)
DK (4) DK1731152T3 (en)
ES (4) ES2380023T3 (en)
HK (3) HK1096847A1 (en)
HU (3) HU230374B1 (en)
IL (4) IL131561A0 (en)
NO (11) NO322515B1 (en)
NZ (1) NZ337386A (en)
PL (1) PL196086B1 (en)
PT (4) PT964677E (en)
SI (3) SI1570823T1 (en)
WO (1) WO1998036728A2 (en)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040265353A1 (en) * 1995-07-28 2004-12-30 Zars, Inc. Systems and methods for treating panic attacks
US20020114827A1 (en) * 1995-07-28 2002-08-22 Jie Zhang Methods and apparatus for improved administration of analgesics
US20040024006A1 (en) * 1996-05-06 2004-02-05 Simon David Lew Opioid pharmaceutical compositions
US20030211157A1 (en) * 1996-05-06 2003-11-13 Simon David Lew Semi-sol delivery blend for water soluble molecules
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
DE19746191C2 (en) * 1997-10-18 2000-05-18 Lohmann Therapie Syst Lts Method of using an active ingredient-containing patch to combat or alleviate addiction
WO1999032119A1 (en) 1997-12-22 1999-07-01 Euro-Celtique, S.A. Opioid agonist/antagonist combinations
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
SE9803240D0 (en) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
HU229705B1 (en) 2000-02-08 2014-05-28 Euro Celtique Sa Tamper-resistant oral opioid agonist formulations
CA2400578C (en) * 2000-02-08 2007-01-02 Euro-Celtique, S.A. Controlled-release compositions containing opioid agonist and antagonist
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
EP1280485A4 (en) * 2000-02-29 2006-11-29 Zars Inc Improved transdermal drug patch
KR100452972B1 (en) * 2000-05-16 2004-10-14 주식회사 삼양사 Hydrogel composition for transdermal drug
AU2001262683A1 (en) * 2000-06-02 2001-12-17 Teijin Limited Buprenorphine-containing patch
GB0021317D0 (en) * 2000-08-30 2000-10-18 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
US7018649B2 (en) * 2000-10-23 2006-03-28 Euro-Celtique, S.A. Felodipine transdermal device and methods
WO2002034206A2 (en) * 2000-10-23 2002-05-02 Euro-Celtique, S.A. Felodipine transdermal device and methods
DE60141596D1 (en) 2000-10-23 2010-04-29 Euro Celtique Sa TRANSDERMALES SYSTEM FOR THE ADMINISTRATION OF LORATADINE AND ITS USE
US6682757B1 (en) * 2000-11-16 2004-01-27 Euro-Celtique, S.A. Titratable dosage transdermal delivery system
US20020106407A1 (en) * 2000-12-11 2002-08-08 Dennis Coleman Method and apparatus for treating breakthrough pain
WO2002083135A2 (en) * 2001-02-16 2002-10-24 Grünenthal GmbH Use of buprenorphine for the manufacture of a transdermal delivery device for the treatment of urinary incontinence, especially urge incontinence
DK1368023T3 (en) * 2001-02-16 2006-02-13 Gruenenthal Chemie Use of buprenoprphine to treat urinary incontinence
KR20030088445A (en) * 2001-03-02 2003-11-19 유로-셀티큐 에스.에이. N-but-3-enyl norbuprenorphine and methods of use
ATE493130T1 (en) 2001-05-11 2011-01-15 Endo Pharmaceuticals Inc MEDICINAL FORM CONTAINING OPIOID AGAINST ABUSE
US7968119B2 (en) * 2001-06-26 2011-06-28 Farrell John J Tamper-proof narcotic delivery system
DE60230632D1 (en) 2001-07-18 2009-02-12 Euro Celtique Sa PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE
ATE431738T1 (en) 2001-08-06 2009-06-15 Euro Celtique Sa OPIOID AGONIST FORMULATIONS WITH RELEASABLE AND SEQUESTRED ANTAGONIST
WO2003013433A2 (en) 2001-08-06 2003-02-20 Euro-Celtique S.A. Sequestered antagonist formulations
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
JPWO2003014247A1 (en) * 2001-08-10 2005-01-13 有限会社コスメディ Skin adhesive and skin tape or sheet using the same
EP1455784A1 (en) * 2001-12-17 2004-09-15 Aryx Therapeutics Analgesic delivery systems and methods of use
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
JP2005528359A (en) * 2002-03-20 2005-09-22 ユーロ−セルティーク エス．エイ． Method of administering buprenorphine for the treatment of depression
EP2243471A1 (en) 2002-04-05 2010-10-27 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
US20050106249A1 (en) * 2002-04-29 2005-05-19 Stephen Hwang Once-a-day, oral, controlled-release, oxycodone dosage forms
US7736665B2 (en) * 2002-05-31 2010-06-15 Titan Pharmaceuticals, Inc. Implantable polymeric device for sustained release of buprenorphine
KR101407131B1 (en) 2002-06-10 2014-06-19 유로-셀티크 소시에떼 아노뉨 Disposal systems of transdermal delivery devices to prevent misuse of the active agents contained therein
PT1526848E (en) * 2002-08-09 2007-08-08 Gruenenthal Gmbh Opioid-receptor antagonists in transdermal systems having buprenorphine
JP4642467B2 (en) * 2002-08-20 2011-03-02 ユーロ−セルティーク エス．エイ． Transdermal dosage form containing active agent and salt and free base form of side effect substance
EP1545468A4 (en) * 2002-09-20 2007-06-20 Alpharma Inc Sustained-release opioid formulations and methods of use
DK1551372T3 (en) 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES
US7084150B2 (en) * 2002-10-25 2006-08-01 Euro-Celtique S.A. Analogs and prodrugs of buprenorphine
EP1913938A1 (en) 2002-12-13 2008-04-23 Euro-Celtique S.A. Transdermal buprenorphine dosage regimen for analgesia
DK1572167T3 (en) * 2002-12-13 2008-10-13 Euro Celtique Sa Transdermal buprenophine dosing regimen for analgesia
AU2003297074A1 (en) * 2002-12-13 2004-07-09 Euro-Celtique S.A. Transdermal buprenorphine to treat pain in sickle cell crisis
NZ542548A (en) 2003-03-31 2009-04-30 Titan Pharmaceuticals Inc Implantable polymeric device for sustained release of dopamine agonist
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
US7879357B2 (en) * 2003-04-28 2011-02-01 Bayer Schering Pharma Ag Pharmaceutical composition in the form of a hydrogel for transdermal administration of active ingredients
US8790689B2 (en) 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
US8778382B2 (en) 2003-04-30 2014-07-15 Purdue Pharma L.P. Tamper resistant transdermal dosage form
WO2004103317A2 (en) * 2003-05-15 2004-12-02 Euro-Celtique S.A. Transdermal buprenorphine dosage regimen for treatment of diarrhea
KR20090031961A (en) * 2003-07-25 2009-03-30 유로-셀티큐 에스.에이. Preoperative treatment of post operative pain
ES2295929T3 (en) 2003-07-25 2008-04-16 Euro-Celtique S.A. TREATMENT OF SUSPENSION OF THE DEPENDENCY.
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
DE602005013490D1 (en) 2004-02-23 2009-05-07 Euro Celtique Sa MISSIBLE TRANSDERMAL DISTRIBUTION DEVICE FOR OPIOIDE, CONTAINING OPIOIDANT AGONIST IN THE FORM OF MICRO BEAMS
US7220842B2 (en) 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
ES2653568T3 (en) 2004-06-12 2018-02-07 Collegium Pharmaceutical, Inc. Drug formulations for abuse prevention
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
US20060281775A1 (en) * 2005-06-14 2006-12-14 Applied Pharmacy Services, Inc. Two-component pharmaceutical composition for the treatment of pain
EP1743638A1 (en) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Pharmaceutical formulations of substituted pyrazoline compounds
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8252329B2 (en) * 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
CA2935569A1 (en) * 2006-04-13 2007-10-25 Teva Pharmaceuticals International Gmbh Transdermal methods and systems for the delivery of anti-migraine compounds
CN101677963B (en) 2006-06-19 2012-05-30 奥尔制药公司 Pharmaceutical compositions
EP1897543A1 (en) 2006-08-30 2008-03-12 Euro-Celtique S.A. Buprenorphine- wafer for drug substitution therapy
DE102006054732B4 (en) * 2006-11-21 2010-12-30 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with ion-pair microreservoirs
DE102006054731B4 (en) * 2006-11-21 2013-02-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for administration of the active ingredient buprenorphine and use thereof in pain therapy
US20110008431A1 (en) * 2007-04-02 2011-01-13 Toyo Boseki Kabushiki Kaisha Therapeutic tablet for postherpetic neuralgia and method of treating postherpetic neuralgia
DK2182902T3 (en) * 2007-08-07 2015-04-13 Acelrx Pharmaceuticals Inc Compositions comprising sufentanil and triazolam for procedure sedation and analgesia using oral transmucosal dosage forms
US20090082383A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched buprenorphine
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
WO2009114118A2 (en) * 2008-03-08 2009-09-17 Theraquest Biosciences, Inc. Oral pharmaceutical compositions of buprenorphine and method of use
ES2663777T3 (en) * 2008-06-23 2018-04-17 Biodelivery Sciences International, Inc. Multidirectional mucosal administration devices and methods of use
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
DK2405915T3 (en) 2009-03-10 2019-02-11 Euro Celtique Sa PHARMACEUTICAL COMPOSITIONS WITH IMMEDIATE RELEASE INCLUDING OXYCODON AND NALOXON
WO2010107761A1 (en) 2009-03-18 2010-09-23 Acelrx Pharmaceuticals, Inc. Improved storage and dispensing devices for administration of oral transmucosal dosage forms
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US20110037455A1 (en) * 2009-08-17 2011-02-17 Oren Navot System for measuring electrical power
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
DE102010024105A1 (en) * 2010-06-17 2011-12-22 Grünenthal GmbH Transdermal administration of memantine
PT2611445T (en) * 2010-09-03 2018-10-24 Zoetis Belgium S A High dose buprenorphine compositions and use as analgesic
EP2606895A4 (en) * 2010-10-12 2014-04-02 Univ Wuhan Transdermal absorption patch of antiviral drug and its preparation method
DK2640389T3 (en) * 2010-11-17 2015-03-09 Hexal Ag Transdermal therapeutic system comprising buprenorphine
DE102011076653A1 (en) 2011-05-27 2012-11-29 Acino Ag Transdermal therapeutic system containing buprenorphine and an alpha hydroxy acid
EP2758134B1 (en) * 2011-09-19 2019-05-29 Carmel - Haifa University Economic Corporation Ltd. Buprenorphine for the treatment of acute suicidality
SG11201403162XA (en) * 2011-12-12 2014-10-30 Lohmann Therapie Syst Lts Transdermal delivery system comprising buprenorphine
CN104125828A (en) * 2011-12-21 2014-10-29 拜欧帝力威瑞科学有限公司 Transmucosal drug delivery devices for use in chronic pain relief
US20130211351A1 (en) * 2012-01-31 2013-08-15 Gruenenthal Gmbh Pharmaceutical patch for transdermal administration of (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine
CA3120681A1 (en) 2012-04-17 2013-10-24 Purdue Pharma L.P. Systems and methods for treating an opioid-induced adverse pharmacodynamic response
CA2882870C (en) * 2012-08-24 2020-12-15 Integurx Therapeutics, Llc Chemical compositions and methods for enhancing transdermal delivery of therapeutic agents
AU2013205080B2 (en) * 2012-12-12 2016-07-07 Lts Lohmann Therapie-Systeme Ag Transdermal Delivery System
WO2014105480A1 (en) * 2012-12-28 2014-07-03 Teikoku Pharma Usa, Inc. Extended buprenorphine transdermal delivery compositions and methods for using the same
CN105377245B (en) 2013-06-04 2018-07-17 Lts勒曼治疗系统股份公司 Transdermal delivery system
KR20180037074A (en) 2013-07-23 2018-04-10 유로-셀티큐 에스.에이. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
DE102014013448A1 (en) 2014-09-16 2016-03-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermal therapeutic system comprising buprenorphine
US9849124B2 (en) 2014-10-17 2017-12-26 Purdue Pharma L.P. Systems and methods for treating an opioid-induced adverse pharmacodynamic response
MY187877A (en) 2014-12-23 2021-10-26 Acelrx Pharmaceuticals Inc Systems, devices and methods for dispensing oral transmucosal dosage forms
US9656441B2 (en) 2015-01-08 2017-05-23 Alfred E. Tiefenbacher ( Gmbh & Co. Kg) Transdermal patch
NZ735736A (en) 2015-03-10 2019-02-22 Rhodes Tech Acetate salt of buprenorphine and methods for preparing buprenorphine
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
CA3092757A1 (en) * 2018-03-13 2019-09-19 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system comprising a silicone acrylic hybrid polymer
WO2021163529A2 (en) * 2020-02-13 2021-08-19 Biodelivery Sciences International, Inc. Methods of treatment with buprenorphine
EP4238669A1 (en) 2022-03-02 2023-09-06 Recutech S.r.o. Method of manufacturing a heat-humidity exchange plate of an enthalpy air-to-air exchanger, a heat-humidity exchange plate and an enthalpy exchanger

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
US4058599A (en) 1973-02-24 1977-11-15 Bayer Aktiengesellschaft Ethyleneimine inactivated organisms
US4262003A (en) * 1975-12-08 1981-04-14 Alza Corporation Method and therapeutic system for administering scopolamine transdermally
US4060084A (en) * 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
US4119713A (en) 1977-02-09 1978-10-10 Sam Carosio Analgesic and anti-inflammatory composition
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
DE3330750A1 (en) * 1983-08-26 1985-03-14 Chemische Werke Hüls AG, 4370 Marl METHOD FOR GENERATING ACETYLENE AND SYNTHESIS OR REDUCING GAS FROM COAL IN AN ARC PROCESS
GB8332556D0 (en) * 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions
US4636539A (en) 1984-01-30 1987-01-13 Loctite (Ireland) Limited Instant adhesive composition utilizing calixarene accelerators
US4601893A (en) 1984-02-08 1986-07-22 Pfizer Inc. Laminate device for controlled and prolonged release of substances to an ambient environment and method of use
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
DE3546830C2 (en) 1984-07-23 1995-07-20 Alza Corp Device for delivering fentanyl across the skin
US4626539A (en) 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4834978A (en) 1984-10-01 1989-05-30 Biotek, Inc. Method of transdermal drug delivery
GB8430346D0 (en) * 1984-11-30 1985-01-09 Reckitt & Colmann Prod Ltd Analgesic compositions
US4806341A (en) * 1985-02-25 1989-02-21 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration
US4698062A (en) 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
DE3634016A1 (en) * 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg AREA-BASED THERAPEUTIC SYSTEM, METHOD FOR THE PRODUCTION THEREOF AND ITS USE
US4673679A (en) 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
USRE33093E (en) 1986-06-16 1989-10-17 Johnson & Johnson Consumer Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
JPS62298530A (en) 1986-06-16 1987-12-25 Otsuka Pharmaceut Co Ltd Pharmaceutical composition for suppository
US4938759A (en) 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
US5091405A (en) * 1987-01-05 1992-02-25 E. I. Du Pont De Nemours And Company Insecticidal pyrazolines
US5171576A (en) 1987-03-09 1992-12-15 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US4879297A (en) * 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
DE3812481A1 (en) * 1987-08-26 1989-03-09 Bayer Ag WATERPROOF POLYMER PREPARATION
US4915954A (en) 1987-09-03 1990-04-10 Alza Corporation Dosage form for delivering a drug at two different rates
US4983395A (en) * 1987-11-12 1991-01-08 Theratech Inc. Device for administering an active agent to the skin or mucosa
US4994278A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Breathable backing
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5236714A (en) 1988-11-01 1993-08-17 Alza Corporation Abusable substance dosage form having reduced abuse potential
US5026556A (en) * 1988-11-10 1991-06-25 Norwich Eaton Pharmaceuticals, Inc. Compositions for the transdermal delivery of pharmaceutical actives
CA2002299A1 (en) * 1988-11-10 1990-05-10 Eugene G. Drust Compositions for the transdermal delivery of buprenorphine salts
US4945103A (en) * 1989-01-17 1990-07-31 Michael Cohen Method of treating pre-menstrual syndrome
US5336210A (en) * 1989-02-28 1994-08-09 Teijin Limited Plaster agent
US5028435A (en) 1989-05-22 1991-07-02 Advanced Polymer Systems, Inc. System and method for transdermal drug delivery
US4956171A (en) * 1989-07-21 1990-09-11 Paco Pharmaceutical Services, Inc. Transdermal drug delivery using a dual permeation enhancer and method of performing the same
US5091186A (en) * 1989-08-15 1992-02-25 Cygnus Therapeutic Systems Biphasic transdermal drug delivery device
DE3939376C1 (en) 1989-11-29 1991-05-08 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg, 5450 Neuwied, De
US5240711A (en) * 1989-11-29 1993-08-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system comprising as active component buprenorphine
US5075341A (en) 1989-12-01 1991-12-24 The Mclean Hospital Corporation Treatment for cocaine abuse
EP0432945A1 (en) * 1989-12-12 1991-06-19 Warner-Lambert Company A transdermal delivery system for treatment of cocaine and heroin addiction
JP2849937B2 (en) * 1990-04-18 1999-01-27 日東電工株式会社 Medical patch
KR950005865B1 (en) * 1990-04-23 1995-06-02 데이진 가부시끼가이샤 Plaster
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine
DE4020144A1 (en) * 1990-06-25 1992-01-09 Lohmann Therapie Syst Lts Patches for topical or transdermal drug delivery - with adhesive layer contg. polyacrylate adhesive and film former
US5688547A (en) 1990-08-03 1997-11-18 American Cyanamid Company Meal replacement composition and method of weight control
GB9021674D0 (en) * 1990-10-05 1990-11-21 Ethical Pharma Ltd Transdermal device
CN1036343C (en) 1990-11-10 1997-11-05 天津市计划生育研究所 Synthesis, products and its application for luleinizing hormone releasing hormone and antagonistic znalogue
PL166095B1 (en) 1991-04-03 1995-03-31 Warszawskie Zaklady Farma Method of obtaining buprenophine
HUT69390A (en) 1991-05-07 1995-09-28 Dynagen Inc Controlled, sustained release delivery system for smoking cessation
US5486362A (en) * 1991-05-07 1996-01-23 Dynagen, Inc. Controlled, sustained release delivery system for treating drug dependency
US5149538A (en) * 1991-06-14 1992-09-22 Warner-Lambert Company Misuse-resistive transdermal opioid dosage form
US5225440A (en) * 1991-09-13 1993-07-06 The United States Of America As Represented By The Department Of Health And Human Services Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase
US5238933A (en) * 1991-10-28 1993-08-24 Sri International Skin permeation enhancer compositions
US5229130A (en) 1991-12-20 1993-07-20 Cygnus Therapeutics Systems Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems
US5478577A (en) 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5958459A (en) 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5272149A (en) 1992-05-05 1993-12-21 Stalling Reginald W Symptom controlled receptor substitution for addiction withdrawl
WO1993023019A1 (en) 1992-05-11 1993-11-25 Sri International Transdermal drug delivery systems and related compositions and methods of use
MX9302812A (en) 1992-05-13 1993-11-01 Alza Corp TRANSDERMIC ADMINISTRATION OF OXYBUTININE.
JPH08501529A (en) 1992-06-11 1996-02-20 セラテック・インコーポレイテッド Use of glycerin to alleviate skin-penetrating drug administration
US6096756A (en) 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5580876A (en) * 1992-09-21 1996-12-03 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
DE4237453C1 (en) 1992-11-06 1993-08-19 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4301783C1 (en) * 1993-01-23 1994-02-03 Lohmann Therapie Syst Lts Transdermal system per admin. of galanthamine - esp. for treatment of Alzheimer's disease and alcohol addiction
US5512593A (en) 1993-03-02 1996-04-30 John S. Nagle Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor
JP3489831B2 (en) 1993-04-20 2004-01-26 ヘクサル・アクチエンゲゼルシャフト Active ingredient patch
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
ATE149349T1 (en) 1993-06-25 1997-03-15 Alza Corp INCORPORATING A POLY-N-VINYLAMIDE INTO A TRANSDERMAL SYSTEM
AU7566994A (en) 1993-08-16 1995-03-14 Cygnus Therapeutic Systems Contact adhesive extends wear time on skin
US5662933A (en) 1993-09-09 1997-09-02 Edward Mendell Co., Inc. Controlled release formulation (albuterol)
WO1995019991A1 (en) 1994-01-20 1995-07-27 Akzo Nobel N.V. New composition of glycoprotein isoforms having follicle stimulating activity
JPH07206710A (en) * 1994-01-21 1995-08-08 Nitto Denko Corp Tape preparation for transcutaneous administration
PE44995A1 (en) 1994-01-27 1995-12-18 Schering Corp MOMETASONE FUROATE FOR THE TREATMENT OF LUNG DISEASES AND RESPIRATORY TRACT
JP2819236B2 (en) * 1994-05-06 1998-10-30 日東電工株式会社 Transdermal formulation
US5635203A (en) 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
US20020006438A1 (en) 1998-09-25 2002-01-17 Benjamin Oshlack Sustained release hydromorphone formulations exhibiting bimodal characteristics
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5468457A (en) 1994-12-22 1995-11-21 Osram Sylvania Inc. Method of making tungsten-copper composite oxides
DE4446600A1 (en) * 1994-12-24 1996-06-27 Lohmann Therapie Syst Lts Transdermal absorption of active ingredients from supercooled melts
US6024974A (en) * 1995-01-06 2000-02-15 Noven Pharmaceuticals, Inc. Composition and methods for transdermal delivery of acid labile drugs
US5601839A (en) * 1995-04-26 1997-02-11 Theratech, Inc. Triacetin as a penetration enhancer for transdermal delivery of a basic drug
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
AU6657396A (en) 1995-07-28 1997-02-26 Novartis Ag Transdermal system
CA2182851A1 (en) * 1995-08-15 1997-02-16 August Masaru Watanabe Method for treating substance abuse withdrawal
FR2739731B1 (en) 1995-10-09 1998-01-02 Axon Cable Sa METHOD FOR CONNECTING COAXIAL MICRO-CABLES TO THE TRACKS OF A PRINTED CIRCUIT
DE19642043A1 (en) * 1995-10-23 1997-04-24 Hexal Ag Transdermal therapeutic system for treating drug dependency
US5792740A (en) 1996-03-08 1998-08-11 Firmenich Sa Fragrant macrocyclic lactones
PT889723E (en) 1996-03-25 2002-11-29 Lohmann Therapie Syst Lts TRANSDERMIC THERAPEUTIC SYSTEM WITH SMALL ESPRESSURE OF THE APPLICATION ZONE AND HIGH FLEXIBILITY AS A PRODUCTION PROCESS
US6004969A (en) 1996-04-15 1999-12-21 National Science Council Transdermal delivery of buprenorphine preparations
US6271240B1 (en) 1996-05-06 2001-08-07 David Lew Simon Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals
SE9602442D0 (en) 1996-06-20 1996-06-20 Astra Ab Administration of pharmaceuticals
JPH1036265A (en) * 1996-07-19 1998-02-10 Nitto Denko Corp Buprenorphine percutaneous absorption preparation
US5837289A (en) * 1996-07-23 1998-11-17 Grasela; John C. Transdermal delivery of medications using a combination of penetration enhancers
EP0821957A3 (en) 1996-08-01 1998-04-22 Eli Lilly And Company Use of 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine (xanomeline) for treating substance abuse
US20010006677A1 (en) 1996-10-29 2001-07-05 Mcginity James W. Effervescence polymeric film drug delivery system
AT405158B (en) * 1996-12-04 1999-06-25 Steyr Daimler Puch Ag METHOD FOR AUTOMATICALLY CONTROLLING THE LOCKING CLUTCHES OF AN ALL-WHEEL DRIVE VEHICLE AND VEHICLE WITH ARTICULATED STEERING AND LOCKABLE DIFFERENTIALS
US6787149B1 (en) 1996-12-12 2004-09-07 El Khoury And Stein Ltd. Topical application of opioid analgesic drugs such as morphine
DE19652188C2 (en) 1996-12-16 2002-02-14 Lohmann Therapie Syst Lts Flat drug preparation for application and release of buprenorphine or a pharmacologically comparable substance in the oral cavity and process for its preparation
CA2280033A1 (en) 1997-02-07 1998-08-13 Susan Rako Composition and method for supplementing testosterone in women with symptoms of testosterone deficiency
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
AU7273898A (en) 1997-04-30 1998-11-24 Human Pheromone Sciences, Inc. Method of fixing fragrances in fragrance composition and other compositions
US5919473A (en) * 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
US5900420A (en) 1997-06-19 1999-05-04 Cole; William L. Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine
GB2328443B (en) 1997-08-21 2001-09-05 Reckitt & Colmann Prod Ltd In situ formation of pharmaceutically acceptable polymeric material
US5942530A (en) 1997-08-28 1999-08-24 Eli Lilly And Company Method for treating pain
DE19738855C2 (en) 1997-09-05 2001-01-04 Lohmann Therapie Syst Lts Transdermal therapeutic system with adhesive reservoir layer and unidirectional elastic back layer
RS49982B (en) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Synergistic analgesic combination of opioid analgesic and cyclooxygenase-2 inhibitor
US7011843B2 (en) 1997-10-01 2006-03-14 Lts Lohmann-Therapie Systeme Ag Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system
DE19746191C2 (en) * 1997-10-18 2000-05-18 Lohmann Therapie Syst Lts Method of using an active ingredient-containing patch to combat or alleviate addiction
US6210705B1 (en) 1997-12-15 2001-04-03 Noven Pharmaceuticals, Nc. Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
UA53774C2 (en) 1997-12-22 2003-02-17 Еро-Селтік, С.А. Method of reducing abuse potential of an oral dosage form of opioid analgesic
AU2981099A (en) 1998-03-09 1999-09-27 Trustees Of Tufts College Treatment of compulsive behaviours in man and animals
EP1064035B1 (en) 1998-03-23 2003-11-26 ELAN CORPORATION, Plc Drug delivery device
EP1079813B1 (en) 1998-04-29 2005-02-09 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
DE19840758A1 (en) 1998-09-07 2000-03-09 Liedtke Pharmed Gmbh Treatment of pain or depression comprises systemic administration of oxytocin
KR100383252B1 (en) 1998-12-17 2003-07-16 주식회사 삼양사 Transdermal Dosage Compositions Containing Buprenoline and Patches Comprising the Same
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
IT1305303B1 (en) 1999-03-10 2001-05-04 Farmigea Spa USE OF NIAOULI ESSENTIAL OIL AS A PROMOTER FOR TRANSDERMAL PERMEAZION.
US6210699B1 (en) 1999-04-01 2001-04-03 Watson Pharmaceuticals, Inc. Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity
US6554851B1 (en) 1999-05-07 2003-04-29 Scimed Life Systems, Inc. Methods of sealing an injection site
US6436977B1 (en) * 1999-09-29 2002-08-20 Pfizer Inc. Dosing regimens for lasofoxifene
US6716449B2 (en) * 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
JP4659943B2 (en) * 2000-02-25 2011-03-30 帝三製薬株式会社 Patch containing buprenorphine hydrochloride
US7067116B1 (en) 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
ATE460939T1 (en) 2000-08-30 2010-04-15 Unimed Pharmaceuticals Llc METHOD FOR TREATING ERECTIVE DISORDER AND INCREASE LIBIDO IN MEN
US6682757B1 (en) * 2000-11-16 2004-01-27 Euro-Celtique, S.A. Titratable dosage transdermal delivery system
KR20030088445A (en) 2001-03-02 2003-11-19 유로-셀티큐 에스.에이. N-but-3-enyl norbuprenorphine and methods of use
DE60236496D1 (en) 2001-03-23 2010-07-08 Einstein Coll Med METHOD FOR INCREASING THE ANALGETIC EFFECT AND REDUCING THE UNWANTED EXITATORY EFFECTS OF BIMODALALLY EFFECTIVE OPIOIDAGONISTS BY THE INHIBITION OF GM1 GANGLIOSIDE
PT2113315E (en) 2001-04-23 2014-08-25 Euro Celtique Sa Disposal system for transdermal dosage form
DE60230138D1 (en) 2001-05-01 2009-01-15 Euro Celtique Sa PROTECTED FROM MISUSE OF OPIOID-CONTAINING TRANSDERMALE SYSTEMS
JP4302991B2 (en) 2001-05-22 2009-07-29 ユーロ−セルティーク エス．エイ． Container and device for dispensing transdermal dosage forms
CN1539028A (en) 2001-06-04 2004-10-20 ���ڵٿ����޹�˾ Patterning method
AU2002355266A1 (en) 2001-07-23 2003-02-17 Brigham And Women's Hospital, Inc. Analgesic methods using endothelin receptor ligands
AU2002348135A1 (en) 2001-10-31 2003-05-12 Recovery Pharmaceuticals, Inc. Methods for the treatment of addiction
JP2005528359A (en) 2002-03-20 2005-09-22 ユーロ−セルティーク エス．エイ． Method of administering buprenorphine for the treatment of depression
ATE382050T1 (en) 2002-11-25 2008-01-15 Chi Mei Foundation Medical Ct BUPRENORPHINE ESTER DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND LONG-ACTING ANALGESIC DRUGS
AU2003297074A1 (en) * 2002-12-13 2004-07-09 Euro-Celtique S.A. Transdermal buprenorphine to treat pain in sickle cell crisis
DK1572167T3 (en) 2002-12-13 2008-10-13 Euro Celtique Sa Transdermal buprenophine dosing regimen for analgesia
WO2004103317A2 (en) 2003-05-15 2004-12-02 Euro-Celtique S.A. Transdermal buprenorphine dosage regimen for treatment of diarrhea
ES2295929T3 (en) * 2003-07-25 2008-04-16 Euro-Celtique S.A. TREATMENT OF SUSPENSION OF THE DEPENDENCY.
KR20090031961A (en) 2003-07-25 2009-03-30 유로-셀티큐 에스.에이. Preoperative treatment of post operative pain
AU2004266731A1 (en) 2003-08-21 2005-03-03 Transoral Pharmaceuticals, Inc. Compositions for delivering 5-HT agonists across the oral mucosa and methods of use thereof
AU2006242246A1 (en) 2005-05-03 2006-11-09 Innozen, Inc. Edible film for transmucosal delivery of nutritional supplements
AU2006326377B2 (en) 2005-12-13 2010-10-07 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
EP2452683A3 (en) 2006-06-26 2012-08-22 Amgen Inc. Methods for treating atherosclerosis
KR101230804B1 (en) 2006-07-21 2013-02-08 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 Transmucosal delivery devices with enhanced uptake
EP1897543A1 (en) 2006-08-30 2008-03-12 Euro-Celtique S.A. Buprenorphine- wafer for drug substitution therapy
HUE038022T4 (en) 2006-10-02 2023-02-28 Spepharm Ag Non-mucoadhesive film dosage forms
CA2665387A1 (en) 2006-10-03 2008-04-10 University Of Southern California Grp78 as a predictor of responsiveness to therapeutic agents
GB2447016A (en) 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Buprenorphine/naloxone compositions
WO2008115811A2 (en) 2007-03-16 2008-09-25 Endo Pharmaceuticals, Inc. Transdermal delivery form disposal systems and methods
ES2663777T3 (en) 2008-06-23 2018-04-17 Biodelivery Sciences International, Inc. Multidirectional mucosal administration devices and methods of use
DK2640389T3 (en) 2010-11-17 2015-03-09 Hexal Ag Transdermal therapeutic system comprising buprenorphine

Also Published As

Publication number Publication date
AU2004218685A1 (en) 2004-11-04
AU6184198A (en) 1998-09-09
NO329838B1 (en) 2011-01-10
BR9815439A (en) 2001-10-16
USRE41571E1 (en) 2010-08-24
DK2305194T3 (en) 2012-08-13
EP0964677A1 (en) 1999-12-22
NO2017011I1 (en) 2017-04-04
NO20151450A1 (en) 1999-10-22
US9642850B2 (en) 2017-05-09
EP2305194B1 (en) 2012-05-09
NO333139B1 (en) 2013-03-11
NO20131533L (en) 1999-10-22
ATE336212T1 (en) 2006-09-15
NO20120563L (en) 1999-10-22
US5968547A (en) 1999-10-19
CN1252705A (en) 2000-05-10
CN1827107A (en) 2006-09-06
US6231886B1 (en) 2001-05-15
KR20000075648A (en) 2000-12-26
NO20101190L (en) 1999-10-22
AU2008261134A1 (en) 2009-01-15
AU2925402A (en) 2002-05-16
HUP1200599A2 (en) 2000-12-28
SI0964677T1 (en) 2006-12-31
PL196086B1 (en) 2007-12-31
CA2276170C (en) 2007-12-04
PT964677E (en) 2006-12-29
NZ337386A (en) 2001-06-29
EP2305192A1 (en) 2011-04-06
EP1731152A2 (en) 2006-12-13
HUP0002342A3 (en) 2001-04-28
PT1731152E (en) 2013-07-31
US20010002259A1 (en) 2001-05-31
CZ2015477A3 (en) 2015-10-21
IL131561A (en) 2010-05-31
US20060216340A1 (en) 2006-09-28
EP1731152B1 (en) 2013-05-01
NO2016013I1 (en) 2016-07-18
SI1570823T1 (en) 2012-03-30
PT2305194E (en) 2012-08-14
NO994087L (en) 1999-10-22
WO1998036728A3 (en) 1998-12-10
AU2004218685B2 (en) 2009-01-22
HU230374B1 (en) 2016-03-29
US20110288112A1 (en) 2011-11-24
NO334290B1 (en) 2014-01-27
USRE41408E1 (en) 2010-06-29
NO340067B1 (en) 2017-03-06
AU774779B2 (en) 2004-07-08
KR100703101B1 (en) 2007-04-06
EP1731152A3 (en) 2007-11-14
ES2271988T3 (en) 2007-04-16
US20030091631A1 (en) 2003-05-15
US20160220559A1 (en) 2016-08-04
DK1570823T3 (en) 2012-02-20
HK1103621A1 (en) 2007-12-28
NO20111441L (en) 1999-10-22
DK0964677T3 (en) 2006-12-11
US20030198675A1 (en) 2003-10-23
NO20064395L (en) 1999-10-22
CZ299414B6 (en) 2008-07-16
HU230608B1 (en) 2017-03-28
HUP1500370D0 (en) 2000-12-28
PT1570823E (en) 2012-03-02
EP0964677A4 (en) 2002-12-18
NO994087D0 (en) 1999-08-24
ATE556682T1 (en) 2012-05-15
CN1827107B (en) 2010-05-26
DE69835584D1 (en) 2006-09-28
CZ300999A3 (en) 2000-03-15
AU2008261134B2 (en) 2012-08-02
US6344212B2 (en) 2002-02-05
EP2305193A1 (en) 2011-04-06
NO322515B1 (en) 2006-10-16
IL207067A (en) 2011-12-29
US20170056393A1 (en) 2017-03-02
DK1731152T3 (en) 2013-07-22
ES2423925T3 (en) 2013-09-25
EP2301493A1 (en) 2011-03-30
AU743071B2 (en) 2002-01-17
EP2305191A1 (en) 2011-04-06
IL201437A (en) 2010-12-30
JP2000511936A (en) 2000-09-12
EP1570823A2 (en) 2005-09-07
US20150157625A1 (en) 2015-06-11
NO332248B1 (en) 2012-08-06
ES2380023T3 (en) 2012-05-07
EP1570823B1 (en) 2011-12-28
NO20130298L (en) 1999-10-22
NO329734B1 (en) 2010-12-13
US20130197020A1 (en) 2013-08-01
ATE538765T1 (en) 2012-01-15
US20140073663A1 (en) 2014-03-13
EP2301494A1 (en) 2011-03-30
DE05011213T1 (en) 2007-09-06
EP2305194A1 (en) 2011-04-06
NO337094B1 (en) 2016-01-18
WO1998036728A2 (en) 1998-08-27
HK1096847A1 (en) 2007-06-15
PL335306A1 (en) 2000-04-10
EP1570823A3 (en) 2006-01-18
NO20074292L (en) 1999-10-22
NO333374B1 (en) 2013-05-13
SI2305194T1 (en) 2012-10-30
HUP0002342A2 (en) 2000-12-28
ES2387752T3 (en) 2012-10-01
IL131561A0 (en) 2001-01-28
USRE41489E1 (en) 2010-08-10
DE69835584T2 (en) 2007-08-16
HK1153377A1 (en) 2012-03-30
EP0964677B1 (en) 2006-08-16

Similar Documents

Publication Publication Date Title
CA2276170A1 (en) Sustained analgesia achieved with buprenorphine
PL312587A1 (en) Method of treating pain by administration of 24-hour oral opioid preparations causing a quick initial increase of a drug concentration in plasma
GB2316004B (en) Novel formulations for transdermal delivery of pergolide
HUP0300218A2 (en) Process for treatment of diabetes, employing combination of metformin and glyburide
CA2628857A1 (en) Formulation and method for treating neoplasms by inhalation
CA2183871A1 (en) Platelet growth accelerator
WO2001043749A3 (en) Pharmaceutical implant containing immediate-release and sustained-release components and method of administration
CA2264852A1 (en) Use of methylphenidate or a pharmaceutically acceptable salt thereof
CA2198916A1 (en) Delivery of solid drug compositions
AUPN603895A0 (en) Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids
HK1031197A1 (en) Osmotic dosage form comprising first and second coats
PL338982A1 (en) Drug for improving duration of muscle action or for treating muscular disorders or diseases
HK1084862A1 (en) Use of omega interferon in the manufacturing of a medicament for treating viral disease in a warm-blooded animal subject
EP1201246A3 (en) Use of Thrombopoietin as a medicament for the therapy and prevention of thrombocytopenia
MY130098A (en) Local drug delivery film for periodontal treatment
CA2139385A1 (en) Products containing g-csf and tnf binding protein
CA2108330A1 (en) Enhancer for the Antianemia Effect of Erythropoietin and Method of Augmenting the Antianemia Effect of Erythropoietin
James DOXIL approved for KS
EP0799618A3 (en) Use of alpha1-adrenoreceptor antagonists in the manufacture of a medicament for the prevention and teatment of cancer
WO2002047688A3 (en) Method and apparatus for treating breakthrough pain
EP1197227A4 (en) Method of the administration of drugs having binding affinity with plasma protein and preparation to be used in the method
Alim et al. Tolerability study of a depot form of naltrexone substance abusers
WO1996020702B1 (en) The use of 2,3-alkylcarbonyloxybenzoic acid in treating adult respiratory distress syndrome
AU1305999A (en) (+)-ephedrine as a sympathomimetic drug
Spiga et al. Effects of Pre-treatment of Diazepam on Methadone Self-Administration

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20180226