CA2283240A1 - Electrode with improved signal to noise ratio - Google Patents

Electrode with improved signal to noise ratio Download PDF

Info

Publication number
CA2283240A1
CA2283240A1 CA002283240A CA2283240A CA2283240A1 CA 2283240 A1 CA2283240 A1 CA 2283240A1 CA 002283240 A CA002283240 A CA 002283240A CA 2283240 A CA2283240 A CA 2283240A CA 2283240 A1 CA2283240 A1 CA 2283240A1
Authority
CA
Canada
Prior art keywords
working electrode
electrode
components
noise ratio
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002283240A
Other languages
French (fr)
Other versions
CA2283240C (en
Inventor
Ronald T. Kurnik
Janet Tamada
Michael J. Tierney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cygnus Inc
Original Assignee
Cygnus, Inc.
Ronald T. Kurnik
Janet Tamada
Michael J. Tierney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25240700&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2283240(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cygnus, Inc., Ronald T. Kurnik, Janet Tamada, Michael J. Tierney filed Critical Cygnus, Inc.
Publication of CA2283240A1 publication Critical patent/CA2283240A1/en
Application granted granted Critical
Publication of CA2283240C publication Critical patent/CA2283240C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose

Abstract

An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of (1) a working electrode made up of a plurality of working electrode surfaces or components, and (2) an electrically insulating gap defined by adjacent edges of (1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provided an overall enhanced signal after sensing for a given period of time.
CA002283240A 1997-03-25 1998-03-16 Electrode with improved signal to noise ratio Expired - Fee Related CA2283240C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/824,143 1997-03-25
US08/824,143 US6139718A (en) 1997-03-25 1997-03-25 Electrode with improved signal to noise ratio
PCT/US1998/005100 WO1998042252A1 (en) 1997-03-25 1998-03-16 Electrode with improved signal to noise ratio

Publications (2)

Publication Number Publication Date
CA2283240A1 true CA2283240A1 (en) 1998-10-01
CA2283240C CA2283240C (en) 2003-07-29

Family

ID=25240700

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002283240A Expired - Fee Related CA2283240C (en) 1997-03-25 1998-03-16 Electrode with improved signal to noise ratio

Country Status (8)

Country Link
US (4) US6139718A (en)
EP (1) EP1011427A1 (en)
JP (1) JP3373530B2 (en)
KR (1) KR20010005569A (en)
AU (1) AU6557598A (en)
CA (1) CA2283240C (en)
GB (1) GB2338561B (en)
WO (1) WO1998042252A1 (en)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US8280682B2 (en) 2000-12-15 2012-10-02 Tvipr, Llc Device for monitoring movement of shipped goods
US20040062759A1 (en) * 1995-07-12 2004-04-01 Cygnus, Inc. Hydrogel formulations for use in electroosmotic extraction and detection of glucose
US6139718A (en) * 1997-03-25 2000-10-31 Cygnus, Inc. Electrode with improved signal to noise ratio
US6587705B1 (en) 1998-03-13 2003-07-01 Lynn Kim Biosensor, iontophoretic sampling system, and methods of use thereof
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
PT1053043E (en) 1998-05-13 2002-11-29 Cygnus Therapeutic Systems COLLECTION ASSEMBLIES FOR TRANSDERMIC SAMPLING SYSTEMS
US6602678B2 (en) * 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
US6180416B1 (en) 1998-09-30 2001-01-30 Cygnus, Inc. Method and device for predicting physiological values
PT1102559E (en) 1998-09-30 2003-10-31 Cygnus Therapeutic Systems METHOD AND DEVICE FOR PREPARING PHYSIOLOGICAL VALUES
DE69904956T2 (en) 1998-10-28 2003-11-13 Cygnus Therapeutic Systems TEST SET AND METHOD FOR QUALITY TESTING OF AN IONTOPHORETIC SAMPLING SYSTEM
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
JP2002536103A (en) 1999-02-12 2002-10-29 シグナス, インコーポレイテッド Devices and methods for frequent measurement of analytes present in biological systems
US6360888B1 (en) * 1999-02-25 2002-03-26 Minimed Inc. Glucose sensor package system
CA2369336A1 (en) * 1999-04-22 2000-11-02 Cygnus, Inc. Hydrogel in an iontophoretic device to measure glucose
DE60133653T2 (en) * 2000-08-18 2009-06-04 Animas Technologies Llc APPARATUS FOR PREDICTING HYPOGLYECURE DROPS
US6633772B2 (en) * 2000-08-18 2003-10-14 Cygnus, Inc. Formulation and manipulation of databases of analyte and associated values
US20020026111A1 (en) * 2000-08-28 2002-02-28 Neil Ackerman Methods of monitoring glucose levels in a subject and uses thereof
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
WO2002078512A2 (en) 2001-04-02 2002-10-10 Therasense, Inc. Blood glucose tracking apparatus and methods
US6837988B2 (en) * 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
US6501976B1 (en) * 2001-06-12 2002-12-31 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US6576416B2 (en) * 2001-06-19 2003-06-10 Lifescan, Inc. Analyte measurement device and method of use
US7011630B2 (en) * 2001-06-22 2006-03-14 Animas Technologies, Llc Methods for computing rolling analyte measurement values, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US8364229B2 (en) * 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
CA2738579C (en) 2002-03-22 2016-11-01 Animas Technologies Llc Improving performance of an analyte monitoring device
US6801804B2 (en) 2002-05-03 2004-10-05 Aciont, Inc. Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis
US7150975B2 (en) * 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
US7587287B2 (en) 2003-04-04 2009-09-08 Abbott Diabetes Care Inc. Method and system for transferring analyte test data
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7655119B2 (en) * 2003-10-31 2010-02-02 Lifescan Scotland Limited Meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials
CA2543957C (en) * 2003-10-31 2013-01-22 Lifescan Scotland Limited Method of reducing the effect of direct interference current in an electrochemical test strip
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
EP1718198A4 (en) 2004-02-17 2008-06-04 Therasense Inc Method and system for providing data communication in continuous glucose monitoring and management system
US7654956B2 (en) 2004-07-13 2010-02-02 Dexcom, Inc. Transcutaneous analyte sensor
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
EP1869414A4 (en) 2005-03-29 2010-07-28 Arkal Medical Inc Devices, systems, methods and tools for continuous glucose monitoring
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
KR100692783B1 (en) * 2005-07-19 2007-03-12 케이엠에이치 주식회사 Patch for extracting glucose
US20090054747A1 (en) * 2005-10-31 2009-02-26 Abbott Diabetes Care, Inc. Method and system for providing analyte sensor tester isolation
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
KR100777776B1 (en) * 2006-03-22 2007-11-21 주식회사 올메디쿠스 Working electrode structure of biosensor for reducing measurement error
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US7920907B2 (en) 2006-06-07 2011-04-05 Abbott Diabetes Care Inc. Analyte monitoring system and method
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US20080107923A1 (en) * 2006-11-08 2008-05-08 Wallace David P Electrode arrangement for gas sensors
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
JP5508861B2 (en) 2007-03-07 2014-06-04 エコー セラピューティクス, インコーポレイテッド Transcutaneous analyte monitoring system
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
EP2152358B1 (en) 2007-04-27 2011-03-02 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
US20080281179A1 (en) * 2007-05-08 2008-11-13 Abbott Diabetes Care, Inc. Analyte monitoring system and methods
US20080281171A1 (en) * 2007-05-08 2008-11-13 Abbott Diabetes Care, Inc. Analyte monitoring system and methods
US20080278332A1 (en) * 2007-05-08 2008-11-13 Abbott Diabetes Care, Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US20200037874A1 (en) * 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US9360398B2 (en) 2007-09-11 2016-06-07 University Of Florida Research Foundation, Inc. Devices and methods for the collection and detection of substances
US8414846B2 (en) 2007-09-11 2013-04-09 University Of Florida Research Foundation, Inc. Devices and methods for the collection and detection of substances
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US8900431B2 (en) 2008-08-27 2014-12-02 Edwards Lifesciences Corporation Analyte sensor
EP2163190A1 (en) * 2008-09-11 2010-03-17 Roche Diagnostics GmbH Electrode system for measurement of an analyte concentration in-vivo
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
WO2010127050A1 (en) 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
US8993331B2 (en) 2009-08-31 2015-03-31 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
US9314195B2 (en) 2009-08-31 2016-04-19 Abbott Diabetes Care Inc. Analyte signal processing device and methods
EP2482720A4 (en) 2009-09-29 2014-04-23 Abbott Diabetes Care Inc Method and apparatus for providing notification function in analyte monitoring systems
US20110186428A1 (en) * 2010-01-29 2011-08-04 Roche Diagnostics Operations, Inc. Electrode arrangements for biosensors
US9084570B2 (en) 2010-10-08 2015-07-21 Roche Diagnostics Operations, Inc. Electrochemical sensor having symmetrically distributed analyte sensitive areas
EP3954781B1 (en) 2010-12-09 2024-02-21 Abbott Diabetes Care, Inc. Analyte sensors with a sensing surface having small sensing spots
US9008744B2 (en) 2011-05-06 2015-04-14 Medtronic Minimed, Inc. Method and apparatus for continuous analyte monitoring
EP2775918B1 (en) 2011-11-07 2020-02-12 Abbott Diabetes Care Inc. Analyte monitoring device and methods
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US10041901B2 (en) 2013-03-15 2018-08-07 Roche Diabetes Care, Inc. Electrode configuration for a biosensor
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
EP3363910B1 (en) 2017-02-17 2023-12-06 Roche Diabetes Care GmbH Continuous analyte monitoring electrode with crosslinked enzyme
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
KR20230043779A (en) 2020-07-29 2023-03-31 바이오링크 인코포레이티드 Continuous Analyte Monitoring System with Microneedle Array
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
CA3184224A1 (en) 2021-05-08 2022-11-17 Joshua Ray Windmiller Fault detection for microneedle array based continuous analyte monitoring device
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954925A (en) * 1972-12-20 1976-05-04 Gesellschaft Fur Kernenergieverwertung In Schiffbau U. Schiffahrt Mbh Method of making semi-permeable asymmetric membranes for reverse osmosis
US3979274A (en) * 1975-09-24 1976-09-07 The Yellow Springs Instrument Company, Inc. Membrane for enzyme electrodes
NL7801867A (en) 1978-02-20 1979-08-22 Philips Nv DEVICE FOR THE TRANSCUTANEOUS MEASUREMENT OF THE PARTIAL OXYGEN PRESSURE IN BLOOD.
US4241150A (en) 1979-07-30 1980-12-23 Energy Development Associates, Inc. Method for control of edge effects of oxidant electrode
US4288507A (en) 1979-07-30 1981-09-08 Energy Development Associates, Inc. Control of edge effects of oxidant electrode
JPS5627643A (en) * 1979-08-14 1981-03-18 Toshiba Corp Electrochemical measuring device
US4633879A (en) 1979-11-16 1987-01-06 Lec Tec Corporation Electrode with disposable interface member
US4416274A (en) 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
US4477971A (en) 1981-11-06 1984-10-23 Motion Control, Inc. Iontophoretic electrode structure
US4457748A (en) 1982-01-11 1984-07-03 Medtronic, Inc. Non-invasive diagnosis method
FR2522823A1 (en) 1982-03-04 1983-09-09 Oreal CELL FOR MEASURING THE DIELECTRIC CONSTANT OF VISCOUS OR PASTY SUBSTANCES
US4571292A (en) * 1982-08-12 1986-02-18 Case Western Reserve University Apparatus for electrochemical measurements
US4655880A (en) * 1983-08-01 1987-04-07 Case Western Reserve University Apparatus and method for sensing species, substances and substrates using oxidase
US4702732A (en) 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
US4781798A (en) 1985-04-19 1988-11-01 The Regents Of The University Of California Transparent multi-oxygen sensor array and method of using same
JPS62133937A (en) * 1985-12-04 1987-06-17 株式会社日立製作所 Percataneous sensor
US4722726A (en) 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US4752285B1 (en) 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
US4722761A (en) 1986-03-28 1988-02-02 Baxter Travenol Laboratories, Inc. Method of making a medical electrode
IE60941B1 (en) 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US5250022A (en) 1990-09-25 1993-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
US4731049A (en) 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
JPH07122624B2 (en) 1987-07-06 1995-12-25 ダイキン工業株式会社 Biosensor
US4821733A (en) 1987-08-18 1989-04-18 Dermal Systems International Transdermal detection system
DE3737059A1 (en) 1987-10-29 1989-05-11 Siemens Ag Measurement converter with a capacitative sensor
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
KR970011449B1 (en) * 1988-01-29 1997-07-11 더 리전트 오브 디 유니버시티 오브 캘리포니아 Device for iontophoretic non-invasive sampling or delivery of substances
US5766934A (en) * 1989-03-13 1998-06-16 Guiseppi-Elie; Anthony Chemical and biological sensors having electroactive polymer thin films attached to microfabricated devices and possessing immobilized indicator moieties
AT403528B (en) 1989-04-04 1998-03-25 Urban Gerald MICRO-MULTI-ELECTRODE STRUCTURE FOR ELECTROCHEMICAL APPLICATIONS AND METHOD FOR THEIR PRODUCTION
US4968297A (en) 1989-05-09 1990-11-06 Iomec, Inc. Iontophoretic electrode with solution containment system
US5140985A (en) * 1989-12-11 1992-08-25 Schroeder Jon M Noninvasive blood glucose measuring device
US5036861A (en) 1990-01-11 1991-08-06 Sembrowich Walter L Method and apparatus for non-invasively monitoring plasma glucose levels
DE69115471T2 (en) 1990-03-30 1996-05-02 Alza Corp DEVICE FOR IONTOPHORETIC ADMINISTRATION OF MEDICINES
US5125894A (en) 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US5161532A (en) * 1990-04-19 1992-11-10 Teknekron Sensor Development Corporation Integral interstitial fluid sensor
GB9211402D0 (en) 1992-05-29 1992-07-15 Univ Manchester Sensor devices
EP0708615A4 (en) 1993-07-16 1996-10-16 Cygnus Therapeutic Systems Noninvasive glucose monitor
DE4427363A1 (en) * 1993-08-03 1995-03-09 A & D Co Ltd A disposable chemical sensor
US5771890A (en) * 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
WO1996000110A1 (en) * 1994-06-24 1996-01-04 Cygnus, Inc. Iontophoretic sampling device and method
GB2291840A (en) * 1994-07-29 1996-02-07 Torrington Co Vehicle steering column reach adjustment and energy absorbing mechanism
EP0840597B1 (en) * 1995-07-12 2003-10-01 Cygnus, Inc. Hydrogel patch
US5735273A (en) * 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
JP3316820B2 (en) * 1995-12-28 2002-08-19 シィグナス インコーポレィティド Apparatus and method for continuous monitoring of a physiological analyte of a subject
AU3373297A (en) 1996-06-17 1998-01-07 Mercury Diagnostics Inc. Electrochemical test device and related methods
US6139718A (en) * 1997-03-25 2000-10-31 Cygnus, Inc. Electrode with improved signal to noise ratio

Also Published As

Publication number Publication date
GB9922725D0 (en) 1999-11-24
JP3373530B2 (en) 2003-02-04
US6139718A (en) 2000-10-31
GB2338561A (en) 1999-12-22
USRE38775E1 (en) 2005-08-16
GB2338561B (en) 2001-08-08
CA2283240C (en) 2003-07-29
KR20010005569A (en) 2001-01-15
JP2000510373A (en) 2000-08-15
AU6557598A (en) 1998-10-20
US6284126B1 (en) 2001-09-04
WO1998042252A1 (en) 1998-10-01
USRE38681E1 (en) 2005-01-04
EP1011427A1 (en) 2000-06-28

Similar Documents

Publication Publication Date Title
CA2283240A1 (en) Electrode with improved signal to noise ratio
CA2284468A1 (en) Anti-inflammatory compounds
AU7269498A (en) Membrane electrode assembly
DE3584605D1 (en) ENZYME ELECTRODES.
NO167156C (en) ENZYMATIC DETERGENT MIXTURE.
NO880329D0 (en) ENZYME ELECTRODE.
PT1097032E (en) PREFABRICATED MEMBER OF LAMINATED WOOD
DE69019905T2 (en) Multipole electrical connector assembly.
AU3927493A (en) Improved enzyme electrodes
ES2022884B3 (en) COMPOSITE CHAMBER.
DE3584548D1 (en) HIGH FREQUENCY CONNECTORS.
FR2709884B1 (en) Improvements to electrical connector housings.
NO862162L (en) METALLIC VEGETABLE CONNECTOR.
DE68922501D1 (en) Enzyme electrode.
CA2150100A1 (en) Electrical connection for track lighting
FR2746972B1 (en) ASSEMBLY OF MODULAR CONNECTORS
NL193664B (en) Electrode boat assembly.
DE69023430T2 (en) Enzyme electrode.
DE3673986D1 (en) MULTIPOLE CONNECTOR.
FR2700642B1 (en) ELECTRICAL CONNECTOR.
AU1902099A (en) Improved hspes membrane electrode assembly
IT8521799A0 (en) SOUND INSULATION SCREEN.
DE3873749T2 (en) MULTIPOLE CONNECTOR.
FR2723802B1 (en) ELECTRICAL CONNECTOR STRUCTURE.
IT8320405V0 (en) ELECTRICAL PANEL STRUCTURE.

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed