CA2284098A1 - Osteogenic devices and methods of use thereof for repair of bone - Google Patents

Osteogenic devices and methods of use thereof for repair of bone Download PDF

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Publication number
CA2284098A1
CA2284098A1 CA002284098A CA2284098A CA2284098A1 CA 2284098 A1 CA2284098 A1 CA 2284098A1 CA 002284098 A CA002284098 A CA 002284098A CA 2284098 A CA2284098 A CA 2284098A CA 2284098 A1 CA2284098 A1 CA 2284098A1
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CA
Canada
Prior art keywords
defects
repair
methods
devices
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002284098A
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French (fr)
Other versions
CA2284098C (en
Inventor
David C. Rueger
Marjorie M. Tucker
An-Cheng Chang
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MARIEL THERAPEUTICS Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2284098A1 publication Critical patent/CA2284098A1/en
Application granted granted Critical
Publication of CA2284098C publication Critical patent/CA2284098C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]

Abstract

Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dissecans.
CA002284098A 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone Expired - Fee Related CA2284098C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/822,186 1997-03-20
US08/822,186 US7041641B2 (en) 1997-03-20 1997-03-20 Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
PCT/US1998/006043 WO1998041246A2 (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone

Publications (2)

Publication Number Publication Date
CA2284098A1 true CA2284098A1 (en) 1998-09-24
CA2284098C CA2284098C (en) 2009-02-10

Family

ID=25235396

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002284098A Expired - Fee Related CA2284098C (en) 1997-03-20 1998-03-20 Osteogenic devices and methods of use thereof for repair of bone

Country Status (11)

Country Link
US (3) US7041641B2 (en)
EP (3) EP1719531A3 (en)
JP (4) JP4477702B2 (en)
AT (1) ATE338569T1 (en)
AU (1) AU751451B2 (en)
CA (1) CA2284098C (en)
DE (1) DE69835810T2 (en)
DK (1) DK0968012T3 (en)
ES (1) ES2273412T3 (en)
PT (1) PT968012E (en)
WO (1) WO1998041246A2 (en)

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CA2284098C (en) 2009-02-10
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DK0968012T3 (en) 2006-12-27
JP2001516262A (en) 2001-09-25

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