CA2285048A1 - Analytical device for membrane-based assays - Google Patents

Analytical device for membrane-based assays Download PDF

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Publication number
CA2285048A1
CA2285048A1 CA002285048A CA2285048A CA2285048A1 CA 2285048 A1 CA2285048 A1 CA 2285048A1 CA 002285048 A CA002285048 A CA 002285048A CA 2285048 A CA2285048 A CA 2285048A CA 2285048 A1 CA2285048 A1 CA 2285048A1
Authority
CA
Canada
Prior art keywords
liquid
reaction membrane
support layer
top support
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002285048A
Other languages
French (fr)
Other versions
CA2285048C (en
Inventor
Albert E. Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
E-Y Laboratories Inc
Original Assignee
Albert E. Chu
E-Y Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert E. Chu, E-Y Laboratories, Inc. filed Critical Albert E. Chu
Publication of CA2285048A1 publication Critical patent/CA2285048A1/en
Application granted granted Critical
Publication of CA2285048C publication Critical patent/CA2285048C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements

Abstract

Methods of making analytical assay devices and methods of using the devices in analytical assays, such as immunoassays, are described. The analytical assay device comprises a liquid-impervious top support layer (10) that defines a rim (12) around an open port (11), and a porous reaction membrane (13) that is proximal to the top support layer (10), such that a portion of the upper surface (14) of the reaction membrane (13) and rim (12) define a sample receiving well (11). The upper surface (14) of the reaction membrane (13) is sealed to the lower surface of the top support layer (10) by a water-insoluble adhesive (19), which forms a liquid-impervious seal therebetween.
An absorbent body (15) is proximal to and in liquid communication with the lower surface of the reaction membrane (13). The analytical assay device is used for the detection of a bindable target substance in a liquid sample potentially containing the target substance.
CA002285048A 1997-03-25 1998-03-18 Analytical device for membrane-based assays Expired - Fee Related CA2285048C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/823,936 1997-03-25
US08/823,936 US5885526A (en) 1997-03-25 1997-03-25 Analytical device for membrane-based assays
PCT/US1998/005373 WO1998043083A1 (en) 1997-03-25 1998-03-18 Analytical device for membrane-based assays

Publications (2)

Publication Number Publication Date
CA2285048A1 true CA2285048A1 (en) 1998-10-01
CA2285048C CA2285048C (en) 2008-11-18

Family

ID=25240175

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002285048A Expired - Fee Related CA2285048C (en) 1997-03-25 1998-03-18 Analytical device for membrane-based assays

Country Status (10)

Country Link
US (1) US5885526A (en)
EP (1) EP0988546B1 (en)
JP (1) JP4040110B2 (en)
CN (1) CN1125983C (en)
AT (1) ATE356354T1 (en)
CA (1) CA2285048C (en)
DE (1) DE69837257T2 (en)
ES (1) ES2283050T3 (en)
HK (1) HK1024743A1 (en)
WO (1) WO1998043083A1 (en)

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US7531362B2 (en) 2001-06-07 2009-05-12 Medmira Inc. Rapid diagnostic assay

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US6214629B1 (en) * 1998-08-06 2001-04-10 Spectral Diagnostics, Inc. Analytical test device and method for use in medical diagnoses
US6171870B1 (en) * 1998-08-06 2001-01-09 Spectral Diagnostics, Inc. Analytical test device and method for use in medical diagnoses
US6410341B1 (en) * 1998-08-06 2002-06-25 Spectral Diagnostics, Inc. Analytical test device and method for use in medical diagnoses
US6281004B1 (en) * 1999-04-14 2001-08-28 Cytologix Corporation Quality control for cytochemical assays
US7011940B1 (en) * 1999-04-14 2006-03-14 Medical Discovery Partners Llc Quality control for cytochemical assays
FR2792724B1 (en) * 1999-04-26 2001-05-25 Biomerieux Sa DEVICE FOR COLLECTING AND PRESERVING A BIOLOGICAL SAMPLE AND ITS IMPLEMENTING METHOD
JP2001083162A (en) * 1999-09-17 2001-03-30 Fuji Photo Film Co Ltd Filmy biopolymer absorbent and absorbing kit
US6632681B1 (en) 2000-07-24 2003-10-14 Ey Laboratories Reagent delivery device and method of use
US20030104492A1 (en) * 2000-12-15 2003-06-05 Albert Chu Flow-through membrane assays for carbohydrates using labeled lectins
US20040241876A1 (en) * 2000-12-22 2004-12-02 France Fannes Flow through assay device, diagnostic kit comprising said assay device and use of said assay device in the detection of an analyte present in a sample
US7087389B2 (en) 2001-02-09 2006-08-08 Council Of Scientific & Industrial Research Highly cost-effective analytical device for performing immunoassays with ultra high sensitivity
WO2003016902A1 (en) * 2001-08-20 2003-02-27 Proteome Systems Intellectual Property Pty Ltd Diagnostic testing process and apparatus
EP1419387B1 (en) * 2001-08-20 2012-01-04 Proteome Systems Ltd. Diagnostic testing process
CA2469935C (en) * 2001-12-12 2014-02-11 Proteome Systems Intellectual Property Pty Ltd. Diagnostic testing process
WO2003098215A1 (en) * 2002-05-16 2003-11-27 Medmira Inc. Rapid vaccinia antibody detection device, method and test kit
WO2004038414A1 (en) * 2002-10-24 2004-05-06 Spectral Diagnostics Inc. Diagnostic device
US7256053B2 (en) * 2002-10-24 2007-08-14 Nanogen, Inc. Diagnostic device for analyte detection
US7488450B2 (en) * 2004-03-04 2009-02-10 Beckman Coulter, Inc. Analyte collection and detection devices
FR2872288B1 (en) * 2004-06-28 2007-08-03 Biomerieux Sa INTEGRATED ANALYSIS DEVICE ADAPTABLE ON A CONTAINER OF A SAMPLE TO BE ANALYZED
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
EP3028765B1 (en) * 2005-01-31 2020-01-08 Realbio Technologies Ltd. Method of sequentially transferring liquids through a lateral flow capillary device
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US20070141723A1 (en) * 2005-12-16 2007-06-21 Sompuram Seshi A Immunohistochemistry staining controls
JP4860489B2 (en) * 2007-01-09 2012-01-25 浜松ホトニクス株式会社 Method for measuring immunochromatographic test strip
US7816090B2 (en) * 2007-01-10 2010-10-19 Ortho-Clinical Diagnostics, Inc. Multiple immunochemistry assays on an element
EP2012126A1 (en) * 2007-07-04 2009-01-07 Koninklijke Philips Electronics N.V. Porous biological assay substrate and method for producing such substrate
CN101603967B (en) * 2008-06-10 2015-02-18 英科新创(厦门)科技有限公司 Method for fast testing human ABO/Rh/MN blood type and kit
US9952211B2 (en) 2008-06-29 2018-04-24 Realbio Technologies Ltd. Liquid-transfer device particularly useful as a capturing device in a biological assay process
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
CN105833925B (en) 2011-12-22 2018-11-13 瑞尔比奥技术有限公司 sequential lateral flow capillary device for analyte determination
CN111077309B (en) 2014-04-02 2023-11-17 生化诊断系统公司 Immunoassay with capture conjugate
US9568404B2 (en) 2014-05-16 2017-02-14 Junyu Mai Method and apparatus for biomolecule analysis
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
US10969388B2 (en) * 2016-03-07 2021-04-06 Nanodx Healthcare Pvt. Ltd. Assay and kit for detection of endotoxin
EP4023338A1 (en) * 2016-04-14 2022-07-06 Roche Diagnostics GmbH Cartridge and optical measurement of an analyte with said cartridge
WO2018128585A1 (en) * 2017-01-04 2018-07-12 Agency For Science, Technology And Research Sieve-through vertical flow system for particle-based bioassays
CN111572053B (en) * 2020-05-29 2021-12-14 常州达姆斯检测技术有限公司 Processing method of composite material test sample strip

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US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4965187A (en) * 1986-09-10 1990-10-23 Idexx Corporation Method and apparatus for assaying whole blood
US5169789A (en) * 1986-12-03 1992-12-08 New Horizons Diagnostics Corporation Device and method for self contained solid phase immunodiffusion assay
EP0301141A1 (en) * 1987-07-30 1989-02-01 Microbiological Research Corporation Solid phase enzyme immunoassay test apparatus and process for detecting antibodies
US5006464A (en) * 1987-10-01 1991-04-09 E-Y Laboratories, Inc. Directed flow diagnostic device and method
US4818677A (en) * 1987-12-03 1989-04-04 Monoclonal Antibodies, Inc. Membrane assay using focused sample application
CA2017329A1 (en) * 1989-05-26 1990-11-26 Albert E. Chu Elongated membrane flow-through diagnostic device and method
US5185127A (en) * 1989-09-21 1993-02-09 Becton, Dickinson And Company Test device including flow control means
US5166051A (en) * 1990-08-08 1992-11-24 Genesis Labs, Inc. Membranes, membrane overlays for exclusion of erythrocytes, and method for immunoassay of whole blood analytes
US5296192A (en) * 1992-04-03 1994-03-22 Home Diagnostics, Inc. Diagnostic test strip
US5354692A (en) * 1992-09-08 1994-10-11 Pacific Biotech, Inc. Analyte detection device including a hydrophobic barrier for improved fluid flow
US5500375A (en) * 1993-04-13 1996-03-19 Serex, Inc. Integrated packaging-holder device for immunochromatographic assays in flow-through or dipstick formats

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7531362B2 (en) 2001-06-07 2009-05-12 Medmira Inc. Rapid diagnostic assay
US8025850B2 (en) 2001-06-07 2011-09-27 Medmira Inc. Rapid diagnostic device, assay and multifunctional buffer
US8287817B2 (en) 2001-06-07 2012-10-16 Medmira, Inc. Rapid diagnostic device, assay and multifunctional buffer
US9164087B2 (en) 2001-06-07 2015-10-20 Medmira Inc. Rapid diagnostic device, assay and multifunctional buffer

Also Published As

Publication number Publication date
CN1125983C (en) 2003-10-29
JP4040110B2 (en) 2008-01-30
DE69837257D1 (en) 2007-04-19
CN1256754A (en) 2000-06-14
EP0988546A4 (en) 2004-04-28
JP2001525063A (en) 2001-12-04
WO1998043083A1 (en) 1998-10-01
EP0988546A1 (en) 2000-03-29
ES2283050T3 (en) 2007-10-16
CA2285048C (en) 2008-11-18
DE69837257T2 (en) 2007-11-08
EP0988546B1 (en) 2007-03-07
US5885526A (en) 1999-03-23
HK1024743A1 (en) 2000-10-20
ATE356354T1 (en) 2007-03-15

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Effective date: 20170320