CA2285417A1 - Process for synthesizing phosphodiesters - Google Patents

Process for synthesizing phosphodiesters Download PDF

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Publication number
CA2285417A1
CA2285417A1 CA002285417A CA2285417A CA2285417A1 CA 2285417 A1 CA2285417 A1 CA 2285417A1 CA 002285417 A CA002285417 A CA 002285417A CA 2285417 A CA2285417 A CA 2285417A CA 2285417 A1 CA2285417 A1 CA 2285417A1
Authority
CA
Canada
Prior art keywords
phosphodiesters
synthesizing
compounds
formation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002285417A
Other languages
French (fr)
Other versions
CA2285417C (en
Inventor
John C. Amedio
Paul J. Bernard
Mark Fountain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
Epix Medical, Inc.
John C. Amedio
Paul J. Bernard
Mark Fountain
Epix Pharmaceuticals, Inc.
Lantheus Medical Imaging, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Medical, Inc., John C. Amedio, Paul J. Bernard, Mark Fountain, Epix Pharmaceuticals, Inc., Lantheus Medical Imaging, Inc. filed Critical Epix Medical, Inc.
Publication of CA2285417A1 publication Critical patent/CA2285417A1/en
Application granted granted Critical
Publication of CA2285417C publication Critical patent/CA2285417C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Abstract

An improved process for the production of phosphodiester compounds having formula (1). These compounds are particularly useful as contrast agents for diagnostic imaging. The process avoids the need for multiple isolation and purification steps otherwise reduced due to the formation of multiple intermediates.
CA002285417A 1997-04-11 1998-01-27 Process for synthesizing phosphodiesters Expired - Lifetime CA2285417C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/833,745 1997-04-11
US08/833,745 US5919967A (en) 1997-04-11 1997-04-11 Process for synthesizing phosphodiesters
PCT/US1998/001473 WO1998046612A1 (en) 1997-04-11 1998-01-27 Process for synthesizing phosphodiesters

Publications (2)

Publication Number Publication Date
CA2285417A1 true CA2285417A1 (en) 1998-10-22
CA2285417C CA2285417C (en) 2006-01-24

Family

ID=25265165

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002285417A Expired - Lifetime CA2285417C (en) 1997-04-11 1998-01-27 Process for synthesizing phosphodiesters

Country Status (21)

Country Link
US (1) US5919967A (en)
EP (1) EP1021452B1 (en)
JP (2) JP4014231B2 (en)
KR (2) KR20060066122A (en)
AT (1) ATE236171T1 (en)
AU (1) AU728902B2 (en)
BR (1) BR9809084B1 (en)
CA (1) CA2285417C (en)
CZ (1) CZ294469B6 (en)
DE (1) DE69812983T2 (en)
DK (1) DK1021452T3 (en)
ES (1) ES2195315T3 (en)
HU (1) HU224257B1 (en)
IL (1) IL131964A (en)
IS (1) IS1994B (en)
NO (1) NO325619B1 (en)
NZ (1) NZ337921A (en)
PL (1) PL188258B1 (en)
PT (1) PT1021452E (en)
SK (1) SK283832B6 (en)
WO (1) WO1998046612A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL134985A0 (en) 1997-10-02 2001-05-20 Epix Medical Inc A method for contrast enhanced diagnostic imaging
US20030203879A1 (en) * 1999-09-09 2003-10-30 Schering Ag Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
DE19964224B4 (en) * 1999-09-09 2005-09-01 Schering Ag Pharmaceutical compositions containing calcium complex of [[(4R) -4- [bis [(carboxy-.kappa.O) methyl] amino-.kappa.N] -6,9-bis [(carboxy-.kappa.O) methyl] -1 - [(4,4-diphenylcyclohexyl) oxy] -1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-acid-.kappa.N6, .kappa.N9, .kappa.011] 1-oxidato (6 -)], tetrahydrogen (MS-325) and its salts, and process for their preparation
US6559330B1 (en) * 1999-09-09 2003-05-06 Schering Aktiengesellschaft Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
WO2003029257A1 (en) * 2001-09-27 2003-04-10 Schering Aktiengesellschaft (ethylene)-(propene/butene)-phosphodiester triamine pentaacetic acid derivatives
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
JP2006514915A (en) 2002-03-01 2006-05-18 ダイアックス、コープ KDR and VEGF / KDR binding peptides and their use in diagnosis and therapy
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
SI2949658T1 (en) 2003-03-03 2018-10-30 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
KR100585219B1 (en) * 2004-05-07 2006-06-01 주식회사 태평양 Derivatives of Phosphate and the method for the preparation thereof
CN100487093C (en) * 2006-03-15 2009-05-13 中国石油化工股份有限公司 Phosphamide ester extreme pressure anti-wear additives and preparation and application thereof
CN102356087A (en) 2009-03-19 2012-02-15 惠氏有限责任公司 Methods for preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid and precursors thereof
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
TW201514188A (en) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc Process for manufacture of gadofosveset trisodium monohydrate
US20150344523A1 (en) 2014-05-05 2015-12-03 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
US10471162B2 (en) 2014-06-20 2019-11-12 The General Hospital Corporation Collagen targeted imaging probes
CN107624115B (en) 2015-03-16 2021-10-26 加州理工学院 Botulinum neurotoxin specific capture agents, compositions, methods of use, and methods of manufacture
EP3322716A2 (en) 2015-07-15 2018-05-23 California Institute of Technology Il-17f-specific capture agents, compositions, and methods of using and making
US11884707B2 (en) 2016-09-29 2024-01-30 Regeneron Pharmaceuticals, Inc. Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same
US11358982B2 (en) 2016-11-01 2022-06-14 Ohio State Innovation Foundation Methods for the iodination of biomolecules
EP3638687A1 (en) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f and il-17a-specific capture agents, compositions, and methods of using and making
US11919972B2 (en) 2018-11-02 2024-03-05 Regeneron Pharmaceuticals, Inc. Peptide libraries with non-canonical amino acids
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
WO2022185843A1 (en) * 2021-03-03 2022-09-09 国立大学法人東京工業大学 Method for producing asymmetric phosphoric acid triester, method for producing symmetric phosphoric acid triester, method for producing phosphoric acid ester, and method for producing organophosphorus compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
TW319763B (en) * 1995-02-01 1997-11-11 Epix Medical Inc
WO1996027379A1 (en) * 1995-03-08 1996-09-12 The Scripps Research Institute Carbopeptoids and carbonucleotoids

Also Published As

Publication number Publication date
BR9809084A (en) 2000-08-01
WO1998046612A1 (en) 1998-10-22
PL188258B1 (en) 2005-01-31
JP4014231B2 (en) 2007-11-28
NO994919D0 (en) 1999-10-08
IS5193A (en) 1999-09-24
HUP0004239A2 (en) 2001-03-28
HUP0004239A3 (en) 2001-11-28
EP1021452B1 (en) 2003-04-02
PL337423A1 (en) 2000-08-14
ES2195315T3 (en) 2003-12-01
DE69812983D1 (en) 2003-05-08
IL131964A (en) 2004-01-04
EP1021452A1 (en) 2000-07-26
AU6042598A (en) 1998-11-11
IL131964A0 (en) 2001-03-19
SK283832B6 (en) 2004-02-03
BR9809084B1 (en) 2010-12-14
JP2002511060A (en) 2002-04-09
CZ355999A3 (en) 2000-01-12
KR20010006177A (en) 2001-01-26
KR100593650B1 (en) 2006-07-03
NZ337921A (en) 2000-09-29
DE69812983T2 (en) 2004-01-08
DK1021452T3 (en) 2003-08-18
US5919967A (en) 1999-07-06
PT1021452E (en) 2003-08-29
KR20060066122A (en) 2006-06-15
HU224257B1 (en) 2005-07-28
IS1994B (en) 2005-03-15
CZ294469B6 (en) 2005-01-12
ATE236171T1 (en) 2003-04-15
AU728902B2 (en) 2001-01-18
JP2005206605A (en) 2005-08-04
NO994919L (en) 1999-10-08
SK138299A3 (en) 2000-05-16
CA2285417C (en) 2006-01-24
NO325619B1 (en) 2008-06-30

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Effective date: 20180129