CA2289462A1 - Intrauterine chemical necrosing method, composition, and apparatus - Google Patents

Intrauterine chemical necrosing method, composition, and apparatus Download PDF

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Publication number
CA2289462A1
CA2289462A1 CA002289462A CA2289462A CA2289462A1 CA 2289462 A1 CA2289462 A1 CA 2289462A1 CA 002289462 A CA002289462 A CA 002289462A CA 2289462 A CA2289462 A CA 2289462A CA 2289462 A1 CA2289462 A1 CA 2289462A1
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CA
Canada
Prior art keywords
composition
tissue
caustic
necrosing
intrauterine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
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CA002289462A
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French (fr)
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CA2289462C (en
Inventor
Robert S. Neuwirth
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Individual
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Publication of CA2289462A1 publication Critical patent/CA2289462A1/en
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Publication of CA2289462C publication Critical patent/CA2289462C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

A method and composition for effecting chemical necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by delivering a caustic tissue necrosing composition, e.g., a silver nitrate and dextran paste, to the tissue to be necrosed and allowing the paste to remain in contact with the target tissue for a period of time sufficient to chemically necrose substantially the entirety of the tissue lining, and then contacting the caustic composition with a deactivating agent, e.g., an aqueous sodium chloride solution, thereby rendering the caustic composition non-caustic, and then rinsing the cavity.
Compositions and methods for delivering medicaments are also disclosed.
CA002289462A 1997-05-12 1998-05-11 Intrauterine chemical necrosing method, composition, and apparatus Expired - Fee Related CA2289462C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/854,604 1997-05-12
US08/854,604 US5891457A (en) 1997-05-12 1997-05-12 Intrauterine chemical necrosing method, composition, and apparatus
PCT/US1998/009560 WO1998051244A1 (en) 1997-05-12 1998-05-11 Intrauterine chemical necrosing method, composition, and apparatus

Publications (2)

Publication Number Publication Date
CA2289462A1 true CA2289462A1 (en) 1998-11-19
CA2289462C CA2289462C (en) 2007-12-11

Family

ID=25319139

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002289462A Expired - Fee Related CA2289462C (en) 1997-05-12 1998-05-11 Intrauterine chemical necrosing method, composition, and apparatus

Country Status (12)

Country Link
US (2) US5891457A (en)
EP (1) EP1006964B1 (en)
JP (1) JP2002500644A (en)
AT (1) ATE292440T1 (en)
AU (1) AU746426B2 (en)
CA (1) CA2289462C (en)
DE (1) DE69829672T2 (en)
ES (1) ES2239390T3 (en)
IN (1) IN191602B (en)
PT (1) PT1006964E (en)
RU (1) RU2246954C2 (en)
WO (1) WO1998051244A1 (en)

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Also Published As

Publication number Publication date
EP1006964B1 (en) 2005-04-06
EP1006964A1 (en) 2000-06-14
IN191602B (en) 2003-12-06
DE69829672T2 (en) 2005-09-29
JP2002500644A (en) 2002-01-08
WO1998051244A1 (en) 1998-11-19
US5891457A (en) 1999-04-06
ES2239390T3 (en) 2005-09-16
US6165492A (en) 2000-12-26
CA2289462C (en) 2007-12-11
DE69829672D1 (en) 2005-05-12
AU7378598A (en) 1998-12-08
RU2246954C2 (en) 2005-02-27
AU746426B2 (en) 2002-05-02
ATE292440T1 (en) 2005-04-15
EP1006964A4 (en) 2000-08-09
PT1006964E (en) 2005-08-31

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