CA2290760C - Method and apparatus for laser removal of hair - Google Patents
Method and apparatus for laser removal of hair Download PDFInfo
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- CA2290760C CA2290760C CA002290760A CA2290760A CA2290760C CA 2290760 C CA2290760 C CA 2290760C CA 002290760 A CA002290760 A CA 002290760A CA 2290760 A CA2290760 A CA 2290760A CA 2290760 C CA2290760 C CA 2290760C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
- A61B2017/00061—Light spectrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
Abstract
A method for removing hairs from living skin is provided which includes steps of measuring with a colorimeter the color of the area of the skin where the hair is to be removed to obtain a color value, employing the color value to select an optimum range of laser energy necessary to kill hair follicles in the area yet minimize inflammatory reaction, and directing the laser energy of the optimum range at the skin area.
Description
J64f31 METHOD AND APPARATUS FOR LASER REMOVAL OF HAIR
BACKGROUND OF THE INVENTION
Field of the Invention The invention concerns a method and apparatus for removing hair from living skin while minimizing irritation to the skin.
The Related Art Location, location, location. Just like in real estate, the beauty of hair is where it rises. A forest of hair on the scalp is a blessing. On the upper lip it may be less desirous, most especially less desirous for females.
Location on the legs is deemed also not attractive.
Removal of unwanted hair is commonly achieved by shaving for short term results. Mechanical epilation with wax or other devices provides a longer respite. Several disadvantages accompany these methods. Frequently they cause irritation, folliculitis and on rare occasions scarring. There are presently two FDA-approved treatments for hair removal. Electrolysis involves resistive heating around an electrode placed deeply into a hair follicle, causing complete or partial destruction. The treatment is painful, tedious and only moderately effective. About 50 to 85% of treated hairs re-grow. There are also significant risk effects here of folliculitis and infection.
J64,81 Another FDA-cleared treatment (Thermolase technique) involves exposure to a Q-switched Nd:YAG laser designed for tattoo removal, following wax epilation and topical application of a suspension of amorphous carbon particles.
This treatment is mildly painful. Despite aggressive marketing, its effectiveness appears to be minimal or nonexistent. The potential complications of this treatment are those of laser surgery in general (infection, scarring, pigmentary changes), plus the risk of inadvertent tattooing by introducing carbon into the dermis through ruptured follicles. However, these complications presumably occur at an acceptably low incidence.
A safer and more effective system has been described by Dr. Rox Anderson of the Harvard Medical School and commercialized by Palomar Corporation. The system uses a ruby laser with light delivered through a transparent actively-cool sapphire hand piece held directly in contact with the skin. The hand piece conducts heat away from the epidermis before, during and after each pulse.
Transient inflammatory reaction (erythema, edema) and pigmentary changes (hypopigmentation, hyperpigmentation) are routine and expected whenever a laser is used to injure some component of the skin. Compared with pulsed dye, Q-switched and other lasers used for cosmetic procedures, the Palomar laser produces similar skin injury followed by rapid healing requiring minimal wound care. Compared with electrolysis, in which bacteria are repeatedly introduced into follicles from the skin surface by a needle-like electrode, the Palomar system may cause less folliculitis. Nonetheless, it is very evident there is a need for much safer procedures to avoid skin damage and to also minimize the number of treatments required for effective removal.
Accordingly, it is an object of the present invention to provide a method for epilation which minimizes transient inflammatory reactions and pigmentary changes.
Another object of the present invention is to provide an epilation method based on laser energy which minimizes the number of treatments necessary to effect full epilation.
These and other objects of the present invention become more apparent from the following summary and detailed description.
SUMMARY OF THE INVENTION
A method is provided for removing hair from body skin which includes:
(i) measuring with a colorimeter color of an area of the skin where hair is to be removed to obtain a color value;
(ii) employing the color value to determine an optimum range of laser energy necessary to kill hair follicles in the area yet minimizing inflammatory reactions; and (iii) directing laser energy of the optimum range at the skin area.
A kit is also provided for removing hair from body skin which includes a laser and instructions for operating the laser to remove the hair from the body skin.
BACKGROUND OF THE INVENTION
Field of the Invention The invention concerns a method and apparatus for removing hair from living skin while minimizing irritation to the skin.
The Related Art Location, location, location. Just like in real estate, the beauty of hair is where it rises. A forest of hair on the scalp is a blessing. On the upper lip it may be less desirous, most especially less desirous for females.
Location on the legs is deemed also not attractive.
Removal of unwanted hair is commonly achieved by shaving for short term results. Mechanical epilation with wax or other devices provides a longer respite. Several disadvantages accompany these methods. Frequently they cause irritation, folliculitis and on rare occasions scarring. There are presently two FDA-approved treatments for hair removal. Electrolysis involves resistive heating around an electrode placed deeply into a hair follicle, causing complete or partial destruction. The treatment is painful, tedious and only moderately effective. About 50 to 85% of treated hairs re-grow. There are also significant risk effects here of folliculitis and infection.
J64,81 Another FDA-cleared treatment (Thermolase technique) involves exposure to a Q-switched Nd:YAG laser designed for tattoo removal, following wax epilation and topical application of a suspension of amorphous carbon particles.
This treatment is mildly painful. Despite aggressive marketing, its effectiveness appears to be minimal or nonexistent. The potential complications of this treatment are those of laser surgery in general (infection, scarring, pigmentary changes), plus the risk of inadvertent tattooing by introducing carbon into the dermis through ruptured follicles. However, these complications presumably occur at an acceptably low incidence.
A safer and more effective system has been described by Dr. Rox Anderson of the Harvard Medical School and commercialized by Palomar Corporation. The system uses a ruby laser with light delivered through a transparent actively-cool sapphire hand piece held directly in contact with the skin. The hand piece conducts heat away from the epidermis before, during and after each pulse.
Transient inflammatory reaction (erythema, edema) and pigmentary changes (hypopigmentation, hyperpigmentation) are routine and expected whenever a laser is used to injure some component of the skin. Compared with pulsed dye, Q-switched and other lasers used for cosmetic procedures, the Palomar laser produces similar skin injury followed by rapid healing requiring minimal wound care. Compared with electrolysis, in which bacteria are repeatedly introduced into follicles from the skin surface by a needle-like electrode, the Palomar system may cause less folliculitis. Nonetheless, it is very evident there is a need for much safer procedures to avoid skin damage and to also minimize the number of treatments required for effective removal.
Accordingly, it is an object of the present invention to provide a method for epilation which minimizes transient inflammatory reactions and pigmentary changes.
Another object of the present invention is to provide an epilation method based on laser energy which minimizes the number of treatments necessary to effect full epilation.
These and other objects of the present invention become more apparent from the following summary and detailed description.
SUMMARY OF THE INVENTION
A method is provided for removing hair from body skin which includes:
(i) measuring with a colorimeter color of an area of the skin where hair is to be removed to obtain a color value;
(ii) employing the color value to determine an optimum range of laser energy necessary to kill hair follicles in the area yet minimizing inflammatory reactions; and (iii) directing laser energy of the optimum range at the skin area.
A kit is also provided for removing hair from body skin which includes a laser and instructions for operating the laser to remove the hair from the body skin.
DETAILED DESCRIPTION OF THE INVENTION
Now it has been discovered that laser-based removal of hair can be rendered more effective while less irritating through guidance by skin coloration type in selecting the most efficient laser energy dosage. Colorimetry values obtained from a spectrophotometer can now guide selection of the optimal laser energy.
According to a first step of the method of this invention, skin color is analyzed by a spectrophotometer/colorimeter. These instruments usually operate with at least one visible light source such as a light emitting diode (LED), xenon-arc, tungsten/halogen or other light source in the wavelength range of 400 to 900 nm.
The visible light source may be co-housed with the sensor portion of the spectrophotometer/colorimeter. Both visible and infrared wavelength light may be utilized in connection with a sensor portion. A suitable hand-held instrument is commercially available from Minolta Camera Company Ltd., Japan (Minolta Spectrophotometer/Colorimeter CM-2002), from Colortec Associates, Accuracy Measurements Inc. and X-Rite.
Skin coloration can be expressed in values of lightness, redness and yellowness respectively denoted by L', a* and b* units.
The L*a*b* color space is related to the Individual Typology Angle, which is essentially the value of 57.3 arctangent [(L*-50) /b'J , identifying skin types. See Chardon et al., International Journal of Cosmetic Science, 13, 191-208 (1991). Type I, the very ~ightest skin color, covers an angle ranging from more than 55 to 60 ; Type II, light skin color, covers an angle ranging from more than 41 to 55 ;
Type III, in=,ermediate skin color, covers an angle ranging from more than 28 to 41 ; Type IV, tan skin color, covers an angle ranging from more than 10 to 28 ; and Type V, brown skin color, covers an angle ranging from 0 to 10 .
Individual Typology Angle correlates to a first approximation with visibly judged Skin Type and to a first approximation determines the correct laser setting.
However, visual judgement of Skin Type may also be influenced by optical contributions from hemoglobin as well as that of melanin. A second shortcoming of the currently practiced art of Skin Typing is the phenomenon called metamerism, in which two skin colors that appear the same to the human eye under one light source are seen to be different under other lighting conditions. Human skin is metameric because people of different ethnic origins can have different optical types of melanin in their skin. The colorimeter used in the present method is designed to provide L*a*b* values that are the best metameric fit (average) for fluorescent lighting, daylight and incandescent light. Since the ruby laser interacts selectively with melanin, the primary optical parameters to be chosen must be those most sensitive to skin melanin content for more accurate selections of laser dosage for epilation.
The melanin absorption of incident light has a lower amplitude for lighter skin and a greater amplitude for darker skin, respectively. In the former case the skin color spectrum is partly dominated by hemoglobin absorbance, in the latter case by melanin absorbance. For lighter skin (low melanin), the absorbance of primarily green light by hemoglobin imparts a reddish remittance to the skin. For darker skin (high melanin content), the strong absorbance of blue light imparts a green-red combination to the remittance, giving skin a brownish color. For Caucasian skin, Types I-III, a change in melanin has a greater impact on total blue remittance than on green remittance, where hemoglobin dominates. It would appear that the best indicator of differences in skin melanin content is an optical parameter that compares remittance intensities in the blue part of the spectrum (heavily reduced by melanin absorbance) against the green remittance (heavily reduced by hemoglobin absorbance). Consequently, for Skin Types I-IV, one can treat the green band remittance as a melanin-independent baseline against which differences in blue-band remittance indicate differences in skin melanin content.
The standard definition of color was set in 1931 with the definition of three types of standard remitted spectra, X,Y and Z. Approximately, X is a red remittance spectrum, Y
is a green spectrum, and Z is a blue spectrum. The psychological color perception parameters L*a*b* are actually algebraic transformations of X,Y,Z that accommodate the human mind's relative sensitivities to the X-, Y- and Z-spectra:
L= 116 (Y/Ya) 1/' - 16 a= 500 [ (X/Xa) 113 _ (y/Ya) 1/3) ]
b* 200 [ (Y/Ya) 1/3 - (Z/Za) 1/3i where Xa, Ya, and Za are maximum values of the remittance for the particular illumination intensity. Looking at these three definitions reveals that the quantity b* compares blue to green remittance, Z versus Y, which is the object of the present method.
Table I shows the range of Skin Types for sixty-seven panelists in a clinical study performed for the present invention. Data correlation between the measured angle and the Skin Type subjectively assigned in the study is weak, pointing out the inferiority of the known Skin Typing method.
TABLE I
PATIENT SKIN TYPE (ARC TAN) ((L-50) /B) ) (57.3) 1 II 33.44 2 III 36.19 3 III 44.41 4 II 52.12 5 I 41.92 6 II 32.35 7 iII 45.00 8 II 54.29 9 III 43.78 10 III 55.25 11 II 35.51 12 II 37.37 13 II 40.68 14 II 44.63 IV 20.24 16 II 50.37 17 III 33.85 18 III 28.79 19 II 50.07 II 23.92 21 III 58.20 22 III 22.85 23 II 34.80 24 III 37.54 III 48.45 26 III 51.51 27 III 43.15 28 III 60.96 29 II 48.57 30 II 41.13 31 III 33.38 32 III 41.36 33 III 24.25 34 I 38.63 35 IV 29.06 36 I 52.86 37 I 58.44 38 II 47.78 39 III 35.86 40 I 53.92 41 III 22.80 42 V 6.98 43 IV 31.88 44 II 36.67 45 II 48.48 46 I 59.56 47 II 54.52 48 III 49.43 49 I 60.54 50 II 52.97 51 II 51.50 52 II 51.63 53 II 52.14 54 II 31.94 55 II 51.17 56 IV 38.13 57 - 37.91 58 IV 35.60 59 II 46.49 60 III 49.52 61 - 48.53 62 III 31.05 63 III 25.52 64 III 44.20 65 III 41.45 66 II 63.19 67 II 33.58 TABLE II
L*a*b* (Laser Dose J/cm2) PATIENT SKIN TYPE L a* b* LASER
DOSE
(J/cIIlz) 1 II 60.26 11.94 15.54 18 2 III 60.74 14.72 14.68 21 3 III 65.40 6.10 15.72 18 4 II 66.84 6.68 13.10 20 I 64.22 8.80 15.84 17 6 II 60.88 13.04 17.18 12 7 III 64.80 8.70 14.80 18 8 II 69.58 5.70 14.08 18 9 III 64.68 9.88 15.32 16 III 72.92 4.70 15.90 19 11 II 61.15 14.68 15.63 16 12 II 61.96 11.10 15.66 18 13 II 63.70 10.06 15.94 16 14 II 60.80 14.20 10.94 20 IV 56.68 11.54 18.12 10 16 II 66.66 10.64 13.80 18 17 III 61.28 12.04 16.82 15 18 III 59.22 11.06 16.78 12 19 II 67.05 7.05 14.28 18 II 56.82 17.42 15.38 12 21 III 70.06 4.80 12.44 18 22 III 56.86 13.78 16.28 12 23 II 61.16 12.66 16.06 18 24 III 62.60 14.90 16.40 18 III 67.60 8.05 15.60 18 26 III 67.10 8.35 13.60 18 27 III 64.23 10.63 15.18 18 28 III 71.67 4.23 12.03 20 29 II 64.66 9.34 12.94 18 II 62.40 12.50 14.20 25 31 III 61.30 11.20 17.15 18 32 III 64.42 7.70 16.38 14 33 III 57.62 14.10 16.92 12 34 I 62.00 11.30 15.02 20 33 IV 59.90 11.40 17.82 20 36 I 64.02 10.80 10.62 35 37 I 67.45 7.50 10.72 35 38 II 62.63 14.13 11.46 22 39 III 62.65 11.42 17.50 25 40 I 67.22 8.07 12.55 33 41 III 56.62 15.80 15.75 15 42 V 52.20 13.86 17.98 13 43 IV 61.32 11.92 18.20 21 44 II 60.70 13.65 14.37 20 45 II 65.47 12.47 13.70 25 46 I 66.42 10.65 9.65 25 47 II 67.70 9.23 12.62 30 48 III 65.80 9.65 13.53 20 49 I 70.00 7.07 11.30 30 50 II 66.30 9.90 12.30 25 51 II 67.60 7.40 14.00 25 52 JI 66.90 9.86 13.38 30 53 II 66.80 7.87 13.06 30 54 II 60.26 13.20 16.46 22 55 II 68.96 8.80 15.26 30 56 IV 63.50 9.50 17.20 25 57 - 61.72 14.25 15.05 26 58 IV 61.67 13.12 16.30 15 59 II 62.85 11.95 12.20 35 60 III 65.85 9.85 13.53 20 61 - 68.80 5.82 16.62 30 62 III 58.97 16.12 14.90 22 63 III 57.70 16.06 16.13 25 64 III 63.37 14.40 13.75 20 65 III 63.00 12.58 14.72 20 66 II 69.15 4.57 9.68 25 67 II 57.90 17.45 11.90 20 TABLE III
LASER DOSE b/L b iv- a*/b*
(J/CM2) 18 0.258 15.54 0.768 21 0.242 14.68 1.003 18 0.240 15.72 0.388 20 0.196 13.10 0.510 17 0.247 15.84 0.556 12 0.282 17.18 0.759 18 0.228 14.80 0.588 18 0.202 14.08 0.405 16 0.237 15.32 0.645 19 0.218 15.90 0.296 16 0.256 15.63 0.939 18 0.253 15.66 0.709 16 0.250 15.94 0.631 20 0.180 10.94 1.298 0.320 18.12 0.637 18 0.207 13.80 0.771 0.274 16.82 0.716 12 0.283 16.78 0.659 18 0.213 14.28 0.494 12 0.271 15.38 1.133 18 0.178 12.44 0.386 12 0.286 16.28 0.846 18 0.263 16.06 0.788 18 0.262 16.40 0.909 18 0.231 15.60 0.516 18 0.203 13.60 0.614 18 0.236 15.18 0.700 0.168 12.03 0.352 18 0.200 12.94 0.722 0.228 14.20 0.880 18 0.280 17.15 0.653 14 0.254 16.38 0.470 12 0.294 16.92 0.833 20 0.242 15.02 0.752 20 0.297 17.82 0.640 0.166 10.62 1.017 35 0.159 10.72 0.700 22 0.183 11.46 1.233 25 0.279 17.50 0.653 33 0.187 12.55 0.643 15 0.278 15.75 1.003 13 0.344 17.98 0.771 21 0.297 18.20 0.655 20 0.237 14.37 0.950 25 0.209 13.70 0.910 25 0.145 9.65 1.104 30 0.186 12.62 0.731 20 0.206 13.53 0.713 30 0.161 11.30 0.626 25 0.186 12.30 0.805 25 0.207 14.00 0.529 30 0.200 13.38 0.737 30 0.196 13.06 0.603 22 0.273 16.46 0.802 30 0.221 15.26 0.577 25 0.271 17.20 0.552 26 0.244 15.05 0.947 15 0.264 16.30 0.805 35 0.194 12.20 0.980 20 0.205 13.53 0.728 30 0.242 16.62 0.350 22 0.253 14.90 1.082 25 0.280 16.13 0.996 20 0.217 13.75 1.047 20 0.234 14.72 0.855 25 0.140 9.68 0.472 20 0.206 11.90 1.466 A stronger determinant of the correct Laser Dose is the ratio of Z/Y, which is derivable from the ratio of b"/L', as can be seen from the above-shown algebraic relations. Table II shows the range of colorimetric values for skin sites from 67 individuals. Table III shows the range of values for Laser Dose versus b', b*/L* and (for an arbitrary comparison) a*/b*. There is a strong linear correlation between laser dose and b* or b*/L'which can be seen when the values are graphed. In contrast, a*/b*, which is dominated by the X coordinate rather than the interrelationship of Z
and Y, has a very poor correlation with Laser Dose.
Based on the calculation of statistical correlatior.
coefficients (R2), the strongest correlation with the correct Laser Dose was found for b*/L*. A linear fit to the data gives the mathematical expression for the Fluence (Laser Dose) in joules/cm 2 as Laser Dose = 39 - 84 (b*/L*) The correlations L. versus Laser Dose and a* versus Laser Dose were found to be weaker. This is expected since both L* and a* are independent of Z and hence less sensitive to melanin.
Changes in the type of laser employed, cooling head configuration applied at the interface between skin and laser energy and temperature, as well as other physical factors may lead to different constants. Therefore the Laser Dose is best described by an overall general equation of the following type:
Laser Dose = k' - k2 (b*/L*) where kl ranges from 1 to 60, preferably from 25 to 50, optimally from 30 to 40; and k 2 ranges from 1 to 120, preferably from 10 to 110, more preferably from 50 to 100, optimally from 55 to 85.
Any of the concepts and theories as well as the mathematical correlation of this invention should not be considered as limiting the actual invention itself.
Adjustments to the theory may be deemed appropriate in the future but this will not negate the underlying discovery of using specific colorimetric parameters to determine the optimum laser energy dosage added for hair removal.
For purposes of this invention, most preferred is a ruby laser with output wavelength of 694 nm. Other types of lasers may also be employed. These include carbon dioxide based lasers and Q-switched Nd:YAG lasers pulsed at 1064 nm.
Particularly useful may be an Alexandrite laser operating at 755 nm, a typical commercial instrument being the Gentle LASE available from the Candela Corporation, Wayland, Massachusetts. A still further potentially useful laser is the KTP Crystal Diode type emitting at 810 nm, available from Coherent Corporation.
Advantageously, probes of lasers according to the present invention may include a cooling head. Temperatures ranging from 0 C down to minus 80 C, preferably between 0 C and minus 10 C are employed for this invention. For instance, the Palomar Ruby Laser 2000 model operates at minus 10 C utilizing a Thermatech Pump with a sapphire tip.
A TFE cryogen sprayhead may also be employed and is commercially available with the Gentle Lase instrument from Candela Corporation.
Pulse duration is best when extended but only to the point falling short of skin damage. With the Palomar Ruby Laser (Epiwand instrument), there is a fixed duration of 3 milliseconds for each pulse. Generally pulse duration may range from about 0.5 to about 10 milliseconds.
A first embodiment of equipment for purposes of this invention includes a spectrophotometer/colorimeter physically separate from the laser. Information gathered from L*a*b* measurement or color matching of skin type is utilized to adjust laser dose levels. Input to the laser on dosage may either be through manual adjustment or automatic by electronic transfer. Skin color values can be sent to a computer program which then automatically sets energy dosage in the laser. A second embodiment of equipment for purposes of this invention combines in a single iristrument the spectrophotometer/colorimeter and laser. Circuitry and a logic chip allows color value to be measured and dosage level set in a seamless, fully automatic mode.
Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material ought to be understood as modified by the word "about".
The foregoing description illustrates selected embodiments of the present invention. In light thereof variations and modifications will be suggested to one skilled in the art, all of which are within the spirit and purview and this invention.
Now it has been discovered that laser-based removal of hair can be rendered more effective while less irritating through guidance by skin coloration type in selecting the most efficient laser energy dosage. Colorimetry values obtained from a spectrophotometer can now guide selection of the optimal laser energy.
According to a first step of the method of this invention, skin color is analyzed by a spectrophotometer/colorimeter. These instruments usually operate with at least one visible light source such as a light emitting diode (LED), xenon-arc, tungsten/halogen or other light source in the wavelength range of 400 to 900 nm.
The visible light source may be co-housed with the sensor portion of the spectrophotometer/colorimeter. Both visible and infrared wavelength light may be utilized in connection with a sensor portion. A suitable hand-held instrument is commercially available from Minolta Camera Company Ltd., Japan (Minolta Spectrophotometer/Colorimeter CM-2002), from Colortec Associates, Accuracy Measurements Inc. and X-Rite.
Skin coloration can be expressed in values of lightness, redness and yellowness respectively denoted by L', a* and b* units.
The L*a*b* color space is related to the Individual Typology Angle, which is essentially the value of 57.3 arctangent [(L*-50) /b'J , identifying skin types. See Chardon et al., International Journal of Cosmetic Science, 13, 191-208 (1991). Type I, the very ~ightest skin color, covers an angle ranging from more than 55 to 60 ; Type II, light skin color, covers an angle ranging from more than 41 to 55 ;
Type III, in=,ermediate skin color, covers an angle ranging from more than 28 to 41 ; Type IV, tan skin color, covers an angle ranging from more than 10 to 28 ; and Type V, brown skin color, covers an angle ranging from 0 to 10 .
Individual Typology Angle correlates to a first approximation with visibly judged Skin Type and to a first approximation determines the correct laser setting.
However, visual judgement of Skin Type may also be influenced by optical contributions from hemoglobin as well as that of melanin. A second shortcoming of the currently practiced art of Skin Typing is the phenomenon called metamerism, in which two skin colors that appear the same to the human eye under one light source are seen to be different under other lighting conditions. Human skin is metameric because people of different ethnic origins can have different optical types of melanin in their skin. The colorimeter used in the present method is designed to provide L*a*b* values that are the best metameric fit (average) for fluorescent lighting, daylight and incandescent light. Since the ruby laser interacts selectively with melanin, the primary optical parameters to be chosen must be those most sensitive to skin melanin content for more accurate selections of laser dosage for epilation.
The melanin absorption of incident light has a lower amplitude for lighter skin and a greater amplitude for darker skin, respectively. In the former case the skin color spectrum is partly dominated by hemoglobin absorbance, in the latter case by melanin absorbance. For lighter skin (low melanin), the absorbance of primarily green light by hemoglobin imparts a reddish remittance to the skin. For darker skin (high melanin content), the strong absorbance of blue light imparts a green-red combination to the remittance, giving skin a brownish color. For Caucasian skin, Types I-III, a change in melanin has a greater impact on total blue remittance than on green remittance, where hemoglobin dominates. It would appear that the best indicator of differences in skin melanin content is an optical parameter that compares remittance intensities in the blue part of the spectrum (heavily reduced by melanin absorbance) against the green remittance (heavily reduced by hemoglobin absorbance). Consequently, for Skin Types I-IV, one can treat the green band remittance as a melanin-independent baseline against which differences in blue-band remittance indicate differences in skin melanin content.
The standard definition of color was set in 1931 with the definition of three types of standard remitted spectra, X,Y and Z. Approximately, X is a red remittance spectrum, Y
is a green spectrum, and Z is a blue spectrum. The psychological color perception parameters L*a*b* are actually algebraic transformations of X,Y,Z that accommodate the human mind's relative sensitivities to the X-, Y- and Z-spectra:
L= 116 (Y/Ya) 1/' - 16 a= 500 [ (X/Xa) 113 _ (y/Ya) 1/3) ]
b* 200 [ (Y/Ya) 1/3 - (Z/Za) 1/3i where Xa, Ya, and Za are maximum values of the remittance for the particular illumination intensity. Looking at these three definitions reveals that the quantity b* compares blue to green remittance, Z versus Y, which is the object of the present method.
Table I shows the range of Skin Types for sixty-seven panelists in a clinical study performed for the present invention. Data correlation between the measured angle and the Skin Type subjectively assigned in the study is weak, pointing out the inferiority of the known Skin Typing method.
TABLE I
PATIENT SKIN TYPE (ARC TAN) ((L-50) /B) ) (57.3) 1 II 33.44 2 III 36.19 3 III 44.41 4 II 52.12 5 I 41.92 6 II 32.35 7 iII 45.00 8 II 54.29 9 III 43.78 10 III 55.25 11 II 35.51 12 II 37.37 13 II 40.68 14 II 44.63 IV 20.24 16 II 50.37 17 III 33.85 18 III 28.79 19 II 50.07 II 23.92 21 III 58.20 22 III 22.85 23 II 34.80 24 III 37.54 III 48.45 26 III 51.51 27 III 43.15 28 III 60.96 29 II 48.57 30 II 41.13 31 III 33.38 32 III 41.36 33 III 24.25 34 I 38.63 35 IV 29.06 36 I 52.86 37 I 58.44 38 II 47.78 39 III 35.86 40 I 53.92 41 III 22.80 42 V 6.98 43 IV 31.88 44 II 36.67 45 II 48.48 46 I 59.56 47 II 54.52 48 III 49.43 49 I 60.54 50 II 52.97 51 II 51.50 52 II 51.63 53 II 52.14 54 II 31.94 55 II 51.17 56 IV 38.13 57 - 37.91 58 IV 35.60 59 II 46.49 60 III 49.52 61 - 48.53 62 III 31.05 63 III 25.52 64 III 44.20 65 III 41.45 66 II 63.19 67 II 33.58 TABLE II
L*a*b* (Laser Dose J/cm2) PATIENT SKIN TYPE L a* b* LASER
DOSE
(J/cIIlz) 1 II 60.26 11.94 15.54 18 2 III 60.74 14.72 14.68 21 3 III 65.40 6.10 15.72 18 4 II 66.84 6.68 13.10 20 I 64.22 8.80 15.84 17 6 II 60.88 13.04 17.18 12 7 III 64.80 8.70 14.80 18 8 II 69.58 5.70 14.08 18 9 III 64.68 9.88 15.32 16 III 72.92 4.70 15.90 19 11 II 61.15 14.68 15.63 16 12 II 61.96 11.10 15.66 18 13 II 63.70 10.06 15.94 16 14 II 60.80 14.20 10.94 20 IV 56.68 11.54 18.12 10 16 II 66.66 10.64 13.80 18 17 III 61.28 12.04 16.82 15 18 III 59.22 11.06 16.78 12 19 II 67.05 7.05 14.28 18 II 56.82 17.42 15.38 12 21 III 70.06 4.80 12.44 18 22 III 56.86 13.78 16.28 12 23 II 61.16 12.66 16.06 18 24 III 62.60 14.90 16.40 18 III 67.60 8.05 15.60 18 26 III 67.10 8.35 13.60 18 27 III 64.23 10.63 15.18 18 28 III 71.67 4.23 12.03 20 29 II 64.66 9.34 12.94 18 II 62.40 12.50 14.20 25 31 III 61.30 11.20 17.15 18 32 III 64.42 7.70 16.38 14 33 III 57.62 14.10 16.92 12 34 I 62.00 11.30 15.02 20 33 IV 59.90 11.40 17.82 20 36 I 64.02 10.80 10.62 35 37 I 67.45 7.50 10.72 35 38 II 62.63 14.13 11.46 22 39 III 62.65 11.42 17.50 25 40 I 67.22 8.07 12.55 33 41 III 56.62 15.80 15.75 15 42 V 52.20 13.86 17.98 13 43 IV 61.32 11.92 18.20 21 44 II 60.70 13.65 14.37 20 45 II 65.47 12.47 13.70 25 46 I 66.42 10.65 9.65 25 47 II 67.70 9.23 12.62 30 48 III 65.80 9.65 13.53 20 49 I 70.00 7.07 11.30 30 50 II 66.30 9.90 12.30 25 51 II 67.60 7.40 14.00 25 52 JI 66.90 9.86 13.38 30 53 II 66.80 7.87 13.06 30 54 II 60.26 13.20 16.46 22 55 II 68.96 8.80 15.26 30 56 IV 63.50 9.50 17.20 25 57 - 61.72 14.25 15.05 26 58 IV 61.67 13.12 16.30 15 59 II 62.85 11.95 12.20 35 60 III 65.85 9.85 13.53 20 61 - 68.80 5.82 16.62 30 62 III 58.97 16.12 14.90 22 63 III 57.70 16.06 16.13 25 64 III 63.37 14.40 13.75 20 65 III 63.00 12.58 14.72 20 66 II 69.15 4.57 9.68 25 67 II 57.90 17.45 11.90 20 TABLE III
LASER DOSE b/L b iv- a*/b*
(J/CM2) 18 0.258 15.54 0.768 21 0.242 14.68 1.003 18 0.240 15.72 0.388 20 0.196 13.10 0.510 17 0.247 15.84 0.556 12 0.282 17.18 0.759 18 0.228 14.80 0.588 18 0.202 14.08 0.405 16 0.237 15.32 0.645 19 0.218 15.90 0.296 16 0.256 15.63 0.939 18 0.253 15.66 0.709 16 0.250 15.94 0.631 20 0.180 10.94 1.298 0.320 18.12 0.637 18 0.207 13.80 0.771 0.274 16.82 0.716 12 0.283 16.78 0.659 18 0.213 14.28 0.494 12 0.271 15.38 1.133 18 0.178 12.44 0.386 12 0.286 16.28 0.846 18 0.263 16.06 0.788 18 0.262 16.40 0.909 18 0.231 15.60 0.516 18 0.203 13.60 0.614 18 0.236 15.18 0.700 0.168 12.03 0.352 18 0.200 12.94 0.722 0.228 14.20 0.880 18 0.280 17.15 0.653 14 0.254 16.38 0.470 12 0.294 16.92 0.833 20 0.242 15.02 0.752 20 0.297 17.82 0.640 0.166 10.62 1.017 35 0.159 10.72 0.700 22 0.183 11.46 1.233 25 0.279 17.50 0.653 33 0.187 12.55 0.643 15 0.278 15.75 1.003 13 0.344 17.98 0.771 21 0.297 18.20 0.655 20 0.237 14.37 0.950 25 0.209 13.70 0.910 25 0.145 9.65 1.104 30 0.186 12.62 0.731 20 0.206 13.53 0.713 30 0.161 11.30 0.626 25 0.186 12.30 0.805 25 0.207 14.00 0.529 30 0.200 13.38 0.737 30 0.196 13.06 0.603 22 0.273 16.46 0.802 30 0.221 15.26 0.577 25 0.271 17.20 0.552 26 0.244 15.05 0.947 15 0.264 16.30 0.805 35 0.194 12.20 0.980 20 0.205 13.53 0.728 30 0.242 16.62 0.350 22 0.253 14.90 1.082 25 0.280 16.13 0.996 20 0.217 13.75 1.047 20 0.234 14.72 0.855 25 0.140 9.68 0.472 20 0.206 11.90 1.466 A stronger determinant of the correct Laser Dose is the ratio of Z/Y, which is derivable from the ratio of b"/L', as can be seen from the above-shown algebraic relations. Table II shows the range of colorimetric values for skin sites from 67 individuals. Table III shows the range of values for Laser Dose versus b', b*/L* and (for an arbitrary comparison) a*/b*. There is a strong linear correlation between laser dose and b* or b*/L'which can be seen when the values are graphed. In contrast, a*/b*, which is dominated by the X coordinate rather than the interrelationship of Z
and Y, has a very poor correlation with Laser Dose.
Based on the calculation of statistical correlatior.
coefficients (R2), the strongest correlation with the correct Laser Dose was found for b*/L*. A linear fit to the data gives the mathematical expression for the Fluence (Laser Dose) in joules/cm 2 as Laser Dose = 39 - 84 (b*/L*) The correlations L. versus Laser Dose and a* versus Laser Dose were found to be weaker. This is expected since both L* and a* are independent of Z and hence less sensitive to melanin.
Changes in the type of laser employed, cooling head configuration applied at the interface between skin and laser energy and temperature, as well as other physical factors may lead to different constants. Therefore the Laser Dose is best described by an overall general equation of the following type:
Laser Dose = k' - k2 (b*/L*) where kl ranges from 1 to 60, preferably from 25 to 50, optimally from 30 to 40; and k 2 ranges from 1 to 120, preferably from 10 to 110, more preferably from 50 to 100, optimally from 55 to 85.
Any of the concepts and theories as well as the mathematical correlation of this invention should not be considered as limiting the actual invention itself.
Adjustments to the theory may be deemed appropriate in the future but this will not negate the underlying discovery of using specific colorimetric parameters to determine the optimum laser energy dosage added for hair removal.
For purposes of this invention, most preferred is a ruby laser with output wavelength of 694 nm. Other types of lasers may also be employed. These include carbon dioxide based lasers and Q-switched Nd:YAG lasers pulsed at 1064 nm.
Particularly useful may be an Alexandrite laser operating at 755 nm, a typical commercial instrument being the Gentle LASE available from the Candela Corporation, Wayland, Massachusetts. A still further potentially useful laser is the KTP Crystal Diode type emitting at 810 nm, available from Coherent Corporation.
Advantageously, probes of lasers according to the present invention may include a cooling head. Temperatures ranging from 0 C down to minus 80 C, preferably between 0 C and minus 10 C are employed for this invention. For instance, the Palomar Ruby Laser 2000 model operates at minus 10 C utilizing a Thermatech Pump with a sapphire tip.
A TFE cryogen sprayhead may also be employed and is commercially available with the Gentle Lase instrument from Candela Corporation.
Pulse duration is best when extended but only to the point falling short of skin damage. With the Palomar Ruby Laser (Epiwand instrument), there is a fixed duration of 3 milliseconds for each pulse. Generally pulse duration may range from about 0.5 to about 10 milliseconds.
A first embodiment of equipment for purposes of this invention includes a spectrophotometer/colorimeter physically separate from the laser. Information gathered from L*a*b* measurement or color matching of skin type is utilized to adjust laser dose levels. Input to the laser on dosage may either be through manual adjustment or automatic by electronic transfer. Skin color values can be sent to a computer program which then automatically sets energy dosage in the laser. A second embodiment of equipment for purposes of this invention combines in a single iristrument the spectrophotometer/colorimeter and laser. Circuitry and a logic chip allows color value to be measured and dosage level set in a seamless, fully automatic mode.
Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material ought to be understood as modified by the word "about".
The foregoing description illustrates selected embodiments of the present invention. In light thereof variations and modifications will be suggested to one skilled in the art, all of which are within the spirit and purview and this invention.
Claims (28)
1. A method for removing hair from body skin comprising:
(i) measuring with a colorimeter color of an area of the skin where hair is to be removed to obtain a color value;
(ii) employing the color value to determine an optimum range of laser energy necessary to kill hair follicles in the area yet minimizing inflammatory reactions; and (iii) directing laser energy of the optimum range at the skin area.
(i) measuring with a colorimeter color of an area of the skin where hair is to be removed to obtain a color value;
(ii) employing the color value to determine an optimum range of laser energy necessary to kill hair follicles in the area yet minimizing inflammatory reactions; and (iii) directing laser energy of the optimum range at the skin area.
2. The method according to claim 1 wherein the laser energy is delivered by a ruby laser.
3. The method according to claim 2 wherein the ruby laser operates at 694 nm.
4. The method according to claim 1 wherein the skin is of a human body in areas selected from the group consisting of face, scalp, hands and legs.
5. The method according to claim 1 wherein the area is between the nose and lips.
6. The method according to claim 1 wherein laser energy is delivered with a 3 millisecond pulse.
7. The method according to claim 1 wherein the color value is defined by the L*a*b* system of color coordinates.
8. The method according to claim 7 wherein the laser energy is provided in a dose following the formula:
Laser Dose = k1 - k2 (b*/L*) wherein k1 ranges from 1 to 60 and k2 ranges from 1 to 120.
Laser Dose = k1 - k2 (b*/L*) wherein k1 ranges from 1 to 60 and k2 ranges from 1 to 120.
9. A kit for removing hair from body skin comprising:
(a) a laser;
(b) a colorimeter; and (c) instructions for operating the laser to remove hair from body skin, the instructions comprising:
(i) measuring within the colorimeter color of an area of the skin where hair is to be removed to obtain a color value;
(ii) employing the color value to determine an optimum range of laser energy necessary to kill hair follicles in the area yet minimizing inflammatory reactions; and (iii) directing laser energy of the optimum range at the skin area.
(a) a laser;
(b) a colorimeter; and (c) instructions for operating the laser to remove hair from body skin, the instructions comprising:
(i) measuring within the colorimeter color of an area of the skin where hair is to be removed to obtain a color value;
(ii) employing the color value to determine an optimum range of laser energy necessary to kill hair follicles in the area yet minimizing inflammatory reactions; and (iii) directing laser energy of the optimum range at the skin area.
10. The kit according to claim 9 wherein the laser energy is delivered by a ruby laser.
11. The kit according to claim 9 wherein the ruby laser operates at 694 nm.
12. The kit according to claim 9 wherein the skin is of a human body in areas selected from the group consisting of face, scalp, hands and legs.
13. The kit according to claim 9 wherein the area is between the nose and lips.
14. The kit according to claim 9 wherein the laser energy is delivered with a 3 millisecond pulse.
15. The kit according to claim 9 wherein the color value is defined by the L*a*b* system of color coordinates.
16. The kit according to claim 9 wherein the laser energy is provided in a dose according to the equation:
Laser Dose = k1 - k2 (b*/L*) wherein k1 ranges from 1 to 60 and k2 ranges from 1 to 120.
Laser Dose = k1 - k2 (b*/L*) wherein k1 ranges from 1 to 60 and k2 ranges from 1 to 120.
17. A method for removing hair from body skin comprising :
(i) measuring with a colorimeter color of an area of the skin where hair is to be removed to obtain a numerical color value expressing the relative green and blue remittance of said skin in a previously validated form related to a therapeutic dosage of laser light which will inactivate hair follicles without permanent harm to surrounding tissues;
(ii) employing the color value to determine an optimum numerical range of laser energy necessary to inactivate hair follicles in the area yet minimize inflammatory reactions; and (iii) directing laser energy of the optimum range at the skin area.
(i) measuring with a colorimeter color of an area of the skin where hair is to be removed to obtain a numerical color value expressing the relative green and blue remittance of said skin in a previously validated form related to a therapeutic dosage of laser light which will inactivate hair follicles without permanent harm to surrounding tissues;
(ii) employing the color value to determine an optimum numerical range of laser energy necessary to inactivate hair follicles in the area yet minimize inflammatory reactions; and (iii) directing laser energy of the optimum range at the skin area.
18. The method according to claim 17 wherein the color value is defined by the L*a*b* system of color coordinates.
19. The method according to claim 18 wherein the laser energy is provided in a dose following the formula:
Laser Dose = k1- k2 (b* /L*) wherein k1 ranges from 1 to 60 and k2 range from 1 to 120.
Laser Dose = k1- k2 (b* /L*) wherein k1 ranges from 1 to 60 and k2 range from 1 to 120.
20. The method according to claim 19 wherein the laser energy is delivered by a ruby laser.
21. The method according to claim 20 wherein the ruby laser operates at 694 nm.
22. The method according to claim 21 wherein laser energy is delivered with a 3 millisecond pulse.
23. The method according to claim 22 wherein the skin is of a human body in areas selected from the group consisting of face, scalp, hands and legs.
24. The method according to claim 23 wherein the area is between the nose and lips.
25. A method of depilation of body skin comprising:
(a) illuminating a portion of the skin which is to be depilated, (b) determining the green and blue color remittance values of such surface, (c) expressing said remittance values in a previously validated form related to a therapeutic dosage of laser light which will deactivate hair follicles without injury to the skin tissues, and (d) adjusting the dosage of a laser to correspond with the expressed value, (e) applying a laser beam of the adjusted dosage to the area to be depilated.
(a) illuminating a portion of the skin which is to be depilated, (b) determining the green and blue color remittance values of such surface, (c) expressing said remittance values in a previously validated form related to a therapeutic dosage of laser light which will deactivate hair follicles without injury to the skin tissues, and (d) adjusting the dosage of a laser to correspond with the expressed value, (e) applying a laser beam of the adjusted dosage to the area to be depilated.
26. A method in accordance with claim 25 wherein the illumination, determination of color remittance value, expression of remittance values and application of a laser beam are accomplished sequentially by a single apparatus.
27. A method in accordance with claim 25 wherein the illumination, determination of color remittance value, expression of the remittance values and application of a laser beam are accomplished sequentially by two or more separate apparatus components.
28. A method of depilation of body skin comprising:
(a) illuminating a portion of the skin which is to be depilated, (b) determining the green and blue color remittance values of such surface, (c) expressing said remittance values in a previously validated form related to a therapeutic dosage of laser light which will deactivate hair follicles without injury to the skin tissues, and (d) adjusting the dosage of a laser to correspond with the expressed value, (e) applying a laser beam of the adjusted dosage to the area to be depilated, wherein the illumination, determination of color remittance value, expression of the remittance values and application of a laser beam are accomplished sequentially by two or more separate apparatus components, such that the laser energy is provided in a dose in accordance with the formula:
Laser Dose = k1- k2 (b*/L*) wherein k' ranges from 1 to 60 and k2 range from 1 to 120.
(a) illuminating a portion of the skin which is to be depilated, (b) determining the green and blue color remittance values of such surface, (c) expressing said remittance values in a previously validated form related to a therapeutic dosage of laser light which will deactivate hair follicles without injury to the skin tissues, and (d) adjusting the dosage of a laser to correspond with the expressed value, (e) applying a laser beam of the adjusted dosage to the area to be depilated, wherein the illumination, determination of color remittance value, expression of the remittance values and application of a laser beam are accomplished sequentially by two or more separate apparatus components, such that the laser energy is provided in a dose in accordance with the formula:
Laser Dose = k1- k2 (b*/L*) wherein k' ranges from 1 to 60 and k2 range from 1 to 120.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11073298P | 1998-12-03 | 1998-12-03 | |
| US60/110732 | 1998-12-03 | ||
| US09/394171 | 1999-09-13 | ||
| US09/394,171 US6514242B1 (en) | 1998-12-03 | 1999-09-13 | Method and apparatus for laser removal of hair |
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| Publication Number | Publication Date |
|---|---|
| CA2290760A1 CA2290760A1 (en) | 2000-06-03 |
| CA2290760C true CA2290760C (en) | 2009-05-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002290760A Expired - Fee Related CA2290760C (en) | 1998-12-03 | 1999-11-25 | Method and apparatus for laser removal of hair |
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| Country | Link |
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| US (2) | US6514242B1 (en) |
| CA (1) | CA2290760C (en) |
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1999
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2003
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| US6514242B1 (en) | 2003-02-04 |
| US7029469B2 (en) | 2006-04-18 |
| CA2290760A1 (en) | 2000-06-03 |
| US20040015156A1 (en) | 2004-01-22 |
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