CA2291022A1 - Nanosecond time-gate spectroscopic diagnosis apparatus - Google Patents
Nanosecond time-gate spectroscopic diagnosis apparatus Download PDFInfo
- Publication number
- CA2291022A1 CA2291022A1 CA002291022A CA2291022A CA2291022A1 CA 2291022 A1 CA2291022 A1 CA 2291022A1 CA 002291022 A CA002291022 A CA 002291022A CA 2291022 A CA2291022 A CA 2291022A CA 2291022 A1 CA2291022 A1 CA 2291022A1
- Authority
- CA
- Canada
- Prior art keywords
- gate
- output
- image intensifier
- oscilloscope
- diagnosis apparatus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
Abstract
A diagnosis apparatus comprises a shutter (11) disposed between a light source (1) and a lens (12) opposed to biological tissue (13); a multi-channel spectrometer (polychromator) (16) for detecting a light emitting plume (14); a photodetector (5) for detecting a portion of a laser pulse from the light source (1); an oscilloscope (6) which monitors an output from the photodetector (5) to thereby measure a delay time of a gate trigger pulse supplied to a high-speed gate image intensifier (17); a pulse generator (8) capable of independently and freely adjusting the delay times of two output pulses in synchronization with the laser pulse;
a gate controller (7) connected to the pulse generator (8) and the oscilloscope (6); the high-speed gate image intensifier (17) intensifying and imaging the output of the multi-channel spectrometer (16) whose gate is opened by the gate controller (7) over a period on the order of nanosecond;
a CCD camera (9) capturing an output image from the high-speed gate image intensifier (17); and a data-processing apparatus comprising a frame image data storage (10A) which inputs spectroscopic image data of one frame from the CCD
camera (9) as a time-series analog signal, and converts the analog signal to a digital signal for transmission to a computer (10).
a gate controller (7) connected to the pulse generator (8) and the oscilloscope (6); the high-speed gate image intensifier (17) intensifying and imaging the output of the multi-channel spectrometer (16) whose gate is opened by the gate controller (7) over a period on the order of nanosecond;
a CCD camera (9) capturing an output image from the high-speed gate image intensifier (17); and a data-processing apparatus comprising a frame image data storage (10A) which inputs spectroscopic image data of one frame from the CCD
camera (9) as a time-series analog signal, and converts the analog signal to a digital signal for transmission to a computer (10).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7535998A JP3594794B2 (en) | 1998-03-24 | 1998-03-24 | Nanosecond time-gated spectroscopic diagnostic equipment |
JP10-75359 | 1998-03-24 | ||
PCT/JP1999/000733 WO1999049300A1 (en) | 1998-03-24 | 1999-02-19 | Nanosecond gate spectroscopic diagnostic device |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2291022A1 true CA2291022A1 (en) | 1999-09-30 |
CA2291022C CA2291022C (en) | 2006-11-21 |
Family
ID=13573961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002291022A Expired - Fee Related CA2291022C (en) | 1998-03-24 | 1999-02-19 | Nanosecond time-gate spectroscopic diagnosis apparatus |
Country Status (6)
Country | Link |
---|---|
US (1) | US6463314B1 (en) |
EP (1) | EP0985922B1 (en) |
JP (1) | JP3594794B2 (en) |
CA (1) | CA2291022C (en) |
DE (1) | DE69922601T2 (en) |
WO (1) | WO1999049300A1 (en) |
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CA2468774C (en) | 2000-11-29 | 2015-06-30 | George E. Seidel | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
US6927359B2 (en) * | 2001-06-14 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Pulsed fiber laser cutting system for medical implants |
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EP2275533B9 (en) | 2002-08-01 | 2016-10-19 | Xy, Llc | Method of assessing sperm cells |
US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
US7855078B2 (en) | 2002-08-15 | 2010-12-21 | Xy, Llc | High resolution flow cytometer |
US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
DK2959774T3 (en) | 2003-03-28 | 2019-05-13 | Inguran Llc | PROCEDURE FOR CRYCONSERVATION OF SEAT CELLS |
WO2004104178A2 (en) | 2003-05-15 | 2004-12-02 | Xy, Inc. | Efficient haploid cell sorting for flow cytometer systems |
US7361171B2 (en) | 2003-05-20 | 2008-04-22 | Raydiance, Inc. | Man-portable optical ablation system |
US9022037B2 (en) | 2003-08-11 | 2015-05-05 | Raydiance, Inc. | Laser ablation method and apparatus having a feedback loop and control unit |
US20050167405A1 (en) * | 2003-08-11 | 2005-08-04 | Richard Stoltz | Optical ablation using material composition analysis |
US8921733B2 (en) | 2003-08-11 | 2014-12-30 | Raydiance, Inc. | Methods and systems for trimming circuits |
US8173929B1 (en) | 2003-08-11 | 2012-05-08 | Raydiance, Inc. | Methods and systems for trimming circuits |
BRPI0509485A (en) | 2004-03-29 | 2007-09-11 | Monsanto Technology Llc | sperm suspensions for use in insemination |
US7820936B2 (en) * | 2004-07-02 | 2010-10-26 | Boston Scientific Scimed, Inc. | Method and apparatus for controlling and adjusting the intensity profile of a laser beam employed in a laser welder for welding polymeric and metallic components |
EP1769067A2 (en) | 2004-07-22 | 2007-04-04 | Monsanto Technology LLC | Process for enriching a population of sperm cells |
US20060264760A1 (en) * | 2005-02-10 | 2006-11-23 | Board Of Regents, The University Of Texas System | Near infrared transrectal probes for prostate cancer detection and prognosis |
US8135050B1 (en) | 2005-07-19 | 2012-03-13 | Raydiance, Inc. | Automated polarization correction |
JP4724831B2 (en) * | 2005-09-06 | 2011-07-13 | 国立大学法人京都大学 | Elemental analysis method of solid surface in liquid |
US20070098596A1 (en) * | 2005-10-14 | 2007-05-03 | University Of South Florida | Handheld microarray reader |
JP5095986B2 (en) * | 2005-11-30 | 2012-12-12 | 学校法人慶應義塾 | Non-nail invasive blood substance measuring device and nail plate transpiration device |
US9130344B2 (en) | 2006-01-23 | 2015-09-08 | Raydiance, Inc. | Automated laser tuning |
US8189971B1 (en) | 2006-01-23 | 2012-05-29 | Raydiance, Inc. | Dispersion compensation in a chirped pulse amplification system |
US8232687B2 (en) | 2006-04-26 | 2012-07-31 | Raydiance, Inc. | Intelligent laser interlock system |
US7444049B1 (en) | 2006-01-23 | 2008-10-28 | Raydiance, Inc. | Pulse stretcher and compressor including a multi-pass Bragg grating |
US7822347B1 (en) | 2006-03-28 | 2010-10-26 | Raydiance, Inc. | Active tuning of temporal dispersion in an ultrashort pulse laser system |
AU2008245585B2 (en) | 2007-04-27 | 2011-10-06 | Echo Therapeutics, Inc. | Skin permeation device for analyte sensing or transdermal drug delivery |
DE102007027284A1 (en) * | 2007-06-11 | 2008-12-18 | OBLF, Gesellschaft für Elektronik und Feinwerktechnik mbH | Method for digital measurement of pulse-type emission spectra, involves generating emission pulse of sample by unit and units for wavelength dependent local focusing of emitted light on semiconductor detector marked by pixel structure |
EP2215441A2 (en) * | 2007-10-25 | 2010-08-11 | The Research Foundation of the State University of New York | Single photon spectrometer |
US7903326B2 (en) | 2007-11-30 | 2011-03-08 | Radiance, Inc. | Static phase mask for high-order spectral phase control in a hybrid chirped pulse amplifier system |
FR2929011B1 (en) * | 2008-03-20 | 2013-01-04 | Commissariat Energie Atomique | METHOD AND DEVICE FOR HIGH QUANTITATIVE QUANTITATIVE MEASUREMENT OF BIOMOLECULAR TARGETS PRESENTED ON OR IN A BIOLOGICAL ANALYSIS MEDIUM. |
JP2009229387A (en) * | 2008-03-25 | 2009-10-08 | Kobelco Kaken:Kk | Spectroscopic analysis method and it device for unsteady luminescent |
US8125704B2 (en) | 2008-08-18 | 2012-02-28 | Raydiance, Inc. | Systems and methods for controlling a pulsed laser by combining laser signals |
US8498538B2 (en) | 2008-11-14 | 2013-07-30 | Raydiance, Inc. | Compact monolithic dispersion compensator |
JP2009222727A (en) * | 2009-07-07 | 2009-10-01 | Canon Inc | Spectrometer |
US20110042564A1 (en) * | 2009-08-20 | 2011-02-24 | Yasuhide Naito | Laser ablation mass analyzing apparatus |
WO2012021748A1 (en) | 2010-08-12 | 2012-02-16 | Raydiance, Inc. | Polymer tubing laser micromachining |
US8556511B2 (en) | 2010-09-08 | 2013-10-15 | Abbott Cardiovascular Systems, Inc. | Fluid bearing to support stent tubing during laser cutting |
WO2012037465A1 (en) | 2010-09-16 | 2012-03-22 | Raydiance, Inc. | Laser based processing of layered materials |
US10239160B2 (en) | 2011-09-21 | 2019-03-26 | Coherent, Inc. | Systems and processes that singulate materials |
US20130258343A1 (en) * | 2012-03-30 | 2013-10-03 | Agilent Technologies, Inc. | Method and apparatus to improve signal-to-noise ratio of ft-ir spectrometers using pulsed light source |
KR102370530B1 (en) * | 2019-03-22 | 2022-03-07 | 스페클립스 주식회사 | Diagnosis method using laser induced breakdown spectroscopy and diagnosis device performing the same |
DE102020117043B3 (en) | 2020-06-29 | 2021-12-02 | Becker & Hickl Gmbh | Short-term spectroscopy method and short-term spectroscopy device |
Family Cites Families (16)
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US3768908A (en) * | 1971-01-04 | 1973-10-30 | S Zaromb | Remote sensing apparatus and methods |
US4802761A (en) * | 1987-08-31 | 1989-02-07 | Western Research Institute | Optical-fiber raman spectroscopy used for remote in-situ environmental analysis |
JPH01321340A (en) * | 1988-06-23 | 1989-12-27 | Osaka Oxygen Ind Ltd | Laser double stage excitation emission analysis method and apparatus |
US4981138A (en) * | 1988-06-30 | 1991-01-01 | Yale University | Endoscopic fiberoptic fluorescence spectrometer |
US5033853A (en) * | 1989-04-10 | 1991-07-23 | Coherent, Inc. | Apparatus for autocorrelating optical radiation signals |
US4973848A (en) * | 1989-07-28 | 1990-11-27 | J. Mccaughan | Laser apparatus for concurrent analysis and treatment |
US5204517A (en) * | 1991-12-24 | 1993-04-20 | Maxwell Laboratories, Inc. | Method and system for control of a material removal process using spectral emission discrimination |
JPH06300694A (en) | 1993-04-19 | 1994-10-28 | Osaka Gas Co Ltd | Relaxation time measuring apparatus |
US5608520A (en) * | 1994-07-11 | 1997-03-04 | The United States Of America As Represented By He Department Of Energy | Plasma emission spectroscopy method of tumor therapy |
RU2096051C1 (en) * | 1995-02-24 | 1997-11-20 | Григорий Борисович Альтшулер | Apparatus for laser treatment of biological tissues (alternative embodiments) |
US5720894A (en) * | 1996-01-11 | 1998-02-24 | The Regents Of The University Of California | Ultrashort pulse high repetition rate laser system for biological tissue processing |
GB9611942D0 (en) * | 1996-06-07 | 1996-08-07 | Lumonics Ltd | Focus control of lasers in material processing operations |
US5842995A (en) * | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
US6156030A (en) * | 1997-06-04 | 2000-12-05 | Y-Beam Technologies, Inc. | Method and apparatus for high precision variable rate material removal and modification |
US6008896A (en) * | 1998-07-01 | 1999-12-28 | National Research Council Of Canada | Method and apparatus for spectroscopic analysis of heterogeneous materials |
US6008897A (en) * | 1999-01-19 | 1999-12-28 | National Research Council Of Canada | Method and apparatus for materials analysis by enhanced laser induced plasma spectroscopy |
-
1998
- 1998-03-24 JP JP7535998A patent/JP3594794B2/en not_active Expired - Fee Related
-
1999
- 1999-02-19 DE DE69922601T patent/DE69922601T2/en not_active Expired - Fee Related
- 1999-02-19 CA CA002291022A patent/CA2291022C/en not_active Expired - Fee Related
- 1999-02-19 WO PCT/JP1999/000733 patent/WO1999049300A1/en active IP Right Grant
- 1999-02-19 EP EP99905243A patent/EP0985922B1/en not_active Expired - Lifetime
- 1999-02-19 US US09/423,354 patent/US6463314B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6463314B1 (en) | 2002-10-08 |
EP0985922A4 (en) | 2001-06-20 |
JP3594794B2 (en) | 2004-12-02 |
JPH11271226A (en) | 1999-10-05 |
EP0985922B1 (en) | 2004-12-15 |
WO1999049300A1 (en) | 1999-09-30 |
DE69922601T2 (en) | 2005-12-08 |
CA2291022C (en) | 2006-11-21 |
EP0985922A1 (en) | 2000-03-15 |
DE69922601D1 (en) | 2005-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |