CA2291022A1 - Nanosecond time-gate spectroscopic diagnosis apparatus - Google Patents

Nanosecond time-gate spectroscopic diagnosis apparatus Download PDF

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Publication number
CA2291022A1
CA2291022A1 CA002291022A CA2291022A CA2291022A1 CA 2291022 A1 CA2291022 A1 CA 2291022A1 CA 002291022 A CA002291022 A CA 002291022A CA 2291022 A CA2291022 A CA 2291022A CA 2291022 A1 CA2291022 A1 CA 2291022A1
Authority
CA
Canada
Prior art keywords
gate
output
image intensifier
oscilloscope
diagnosis apparatus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002291022A
Other languages
French (fr)
Other versions
CA2291022C (en
Inventor
Masamitsu Haruna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Original Assignee
Japan Science And Technology Corporation
Masamitsu Haruna
Japan Science And Technology Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science And Technology Corporation, Masamitsu Haruna, Japan Science And Technology Agency filed Critical Japan Science And Technology Corporation
Publication of CA2291022A1 publication Critical patent/CA2291022A1/en
Application granted granted Critical
Publication of CA2291022C publication Critical patent/CA2291022C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium

Abstract

A diagnosis apparatus comprises a shutter (11) disposed between a light source (1) and a lens (12) opposed to biological tissue (13); a multi-channel spectrometer (polychromator) (16) for detecting a light emitting plume (14); a photodetector (5) for detecting a portion of a laser pulse from the light source (1); an oscilloscope (6) which monitors an output from the photodetector (5) to thereby measure a delay time of a gate trigger pulse supplied to a high-speed gate image intensifier (17); a pulse generator (8) capable of independently and freely adjusting the delay times of two output pulses in synchronization with the laser pulse;
a gate controller (7) connected to the pulse generator (8) and the oscilloscope (6); the high-speed gate image intensifier (17) intensifying and imaging the output of the multi-channel spectrometer (16) whose gate is opened by the gate controller (7) over a period on the order of nanosecond;
a CCD camera (9) capturing an output image from the high-speed gate image intensifier (17); and a data-processing apparatus comprising a frame image data storage (10A) which inputs spectroscopic image data of one frame from the CCD
camera (9) as a time-series analog signal, and converts the analog signal to a digital signal for transmission to a computer (10).
CA002291022A 1998-03-24 1999-02-19 Nanosecond time-gate spectroscopic diagnosis apparatus Expired - Fee Related CA2291022C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP7535998A JP3594794B2 (en) 1998-03-24 1998-03-24 Nanosecond time-gated spectroscopic diagnostic equipment
JP10-75359 1998-03-24
PCT/JP1999/000733 WO1999049300A1 (en) 1998-03-24 1999-02-19 Nanosecond gate spectroscopic diagnostic device

Publications (2)

Publication Number Publication Date
CA2291022A1 true CA2291022A1 (en) 1999-09-30
CA2291022C CA2291022C (en) 2006-11-21

Family

ID=13573961

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002291022A Expired - Fee Related CA2291022C (en) 1998-03-24 1999-02-19 Nanosecond time-gate spectroscopic diagnosis apparatus

Country Status (6)

Country Link
US (1) US6463314B1 (en)
EP (1) EP0985922B1 (en)
JP (1) JP3594794B2 (en)
CA (1) CA2291022C (en)
DE (1) DE69922601T2 (en)
WO (1) WO1999049300A1 (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2279574C (en) 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
NZ509434A (en) 1998-07-30 2004-03-26 Univ Colorado State Res Found Equine system for non-surgical artificial insemination
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
WO2001085913A2 (en) 2000-05-09 2001-11-15 Xy, Inc. High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa
CA2468774C (en) 2000-11-29 2015-06-30 George E. Seidel System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US6927359B2 (en) * 2001-06-14 2005-08-09 Advanced Cardiovascular Systems, Inc. Pulsed fiber laser cutting system for medical implants
US6887239B2 (en) * 2002-04-17 2005-05-03 Sontra Medical Inc. Preparation for transmission and reception of electrical signals
EP2275533B9 (en) 2002-08-01 2016-10-19 Xy, Llc Method of assessing sperm cells
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
DK2959774T3 (en) 2003-03-28 2019-05-13 Inguran Llc PROCEDURE FOR CRYCONSERVATION OF SEAT CELLS
WO2004104178A2 (en) 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
US7361171B2 (en) 2003-05-20 2008-04-22 Raydiance, Inc. Man-portable optical ablation system
US9022037B2 (en) 2003-08-11 2015-05-05 Raydiance, Inc. Laser ablation method and apparatus having a feedback loop and control unit
US20050167405A1 (en) * 2003-08-11 2005-08-04 Richard Stoltz Optical ablation using material composition analysis
US8921733B2 (en) 2003-08-11 2014-12-30 Raydiance, Inc. Methods and systems for trimming circuits
US8173929B1 (en) 2003-08-11 2012-05-08 Raydiance, Inc. Methods and systems for trimming circuits
BRPI0509485A (en) 2004-03-29 2007-09-11 Monsanto Technology Llc sperm suspensions for use in insemination
US7820936B2 (en) * 2004-07-02 2010-10-26 Boston Scientific Scimed, Inc. Method and apparatus for controlling and adjusting the intensity profile of a laser beam employed in a laser welder for welding polymeric and metallic components
EP1769067A2 (en) 2004-07-22 2007-04-04 Monsanto Technology LLC Process for enriching a population of sperm cells
US20060264760A1 (en) * 2005-02-10 2006-11-23 Board Of Regents, The University Of Texas System Near infrared transrectal probes for prostate cancer detection and prognosis
US8135050B1 (en) 2005-07-19 2012-03-13 Raydiance, Inc. Automated polarization correction
JP4724831B2 (en) * 2005-09-06 2011-07-13 国立大学法人京都大学 Elemental analysis method of solid surface in liquid
US20070098596A1 (en) * 2005-10-14 2007-05-03 University Of South Florida Handheld microarray reader
JP5095986B2 (en) * 2005-11-30 2012-12-12 学校法人慶應義塾 Non-nail invasive blood substance measuring device and nail plate transpiration device
US9130344B2 (en) 2006-01-23 2015-09-08 Raydiance, Inc. Automated laser tuning
US8189971B1 (en) 2006-01-23 2012-05-29 Raydiance, Inc. Dispersion compensation in a chirped pulse amplification system
US8232687B2 (en) 2006-04-26 2012-07-31 Raydiance, Inc. Intelligent laser interlock system
US7444049B1 (en) 2006-01-23 2008-10-28 Raydiance, Inc. Pulse stretcher and compressor including a multi-pass Bragg grating
US7822347B1 (en) 2006-03-28 2010-10-26 Raydiance, Inc. Active tuning of temporal dispersion in an ultrashort pulse laser system
AU2008245585B2 (en) 2007-04-27 2011-10-06 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
DE102007027284A1 (en) * 2007-06-11 2008-12-18 OBLF, Gesellschaft für Elektronik und Feinwerktechnik mbH Method for digital measurement of pulse-type emission spectra, involves generating emission pulse of sample by unit and units for wavelength dependent local focusing of emitted light on semiconductor detector marked by pixel structure
EP2215441A2 (en) * 2007-10-25 2010-08-11 The Research Foundation of the State University of New York Single photon spectrometer
US7903326B2 (en) 2007-11-30 2011-03-08 Radiance, Inc. Static phase mask for high-order spectral phase control in a hybrid chirped pulse amplifier system
FR2929011B1 (en) * 2008-03-20 2013-01-04 Commissariat Energie Atomique METHOD AND DEVICE FOR HIGH QUANTITATIVE QUANTITATIVE MEASUREMENT OF BIOMOLECULAR TARGETS PRESENTED ON OR IN A BIOLOGICAL ANALYSIS MEDIUM.
JP2009229387A (en) * 2008-03-25 2009-10-08 Kobelco Kaken:Kk Spectroscopic analysis method and it device for unsteady luminescent
US8125704B2 (en) 2008-08-18 2012-02-28 Raydiance, Inc. Systems and methods for controlling a pulsed laser by combining laser signals
US8498538B2 (en) 2008-11-14 2013-07-30 Raydiance, Inc. Compact monolithic dispersion compensator
JP2009222727A (en) * 2009-07-07 2009-10-01 Canon Inc Spectrometer
US20110042564A1 (en) * 2009-08-20 2011-02-24 Yasuhide Naito Laser ablation mass analyzing apparatus
WO2012021748A1 (en) 2010-08-12 2012-02-16 Raydiance, Inc. Polymer tubing laser micromachining
US8556511B2 (en) 2010-09-08 2013-10-15 Abbott Cardiovascular Systems, Inc. Fluid bearing to support stent tubing during laser cutting
WO2012037465A1 (en) 2010-09-16 2012-03-22 Raydiance, Inc. Laser based processing of layered materials
US10239160B2 (en) 2011-09-21 2019-03-26 Coherent, Inc. Systems and processes that singulate materials
US20130258343A1 (en) * 2012-03-30 2013-10-03 Agilent Technologies, Inc. Method and apparatus to improve signal-to-noise ratio of ft-ir spectrometers using pulsed light source
KR102370530B1 (en) * 2019-03-22 2022-03-07 스페클립스 주식회사 Diagnosis method using laser induced breakdown spectroscopy and diagnosis device performing the same
DE102020117043B3 (en) 2020-06-29 2021-12-02 Becker & Hickl Gmbh Short-term spectroscopy method and short-term spectroscopy device

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3768908A (en) * 1971-01-04 1973-10-30 S Zaromb Remote sensing apparatus and methods
US4802761A (en) * 1987-08-31 1989-02-07 Western Research Institute Optical-fiber raman spectroscopy used for remote in-situ environmental analysis
JPH01321340A (en) * 1988-06-23 1989-12-27 Osaka Oxygen Ind Ltd Laser double stage excitation emission analysis method and apparatus
US4981138A (en) * 1988-06-30 1991-01-01 Yale University Endoscopic fiberoptic fluorescence spectrometer
US5033853A (en) * 1989-04-10 1991-07-23 Coherent, Inc. Apparatus for autocorrelating optical radiation signals
US4973848A (en) * 1989-07-28 1990-11-27 J. Mccaughan Laser apparatus for concurrent analysis and treatment
US5204517A (en) * 1991-12-24 1993-04-20 Maxwell Laboratories, Inc. Method and system for control of a material removal process using spectral emission discrimination
JPH06300694A (en) 1993-04-19 1994-10-28 Osaka Gas Co Ltd Relaxation time measuring apparatus
US5608520A (en) * 1994-07-11 1997-03-04 The United States Of America As Represented By He Department Of Energy Plasma emission spectroscopy method of tumor therapy
RU2096051C1 (en) * 1995-02-24 1997-11-20 Григорий Борисович Альтшулер Apparatus for laser treatment of biological tissues (alternative embodiments)
US5720894A (en) * 1996-01-11 1998-02-24 The Regents Of The University Of California Ultrashort pulse high repetition rate laser system for biological tissue processing
GB9611942D0 (en) * 1996-06-07 1996-08-07 Lumonics Ltd Focus control of lasers in material processing operations
US5842995A (en) * 1996-06-28 1998-12-01 Board Of Regents, The Univerisity Of Texas System Spectroscopic probe for in vivo measurement of raman signals
US6156030A (en) * 1997-06-04 2000-12-05 Y-Beam Technologies, Inc. Method and apparatus for high precision variable rate material removal and modification
US6008896A (en) * 1998-07-01 1999-12-28 National Research Council Of Canada Method and apparatus for spectroscopic analysis of heterogeneous materials
US6008897A (en) * 1999-01-19 1999-12-28 National Research Council Of Canada Method and apparatus for materials analysis by enhanced laser induced plasma spectroscopy

Also Published As

Publication number Publication date
US6463314B1 (en) 2002-10-08
EP0985922A4 (en) 2001-06-20
JP3594794B2 (en) 2004-12-02
JPH11271226A (en) 1999-10-05
EP0985922B1 (en) 2004-12-15
WO1999049300A1 (en) 1999-09-30
DE69922601T2 (en) 2005-12-08
CA2291022C (en) 2006-11-21
EP0985922A1 (en) 2000-03-15
DE69922601D1 (en) 2005-01-20

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