CA2298733A1 - Hyaluronic acid derivatives for the preparation of haemostatic biomaterials for use following anastomosis - Google Patents

Hyaluronic acid derivatives for the preparation of haemostatic biomaterials for use following anastomosis Download PDF

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Publication number
CA2298733A1
CA2298733A1 CA002298733A CA2298733A CA2298733A1 CA 2298733 A1 CA2298733 A1 CA 2298733A1 CA 002298733 A CA002298733 A CA 002298733A CA 2298733 A CA2298733 A CA 2298733A CA 2298733 A1 CA2298733 A1 CA 2298733A1
Authority
CA
Canada
Prior art keywords
preparation
biomaterials
haemostatic
hyaluronic acid
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002298733A
Other languages
French (fr)
Other versions
CA2298733C (en
Inventor
Alberto Rivarossa
Daniele Pressato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anika Therapeutics SRL
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2298733A1 publication Critical patent/CA2298733A1/en
Application granted granted Critical
Publication of CA2298733C publication Critical patent/CA2298733C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical haemostatic activity, to be used in both venous and arterial vascular anastomoses and to prevent the formation of post-surgical adherence of the vessels with the surrounding tissues scar formation.
CA002298733A 1997-07-28 1998-07-28 Hyaluronic acid derivatives for the preparation of haemostatic biomaterials for use following anastomosis Expired - Lifetime CA2298733C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT97PD000170A IT1294797B1 (en) 1997-07-28 1997-07-28 USE OF HYALURONIC ACID DERIVATIVES IN THE PREPARATION OF BIOMATERIALS WITH PHYSICAL AND BUFFERING HEMOSTATIC ACTIVITIES
ITPD97A000170 1997-07-28
PCT/EP1998/004716 WO1999004828A2 (en) 1997-07-28 1998-07-28 Use of hyaluronic acid derivatives in the preparation of biomaterials

Publications (2)

Publication Number Publication Date
CA2298733A1 true CA2298733A1 (en) 1999-02-04
CA2298733C CA2298733C (en) 2009-09-01

Family

ID=11391877

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002298733A Expired - Lifetime CA2298733C (en) 1997-07-28 1998-07-28 Hyaluronic acid derivatives for the preparation of haemostatic biomaterials for use following anastomosis

Country Status (13)

Country Link
US (1) US7202230B2 (en)
EP (1) EP0999859B1 (en)
JP (1) JP4417547B2 (en)
AT (1) ATE311208T1 (en)
AU (1) AU749627B2 (en)
CA (1) CA2298733C (en)
DE (1) DE69832616T2 (en)
DK (1) DK0999859T3 (en)
ES (1) ES2253827T3 (en)
HK (1) HK1028210A1 (en)
IL (2) IL134140A0 (en)
IT (1) IT1294797B1 (en)
WO (1) WO1999004828A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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IT1306679B1 (en) * 1999-06-29 2001-10-02 Fidia Advanced Biopolymers Srl USE OF HYALURONIC ACID DERIVATIVES FOR THE PREPARATION OF PHARMACEUTICAL AND BIOMATERIAL COMPOSITIONS FOR THE PREVENTION OF
US7094428B2 (en) 2000-06-16 2006-08-22 The University Of Medicine And Dentistry Of New Jersey Hemostatic compositions, devices and methods
WO2001097826A2 (en) * 2000-06-16 2001-12-27 University Of Medicine And Dentistry Of New Jersey Hemostatic compositions, devices and methods
US6235796B1 (en) * 2000-06-26 2001-05-22 Sarfaraz K. Niazi Use of fluorocarbons for the prevention of surgical adhesions
EP1659143A4 (en) * 2003-07-28 2008-10-08 Teijin Ltd Temperature-responsive hydrogel
DE10349722A1 (en) * 2003-10-23 2005-06-16 Beschorner, Katharina, Dr. Composition for arthritis / arthritis treatment, in particular of joints
AU2005262070B2 (en) * 2004-07-09 2011-01-27 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
ITPD20040245A1 (en) * 2004-10-08 2005-01-08 Fidia Advanced Biopolymers Srl BIOMATERIALS MADE UP OF HYALURONIC ACID, SULFATE AND GELL, USABLE IN THE PREVENTION OF SPINAL ADHESIONS
ES2313445T3 (en) * 2004-12-14 2009-03-01 Fidia Advanced Biopolymers S.R.L. PROCEDURE FOR THE PREPARATION OF BI- AND THREE-DIMENSIONAL POLYMER ARMS.
ITPD20040312A1 (en) * 2004-12-15 2005-03-15 Fidia Advanced Biopolymers Srl PROSTHESIS AND SUPPORT FOR REPLACEMENT, REPAIR, REGENERATION OF THE MENISCUS
ITPD20050206A1 (en) * 2005-07-07 2007-01-08 Fidia Advanced Biopolymers Srl BIOMATERIALS IN THE FORM OF FIBER TO BE USED AS MEDICAL DEVICES IN THE TREATMENT OF WOUNDS AND THEIR PROCESSES OF PRODUCTION
ITMI20051415A1 (en) * 2005-07-22 2007-01-23 Fidia Advanced Biopolymers Srl BIOMATERIALS BASED ON SALT-MADE CORBOSSIMETHYLCELLULOSE WITH ZINC ASSOCIATED WITH IALURONIC ACID DERIVATIVES TO BE USED AS MEDICAL DEVICES WITH ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY AND THEIR PRODUCTION PROCESS
JP2009529374A (en) * 2006-03-07 2009-08-20 アクスル インターナショナル Bioactive scaffolds for treatment and adhesion prevention
ITPD20060219A1 (en) 2006-05-31 2007-12-01 Fidia Farmaceutici PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID SULFATED IN THE TREATMENT OF OSTEOARTHROSIS
JP5569398B2 (en) 2008-02-29 2014-08-13 フェッローサン メディカル ディバイス エー／エス Device for promoting hemostasis and / or wound healing
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
KR101594552B1 (en) * 2008-04-04 2016-02-17 유니버시티 오브 유타 리서치 파운데이션 Alkylated sem-synthetic glycosaminoglycosan ethers, and methods for making and using thereof
AU2009288118B2 (en) 2008-09-02 2014-12-11 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
TWI458833B (en) 2010-05-11 2014-11-01 Univ China Medical Nanometal dispersion and method for preparing the same
EP2688402B1 (en) 2011-03-23 2018-10-24 University of Utah Research Foundation Means for treating or preventing urological inflammation
EP2822474B1 (en) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
AU2013275758B2 (en) 2012-06-12 2015-03-12 Ferrosan Medical Devices A/S Dry haemostatic composition
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
JP6489485B2 (en) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ／エス Dry composition containing an extrusion enhancing factor
HUE057871T2 (en) 2014-02-27 2022-06-28 Synartro Ab Hyaluronan conjugates with pharmaceutically active substances, methods and compositions
BR112017007466B1 (en) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S method for preparing a dry composition, method for reconstituting the dry composition, paste, dry composition, container, homeostatic kit, and, using a dry composition
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
KR20180027126A (en) * 2016-09-06 2018-03-14 (주)한국비엠아이 Hemostatic Composition comprising cross-linked hyaluronic acid derivative matrix
US11337994B2 (en) 2016-09-15 2022-05-24 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
AU2019266529A1 (en) 2018-05-09 2020-12-03 Ethicon Inc. Method for preparing a haemostatic composition
KR101980063B1 (en) * 2019-01-25 2019-05-17 주식회사 휴메딕스 Sponge Type Biodegradable Hemostatic Compositions Containing Hyaluronic Acid
CN113754795B (en) * 2021-10-19 2023-03-10 澳门大学 Sulfonated hyaluronic acid compound, preparation method and application thereof

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US5202431A (en) 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
IT1203814B (en) 1986-06-30 1989-02-23 Fidia Farmaceutici ESTERS OF ALGINIC ACID
IT1198449B (en) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani ESTERS OF POLYVALENT ALCOHOLS OF HYALURONIC ACID
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1219587B (en) * 1988-05-13 1990-05-18 Fidia Farmaceutici SELF-CROSS-LINKED CARBOXYLY POLYSACCHARIDES
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Also Published As

Publication number Publication date
IT1294797B1 (en) 1999-04-15
WO1999004828A2 (en) 1999-02-04
WO1999004828A3 (en) 1999-06-10
ATE311208T1 (en) 2005-12-15
JP4417547B2 (en) 2010-02-17
EP0999859A2 (en) 2000-05-17
DE69832616D1 (en) 2006-01-05
JP2001510713A (en) 2001-08-07
ES2253827T3 (en) 2006-06-01
US7202230B2 (en) 2007-04-10
CA2298733C (en) 2009-09-01
HK1028210A1 (en) 2001-02-09
IL134140A0 (en) 2001-04-30
EP0999859B1 (en) 2005-11-30
AU9255598A (en) 1999-02-16
DK0999859T3 (en) 2006-03-27
AU749627B2 (en) 2002-06-27
IL134140A (en) 2006-08-20
US20030060448A1 (en) 2003-03-27
ITPD970170A1 (en) 1999-01-28
DE69832616T2 (en) 2006-08-17

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