CA2304819A1 - Perforated microparticles and methods of use - Google Patents
Perforated microparticles and methods of use Download PDFInfo
- Publication number
- CA2304819A1 CA2304819A1 CA002304819A CA2304819A CA2304819A1 CA 2304819 A1 CA2304819 A1 CA 2304819A1 CA 002304819 A CA002304819 A CA 002304819A CA 2304819 A CA2304819 A CA 2304819A CA 2304819 A1 CA2304819 A1 CA 2304819A1
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- CA
- Canada
- Prior art keywords
- particles
- methods
- perforated microparticles
- microparticles
- perforated
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen
Abstract
Engineered particles are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the particles may be used in conjunction with an inhalation device such as a dry powder inhaler, metered dose inhaler or a nebulizer.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6033797P | 1997-09-29 | 1997-09-29 | |
US60/060,337 | 1997-09-29 | ||
US10693298A | 1998-06-29 | 1998-06-29 | |
US09/106,932 | 1998-06-29 | ||
US13384898A | 1998-08-14 | 1998-08-14 | |
US09/133,848 | 1998-08-14 | ||
PCT/US1998/020602 WO1999016419A1 (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2304819A1 true CA2304819A1 (en) | 1999-04-08 |
CA2304819C CA2304819C (en) | 2008-04-08 |
Family
ID=27369827
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002304820A Expired - Fee Related CA2304820C (en) | 1997-09-29 | 1998-09-29 | Stabilized bioactive preparations and methods of use |
CA002304975A Expired - Lifetime CA2304975C (en) | 1997-09-29 | 1998-09-29 | Stabilized preparations for use in metered dose inhalers |
CA002304973A Expired - Fee Related CA2304973C (en) | 1997-09-29 | 1998-09-29 | Stabilized preparations for use in nebulizers |
CA002304819A Expired - Lifetime CA2304819C (en) | 1997-09-29 | 1998-09-29 | Perforated microparticles and methods of use |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002304820A Expired - Fee Related CA2304820C (en) | 1997-09-29 | 1998-09-29 | Stabilized bioactive preparations and methods of use |
CA002304975A Expired - Lifetime CA2304975C (en) | 1997-09-29 | 1998-09-29 | Stabilized preparations for use in metered dose inhalers |
CA002304973A Expired - Fee Related CA2304973C (en) | 1997-09-29 | 1998-09-29 | Stabilized preparations for use in nebulizers |
Country Status (28)
Country | Link |
---|---|
EP (4) | EP1019021B2 (en) |
JP (9) | JP5372306B2 (en) |
KR (4) | KR100589926B1 (en) |
CN (1) | CN1169520C (en) |
AT (3) | ATE248583T1 (en) |
AU (4) | AU757337C (en) |
BG (1) | BG64816B1 (en) |
BR (1) | BR9812693A (en) |
CA (4) | CA2304820C (en) |
CZ (1) | CZ300758B6 (en) |
DE (2) | DE69813853T3 (en) |
DK (2) | DK1019022T4 (en) |
EA (2) | EA002562B1 (en) |
EE (1) | EE04628B1 (en) |
ES (3) | ES2195415T3 (en) |
HK (1) | HK1031680A1 (en) |
HR (1) | HRP20000175B1 (en) |
IL (2) | IL135126A0 (en) |
IS (1) | IS2154B (en) |
ME (1) | MEP4108A (en) |
NO (1) | NO340149B1 (en) |
NZ (1) | NZ503464A (en) |
PL (1) | PL195212B1 (en) |
PT (1) | PT1019022E (en) |
RS (1) | RS50182B (en) |
SK (1) | SK285068B6 (en) |
TR (1) | TR200000819T2 (en) |
WO (3) | WO1999016421A1 (en) |
Families Citing this family (233)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6433040B1 (en) | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6946117B1 (en) * | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
EP1019021B2 (en) * | 1997-09-29 | 2012-12-26 | Novartis AG | Stabilized preparations for use in metered dose inhalers |
GB9727102D0 (en) * | 1997-12-22 | 1998-02-25 | Andaris Ltd | Microparticles and their therapeutic use |
WO2000000215A1 (en) * | 1998-06-29 | 2000-01-06 | Inhale Therapeutic Systems, Inc. | Particulate delivery systems and methods of use |
EP1091755A1 (en) * | 1998-06-29 | 2001-04-18 | Alliance Pharmaceutical Corporation | Particulate delivery systems and methods of use |
US6630169B1 (en) | 1999-03-31 | 2003-10-07 | Nektar Therapeutics | Particulate delivery systems and methods of use |
US6223455B1 (en) † | 1999-05-03 | 2001-05-01 | Acusphere, Inc. | Spray drying apparatus and methods of use |
KR100752000B1 (en) * | 1999-05-27 | 2007-08-28 | 아쿠스피어 인코포레이티드. | Methods of manufacturing porous drug matrices |
CN1198593C (en) | 1999-06-09 | 2005-04-27 | 罗伯特·E·希弗斯 | Supercritical fluid-assisted nebulization and bubble drying |
US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
EP1210067A2 (en) * | 1999-08-25 | 2002-06-05 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
US6761909B1 (en) | 1999-12-21 | 2004-07-13 | Rxkinetix, Inc. | Particulate insulin-containing products and method of manufacture |
AU2729101A (en) | 1999-12-21 | 2001-07-03 | Rxkinetix, Inc. | Particulate drug-containing products and method of manufacture |
DE60113388T2 (en) | 2000-02-08 | 2006-06-14 | 3M Innovative Properties Co | IMPROVED METHODS FOR COLD IMAGE TRANSFER |
JP2003522304A (en) | 2000-02-08 | 2003-07-22 | スリーエム イノベイティブ プロパティズ カンパニー | Ink fixing material and ink fixing method |
GB0003935D0 (en) * | 2000-02-08 | 2000-04-12 | King S College London | Formulation for dry powder inhaler |
MXPA02001323A (en) | 2000-05-10 | 2004-07-16 | Alliance Pharma | Phospholipid-based powders for drug delivery. |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
US7871598B1 (en) * | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
WO2001087277A2 (en) * | 2000-05-15 | 2001-11-22 | Vectura Limited | Method of manufacturing particles |
NZ523693A (en) * | 2000-07-10 | 2004-08-27 | Chiron Corp | Macrolide formulations for inhalation and methods of treatment of endobronchial infections |
US7141236B2 (en) | 2000-07-28 | 2006-11-28 | Nektar Therapeutics | Methods and compositions for delivering macromolecules to or via the respiratory tract |
DE10064219B9 (en) * | 2000-12-22 | 2009-02-12 | Nasalis Pain Relief International Gmbh | Novel pharmaceutical composition containing fentanyl and / or its derivatives |
US20030072717A1 (en) | 2001-02-23 | 2003-04-17 | Vapotronics, Inc. | Inhalation device having an optimized air flow path |
GB0106403D0 (en) * | 2001-03-15 | 2001-05-02 | Pharmaceutical Profiles | Labelling of dry powder formulations for inhalation |
GB0107106D0 (en) * | 2001-03-21 | 2001-05-09 | Boehringer Ingelheim Pharma | Powder inhaler formulations |
EP1390012A4 (en) * | 2001-04-26 | 2009-10-28 | Novartis Ag | Novel methods and compositions for delivering macromolecules to or via the respiratory tract |
US7905230B2 (en) | 2001-05-09 | 2011-03-15 | Novartis Ag | Metered dose inhaler with lockout |
CN1236831C (en) * | 2001-05-21 | 2006-01-18 | 茵捷特数码浮质有限公司 | Compositions for protein delivery via the pulmonary route |
US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
ATE415155T1 (en) | 2001-05-24 | 2008-12-15 | Alexza Pharmaceuticals Inc | ADMINISTRATION OF ALPRAZOLAM, ESTAZOLAM, MIDAZOLAM, OR TRIAZOLAM BY INHALATION |
US7078016B2 (en) | 2001-11-21 | 2006-07-18 | Alexza Pharmaceuticals, Inc. | Delivery of caffeine through an inhalation route |
JP2005503425A (en) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | Delivery of drug ester by the prescribed inhalation route |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
WO2002094242A1 (en) | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of rizatriptan or zolmitriptan through an inhalation route |
US6805853B2 (en) | 2001-11-09 | 2004-10-19 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
TW553752B (en) | 2001-06-20 | 2003-09-21 | Inhale Therapeutic Syst | Powder aerosolization apparatus and method |
EP1487417A4 (en) * | 2001-09-17 | 2010-03-17 | Glaxo Group Ltd | Dry powder medicament formulations |
WO2003037303A1 (en) | 2001-11-01 | 2003-05-08 | Nektar Therapeutics | Spray drying methods and compositions thereof |
CA2468958C (en) | 2001-12-19 | 2012-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
AU2002351271A1 (en) | 2001-12-21 | 2003-07-24 | Nektar Therapeutics | Capsule package with moisture barrier |
JPWO2003077891A1 (en) * | 2002-03-18 | 2005-07-14 | アステラス製薬株式会社 | Powder pharmaceutical composition for inhalation and method for producing the same |
US7008644B2 (en) | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
US6941980B2 (en) | 2002-06-27 | 2005-09-13 | Nektar Therapeutics | Apparatus and method for filling a receptacle with powder |
PA8578501A1 (en) | 2002-07-25 | 2005-02-04 | Pharmacia Corp | DOSAGE FORM ONCE A DAY OF PRAMIPEXOL |
WO2004030659A1 (en) * | 2002-09-30 | 2004-04-15 | Acusphere, Inc. | Sustained release porous microparticles for inhalation |
US7516741B2 (en) | 2002-12-06 | 2009-04-14 | Novartis Ag | Aerosolization apparatus with feedback mechanism |
WO2004054556A1 (en) * | 2002-12-13 | 2004-07-01 | Adagit | Pharmaceutical porous particles |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
US7669596B2 (en) | 2002-12-31 | 2010-03-02 | Novartis Pharma Ag | Aerosolization apparatus with rotating capsule |
BR0317810A (en) * | 2002-12-31 | 2005-11-29 | Nektar Therapeutics | Pharmaceutical formulation and method of manufacturing the same |
US7638138B2 (en) | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
JP4607010B2 (en) * | 2003-02-28 | 2011-01-05 | 中外製薬株式会社 | Protein-containing stabilized preparation |
KR100974482B1 (en) | 2003-03-27 | 2010-08-10 | 가부시키가이샤 바이오악티스 | Powder medicine applicator for nasal cavity |
PT1610850E (en) | 2003-04-09 | 2012-06-15 | Novartis Ag | Aerosolization apparatus with air inlet shield |
EP1615689B1 (en) | 2003-04-09 | 2016-02-03 | Novartis AG | Aerosolization apparatus with capsule puncture alignment guide |
US8869794B1 (en) | 2003-04-09 | 2014-10-28 | Novartis Pharma Ag | Aerosolization apparatus with capsule puncturing member |
ATE510174T1 (en) | 2003-05-21 | 2011-06-15 | Alexza Pharmaceuticals Inc | IMPACT LIT INDEPENDENT HEATING UNIT |
MXPA05012821A (en) | 2003-05-28 | 2006-02-13 | Nektar Therapeutics | Pharmaceutical formulation comprising a water-insoluble active agent. |
CN1856296A (en) * | 2003-09-30 | 2006-11-01 | 阿库斯菲尔公司 | Injectable, oral, or topical sustained release pharmaceutical formulations |
US7621299B2 (en) | 2003-10-03 | 2009-11-24 | Cabot Corporation | Method and apparatus for filling a vessel with particulate matter |
JP2007509989A (en) * | 2003-10-31 | 2007-04-19 | ポイント バイオメディカル コーポレイション | Reconfigurable microsphere composition useful as an ultrasound contrast agent |
EP1701714A2 (en) | 2004-01-07 | 2006-09-20 | Nektar Therapeutics | Improved sustained release compositions for pulmonary administration of insulin |
JP2007532619A (en) * | 2004-04-13 | 2007-11-15 | ケンブリッジ バイオスタビリティ リミテッド | Liquid containing suspended glass particles |
ITMI20040795A1 (en) | 2004-04-23 | 2004-07-23 | Eratech S R L | DRY SOLID PHARMACEUTICAL COMPOSITION ON ITS STABLE WATER PREPARATION AND SUSPENSION PROCESS OBTAINED BY ITSELF |
US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
MXPA06015220A (en) | 2004-06-21 | 2007-12-13 | Nektar Therapeutics | Compositions comprising amphotericin b. |
WO2006016530A1 (en) | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | Transnasal composition having immediate action and high absorbability |
PT1789021E (en) | 2004-08-13 | 2011-12-22 | Boehringer Ingelheim Int | Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof |
JP4971159B2 (en) | 2004-08-13 | 2012-07-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Sustained release pellet preparation containing pramipexole or a pharmaceutically acceptable salt thereof, its production method and use |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
CN101180038A (en) | 2005-03-23 | 2008-05-14 | 伊兰制药国际有限公司 | Nanoparticulate corticosteroid and antihistamine formulations |
PA8672101A1 (en) | 2005-04-29 | 2006-12-07 | Centocor Inc | ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES |
WO2006124446A2 (en) * | 2005-05-12 | 2006-11-23 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
EP1893273B1 (en) | 2005-05-18 | 2014-06-25 | Nektar Therapeutics | Adapter for use with aerosolization device for endobronchial therapy |
PA8675801A1 (en) | 2005-05-19 | 2006-12-07 | Centocor Inc | ANTI-MCP-1 ANTIBODIES, COMPOSITIONS, METHODS AND USES |
EP1896073B1 (en) | 2005-06-30 | 2013-03-06 | Janssen Biotech, Inc. | Anti-il-23 antibodies, compositions, methods and uses |
ITMI20051999A1 (en) * | 2005-10-21 | 2007-04-22 | Eratech S R L | INHALATION FORMULATIONS OF DRUGS IN DRY POWDER FOR ADMINISTRATION AS SUCH OR WITH NEBULIZER AND EQUIPPED WITH HIGH EROGABILITY RESPIRABILITY AND STABILITY |
JP5113328B2 (en) * | 2005-11-07 | 2013-01-09 | 田辺三菱製薬株式会社 | Emulsion, method for producing target substance particles using the same, and pharmaceutical product |
JP5096363B2 (en) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | GLP-1 polymer complex |
HUE049832T2 (en) | 2005-12-29 | 2020-10-28 | Janssen Biotech Inc | Human anti-il-23 antibodies, compositions, method and uses |
US20100226990A1 (en) * | 2006-01-27 | 2010-09-09 | The Provost, Fellows And Scholars Of The College O | Method of Producing Porous Microparticles |
DE602007009377D1 (en) | 2006-05-30 | 2010-11-04 | Intarcia Therapeutics Inc | SECONDARY FLOW MODULATOR WITH AN INTERNAL CHANNEL FOR AN OSMOTIC OUTPUT SYSTEM |
CN102274557B (en) | 2006-08-09 | 2014-12-03 | 精达制药公司 | Osmotic delivery systems and piston assemblies |
US8337817B2 (en) | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
DK2157967T3 (en) | 2007-04-23 | 2013-04-08 | Intarcia Therapeutics Inc | Suspension formulations of insulinotropic peptides and applications thereof |
WO2009023803A2 (en) * | 2007-08-15 | 2009-02-19 | Abbott Respiratory Llc | Modulated release formulation for the delivery of one or more medicaments |
US8343140B2 (en) | 2008-02-13 | 2013-01-01 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
WO2009120619A2 (en) * | 2008-03-24 | 2009-10-01 | Novartis Ag | Nuclease compositions, methods of making and using such compositions, and systems for pulmonary delivery of such compositions |
PL220269B1 (en) | 2008-04-21 | 2015-09-30 | Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna | Composite carrier of powdered medicines, method of production the medicine carrier and equipment for production of particles of composite carrier |
MX2010012452A (en) | 2008-05-15 | 2011-03-15 | Novartis Ag Star | Pulmonary delivery of a fluoroquinolone. |
WO2010033240A2 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
BRPI0919881B1 (en) | 2008-10-31 | 2021-09-08 | Centocor Ortho Biotech Inc | FRAMEWORK PROTEIN AND ITS GENERATION METHOD, LIBRARY AND ITS CONSTRUCTION METHOD, NUCLEIC ACID MOLECULE, NUCLEIC ACID VECTOR, HOST CELL, COMPOSITION, MEDICAL DEVICE AND MANUFACTURING ARTICLE |
BRPI0916047A2 (en) * | 2008-11-04 | 2015-11-10 | Cipla Ltd | aerosol pharmaceutical composition, use of an aerosol pharmaceutical composition, method for treating severe, moderate or mild acute or chronic symptoms, or for prophylactic treatment of a respiratory disorder, aerosol pharmaceutical dispenser, process for manufacturing an aerosol pharmaceutical dispenser and process for making a complex of an active agent and an adjuvant |
US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
EP2396011B1 (en) | 2009-02-12 | 2016-04-13 | Janssen Biotech, Inc. | Fibronectin type iii domain based scaffold compositions, methods and uses |
EP2221048A1 (en) | 2009-02-18 | 2010-08-25 | Siegfried Generics International AG | Pharmaceutical composition for inhalation |
DK2413902T3 (en) | 2009-03-18 | 2019-10-07 | Incarda Therapeutics Inc | Unit doses, aerosols, kits and methods for treating cardiac conditions by pulmonary administration |
CA2754691C (en) | 2009-03-26 | 2019-07-30 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
GB0908129D0 (en) * | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
KR20100123240A (en) * | 2009-05-15 | 2010-11-24 | 포항공과대학교 산학협력단 | Respiratory administering pharmaceutical agent for treating or preventing respiratory inflammatory diseases and method for treating or preventing the same diseases |
US9101539B2 (en) | 2009-05-15 | 2015-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
AR076621A1 (en) * | 2009-05-29 | 2011-06-22 | Pearl Therapeutics Inc | COMPOSITIONS FOR THE SUPPLY OF MUSCARINIC ANTAGONISTS OF PROLONGED ACTION AND AGONIST OF THE ADRENERGIC RECEIVER B2 OF PROLONGED ACTION. TREATMENT METHOD ASSOCIATED SYSTEMS. DOSING INHALER |
GB2472327B (en) | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
LT2462246T (en) | 2009-09-28 | 2017-11-27 | Intarcia Therapeutics, Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
CN102811715A (en) * | 2009-12-08 | 2012-12-05 | 悉尼大学 | Inhalable Formulations |
CN103200938B (en) | 2010-08-30 | 2018-07-31 | 普马特里克斯营业公司 | Dried powder formula and method for treating pulmonary disease |
EP2464346A1 (en) | 2010-08-30 | 2012-06-20 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
AU2011314007B2 (en) | 2010-09-29 | 2017-01-19 | Pulmatrix, Inc. | Cationic dry powders |
EP4008326A1 (en) | 2010-09-29 | 2022-06-08 | Pulmatrix Operating Company, Inc. | Monovalent metal cation dry powders for inhalation |
AU2011320159B2 (en) * | 2010-10-29 | 2016-12-22 | Western University Of Health Sciences | Ternary mixture formulations |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
CA2827990A1 (en) * | 2011-02-25 | 2012-08-30 | The Johns Hopkins University | Chalcone derivatives as nrf2 activators |
GB201108039D0 (en) | 2011-05-13 | 2011-06-29 | Mexichem Amanco Holding Sa | Compositions |
EA201490991A1 (en) * | 2011-05-17 | 2014-09-30 | Перл Терапьютикс, Инк. | COMPOSITIONS, METHODS AND DEVICES FOR RESPIRATORY DELIVERY TWO OR MORE ACTIVE MEANS |
GB201117621D0 (en) | 2011-10-12 | 2011-11-23 | Mexichem Amanco Holding Sa | Compositions |
GB201117619D0 (en) | 2011-10-12 | 2011-11-23 | Mexichem Amanco Holding Sa | Compositions |
EP2601941A1 (en) | 2011-12-06 | 2013-06-12 | Ludwig-Maximilians-Universität München | Beta-O/S/N fatty acid based compounds as antibacterial and antiprotozoal agents |
CA2869849A1 (en) | 2012-04-13 | 2013-10-17 | Glaxosmithkline Intellectual Property Development Limited | Aggregate particles comprising nanoparticulate drug particles of umeclidinium bromide, vilanterol trifenatate and fluticasone furoate |
US9855276B2 (en) | 2012-10-25 | 2018-01-02 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
CN105188679B (en) | 2013-03-15 | 2018-10-16 | 珍珠治疗公司 | The method and system of status adjustment for Fine crystals material |
GB201306984D0 (en) * | 2013-04-17 | 2013-05-29 | Mexichem Amanco Holding Sa | Composition |
JP2016518388A (en) | 2013-04-30 | 2016-06-23 | オティトピック インク. | Dry powder formulation and usage |
KR101543507B1 (en) * | 2013-05-15 | 2015-08-11 | 씨제이헬스케어 주식회사 | A continuous process for preparing microspheres and microspheres prepared thereby |
JP2016534976A (en) * | 2013-05-23 | 2016-11-10 | アズセラピーズ インコーポレイテッド | Methods for delivering cromolyn |
US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
WO2014207213A1 (en) | 2013-06-28 | 2014-12-31 | Medizinische Universität Innsbruck | Novel inhibitors of protein kinase c epsilon signaling |
CN110305095A (en) * | 2013-10-22 | 2019-10-08 | 综合医院公司 | Cromoglycic acid derivative and the correlation technique of imaging and treatment |
CN106456595A (en) | 2014-02-10 | 2017-02-22 | 帕塔拉制药有限责任公司 | Mast cell stabilizers treatment for systemic disorders |
DK3104854T3 (en) | 2014-02-10 | 2020-05-04 | Respivant Sciences Gmbh | MAST-CELL STABILIZERS FOR HEALTH DISEASE TREATMENT |
WO2015127315A1 (en) | 2014-02-20 | 2015-08-27 | Otitopic Inc. | Dry powder formulations for inhalation |
EP2947460A1 (en) | 2014-05-22 | 2015-11-25 | Medizinische Universität Wien | Personalized therapy of inflammation-associated cancer using methods of assessing the susceptibility of a subject to the treatment with EGFR inhibitors/antagonists |
PL3179986T3 (en) | 2014-07-31 | 2023-06-26 | Vectura Inc. | Dry powder formulations for inhalation |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
DK3212212T3 (en) | 2014-10-31 | 2020-12-21 | Univ Monash | POWDER FORMULATION |
JP6395216B2 (en) * | 2014-11-13 | 2018-09-26 | 国立大学法人大阪大学 | Method and apparatus for measuring ultrafine bubbles contained in liquid |
EP3247332A1 (en) | 2015-01-20 | 2017-11-29 | Incarda Therapeutics, Inc. | Unit aerosol doses for anticoagulation |
WO2016135140A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | 4-aminoquinazoline derivatives as mth1 inhibitors for the therapy of cancer |
WO2016135137A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Substituted 4-(phenylamino)quinoline derivatives as mth1 inhibitors for the therapy of cancer |
WO2016135139A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | 2,3-dihydrocyclopenta[b]quinoline derivatives as mth1 inhibitors for the therapy of cancer |
WO2016135138A1 (en) | 2015-02-23 | 2016-09-01 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Oxoquinoline derivatives as mth1 inhibitors for the therapy of cancer |
US10864190B2 (en) | 2015-04-22 | 2020-12-15 | CeMM—FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GmbH | Combination of an antiandrogen with a vitamin K antagonist or with a gamma-glutamyl carboxylase inhibitor for the therapy of androgen receptor positive cancer |
CN113598842A (en) | 2015-06-03 | 2021-11-05 | 因塔西亚制药公司 | Implant placement and removal system |
US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
US11559505B2 (en) | 2015-12-04 | 2023-01-24 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
US10723748B2 (en) | 2015-12-09 | 2020-07-28 | Medizinische Universität Wien | Monomaleimide-functionalized platinum compounds for cancer therapy |
KR20190031425A (en) | 2016-01-15 | 2019-03-26 | 함부르크대학교 | Flavonoid-type compounds having an O-lambsyl residue |
SG10202012584UA (en) | 2016-02-01 | 2021-01-28 | Incarda Therapeutics Inc | Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation |
AU2017220611A1 (en) | 2016-02-15 | 2018-08-30 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | TAF1 inhibitors for the therapy of cancer |
CN109071653A (en) | 2016-03-29 | 2018-12-21 | 詹森生物科技公司 | Psoriasis is treated with the increased anti-antibody administration of IL12 and/or -23 interval |
WO2017178820A1 (en) | 2016-04-15 | 2017-10-19 | Oxford University Innovation Limited | Adenosine receptor modulators for the treatment of circadian rhythm disorders |
EP3458084B1 (en) | 2016-05-16 | 2020-04-01 | Intarcia Therapeutics, Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
RU2019104075A (en) | 2016-07-15 | 2020-08-17 | Посейда Терапьютикс, Инк. | CHIMERIC ANTIGEN RECEPTORS (CAR) SPECIFIC FOR MUC1 AND METHODS OF THEIR APPLICATION |
US20190177421A1 (en) | 2016-07-15 | 2019-06-13 | Poseida Therapeutics, Inc. | Chimeric antigen receptors and methods for use |
JP2019528320A (en) | 2016-08-31 | 2019-10-10 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングRespivant Sciences Gmbh | Cromolyn composition for the treatment of chronic cough due to idiopathic pulmonary fibrosis |
AU2017321782B2 (en) | 2016-08-31 | 2022-03-10 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
EP3515432B1 (en) | 2016-09-19 | 2021-08-25 | Mexichem Fluor S.A. de C.V. | Pharmaceutical composition comprising glycopyrrolate |
MX2019003103A (en) | 2016-09-19 | 2019-08-01 | Mexichem Fluor Sa De Cv | Pharmaceutical composition. |
CN113288869A (en) | 2016-09-19 | 2021-08-24 | 墨西哥氟石股份公司 | Pharmaceutical composition |
AU2017328910B2 (en) | 2016-09-19 | 2020-04-09 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
JP2020500152A (en) | 2016-09-30 | 2020-01-09 | ヤンセン バイオテツク,インコーポレーテツド | Safe and effective method of treating psoriasis with anti-IL23 specific antibody |
WO2018067341A1 (en) | 2016-10-07 | 2018-04-12 | Patara Pharma, LLC | Cromolyn compositions for treatment of pulmonary fibrosis |
CN110225755A (en) | 2016-11-14 | 2019-09-10 | 分子医学研究中心责任有限公司 | The combination of BRD4 inhibitor and antifol is used for treating cancer |
MX2019005661A (en) | 2016-11-16 | 2019-10-07 | Janssen Biotech Inc | Method of treating psoriasis with anti-il-23 specific antibody. |
EP3565580B1 (en) | 2017-01-03 | 2024-03-06 | i2o Therapeutics, Inc. | Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel |
KR20200003199A (en) | 2017-05-10 | 2020-01-08 | 인카다 테라퓨틱스, 인크. | Unit doses, aerosols, kits and methods for treating heart conditions by pulmonary administration |
EP3630154A4 (en) | 2017-05-22 | 2021-03-10 | Insmed Incorporated | Lipo-glycopeptide cleavable derivatives and uses thereof |
MX2020000577A (en) | 2017-07-20 | 2020-09-10 | Aztherapies Inc | Powdered formulations of cromolyn sodium and ibuprofen. |
CN111727256A (en) | 2017-09-08 | 2020-09-29 | 波赛达治疗公司 | Compositions and methods for Chimeric Ligand Receptor (CLR) -mediated conditional gene expression |
TW201922780A (en) | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | Safe and effective method of treating Lupus with anti-IL12/IL23 antibody |
US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
WO2019110139A1 (en) | 2017-12-05 | 2019-06-13 | Eth Zurich | New compounds for use as a therapeutically active substance and in particular for use in the treatment of tumors |
EP3728305A1 (en) | 2017-12-20 | 2020-10-28 | Poseida Therapeutics, Inc. | Vcar compositions and methods for use |
EP3762015A4 (en) | 2018-03-05 | 2022-04-27 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
WO2019173636A1 (en) | 2018-03-07 | 2019-09-12 | Poseida Therapeutics, Inc. | Cartyrin compositions and methods for use |
US10744087B2 (en) | 2018-03-22 | 2020-08-18 | Incarda Therapeutics, Inc. | Method to slow ventricular rate |
AU2019247641A1 (en) | 2018-04-06 | 2020-11-12 | Zilentin AG | Bumetanide derivatives for the therapy of hyperhidrosis |
WO2019193161A1 (en) | 2018-04-06 | 2019-10-10 | Universität Wien | Bumetanide derivatives for the therapy of stroke and other neurological diseases/disorders involving nkccs |
JP2021523138A (en) | 2018-05-11 | 2021-09-02 | ヤンセン バイオテツク,インコーポレーテツド | How to treat depression with IL-23 antibody |
US10414721B1 (en) | 2018-06-04 | 2019-09-17 | University Of Bern | Inhibitor of endocannabinoid cellular reuptake |
EP3817739A4 (en) | 2018-07-02 | 2022-04-13 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and ?-lactose |
JP2021530697A (en) | 2018-07-18 | 2021-11-11 | ヤンセン バイオテツク,インコーポレーテツド | Sustained response predictor after treatment with anti-IL23 specific antibody |
BR112021005467A2 (en) | 2018-09-24 | 2021-06-22 | Janssen Biotech, Inc. | safe and effective method to treat ulcerative colitis with anti-il12/il23 antibody |
CN113395979A (en) | 2018-11-20 | 2021-09-14 | 詹森生物科技公司 | Safe and effective methods for treating psoriasis with anti-IL-23 specific antibodies |
EP3898614A1 (en) | 2018-12-17 | 2021-10-27 | Tolremo Therapeutics AG | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of cancer |
MA54562A (en) | 2018-12-18 | 2021-10-27 | Janssen Biotech Inc | SAFE AND EFFECTIVE METHOD OF TREATING LUPUS WITH AN ANTI-IL12/IL23 ANTIBODY |
WO2020142707A1 (en) | 2019-01-03 | 2020-07-09 | Aqua Yield Operations LLC | Pamam dendrimers for fertilizer delivery |
CA3133395A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-il12/il23 antibody compositions |
KR20210141583A (en) | 2019-03-18 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | Methods of Treating Psoriasis in Children Using Anti-IL-12/IL-23 Antibodies |
US11932585B2 (en) * | 2019-04-12 | 2024-03-19 | Aqua Yield Operations LLC | Blended nanoparticle fertilizer delivery |
CN110051868A (en) * | 2019-04-15 | 2019-07-26 | 宝盈联华(厦门)生物科技有限公司 | A kind of cabinet sterilizer with silicon-carbon rock, Lei mountain flour |
JP7404671B2 (en) * | 2019-06-25 | 2023-12-26 | 株式会社リコー | Porous fine particles and their manufacturing method, and pharmaceutical compositions |
US11020384B2 (en) | 2019-08-01 | 2021-06-01 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
MX2022003617A (en) | 2019-10-02 | 2022-05-30 | Tolremo Therapeutics Ag | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer. |
WO2021064141A1 (en) | 2019-10-02 | 2021-04-08 | Tolremo Therapeutics Ag | Inhibitors of dual specificity tyrosine phosphorylation regulated kinase 1b |
CA3157896A1 (en) | 2019-10-16 | 2021-04-22 | Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh | Oxazole and thioazole-type cullin ring ubiquitin ligase compounds and uses thereof |
WO2021074418A1 (en) | 2019-10-16 | 2021-04-22 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Carbazole-type cullin ring ubiquitin ligase compounds and uses thereof |
CN115996747A (en) | 2020-04-14 | 2023-04-21 | 波赛达治疗公司 | Compositions and methods for treating cancer |
EP4138884A1 (en) | 2020-04-20 | 2023-03-01 | Sorrento Therapeutics, Inc. | Pulmonary administration of ace2 polypeptides |
WO2021214588A1 (en) | 2020-04-21 | 2021-10-28 | Janssen Biotech, Inc. | Anti-tnf alpha agent for treating coronavirus infections |
WO2021214587A1 (en) | 2020-04-21 | 2021-10-28 | Janssen Biotech, Inc. | Anti-tnf alpha agent for treating viral infections |
CN116113417A (en) | 2020-06-25 | 2023-05-12 | 托雷莫治疗股份公司 | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of fibrotic diseases |
EP3939578A1 (en) | 2020-07-13 | 2022-01-19 | Novaremed Ltd. | Compounds for treatment or prevention of an infection resulting from a coronavirus and/or a coronavirus-induced disease |
CN111700883B (en) * | 2020-07-23 | 2021-04-06 | 深圳大佛药业股份有限公司 | Salbutamol sulfate sustained-release inhalation preparation and production process thereof |
EP3964497A1 (en) | 2020-09-04 | 2022-03-09 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Substituted vicinal diamine compounds and their use in the treatment, amelioration or prevention of pain |
US20230270669A1 (en) | 2020-09-04 | 2023-08-31 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
EP4229037A2 (en) | 2020-10-16 | 2023-08-23 | CeMM - Forschungszentrum für Molekulare Medizin GmbH | Heterocyclic cullin ring ubiquitin ligase compounds and uses thereof |
CN112495316B (en) * | 2020-10-20 | 2021-11-19 | 大连理工大学 | Method for preparing micro-nano gel microspheres based on metastable emulsion |
CN116546980A (en) * | 2020-12-11 | 2023-08-04 | 江苏恒瑞医药股份有限公司 | Pharmaceutical composition for pulmonary delivery |
WO2022189662A1 (en) | 2021-03-12 | 2022-09-15 | Alvarius Pharmaceuticals Ltd. | Compositions and methods for treating addictions comprising 5-meo-dmt |
IL305802A (en) | 2021-03-12 | 2023-11-01 | Janssen Biotech Inc | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
EP4305062A1 (en) | 2021-03-12 | 2024-01-17 | Janssen Biotech, Inc. | Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody |
AR125312A1 (en) | 2021-04-07 | 2023-07-05 | Tolremo Therapeutics Ag | HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OR IMPROVEMENT OF CANCER |
KR20240034215A (en) | 2021-07-09 | 2024-03-13 | 얀센 바이오테크 인코포레이티드 | Manufacturing Methods for Producing Anti-IL12/IL23 Antibody Compositions |
WO2023073615A1 (en) | 2021-10-29 | 2023-05-04 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
US20230151087A1 (en) | 2021-11-15 | 2023-05-18 | Janssen Biotech, Inc. | Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody |
US20230159633A1 (en) | 2021-11-23 | 2023-05-25 | Janssen Biotech, Inc. | Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody |
WO2023187707A1 (en) | 2022-03-30 | 2023-10-05 | Janssen Biotech, Inc. | Method of treating mild to moderate psoriasis with il-23 specific antibody |
WO2023203172A1 (en) | 2022-04-20 | 2023-10-26 | Proxygen Gmbh | Heterocyclic cullin ring ubiquitin ligase compounds and uses thereof |
WO2023223265A1 (en) | 2022-05-18 | 2023-11-23 | Janssen Biotech, Inc. | Method for evaluating and treating psoriatic arthritis with il23 antibody |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1410588A (en) † | 1971-08-10 | 1975-10-22 | Fisons Ltd | Composition |
JPS5134879A (en) * | 1974-09-19 | 1976-03-24 | Eisai Co Ltd | Bishochukuryushinoseizoho |
US4147766A (en) † | 1976-06-09 | 1979-04-03 | Armour Pharmaceutical Company | Macrospherical particles of anti-perspirants |
EP0072046B1 (en) * | 1981-07-24 | 1986-01-15 | FISONS plc | Inhalation drugs, methods for their production and pharmaceutical formulations containing them |
ATE93384T1 (en) * | 1983-11-14 | 1993-09-15 | Univ Kentucky Res Found | POROUS MICROBALLS FOR DRUG DELIVERY AND PROCESS FOR THEIR MANUFACTURE. |
US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
GB8502892D0 (en) * | 1985-02-05 | 1985-03-06 | Sterwin Ag | Aerosol composition |
JPS63500175A (en) * | 1985-05-22 | 1988-01-21 | リポソ−ム テクノロジ−,インコ−ポレイテツド | Liposome inhalation method and inhalation system |
US4950477A (en) † | 1988-08-23 | 1990-08-21 | Memorial Hospital For Cancer And Allied Dieseas | Method of preventing and treating pulmonary infection by fungi using aerosolized polyenes |
GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
AU620253B2 (en) * | 1989-05-01 | 1992-02-13 | Alkermes Controlled Therapeutics, Inc. | Process for producing small particles of biologically active molecules |
US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
JPH05507090A (en) * | 1990-05-08 | 1993-10-14 | リポサーム テクノロジー インコーポレイテッド | Direct spray-dried drug/lipid powder compositions |
US5126123A (en) † | 1990-06-28 | 1992-06-30 | Glaxo, Inc. | Aerosol drug formulations |
US5230884A (en) † | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
US5304125A (en) † | 1990-10-05 | 1994-04-19 | The University Of North Carolina | Apparatus for administering solid particulate aerosols to the lungs |
US5616311A (en) * | 1991-01-15 | 1997-04-01 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
DK0495187T3 (en) * | 1991-01-15 | 1997-08-11 | Hemosphere Inc | Protein nanomatrices and method of preparation. |
US5182097A (en) † | 1991-02-14 | 1993-01-26 | Virginia Commonwealth University | Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content |
CA2082951C (en) † | 1991-03-15 | 1999-12-21 | Robert M. Platz | Pulmonary administration of granulocyte colony stimulating factor |
SE9101090D0 (en) * | 1991-04-11 | 1991-04-11 | Astra Ab | PROCESS FOR CONDITIONING OF WATER-SOLUBLE SUBSTANCES |
JPH05500229A (en) * | 1991-04-12 | 1993-01-21 | 東レ株式会社 | Aerosol formulation of solid polypeptide microparticles and its manufacturing method |
DK0656206T3 (en) * | 1991-06-10 | 2001-10-08 | Schering Corp | Aerosol formulations without chlorofluorocarbon compounds |
DE69233319T2 (en) * | 1991-12-18 | 2005-02-17 | Minnesota Mining & Manufacturing Company, St. Paul | Aerosol compositions for drug suspensions |
US5376359A (en) † | 1992-07-07 | 1994-12-27 | Glaxo, Inc. | Method of stabilizing aerosol formulations |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US5354934A (en) † | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
DE4323636A1 (en) * | 1993-07-15 | 1995-01-19 | Hoechst Ag | Pharmaceutical preparations from coated, poorly water-soluble pharmaceutical substances for inhalation pharmaceutical forms and processes for their preparation |
US5798091A (en) † | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
AU694135B2 (en) * | 1993-07-30 | 1998-07-16 | Imcor Pharmaceutical Company | Stabilized microbubble compositions for ultrasound |
EP0655237A1 (en) * | 1993-11-27 | 1995-05-31 | Hoechst Aktiengesellschaft | Medicinal aerosol formulation |
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
AU701440B2 (en) * | 1994-09-29 | 1999-01-28 | Quadrant Drug Delivery Limited | Spray-dried microparticles as therapeutic vehicles |
GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
US6524557B1 (en) * | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
JP4155594B2 (en) * | 1994-12-22 | 2008-09-24 | アストラゼネカ・アクチエボラーグ | Aerosol formulation |
AU706195B2 (en) * | 1995-04-14 | 1999-06-10 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
EP1444991A1 (en) † | 1995-06-07 | 2004-08-11 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
US6041777A (en) * | 1995-12-01 | 2000-03-28 | Alliance Pharmaceutical Corp. | Methods and apparatus for closed-circuit ventilation therapy |
GB9606677D0 (en) * | 1996-03-29 | 1996-06-05 | Glaxo Wellcome Inc | Process and device |
PT954282E (en) † | 1997-01-16 | 2005-06-30 | Massachusetts Inst Technology | PREPARATION OF PARTICLES FOR INHALATION |
EP1019021B2 (en) * | 1997-09-29 | 2012-12-26 | Novartis AG | Stabilized preparations for use in metered dose inhalers |
-
1998
- 1998-09-29 EP EP98950826A patent/EP1019021B2/en not_active Expired - Lifetime
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