CA2306103A1 - Novel once-a-day controlled release sulfonylurea formulation - Google Patents
Novel once-a-day controlled release sulfonylurea formulation Download PDFInfo
- Publication number
- CA2306103A1 CA2306103A1 CA002306103A CA2306103A CA2306103A1 CA 2306103 A1 CA2306103 A1 CA 2306103A1 CA 002306103 A CA002306103 A CA 002306103A CA 2306103 A CA2306103 A CA 2306103A CA 2306103 A1 CA2306103 A1 CA 2306103A1
- Authority
- CA
- Canada
- Prior art keywords
- controlled release
- matrix
- day controlled
- dosage form
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Abstract
This invention is directed to a novel solid matrixed controlled release, oral dosage form where the dosage form contains a therapeutically effective amount of a sulfonylurea or a salt or derivative thereof in the matrix. Further, the use of an aqueous alkalizing medium affords substantially complete bioavailability of the drug from the matrix of the tablet. The core tablets may optionally be coated with a coating material in the range of 2 % to 10 %
with an enteric material or with a water insoluble material like ethyl cellulose.
with an enteric material or with a water insoluble material like ethyl cellulose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/950,732 US6056977A (en) | 1997-10-15 | 1997-10-15 | Once-a-day controlled release sulfonylurea formulation |
US08/950,732 | 1997-10-15 | ||
PCT/US1998/021752 WO1999018932A1 (en) | 1997-10-15 | 1998-10-15 | Novel once-a-day controlled release sulfonylurea formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2306103A1 true CA2306103A1 (en) | 1999-04-22 |
CA2306103C CA2306103C (en) | 2003-12-09 |
Family
ID=25490807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002306103A Expired - Fee Related CA2306103C (en) | 1997-10-15 | 1998-10-15 | Novel once-a-day controlled release sulfonylurea formulation |
Country Status (6)
Country | Link |
---|---|
US (3) | US6056977A (en) |
EP (1) | EP1028709A4 (en) |
JP (1) | JP2001519377A (en) |
AU (1) | AU1087799A (en) |
CA (1) | CA2306103C (en) |
WO (1) | WO1999018932A1 (en) |
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-
1997
- 1997-10-15 US US08/950,732 patent/US6056977A/en not_active Expired - Lifetime
-
1998
- 1998-10-15 JP JP2000515570A patent/JP2001519377A/en active Pending
- 1998-10-15 WO PCT/US1998/021752 patent/WO1999018932A1/en active Application Filing
- 1998-10-15 CA CA002306103A patent/CA2306103C/en not_active Expired - Fee Related
- 1998-10-15 AU AU10877/99A patent/AU1087799A/en not_active Abandoned
- 1998-10-15 EP EP98953532A patent/EP1028709A4/en not_active Withdrawn
-
2000
- 2000-01-07 US US09/479,465 patent/US6537578B1/en not_active Expired - Fee Related
-
2003
- 2003-03-25 US US10/396,114 patent/US6875793B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2306103C (en) | 2003-12-09 |
US20030219481A1 (en) | 2003-11-27 |
AU1087799A (en) | 1999-05-03 |
US6875793B2 (en) | 2005-04-05 |
JP2001519377A (en) | 2001-10-23 |
US6537578B1 (en) | 2003-03-25 |
US6056977A (en) | 2000-05-02 |
WO1999018932A1 (en) | 1999-04-22 |
EP1028709A1 (en) | 2000-08-23 |
EP1028709A4 (en) | 2003-02-12 |
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EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20141015 |