CA2310378A1 - Analytic measuring instrument with lancing device - Google Patents

Analytic measuring instrument with lancing device Download PDF

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Publication number
CA2310378A1
CA2310378A1 CA002310378A CA2310378A CA2310378A1 CA 2310378 A1 CA2310378 A1 CA 2310378A1 CA 002310378 A CA002310378 A CA 002310378A CA 2310378 A CA2310378 A CA 2310378A CA 2310378 A1 CA2310378 A1 CA 2310378A1
Authority
CA
Canada
Prior art keywords
measuring instrument
lancing device
blood
analyte
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002310378A
Other languages
French (fr)
Inventor
Hans Kintzig
Michael Schabbach
Hans-Ruediger Murawski
Wolfgang Obermeier
Karl Miltner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2310378A1 publication Critical patent/CA2310378A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150763—Details with identification means
    • A61B5/150778—Details with identification means having complementary physical shapes for indexing or registration purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188—Constructional features of reusable driving devices
    • A61B5/1519—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for propelling the piercing unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin

Abstract

The invention relates to a system for determining the presence or the content of an analyte in blood. The system comprises a measuring device (1) for measuring and displaying the change of a characteristic property of a test element, said property being correlated to the analyte, and comprises a puncturing aid (2) for obtaining the blood from a body part of a testee. The invention is characterized in that the measuring device (1) and the puncturing aid (2) are directly connected to one another in a detachable manner. The invention also relates to the utilization of such a system for determining the presence or the content of an analyte in blood.

Description

Analytical msasuring instrument with lancing device The invention concerns a system and its use for determining the presence or the content of an analyte in blood wherein the system comprises a measuring instrument for measuring and displaying the change of a characteristic property of a test element which correlates with the analyte and it concerns a lancing device for obtaining blood from a body region of a test person.
The determination of the content of a particular analyte in blood, for example glucose or lactate, requires the collection of an adequate amount of sample (blood) and the provision of a suitable measuring system for the analyte. In addition to medical practices and laboratories, medical laymen are increasingly carrying out such determinations for their own use. Measuring systems that are designed to be used by the test persons themselves are wide-spread especially for the determination and monitoring of the blood sugar value i.e. the blood glucose content in the case of diabetics and also to determine other parameters such as the lactate content or cholesterol level.
Conventional measuring systems often contain test elements in the form of so-called test strips which, together with appropriate measuring instruments, allow the determination of one or several analytes in the blood. In addition the user generally also requires a lancet which is used to pierce the skin of particular body regions for example of the finger pad or earlobe and thus obtain blood which is to be used for the measurement. Various manufacturers offer lancing devices for a comfortable blood collection which insert the lancets into the skin in a controlled and guided manner in order to thus control the piercing depth and to minimize the pain.
Since the user requires several separate components (test elements, measuring instrument, lancing device, lancets etc.) in order to measure an analyte in blood and has to carry them with him for an outside analysis for example when travelling or for sport, it is understandable that especially diabetics, which additionally have to carry insulin and a syringe, consider it desirable to reduce the individual components that they have to have with them.
There have therefore been no lack of various attempts at reducing the number of individual components. One solution is to package the necessary components such as measuring instrument, lancing device, lancets and test strips in a common transport case. However, these are often voluminous and for example too large and too heavy to be kept in a jacket or shirt pocket.
Another solution is to integrate as many of the above-mentioned components as possible into one instrument. An example of this is the integration of a test strip storage system into a measuring instrument as described in US 5,489,414 or US 5,645,798.
Systems in which the lancing device and measuring instrument have been amalgamated into one instrument are described for example in US 5,029,583 and US 4,637,403.
Although these integrated systems essentially solve the problem of reducing the number of individual components that one has to carry, the handling of such integrated systems for blood collection is unsatisfactory since the systems are usually cumbersome and comparatively heavy and thus make it difficult to precisely aim at a lancing site.
The object of the present invention was to eliminate the disadvantages of the prior art. In particular the aim was to find a system which combines the measuring instrument and lancing device and allows a precise aiming at the lancing site with an overall reduction of the number of individual components that one has to carry.
The object is achieved by the subject matter of the invention as characterized in the patent claims.
The invention concerns a system for determining the presence or the content of an analyte in blood comprising a measuring instrument for measuring and displaying the change of a characteristic property of a test element which correlates with the analyte and a lancing device for obtaining blood from a body region of a test person characterized in that the measuring instrument and the lancing device are directly connected to one another in a detachable manner.
The invention also concerns the use of the system according to the invention to determine the presence or the content of an analyte in blood.
Finally the invention concerns the individual components of the system according to the invention i.e. a lancing device and a measuring instrument that are suitable for a direct detachable connection to one another.
The system according to the invention is suitable for the determination of the presence or the content of an analyte in blood. The determination of the presence of an analyte can for example be used for the qualitative diagnosis of an infection (e.g. with viruses such as HIV
or HCV) or for the qualitative determination of a particular state of the body (e. g. pregnancy, cardiac infarction). The determination of the content of an analyte can be used to monitor the course of a disease or response to therapy and gives detailed information on the state of the body of a test person. Examples of this are the measurement of the blood glucose, the lactate or cholesterol concentration in the blood and such like.
The system according to the invention preferably enables the determination of one parameter. The simultaneous determination of several parameters is also possible in a further embodiment of the system according to the invention.
According to the invention the measuring instrument of the system measures and displays the change of a characteristic property of a test element that correlates with the analyte. The test element can be present in any form that is well-known to a person skilled in the art for example in the form of a test strip or a cuvette where the reagents required for the detection reaction are present in or on the test element. When one or several analytes are present, the test element enables the generation of a detectable signal as a characteristic property of the test element which correlates with the analyte. Examples of this are colour changes in a detection reagent layer which can be measured photometrically, or electrical currents or changes in potential which can be detected by electrode systems. The signals generated in this manner are then measured and evaluated by the measuring instrument by for example comparison with calibration values.
Different detection and determination methods are possible depending on the analyte to be examined which differ in the physicochemical detection principle (e. g.
photometry, electrochemistry) and, on the other hand, in the biochemical) interactions which lead to the characteristic, detectable changes (e.g. detection by means of enzymatic or immunological reactions, nucleic acid sequence test).
In addition to the measuring instrument, the system according to the invention contains a lancing device which can be used to obtain a blood sample of a test person. Lancing devices are known for example to a person skilled in the art from EP-B 0 565 970 and are sold commercially in different forms by various vendors.
They are used in combination with lancets to obtain blood for example from the finger pad or the earlobe in a comfortable, reproducible and painless manner.
In the claimed system the lancing device is connected according to the invention with the measuring instrument in a direct and detachable manner. Direct connection should be understood to mean that apart from the lancing device and the measuring instrument, no additional separate devices such as pockets, covers, tapes or cases are necessary to connect the lancing device and measuring instrument. In contrast the measuring instrument or the lancing device or both components contain appropriate connecting means which preferably match and fit one another and allow a detachable connection of the two components of the system. Possible connecting means are plug connections, clamp connections, connections using profiled rails, connections by means of magnets or Velcro fastenings.
The connection is preferably by means of plug connections in which case a connection with the aid of a clip is particularly preferred.
The connection according to the invention between the lancing device and measuring instrument can be easily and rapidly detached and closed again and thus allows the system according to the invention to be handled comfortably which makes it more acceptable to the users.
Since in a preferred embodiment of the invention it should be equally possible to obtain blood of a test person by the lancing device in a detached state and also when connected to the measuring instrument, a stable connection has proven to be particularly advantageous i.e. a connection which resists the shear forces which are exerted on the connection during operation of the lancing device. A connection with the aid of a clip is particularly preferred. Clips are known in various shapes, materials and designs for example for writing utensils such as fountain pens, ball-point pens or felt-tip pens.
The clip is especially preferably attached to the lancing device which especially preferably has an essentially cylindrical, fountain-pen-like shape as in EP-B 0 565 970 and the measuring instrument which preferably essentially has the shape of a flat cuboid _ 7 _ contains a recess with a corresponding shape particularly preferably on one of its narrow side faces which allows the clip to be held with an accurate fit and thus enables a stable, detachable and direct connection of the lancing device and measuring instrument. The clip and the corresponding recess to hold the clip are preferably shaped such that when the stable connecting position is reached, this is tactually or audibly discernible to the user. The combination of the clip on the lancing device and an essentially complementary recess in the housing of the measuring instrument enables an unequivocal, orientated and guided connection of the two system components according to the invention whereby the play between the lancing device and measuring instrument is optimized in order to create a stable connection which resists shear forces and, on the other hand, can be easily and rapidly detached. The lancing device particularly preferably ends up essentially resting against the narrow side of the measuring instrument as a result of its connection with the measuring instrument.
The lancing device and housing of the measuring instrument are preferably designed such that a compact overall shape results. For example a recess in the shape of a trough which at least partially encloses the lancing device can be provided in the housing of the measuring instrument. In addition to the compactness of the arrangement, this also additionally stabilizes the detachable connection between the lancing device and measuring instrument.
The clip for connecting the lancing device and measuring instrument can be manufactured from the housing material of the lancing device or of the measuring instrument as g well as from another suitable material. Suitable materials are for example metals, alloys or plastics or combinations thereof e.g. plastic-coated metals or metallized plastics. The clip can be a component of the housing which is for example manufactured as an injection moulded part or it can be a separate component which is, however, permanently connected to the housing.
It has also turned out that the lancing device and measuring instrument can be also advantageously connected by the shaping of the measuring instrument housing. For example the measuring instrument can contain a flexible gripping jaw on one, preferably narrow side of the housing which partially encloses the lancing device and thus enables it to be detachably attached to the measuring instrument. In this case it is not necessary to attach devices to the lancing device to attach it to the measuring instrument. In this preferred embodiment the means for detachably connecting the lancing device and measuring instrument can be an integral component of the housing of the measuring instrument and can for example be incorporated into it during the injection moulding process. However, the said means can also be moulded as a separate component that is, however, permanently connected to the housing.
The system according to the invention provides the user with a compact lancing device-measuring instrument system which reduces the number of individual components that the user needs to obtain blood and subsequently measure a blood parameter. An additional advantage is that the user can decide whether he wants to use the lancing device connected to the measuring instrument or detached from the measuring instrument which enables a high degree of flexibility in operation. Moreover the v g lancing device can be cleaned safely and hygienically without a risk of damaging the measuring instrument.
The invention is elucidated in more detail by the following figures 1 to 5.
Figure 1 shows schematically a top-view from above of a preferred embodiment of the system according to the invention.
Figure 2 is a schematic top-view from direction A of the system according to the invention shown in figure 1.
Figure 3 shows schematically the connecting mechanism for the lancing device and measuring instrument of the system according to the invention of figure 1 on the basis of a partial sectional view.
Figure 4 shows a preferred embodiment of the system according to the invention as an alternative to figures 1 to 3 based on three partial figures (A to C).
Figure 5 also shows a preferred embodiment of the system according to the invention as an alternative to figures 1 to 4 which is also based on three partial figures (A
to C ) .
The numbers in the figures denote:
1 measuring instrument 2 lancing device 3 display 4 operating element for the measuring instrument 5 operating element for the lancing device 6 connecting element 1 (clip) 7 connecting element 2 (complementary recess) 8 housing wall of the measuring instrument 1 9 clamping jaw The system shown in figures 1 to 3 which represents a particularly preferred embodiment of the invention is composed of a measuring instrument 1 and a lancing device 2 which are connected directly and detachably to one another. In this case the lancing device 2 ends up resting essentially against the side of the measuring instrument 1.
The dimensions of the measuring instrument 1 are preferably such that it can be held comfortably in one hand. The lancing device 2 has essentially the shape of a fountain pen and its size (length, diameter) is essentially matched to the measuring instrument 1 in such a way that no overhanging or protruding parts are present for the transport and operation of the system.
The measuring instrument 1 contains all necessary functional components of which only the display 3 and an operating element 4 are shown schematically in figures 1 and 3. The test elements which are to be measured with the measuring instrument 1 are inserted into the instrument 1 from side A in figure 1 or, alternatively to instrument 1, can for example be provided by an integrated test element magazine.
The lancing device 2 also contains all necessary functional components of which only an operating element 5 is shown schematically. The lancets for obtaining blood are inserted into the lancing device 2 from side A
(fig. 1) .
Figure 3 shows a schematic detailed view of the connecting elements 1 (clip) 6 and 2 (complementary recess) 7 for which a part of the upper side of the measuring instrument has been left out. The clip 6 fits exactly into the complementary recess 7 which is formed by the wall of the housing 8 of the measuring instrument 1.
When using the lancing device 2 the operator will usually detach it from the measuring instrument 1 in order to collect blood as precisely and painlessly as possible. For this purpose a corresponding lancet has to be inserted into the lancing device 2, the lancing device 2 is activated by for example tensioning a spring and is subsequently moved to the desired body region such as a finger pad or earlobe from which it is intended to draw the blood. When the operating element 5 is actuated, the lancet pierces the desired body region and thus blood is obtained.
The blood is subsequently applied to the sample application region of a test element which is preferably already located in the measuring instrument 1 and at least the sample application region of the test element protrudes from the measuring instrument 1. The actual measurement is started by actuating the operating element 4. After the detection reaction is completed on the test element the measured value of the analyte determination appears in the display 3.
In the other preferred embodiment of the system according to the invention shown in figure 4 which is composed of lancing device 2 and measuring instrument 1, the detachable connection between these two system components is also accomplished by a clip 6 on the lancing device 2 and a corresponding complementary recess 7 on the measuring instrument 1. The recess 7 is located in a side wall of the measuring instrument housing which matches the contours of the lancing device in order to stabilize the connection between the measuring instrument 1 and lancing device 2.
The top-view in figure 4A shows the locations of the measuring instrument 1 and lancing device 2 in the connected state. Figure 4B is a section through the plane of measuring instrument 1 and lancing device 2 indicated by the arrows in figure 4A. This cross-section shows well how the side wall of the measuring instrument housing matches the contour of the lancing device 2.
Figure 4C illustrates how the lancing device 2 docks with the measuring instrument 1. The lancing device 2 is orientated parallel to the measuring instrument 1 with the clip 6 facing the side of the housing which contains the recess 7 that is complementary to the clip 6 and the lancing device is connected to the measuring instrument 1 by inserting the clip 6 into the recess 7. Clip 6, recess 7 and the matching of the side wall of the measuring instrument 1 to the lancing device 2 ensure that the connection is stable but can be detached again.
The connection is detached in the reverse sequence to making the connection.
Figure 5 ffinally shows an alternative connecting mechanism for the lancing device 2 and measuring instrument 1. In this case the lancing device 2 contains no special devices which allow a connection to the measuring instrument but rather the connection is made by a special shape of one of the side walls of the housing of the measuring instrument 1. This wall of the housing contains clamping jaws 9 which in the preferred embodiment of the lancing device 2 shown that has a round cross-section (figure 5B and C) partially surround it and hold it in such a way that it can be readily detached. The material from which the jaws 9 are made is on the one hand flexible enough so that it can be pressed apart to hold the lancing device 2 and on the other hand is stiff enough that it fixes the lancing device 2 once it has been partially surrounded by the jaws 9 and rests against the measuring instrument 1.
Figure 5A shows in a top-view how the lancing device 2 approaches the measuring instrument 1 and is held by the clamping jaws 9 on the measuring instrument 1. A
schematic section through the plane of the measuring instrument 1 and lancing device 2 indicated by the arrows in figure 5A is shown in figure 5B. In this cross-section it can be readily seen how the clamping jaws 9 are components of the housing wall of the measuring instrument 1 which surround the lancing device 2. Figure 5C is like figure 5B a schematic cross-section through the lancing device 2 and measuring instrument and in this case the arrows are intended to illustrate how the jaws 9 of the measuring instrument housing move apart when the lancing device 2 is inserted.

Claims (6)

Claims
1. System for determining the presence or the content of an analyte in blood comprising a photometric or electrochemical measuring instrument (1) for measuring and displaying the change of a characteristic property of a test element which correlates with the analyte and a lancing device (2) in a cylindrical, fountain-pen-like form for obtaining blood from a body region of a test person, wherein the measuring instrument (1) and the lancing device (2) are directly and detachably connected to one another so that blood can be obtained from a body region of a test person with the aid of the lancing device (2) when it is connected to the measuring instrument (1) as well as when the lancing device (2) is detached from the measuring instrument (1).
2. System as claimed in claim 1, wherein the lancing device (2) is connected directly and detachably to the measuring instrument (1) by means of a clip (6).
3. System as claimed in claim 1 or 2, wherein the lancing device (2) is directly and detachably connected essentially to the side of the measuring instrument (1).
4. System as claimed in one of the claims 1 to 3, wherein devices (6, 7) are present on the measuring instrument (1) as well as on the lancing device (2) which enable the measuring instrument (1) and lancing device (2) to be connected detachably and directly.
5. Lancing device (2) suitable for a system as claimed in one of the claims 1 to 4 which is designed such that it can directly and detachably connect to a measuring instrument (1) for measuring and displaying the change of a characteristic property of a test element which correlates with the analyte.
6. Measuring instrument (1) suitable for a system as claimed in one of the claims 1 to 4 which is designed such that it can directly and detachably connect to a lancing device (2) for obtaining blood from a body region of a test person.
CA002310378A 1997-11-28 1998-11-30 Analytic measuring instrument with lancing device Abandoned CA2310378A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19752688.8 1997-11-28
DE19752688 1997-11-28
DE19824036A DE19824036A1 (en) 1997-11-28 1998-05-29 Analytical measuring device with lancing device
DE19824036.8 1998-05-29
PCT/EP1998/007706 WO1999027854A1 (en) 1997-11-28 1998-11-30 Analytic measuring device with a puncturing aid

Publications (1)

Publication Number Publication Date
CA2310378A1 true CA2310378A1 (en) 1999-06-10

Family

ID=26041971

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002310378A Abandoned CA2310378A1 (en) 1997-11-28 1998-11-30 Analytic measuring instrument with lancing device

Country Status (13)

Country Link
US (1) US6379317B1 (en)
EP (1) EP1032307B1 (en)
JP (1) JP3569228B2 (en)
KR (1) KR20010032500A (en)
CN (1) CN1283972A (en)
AT (1) ATE361025T1 (en)
AU (1) AU736568B2 (en)
CA (1) CA2310378A1 (en)
DE (2) DE19824036A1 (en)
ES (1) ES2285797T3 (en)
HU (1) HUP0100071A3 (en)
PL (1) PL340720A1 (en)
WO (1) WO1999027854A1 (en)

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