CA2310643A1 - Expandable body device for the gastric cavity and method - Google Patents

Expandable body device for the gastric cavity and method Download PDF

Info

Publication number
CA2310643A1
CA2310643A1 CA002310643A CA2310643A CA2310643A1 CA 2310643 A1 CA2310643 A1 CA 2310643A1 CA 002310643 A CA002310643 A CA 002310643A CA 2310643 A CA2310643 A CA 2310643A CA 2310643 A1 CA2310643 A1 CA 2310643A1
Authority
CA
Canada
Prior art keywords
expandable body
delivery tube
fillant
fillant delivery
gastric cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002310643A
Other languages
French (fr)
Inventor
Mei H. Chan
Yung C. Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2310643A1 publication Critical patent/CA2310643A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00Dilators with or without means for introducing media, e.g. remedies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013Implantable devices or invasive measures
    • A61F5/003Implantable devices or invasive measures inflatable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013Implantable devices or invasive measures
    • A61F5/0036Intragastrical devices
    • A61F5/004Intragastrical devices remotely adjustable

Abstract

This invention is an expandable body device (14) for a gastric cavity including an elastic expandable body (16), a rigid filling delivery tube (18) sealable connected to the expandable body (16) having a base portion (28), an extending portion (32), and a tip portion (34). An anchor (22), and a valve (26) are included on the base portion (28) of the filling delivery tube (18).
A method of treating obesity including the steps of performing a percutaneous endoscopic gastrostomy to establish a gastro-cutaneous fistula, pushing an expandable body (16) through said fistula into the gastric cavity with a rigid filling delivery tube (18), delivering a filling through a valve (26), delivering the filling through the valve (26) out of the filling delivery tube (18) and the expandable body (16), removing the filling delivery tube (18) and the expandable body (16) from the fistula.

Description

wo ~nsa~8 pcTnJS9sn3asa Title of the Invention EXPANDABLE BODY DEVICE FOR THE
GASTRIC CAVITY AND METHOD
Field of the Invention This invention is directed to an expandable body device for the gastric cavity and method, particularly, for the treatment of obesity.
Background of the Invention Obesity is a major health problem for many individuals. Many solutions for achieving the weight loss necessary to treat this problem have been proposed.
Common to many of these solutions is the requirement of the obese individual to decrease overall caloric intake andlor to increase energy output. One solution for reducing caloric intake may involve instructing the obese individual to consume foods which have a relatively low calorie to volume ratio, for example, low fat foods. Typically, however, this solution, by itself, is not sufficient for many overweight individuals because of an inability to select such foods for consumption. Oftentimes this is due to a lack of knowledge about nutrition and/or a lack of self control.

In many cases vigorous exercise is recommended to achieve an increase in energy output. However, many overweight individuals, particularly, the morbidly obese, risk further damage to their health, for example, heart attacks, from such activity.
Other solutions involve the use of pharmaceuticals, for example, stimulative or appetite suppressive drugs. While this may be a satisfactory solution for many, the use of pharmaceuticals in the treatment of obesity is not without drawbacks. For example, individuals using such dn~gs are at risk of becoming addicted or ill-affected by side effects of the drugs. Further, these drugs oftentimes become less potent over time due to the development of a high drug tolerance.
Surgical solutions to the problem of obesity have also been proposed. Some of these procedures involve reducing the volume of the gastric cavity, for example, by creating a small pouch gastric bypass, or reducing the capacity of the stomach to expand, for example, by placing a constrictive band around the stomach. These surgical procedures are particularly traumatic to the body and are thus often associated with serious complications and increased mortality rates.
Thus, there continues to be a need for effective solutions to the problem of obesity.
Accordingly, it is a first object of the present invention to provide an expandable body device for the gastric cavity and method.
2 It is a second object of the present invention to provide an improved expandable body device for the gastric cavity and method.
It is a third object of the present invention to provide an expandable body device for the gastric cavity and method of treating obesity.
It is a fourth object of the present invention to provide an expandable body device for the gastric cavity which is easily introduced to and removed from the gastric cavity.
It is a fifth object of the present invention to provide an expandable body device for the gastric cavity which may be introduced to and removed from the gastric cavity through a gastro-cutaneous fistula having a transverse cross-sectional profile which defines a relatively small area.
It is a sixth object of the present invention to provide an expandable body device for the gastric cavity which minimally contacts the inner surface of the gastric wall.
It is a seventh object of the present invention to provide an expandable body device for the gastric cavity which is prevented from moving relative to the individual in whose gastric cavity the device has been introduced.
3 WO 99/25418 PCT/tTS98/Z3Z58 It is an eighth object of the present invention to provide an expandable body device for the gastric cavity which includes an expandable body which is prevented from excessive movement while in the gastric cavity.
It is a ninth object of the present invention to provide an expandable body device for the gastric cavity which is comfortable for the person in whose gastric cavity the device has been introduced.
It is a tenth object of the present invention to provide an expandable body device for the gastric cavity which does not allow for gastric juices to escape from the gastric cavity.
It is an eleventh object of the present invention to provide an expandable body device for the gastric cavity which includes a minimum number of parts.
It is a twelfth object of the present invention to provide an expandable body device for the gastric cavity which is inconspicuous while in use.
It is a thirteenth object of the present invention to provide an expandable body device for the gastric cavity which is easy to manufacture.
It is a fourteenth object of the present invention to provide an expandable body device for the gastric cavity which is safe to use.
4 It is a fifteenth object of the present invention to provide an expandable body device for the gastric cavity which includes a small number of parts.
The present invention provides an expandable body device for the gastric cavity and method. The preferred embodiment of the present invention includes a rigid to semi-rigid fillant delivery tube having a base portion, an extending portion, and a tip portion.
The fillant delivery tube is sealedly connected to an expandable body which is preferably constructed of surgical grade latex rubber. In a preferred embodiment, the extending portion and tip portion of the fillant delivery tube extend into the expandable body, which forms a substantially proximal and uniformly congruent layer thereover. An anchor and a valve are provided on the base portion of the fillant delivery tube.
To use a device constructed according to a preferred embodiment of the present invention for the treatment of obesity, a gastro-cutaneous fistula is established in the obese individual via a percutaneous endoscopic gastrostomy, a procedure well known to persons skilled in the art. The cross-sectional profile of the fistula tract is configured to correspond with the cross-sectional profile of the device along the expandable body.
Preferably, the fistula tract is allowed to mature (i.e., form scar tissue) over a period of from 1-2 weeks. Then, the device is brought into proximity of the fistula tract and a bio-compatible lubricant is applied to the device and/or to the fistula tract. The tip portion of the fillant delivery tube and the expandable body are placed at the entrance of the fistula tract and passed through the fistula by the application of a gentle force at the
5 base portion of the fillant delivery tube. The anchor provides a convenient surface against which such a force may be applied.
The device is fully inserted when the anchor contacts the abdominal wall. The expandable body may then be expanded with a biocompatible fillant. A graduated syringe is loaded with an appropriate amount, typically 100-500 ml, of saline solution. The syringe is then sealedly engaged with the valve on the proximal end of the fillant delivery tube and the fillant is forced into the fillant delivery tube by depressing the syringe plunger, thereby causing the expandable body to expand within the gastric cavity. Once appropriate expansion size is reached, the tip of the syringe is removed from the valve which is preferably configured to seal upon withdrawal of the syringe.
The size of the of the expandable body is preferably configured so that when appropriate expansion size is reached, the expandable body occupies a substantial fraction of the total volume of the gastric cavity of the person in whose gastric cavity the device is introduced. This enables the individual to feel satiated or "full" after consuming a relatively small portion of food.
After a period of time, preferably 3 to 6 months, the syringe is again engaged with the valve. The plunger of the syringe is operated to create a vacuum condition in the syringe cylinder, thereby causing fillant to flow from the device into the syringe until the expandable body is returned to a non-expanded configuration. Once the expandable body is returned to a non-expanded configuration, the device may be re-filled, for example, to
6 a new volume, or easily removed from the gastric cavity by simply pulling on the base portion of the fillant delivery tube.
Alternatively, a hose may be connected between a fillant supply pump and a valve on the fillant delivery tube. The valve is opened and a biocompatible fillant, for example, air or saline, is pumped through the valve and into the fillant delivery tube.
The fillant goes through the fillant delivery tube and enters the expandable body causing the expandable body to expand within the gastric cavity. After a period of time, the hose is again connected to the valve. Upon opening of the valve, the force of the elastic expandable body forces fillant from the expandable body into the fillant delivery tube and out of the device. Thereafter, the device may be re-filled with fillant or easily removed from the gastric cavity by simply pulling on the base portion of the fillant delivery tube.
While the function of the present invention to provide a deterrent to the consumption of food is easily appreciated, it is important to realize that the present invention allows this benefit to be realized with a lower risk of health problems, smaller loss of healthy social activity, and lower monetary cost than known methods of treating obesity.
To begin, the fillant delivery tube is preferably provided with a tapering, closed tip portion having a rounded distal end which is easily placed at the opening of the fistula by sliding the tip portion along the abdomen until the rounded distal end engages the entrance
7
8 PCT/ITS98/23258 ofthe fistula tract. During insertion, the tip portion gently and gradually forces open the fistula to accommodate the fillant delivery tube.
Second, the rigid to semi-rigid fillant delivery tube preferably has a circular transverse cross-sectional profile and the ratio of the longitudinal length of the tube to the diameter thereof is relatively large. Thus, the is device easily translated through the fistula tract.
Third, the tip portion and the extending portion of the fillant delivery tube are covered by the expandable body which forms a single layer of material thereover. During insertion, the tissue of the fistula contacts only the relatively soft material of the expandable body. The device may be passed through a fistula tract having a transverse cross-sectional profile only slightly larger than the transverse cross-sectional profile of the device distal of the anchor.
Further, the expandable body expands within the gastric cavity such that contact with the gastric wall or lining is minimized (i. e., a space is maintained between substantially all surfaces of the expanded expandable body and the gastric wall). Since a tip portion of the fillant delivery tube is proximal to the internal surface of the spherically shaped expandable body, if the expandable body pivots slightly, it will contact the tip portion. Since these features prevent the expandable body from contacting the gastric wall and causing for example, ulcers, the device may be maintained in an expanded configuration within the gastric cavity for extended periods of time, preferably, three (3) to six (6) months.
The distance between the proximal surface of the expandable body and the distal surface of the anchor is preferably slightly smaller than the distance between the gastric entrance of the fistula tract and the surface of the abdomen proximal to the abdominal entrance of the fistula tract. Thus, as the expandable body expands, the proximal portion of the expandable body contacts the gastric entrance of the fistula tract which causes the anchor on the fillant delivery tube to which the expandable body is sealedly connected to abut the abdominal surface proximal to the fistula entrance. The associated compressive force causes the expandable body to sealingly contact the gastric entrance of the fistula tract, thus preventing the escape of gastric juices from the gastric cavity.
The force also fixates the device relative to the individual in whose gastric cavity the device has been inserted. Thus, the present invention allows a morbidly obese person to remain active during treatment involving use of the present invention without fear of gastric juices leaking from the fistula tract or discomfort which could have been caused by shifting of the device.
Moreover, when the device of the present invention is inserted in the gastric cavity, the preferably disk shaped anchor mounted on the fillant delivery tube lies substantially flush with the surface of the abdomen and the base portion of the delivery
9 tube and the valve mounted thereon protrudes only minimally, preferably, less than three (3) centimeters. The present invention is thus inconspicuous during use.
A device according to the present invention is also easy to manufacture. For example, an expandable body may be placed over a rigid to semi-rigid fillant delivery tube in a first manufacturing step. In a second manufacturing step, an integral anchor and valve component may be press-fit onto the proximal end of the fillant delivery tube to sealedly connect the fillant delivery tube to the expandable body and to mount the anchor and valve component to the proximal end of the fillant delivery tube.
Thus, the present invention provides a device which may be easily inserted into the gastric cavity through a gastro-cutaneous fistula having a relatively small transverse cross-sectional profile. Further, an individual in whose gastric cavity the device has been introduced may remain active while the device is within the gastric cavity since the device prevents leakage of gastric juices from the fistula tract and otherwise does not present a threat of injury or discomfort to the individual. Use of a device according to the present invention also facilitates social activity since it is relatively inconspicuous while inserted in the gastric cavity. Moreover, since the fillant delivery tube inhibits the expandable body of the device from contacting the gastric wall, the expandable body may be maintained in an expanded configuration, within the gastric cavity for extended periods of time. Still further, the device of the present invention may be easily manufactured in, for example, as little as two steps. Thus, the present invention provides an expandable body device and method which are particularly useful in the treatment of obesity.

wo ~nsais pc~rnJS9sn3zss Brief Description of the Drawings Figure 1 shows a perspective view of a preferred embodiment of an expandable body device for the gastric cavity according to the present invention.
Figure 2 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 1.
IO Figure 3 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 1 while the expandable body is in a partially expanded configuration.
Figure 4 shows a perspective view of a second embodiment of an expandable body device for the gastric cavity according to the present invention.
Figure 5 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 4.
Figure 6 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 3 while the expandable body is in an expanded configuration.

wo ~ns4is Prrius9sn3ass Figure 7 shows a longitudinal partial cross-sectional view of a third embodiment of an expandable body device according to the present invention.
Figure 8 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 7 while the expandable body is in an expanded configuration.
Figure 9 shows a longitudinal partial cross-sectional view of a fourth embodiment of an expandable body device according to the present invention.
Figure 10 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 9 while the expandable body is in an expanded configuration.
Figure 11 shows an end view of the expandable body device shown in Figure 10.
Figure 12 shows a longitudinal partial cross-sectional view of a fifth embodiment of an expandable body device according to the present invention.
Figure 13 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 12 while the expandable body is in a partially expanded configuration.

WO 99/25418 PCT/US98n3258 Figure 14 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 12 while the expandable body is in a fully expanded configuration.
Figure 15 shows a longitudinal partial cross-sectional view of a sixth embodiment of an expandable body device according to the present invention.
Figure 16 shows a longitudinal partial cross-sectional view of the expandable body device shown in Figure 15 while the expandable body is in a fully expanded configuration.
Figure 17 shows a schematic view of the expandable body device of the present invention introduced to the gastric cavity of an obese individual.
Figure 18 shows a partial longitudinal cross-sectional view of the expandable body device within the gastric cavity of an individual.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
The present invention is directed to a device for insertion into the gastric cavity, and more particularly, to a device for insertion into the gastric cavity for the treatment of obesity.

wo ~ns4ia pc~rius98n32s8 A preferred embodiment of a device 14 according to the present invention is shown in Figures 1-3. The device I4 includes generally, an expandable body 16 having an integral band portion 38 sealedly connected to a rigid fillant delivery tube 18 such that an extending portion 32 and a tip portion 34 of the fillant delivery tube 18 extend into the expandable body 16. A valve 26 for controlling the flow of a fillant which is delivered into and from the expandable body 16 via the fillant delivery tube 18 and an anchor 22, integral with valve 26, are connected to a base portion 28 of fillant delivery tube 18.
A fillant introduced to the fillant delivery tube 18 through port 27 in valve 2b passes through passages 24 in tip portion 34 to expand the expandable body 16 as shown in Fig. 3.
The fillant delivery tube 18 shown in Figs. 1-3 is a cylindrical and rigid tube having a linear centerline and a uniform cross-section. Fivant delivery tube is typically 6.0 to 12.0 cm in length and 0.75 to 2.0 cm in diameter. Fillant delivery tube 18 may be constructed of a metal, for example, surgical grade stainless steel, or a plastic, for example, polyethylene or polysulfone. Other materials may also be suitable of fillant delivery tube 18, for example, a semi-rigid fillant delivery tube may be constructed of silastic.
The integral anchor 22 and valve 26 of device 14 includes a circular flange portion forming anchor 22, a proximally extending first cylindrical portion which is configured to mount, for example, by a press-fit, to the base portion 28 of the fillant delivery tube 18 and a proximally extending second cylindrical portion which houses valve 26.
Second cylindrical portion includes a port 27 for introducing fillant through valve 26 to fillant delivery tube 18. Valve 26 is preferably constructed of an appropriately sized cylindrical section of rubber pressed into the second cylindrical portion. The rubber section is preferably configured to automatically seal after being pierced by a small diameter cannula, for example, a syringe needle, thereby preventing the passage of fillant out of device 14.
In the preferred embodiment shown in Figs. 1-3, tip portion 34 and extending portion 32 of fillant delivery tube 18 extend into expandable body 16 which is sealedly connected by adhesive along integral band portion 38 to fillant delivery tube 18 to form a sealed connection 36. Note that the first cylindrical portion of integral anchor 22 and valve 26 is press-fit to fillant delivery tube 18 with a portion of integral band portion 38 therebetween to further secure and sealedly connect expandable body 16 to fillant delivery tube 18.
The tip portion 34 of the preferred fillant delivery tube 18 shown in Figure 1 is closed and rounded and has two (2) pairs of diametrically opposed passages 24 through which a fillant is delivered to the expandable body 16. The edges of passages 24 are preferably chamfered to prevent damage to the expandable body 16 during contact of fillant delivery tube 18 therewith.
In Figures 1-2, the expandable body 16 of device 14 is shown in a substantially non-expanded configuration. While in a non-expanded configuration, expandable body 16 conforms to and forms a single layer of material substantially congruent with the - wo ~ns4is pc~r~rs9srt.~2s8 surface of fillant delivery tube 18. Expandable body 16 is preferably made of surgical grade latex rubber and is configured to expand into a substantially spherical shape having a volume of 10-500 ml upon the introduction of a bio-compatible fillant thereto.
Expandable body 16 is also preferably configured to return to its original shape upon removal of fillant therefrom. Note that Figure 3 shows the expandable body 16 of device 14 in only a partially expanded spherical configuration.
A second embodiment of a expandable body device for the gastric cavity is shown in Figs. 4-6. The fillant delivery tube 18' of the embodiment shown in Figs. 4-6 is, like the fillant delivery tube of the device shown in the first embodiment, a cylindrical and substantially rigid tube having a linear centerline and a uniform cross-section. The centerline of fillant delivery tube 18' may vary according to the present invention. For example, the centerline of a fillant delivery tube according to the present invention may define a curvilinear path, such as a single plane S-like path, or, as another example, a substantially corkscrew-like path. Further, the longitudinal or transverse cross-sectional profile of fillant delivery tube may vary. For example, fillant delivery tube 18' may have a longitudinal cross-sectional profile which expands or tapers along the centerline of fillant delivery tube 18'. As another example, the transverse cross-sectional profile of fiUant delivery tube 18' may have a non-circular shape such as eye-shaped or polygon-shaped.
Base portion 28', extending portion 32', and tip portion 34' of fillant delivery tube 18' are integral, as shown in Figures 4-6. In other embodiments (not shown) base portion 28' may be configured to releasably connect to extending portion 32' so that a user of the device is able to select a combination of base portion 28' and extending portion 32' appropriate for a particular individual. That is, for some individuals it may be desirous to have a somewhat flexible base portion connected to a rigid extending portion.
As another example, for some individuals it may be desirous to connect an extending portion having a relatively large longitudinal dimension to a base portion having a relatively small longitudinal dimension.
A detachable connection between base portion 28 and extending portion 32 may be established by including a proximal internally threaded surface on extending portion 32 which threadedly engages a corresponding distal externally threaded surface of base portion 28'. Other connections could also be utilized, for example, a press-fit or an interference fit.
A detachable connection between base portion 28' and extending portion 32' may be dynamic. For example, extending portion 32' may be configured to rotate relative to base portion 28'. Alternatively, extending portion 32' may be configured to slide axially relative to base portion 28'.
Fivant delivery tube 18' shown in Figure 4 also includes a closed and substantially rounded distal tip portion 34' provided with two (2} pairs of diametrically opposed passages 24' through which a fillant may be delivered to expandable body 16'.
The expandable body 16' of the embodiment shown in Figs. 4-6 is sealedly connected to fillant delivery tube 18' at sealed connection 36'. Preferably, sealed connection 36' is provided chemically, as shown in Figures. 4-6, by an adhesive disposed between expandable body 16' and fillant delivery tube 18', or for example, by sonic welding. However, sealed connection 36' may be provided mechanically, for example by a band, a sleeve, a length of cord, or some other form of mechanical constricting device (not shown) having a profile which would not impede passage of the device through the gastric fistula. As another example, sealed connection 36' may be provided by configuring a base portion of fillant delivery tube 18' to engage an extending portion with a portion of expandable body 16' secured therebetween.
Note from Figures S and 6 that expandable body I6' is partially inverted such that the outer surface of integral band portion 38' is in contact with the outer surface of fillant delivery tube 18' at sealed connection 36'. This partial inversion of expandable body 16' allows for a large amount of surface area of fillant delivery tube 18' to be exposed between anchor 22' and expandable body 16'.
To prevent potentially injurious rupturing of the expandable body, the sealed connection between the expandable body and the fillant delivery tube may be configured to release at or prior to the internal pressure of the device reaching a predetermined maximum.

wo ~ns4is rcr~rs9sn3zss The expandable body 16' of device 14' shown in Figures 4-6 is an elastic structure preferably having predetermined memory characteristics, i. e., configured to expand to a predetermined shape and to resume original shape upon evacuation of fillant therefrom.
Porous or selectively permeable materials which allow passage of a fillant in a controlled manner into the gastric cavity or materials impregnated or saturated with a biocompatible lubricant may also be used to construct expandable body 16'.
In Figures 4-5, the expandable body 16' of device 14' is shown in a substantially non-expanded configuration. While in a non-expanded configuration, expandable body 16' forms a single layer of material which is substantially congruent with the surface of tip portion 34'.
In some embodiments (not shown), it is preferable to sealedly connect expandable body 16' to fillant delivery tube 18' such that the tip portion 34' of fillant delivery tube 18' is in contact with the inner surface of expandable body 18'. In embodiments where tip portion 34' contacts the inner surface of expandable body 18', expandable body 18' may be slightly taut while in a non-expanded configuration so as to further ensure the uniformity of expandable body 16' around tip portion 34'.
Figure 6 shows the expandable body 16' of device 14' in an expanded configuration. Note from Figure 3 that expandable body 16' is preferably configured to expand into a substantially spherical shape.

Device 14' shown in Figures 4-6 also includes an annular disc-shaped plastic anchor 22' mounted proximally on fillant delivery member 18' for controlling the depth to which device 14' is inserted through a gastric fistula. Anchor 22' is preferably of su~cient diameter to provide a surface against which a force may be applied by the fingers of the user for pushing the device 14' through a gastric fistula. The shape and texture of anchor 22' may vary, for example, anchor 22' may be concave or convex. As another example, anchor 22' may be knurled, ridged or bumped.
Anchors 22' may be configured for interchangeability such that an appropriate anchor 22' for any individual may be selected. For example, in embodiments where base portion 28' and extending portion 32' are separable and attachable, anchor 22' may be configured to mount therebetween for easy replacement.
The embodiment shown in Figures 4-6 also includes a valve 26' for allowing fillant to be introduced and released from the fillant delivery tube 18'. Valve 26' may include a pressure regulator such that when the pressure within device 14 reaches or exceeds a predetermined maximum, valve 26' opens to release the excess pressure from the device 14'.
A third embodiment of a device 114 according to the present invention is shown in Figures 7 and 8. Device 114 includes an expandable body 116 having a nose portion 1161 of a relatively greater elasticity (i.e., less elastic) than the remaining portion of expandable body 116. Thus, note that when a fillant is pumped into expandable body 116 WO 99/25418 PCT/(JS98/23258 as shown in Figure 5, the nose portion 1161 does not expand to the same extent as the remaining portion of expandable body 116. Because nose portion 1161 remains substantially and closely congruent with tip portion 134 while expandable body l I6 is in an expanded configuration, the relative movement between expandable body 116 and fillant delivery tube 118 is limited. To even further decrease relative movement between expandable body 116 and fillant delivery tube 118, tip portion 134 may be attached to the interior surface of expandable body 116 at nose portion 1161, however, this may necessitate the relocation of passages 124 in extending portion 132 further proximally on fillant delivery tube 18.
A fourth embodiment of a device 214 according to the present invention is shown in Figures 9-11. Device 214 includes a substantially annular expandable body 216 through which the extending portion 232 of fillant delivery tube 218 passes. Note that this configuration prevents relative pivoting movement between expandable body 216 and fillant delivery tube 218. Relative rotational movement about the coincidental longitudinal axis of fillant delivery tube 218 and expandable body 216 is prevented by sealed connection 236.
A fifth embodiment of a device for insertion into the gastric cavity for the treatment of obesity is shown in Figures 12-14. Device 314 includes an expandable body 316 which is mounted within and extends distally from a passage 324 at the tip portion 334 of fillant delivery tube extending portion 332. The expandable body 316 of device 314 is made of an elastic material having predetermined memory characteristics, in wo m~ns4ia pc~r~s9an32sa particular, expandable body 216 assumes the spiral-shaped configuration shown in Figure 12 while in a non-expanded configuration. Note the relatively small transverse and longitudinal cross-sectianal profile of expandable body 316 in Figure 12.
S As expandable body 316 expands with the delivery of fillant from passage 324, each turn 342 of expandable body 316 is forced from the spiral-shaped configuration shown in Figure 12 into the substantially cylindrical configuration shown in Figure 13. As more fillant is delivered to expandable body 316, the expandable body 316 of device 314 expands to the substantially spherical configuration shown in Figure 14.
Preferably, expandable body 316 is configured to return to the spiral-shaped configuration shown in Figure 14 simply by the release of fillant therefrom.
However, with the additional step of providing a vacuum to the expandable body 316 via the fillant delivery tube 318 and valve 326, a more rapid and complete removal of fillant from expandable body 316 may be effected. Note that the application of a vacuum to the expandable body 316 would also substantially decrease the flexibility of expandable body 316 thus further easing introduction of device 3I4 to, and removal of device 314 from, the gastric cavity.
A sixth embodiment of a device 414 according to the present invention is shown in Figures 15-16. Device 416 includes a passage 424 in the tip portion 434 of the fillant delivery tube 418. Expandable body 416 is mounted to the outer surface of fillant delivery tube 418 at tip portion 434. Note from Figure 15 that, while in a non-expanded configuration, expandable body 416 is stored within the fillant delivery tube 418, thus minimizing the transverse cross-sectional profile of device 414. Once within the gastric cavity, expandable body 4I6 is caused to expand, as shown in Figure 16, by the delivery of fillant from fillant delivery tube 418. Preferably, expandable body 418 is returned to the configuration shown in Figure 15 by the creation of a vacuum condition within the fillant delivery tube 418.
A preferred method of inserting the device of the present invention into the gastric cavity, and more particularly, a preferred method of inserting the device into the gastric cavity for the treatment of obesity will now be described. In Figures 17 and 18, device 14 shown in Figures 1-3 is shown inserted into the gastric cavity of a human
10 according to a preferred method of the present invention.
In the first step of the method, a gastro-cutaneous fistula 2002 is established in the obese individual via a percutaneous endoscopic gastrostomy, a procedure known to persons skilled in the art. The cross-sectional profile of the fistula tract is configured to correspond with the cross-sectional profile of the device along the expandable body.
Preferably, the fistula tract is allowed to mature (i.e., form scar tissue), typically, over a period of from 1-2 weeks.
In the second step of the method, the device 14 is brought into proximity of the fistula tract and a bio-compatible lubricant is applied to the device and/or to the fistula tract. The expandable body 16 along tip portion 34 of fillant delivery tube 18 is placed wo ~ns4i8 pc~rms98n32s8 at the entrance of the fistula tract and passed through the fistula 2002 by the application of a gentle force at the base portion of the fillant delivery tube 18. The proximal surface of anchor 22 provides a convenient surface against which such a force may be applied.
The device is preferably configured so that complete insertion is indicated when the anchor 22 contacts the abdominal wall.
Since the relatively soft material of expandable body 16 covers tip portion 34 and at least a substantial fraction of extending portion 32, a gentle surface is provided for contacting the tissue of fistula 2002 during insertion of the device 14 into the gastric cavity. Further, the soft material of expandable body 16 in combination with the rounded tip portion 34 may be used to gently and safely stretch the elastic tissue of the fistula 2002. Thus, the present invention allows for the use of a fistula 2002 having a transverse cross-sectional profile which is approximately the same size or even somewhat smaller than the largest transverse cross-sectional profile of the device I4 distal of anchor 22.
In the third step, a biocompatible fillant, preferably, saline solution, is introduced to the device. Preferably, a graduated syringe (not shown) is loaded with an appropriate amount of biocompatible fillant, typically 10-500 ml. The syringe is then sealedly engaged with the valve 26 on the proximal end of the fillant delivery tube 18. The syringe plunger is advanced and fillant passes through the fillant delivery tube 18 and into the expandable body 16 which is thereby caused to expand within the gastric cavity. Once appropriate expansion size is reached, the tip of the syringe is removed from the valve 26 which is preferably configured to close upon withdrawal of the syringe.

Alternatively, a hose (not shown) may be connected between a fillant supply pump (not shown) and valve 26 on the preferred embodiment of device 14. Valve 26 is opened and a preferably biocompatible fillant in liquid, gas, or gel form is pumped through valve 26 and into filiant delivery tube 18. The fillant exits passages 24 in fillant delivery tube 18 and enters expandable body 16 causing the expandable body 16 to expand within the gastric cavity. The fourth step is completed upon closure of the valve 26 and removal of the hose 52 therefrom.
The size of the of the expandable body 16 is preferably configured so that when appropriate expansion size is reached, the expandable body 16 occupies a substantial fraction of the total volume of the gastric cavity of the person in whose gastric cavity the device has been inserted but remains substantially free of contact with the gastric wall.
The loss in stomach capacity available for food enables the individual to feel satiated or "full" after consuming a relatively small portion of food.
Note from Figure 18 that as expandable body 16 expands, a proximal portion of expandable body 16 contacts the surface of the gastric entrance of the fistula, indicated as 52. The contact between the outer surface of expandable body 16 and the fistula entrance serves to prevent the escape of gastric juices from the gastric cavity and to maintain the device 14 in a fixed position relative to the person in whose gastric cavity the device has been introduced. Thus, the individual may remain active while the expandable body 16 is in an expanded configuration within the gastric cavity. It is also important to note that, when the device is fixlly inserted, the distance from the surface of the abdomen WO 99/25418 PCT/US98l23258 proximal of the anchor 22 to the valve 26 is relatively small, preferably less than 3 centimeters, thus preventing others from easily noticing the device during use.
In the fourth step, a period of time is allowed to elapse, preferably 3 to 6 months, and the syringe is again engaged with the valve 26. The syringe is operated to create a vacuum condition in the device 14, thereby causing fillant to flow from the device 14 into the syringe until the expandable body 16 is returned to a non-expanded configuration.
After the expandable body is returned to a non-expanded configuration, the device 14 may be, for example, removed from the gastric cavity and replaced with another device 14 having an expandable body with a different volume.
Alternatively, a hose may be connected to the valve 26. Upon opening of the valve, the compressive force created by the elastic material of expandable body 16 causes the fillant to flow from the expandable body 16 into the fillant delivery tube 18 and out of the device 14. The device 14 may then be re-filled with fillant or removed from the gastric cavity.
During withdrawal, the fistula may contact the outer surface of the expandable body 16 which in turn causes the expandable body to contact the extending portion of fillant delivery tube 18. The compression of the expandable body causes any remaining fillant to be pushed into passages 24. Since the passages are located at the tip portion 34 of the fillant delivery tube 18, they are not blocked due to the contact of the expandable with the extending portion 32 of the fillant delivery tube 18.

Thus, the present invention is particularly suitable far use as part of a therapy for weight toss in morbidly obese patients. It is important to recognize however, that the present invention may be introduced to the gastric cavity for other purposes.
For example, the present invention may be introduced to the gastric cavity for the treatment of hypothermia. In such a use, the device may be inserted as described above, however, a fillant having a temperature higher than normal body temperature may be delivered to expandable body for supplying heat energy internally of the hypothermic individual.
Alternatively, in embodiments where an expandable body made of a porous or selectively permeable material is used, the present invention may be used to deliver a drug, for example, by diffusion through the expandable body, to the individual in whose gastric cavity the device has been introduced.
Thus, the present invention has many uses and configurations, and while certain representative embodiments and details have been described for the purpose of illustrating the invention, it will be apparent to those skilled in the art that various changes and modifications may be made therein without departing from the spirit or scope of the invention.

Claims (13)

1. An expandable body device for the gastric cavity, said device comprising:
an elastic expandable body;
a rigid fillant delivery tube[,] for delivering fillant to said expandable body, said fillant delivery tube being sealedly connected to said expandable body and having a base portion, an extending portion, and a tip portion, said rigid fillant delivery tube being configured to be sufficiently long so as to extend a substantial distance into the gastric cavity. said tip portion being closed and rounded and said fillant delivery tube including at least one passageway for allowing said fillant to be delivered into said expandable body;
an anchor attached to said base portion of said fillant delivery tube:
and[,]
a valve attached to said base portion of said fillant delivery tube.
2. Cancel.
3. A device according to claim 1, wherein said tip portion and extending portion extend into said expandable body.
4. A device according to claim 1, wherein said expandable body includes an integral band portion attached to said fillant delivery tube.
5. A device according to claim 1, wherein said expandable body is configured to expand to a specific shape.
6. A device according to claim 5, wherein said expandable body is configured to expand to a substantially spherical shape.
7. A device according to claim 5, wherein said expandable body is configured to maintain a specific shape while in a non-expanded configuration.
8. A device according to claim 7, wherein said expandable body is sealedly connected to and extends distally from said tip portion and is configured to maintain a substantially spiral shape while in a non-expanded configuration.
9. A device according to claim 1, wherein said expandable body is stored within said fillant delivery tube while in a non-expended configuration.
10. A device according to claim 1, wherein said expandable body includes a nose portion.
11. A device according to claim 10, wherein said nose portion maintains a predefined shape during expansion and white expanded.
l2. A device according to claim 1, wherein said tip portion of said extending portion is connected to an inner surface of said expandable body.
13. A method of treating obesity comprising the steps of:
performing a percutaneous endoscopic gastrostomy to establish a gastro-cutaneous fistula;
pushing an expandable body through said fistula into said gastric cavity with a rigid fillant delivery tube to which said expandable body is sealedly connected, said rigid fillant delivery tube including a base portion, an extending portion, a tip portion, and an anchor attached to said base portion said rigid fillant delivery tube being configured to be sufficiently long so as to extend a substantial distance into the cavity, said tip portion~being closed and rounded and said fillant delivery tube including at least one passage for allowing said fillant to be delivered to said expandable body;
an anchor attached to said base portion of said fillant delivery tube; and, a valve attached to said base portion of said fillant delivery tube.
delivering a fillant through a valve connected to said fillant delivery tube such that said fillant flows into said fillant delivery tube and said expandable body to cause said expandable body to expand within said gastric cavity; and, delivering said fillant through said valve out of said fillant delivery tube and said expandable body to cause said expandable body to return to a non-expanded configuration; and, removing said fillant delivery tube and said expandable body from said fistula.
CA002310643A 1997-11-19 1998-11-19 Expandable body device for the gastric cavity and method Abandoned CA2310643A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/972,965 US5993473A (en) 1997-11-19 1997-11-19 Expandable body device for the gastric cavity and method
US08/972,965 1997-11-19
PCT/US1998/023258 WO1999025418A1 (en) 1997-11-19 1998-11-19 Expandable body device for the gastric cavity and method

Publications (1)

Publication Number Publication Date
CA2310643A1 true CA2310643A1 (en) 1999-05-27

Family

ID=25520344

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002310643A Abandoned CA2310643A1 (en) 1997-11-19 1998-11-19 Expandable body device for the gastric cavity and method

Country Status (7)

Country Link
US (1) US5993473A (en)
EP (1) EP1032451A4 (en)
JP (1) JP2001523491A (en)
KR (1) KR20010032290A (en)
AU (1) AU1374299A (en)
CA (1) CA2310643A1 (en)
WO (1) WO1999025418A1 (en)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA00001922A (en) 2000-02-24 2002-03-08 De Hayos Garza Andres Percutaneous intra-gastric balloon catheter for obesity treatment.
FR2805986B1 (en) * 2000-03-13 2002-10-11 Districlass Madical INTRA-GASTRIC DEVICE WITH VARIABLE VOLUME
US6589208B2 (en) * 2000-06-20 2003-07-08 Applied Medical Resources Corporation Self-deploying catheter assembly
US7033373B2 (en) * 2000-11-03 2006-04-25 Satiety, Inc. Method and device for use in minimally invasive placement of space-occupying intragastric devices
DE60110469T2 (en) * 2001-03-09 2006-02-23 Jose Rafael Garza Alvarez INTRAGASTRIC BALLOON ARRANGEMENT
US7020531B1 (en) 2001-05-01 2006-03-28 Intrapace, Inc. Gastric device and suction assisted method for implanting a device on a stomach wall
US7616996B2 (en) 2005-09-01 2009-11-10 Intrapace, Inc. Randomized stimulation of a gastrointestinal organ
US20080065169A1 (en) * 2001-05-01 2008-03-13 Intrapace, Inc. Endoscopic Instrument for Engaging a Device
US9668690B1 (en) 2001-05-01 2017-06-06 Intrapace, Inc. Submucosal gastric implant device and method
US7689284B2 (en) 2001-05-01 2010-03-30 Intrapace, Inc. Pseudounipolar lead for stimulating a digestive organ
US7756582B2 (en) * 2001-05-01 2010-07-13 Intrapace, Inc. Gastric stimulation anchor and method
US7747322B2 (en) * 2001-05-01 2010-06-29 Intrapace, Inc. Digestive organ retention device
US7702394B2 (en) 2001-05-01 2010-04-20 Intrapace, Inc. Responsive gastric stimulator
US7643887B2 (en) 2001-05-01 2010-01-05 Intrapace, Inc. Abdominally implanted stimulator and method
US7979127B2 (en) 2001-05-01 2011-07-12 Intrapace, Inc. Digestive organ retention device
US20050143784A1 (en) * 2001-05-01 2005-06-30 Imran Mir A. Gastrointestinal anchor with optimal surface area
US6535764B2 (en) * 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
US6558400B2 (en) 2001-05-30 2003-05-06 Satiety, Inc. Obesity treatment tools and methods
US20050119617A1 (en) * 2001-07-09 2005-06-02 Stecker Eric C. Multifunctional devices
US6620129B2 (en) 2001-07-09 2003-09-16 Eric C. Stecker Enlargeable multifunctional devices
US6675809B2 (en) 2001-08-27 2004-01-13 Richard S. Stack Satiation devices and methods
US7097665B2 (en) 2003-01-16 2006-08-29 Synecor, Llc Positioning tools and methods for implanting medical devices
US6845776B2 (en) 2001-08-27 2005-01-25 Richard S. Stack Satiation devices and methods
CN101810521B (en) 2001-08-27 2015-05-13 辛尼科有限责任公司 Satiation devices and methods
US20050080425A1 (en) * 2002-03-18 2005-04-14 Mohit Bhatnagar Minimally invasive bone manipulation device and method of use
US7146984B2 (en) 2002-04-08 2006-12-12 Synecor, Llc Method and apparatus for modifying the exit orifice of a satiation pouch
US8845672B2 (en) * 2002-05-09 2014-09-30 Reshape Medical, Inc. Balloon system and methods for treating obesity
DE60328476D1 (en) * 2002-05-09 2009-09-03 Reshape Medical MEDICAL BALLOON SYSTEM FOR THE TREATMENT OF ADIPOSITAS
US20090048624A1 (en) * 2004-11-02 2009-02-19 Alverdy John C Balloon system and methods for treating obesity
US6746460B2 (en) 2002-08-07 2004-06-08 Satiety, Inc. Intra-gastric fastening devices
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
DE60331457D1 (en) 2002-08-28 2010-04-08 Allergan Inc TEMPTING MAGNETIC BANDING DEVICE
US7033384B2 (en) * 2002-08-30 2006-04-25 Satiety, Inc. Stented anchoring of gastric space-occupying devices
US7214233B2 (en) 2002-08-30 2007-05-08 Satiety, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US6981978B2 (en) * 2002-08-30 2006-01-03 Satiety, Inc. Methods and devices for maintaining a space occupying device in a relatively fixed location within a stomach
US7220237B2 (en) 2002-10-23 2007-05-22 Satiety, Inc. Method and device for use in endoscopic organ procedures
US9055995B2 (en) 2002-11-04 2015-06-16 Aspire Bariatrics, Inc. Method for treating obesity by extracting food
US7740624B2 (en) 2002-11-04 2010-06-22 Aspiration Medical Technology, Llc Method for treating obesity by extracting food
US7815629B2 (en) 2002-11-04 2010-10-19 Deka Products Limited Partnership Apparatus for treating obesity by extracting food
US20040143342A1 (en) 2003-01-16 2004-07-22 Stack Richard S. Satiation pouches and methods of use
US7291160B2 (en) * 2003-03-17 2007-11-06 Delegge Rebecca Intragastric catheter
FR2852821B1 (en) * 2003-03-31 2007-06-01 Cie Euro Etude Rech Paroscopie PARYLENE-COATED INTRA-GASTRIC BALLOON, PROCESS FOR PRODUCING SUCH BALLOON AND USE OF PARYLENE FOR COATING INTRA-GASTRIC BALLOON
US7175638B2 (en) 2003-04-16 2007-02-13 Satiety, Inc. Method and devices for modifying the function of a body organ
CA2540653C (en) 2003-08-13 2012-09-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compressive device for percutaneous treatment of obesity
US20050247320A1 (en) 2003-10-10 2005-11-10 Stack Richard S Devices and methods for retaining a gastro-esophageal implant
US8206456B2 (en) * 2003-10-10 2012-06-26 Barosense, Inc. Restrictive and/or obstructive implant system for inducing weight loss
US7914543B2 (en) 2003-10-14 2011-03-29 Satiety, Inc. Single fold device for tissue fixation
US7097650B2 (en) 2003-10-14 2006-08-29 Satiety, Inc. System for tissue approximation and fixation
US8900117B2 (en) 2004-01-23 2014-12-02 Apollo Endosurgery, Inc. Releasably-securable one-piece adjustable gastric band
US20050177176A1 (en) 2004-02-05 2005-08-11 Craig Gerbi Single-fold system for tissue approximation and fixation
US8828025B2 (en) 2004-02-13 2014-09-09 Ethicon Endo-Surgery, Inc. Methods and devices for reducing hollow organ volume
MXPA06009971A (en) 2004-02-27 2007-08-08 Satiety Inc Methods and devices for reducing hollow organ volume.
BRPI0508527A (en) 2004-03-08 2007-08-14 Endoart Sa tubular system closure system
US8449560B2 (en) 2004-03-09 2013-05-28 Satiety, Inc. Devices and methods for placement of partitions within a hollow body organ
US9028511B2 (en) 2004-03-09 2015-05-12 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US8628547B2 (en) 2004-03-09 2014-01-14 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US8252009B2 (en) 2004-03-09 2012-08-28 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
ES2368149T3 (en) 2004-03-18 2011-11-14 Allergan, Inc. APPARATUS FOR ADJUSTMENT OF THE VOLUME OF INTRAGASTRIC BALLOONS.
US20070233170A1 (en) * 2004-03-23 2007-10-04 Michael Gertner Extragastric Balloon
US7255675B2 (en) * 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US7946976B2 (en) 2004-03-23 2011-05-24 Michael Gertner Methods and devices for the surgical creation of satiety and biofeedback pathways
US20060142790A1 (en) * 2004-03-23 2006-06-29 Michael Gertner Methods and devices to facilitate connections between body lumens
WO2006049725A2 (en) 2004-03-23 2006-05-11 Minimus Surgical Systems Surgical systems and devices to enhance gastric restriction therapies
AU2005231323B2 (en) 2004-03-26 2011-03-31 Ethicon Endo-Surgery, Inc Systems and methods for treating obesity
WO2005105003A1 (en) * 2004-04-26 2005-11-10 Synecor, Llc Restrictive and/or obstructive implant for inducing weight loss
WO2005107641A2 (en) 2004-05-03 2005-11-17 Fulfillium, Inc. Method and system for gastric volume control
US20050267415A1 (en) * 2004-05-14 2005-12-01 C. R. Bard, Inc. Medical devices and methods of use
EP1744704A4 (en) * 2004-05-14 2011-03-23 Bard Inc C R Gastric balloon devices and methods of use
US7846171B2 (en) 2004-05-27 2010-12-07 C.R. Bard, Inc. Method and apparatus for delivering a prosthetic fabric into a patient
JP5102023B2 (en) 2004-06-29 2012-12-19 シー アール バード インコーポレイテッド Method and system for fluid communication with a gastrostomy tube
DK1814622T3 (en) * 2004-08-13 2016-02-29 Obalon Therapeutics Inc Intragastric volume-receiving device
MX2007005390A (en) * 2004-11-05 2007-08-23 Electronic Dietary Foods Inc Controlled degradation of expandable polymers in gastric volume reduction treatment.
US20060106288A1 (en) 2004-11-17 2006-05-18 Roth Alex T Remote tissue retraction device
US8070807B2 (en) 2004-11-19 2011-12-06 Fulfillium, Inc. Wireless breach detection
US9456915B2 (en) 2004-11-19 2016-10-04 Fulfilium, Inc. Methods, devices, and systems for obesity treatment
US7699863B2 (en) 2005-03-01 2010-04-20 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
US7785291B2 (en) * 2005-03-01 2010-08-31 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
US8251888B2 (en) 2005-04-13 2012-08-28 Mitchell Steven Roslin Artificial gastric valve
US9345604B2 (en) * 2005-05-02 2016-05-24 Almuhannad Alfrhan Percutaneous intragastric balloon device and method
AU2006323195A1 (en) * 2005-05-10 2007-06-14 Michael Gertner Obesity treatment systems
US7819840B2 (en) * 2005-06-06 2010-10-26 C. R. Bard, Inc. Feeding device including balloon tip and method of manufacture
WO2006135690A1 (en) 2005-06-10 2006-12-21 Wilson-Cook Medical Inc. Cautery catheter
US8216266B2 (en) * 2005-06-16 2012-07-10 Hively Robert L Gastric bariatric apparatus with selective inflation and safety features
US8021384B2 (en) * 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
US7490602B2 (en) * 2005-10-03 2009-02-17 Mahmoud Talaat Sabri Stomach belt for weight loss
US9055942B2 (en) 2005-10-03 2015-06-16 Boston Scienctific Scimed, Inc. Endoscopic plication devices and methods
US7509175B2 (en) 2006-08-03 2009-03-24 Intrapace, Inc. Method and devices for stimulation of an organ with the use of a transectionally placed guide wire
US20070100368A1 (en) 2005-10-31 2007-05-03 Quijano Rodolfo C Intragastric space filler
WO2007076021A2 (en) 2005-12-22 2007-07-05 Wilson-Cook Medical Inc. Intragastric bag for treating obesity
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
US7798954B2 (en) 2006-01-04 2010-09-21 Allergan, Inc. Hydraulic gastric band with collapsible reservoir
US20070198039A1 (en) * 2006-01-27 2007-08-23 Wilson-Cook Medical, Inc. Intragastric device for treating obesity
FR2897529B1 (en) * 2006-02-17 2008-10-31 Cie Euro Etude Rech Paroscopie INTRA-GASTRIC BALLOON WITH SHAPE MEMORY
US9579227B2 (en) 2006-03-29 2017-02-28 Eat Little Inc. Ingestible implement for weight control
MX2008012587A (en) * 2006-03-29 2009-01-14 Electronic Dietary Foods Inc Ingestible implement for weight control.
CN101415382A (en) * 2006-03-30 2009-04-22 皇家飞利浦电子股份有限公司 Expandable digestive pill
US8585733B2 (en) 2006-04-19 2013-11-19 Vibrynt, Inc Devices, tools and methods for performing minimally invasive abdominal surgical procedures
US7976554B2 (en) 2006-04-19 2011-07-12 Vibrynt, Inc. Devices, tools and methods for performing minimally invasive abdominal surgical procedures
US8556925B2 (en) 2007-10-11 2013-10-15 Vibrynt, Inc. Devices and methods for treatment of obesity
US8342183B2 (en) * 2006-04-19 2013-01-01 Vibrynt, Inc. Devices and methods for treatment of obesity
US8398668B2 (en) 2006-04-19 2013-03-19 Vibrynt, Inc. Devices and methods for treatment of obesity
US8187297B2 (en) 2006-04-19 2012-05-29 Vibsynt, Inc. Devices and methods for treatment of obesity
US8070768B2 (en) 2006-04-19 2011-12-06 Vibrynt, Inc. Devices and methods for treatment of obesity
WO2007124167A2 (en) * 2006-04-21 2007-11-01 C. R. Bard, Inc. Feeding device and bolster apparatus and method for making the same
US20080109027A1 (en) * 2006-08-01 2008-05-08 Fulfillium, Inc. Method and system for gastric volume control
US8062285B2 (en) 2006-08-03 2011-11-22 Aspire Bariatrics, Llc Systems and methods for removing ingested material from a stomach
EP2572673B1 (en) 2006-09-02 2015-08-19 Boston Scientific Scimed, Inc. Intestinal sleeves and associated deployment systems and methods
DE102006042955B3 (en) * 2006-09-13 2008-04-03 Merkle, Dominique, Dr. Device for the treatment of obesity
US9314361B2 (en) 2006-09-15 2016-04-19 Boston Scientific Scimed, Inc. System and method for anchoring stomach implant
FR2907665B1 (en) * 2006-10-31 2009-04-17 Cie Euro Etude Rech Paroscopie IMPLANTABLE MEDICAL DEVICE WITH PRESSURE LIMITER
US8795721B2 (en) * 2006-12-18 2014-08-05 Eatlittle Inc. Device for delivery of a substance
EP2066272A2 (en) 2006-12-28 2009-06-10 Vibrynt, Inc. Devices and methods for treatment of obesity
US20100145301A1 (en) * 2007-02-26 2010-06-10 Duocure, Inc. Spray administration of compositions including active agents such as peptides to the gastrointestinal tract
US20090082644A1 (en) * 2007-03-15 2009-03-26 Jiayi Li Devices, Systems, Kits and Methods for Treatment of Obesity
US8226602B2 (en) 2007-03-30 2012-07-24 Reshape Medical, Inc. Intragastric balloon system and therapeutic processes and products
US8007507B2 (en) 2007-05-10 2011-08-30 Cook Medical Technologies Llc Intragastric bag apparatus and method of delivery for treating obesity
US8142469B2 (en) * 2007-06-25 2012-03-27 Reshape Medical, Inc. Gastric space filler device, delivery system, and related methods
CA2696993C (en) 2007-07-18 2017-01-03 Samuel T. Crews Endoscopic implant system and method
US20090030284A1 (en) 2007-07-18 2009-01-29 David Cole Overtube introducer for use in endoscopic bariatric surgery
US8147480B2 (en) 2007-09-28 2012-04-03 Codman & Shurtleff, Inc. Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent
US7766875B2 (en) * 2007-09-28 2010-08-03 Codman & Shurtleff, Inc. Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent
US7883524B2 (en) 2007-12-21 2011-02-08 Wilson-Cook Medical Inc. Method of delivering an intragastric device for treating obesity
US8016851B2 (en) 2007-12-27 2011-09-13 Cook Medical Technologies Llc Delivery system and method of delivery for treating obesity
US20090171383A1 (en) 2007-12-31 2009-07-02 David Cole Gastric space occupier systems and methods of use
EP2240140B8 (en) * 2008-01-29 2022-05-18 Implantica Patent Ltd. An apparatus for treating gerd
US8020741B2 (en) 2008-03-18 2011-09-20 Barosense, Inc. Endoscopic stapling devices and methods
US8226593B2 (en) * 2008-04-09 2012-07-24 E2 Llc Pyloric valve
WO2009126331A1 (en) * 2008-04-09 2009-10-15 Endocore Llc Pyloric valve devices and methods
US9066877B2 (en) * 2008-04-28 2015-06-30 Eat Little Inc. Bezoar-forming units for weight control
US20100087706A1 (en) * 2008-09-30 2010-04-08 Intrapace, Inc. Lead Access
EP2362762A1 (en) 2008-10-06 2011-09-07 Allergan Medical Sàrl Mechanical gastric band with cushions
US8162969B2 (en) 2008-10-16 2012-04-24 Obalon Therapeutics, Inc. Intragastric device
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
US7934631B2 (en) 2008-11-10 2011-05-03 Barosense, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
CA2783009A1 (en) 2008-12-27 2010-07-01 John Hancock High specific gravity intragastric device
CN102348478A (en) * 2009-02-13 2012-02-08 内测公司 Endoscopic forceps with removable handle
US9174031B2 (en) 2009-03-13 2015-11-03 Reshape Medical, Inc. Device and method for deflation and removal of implantable and inflatable devices
CA2757612A1 (en) 2009-04-03 2010-10-07 Intrapace, Inc. Feedback systems and methods to enhance obstructive and other obesity treatments
JP5670424B2 (en) * 2009-04-03 2015-02-18 リシェイプ メディカル, インコーポレイテッド Improved gastric space filling and manufacturing method including in vitro testing
US8961539B2 (en) 2009-05-04 2015-02-24 Boston Scientific Scimed, Inc. Endoscopic implant system and method
US8715244B2 (en) 2009-07-07 2014-05-06 C. R. Bard, Inc. Extensible internal bolster for a medical device
WO2011011629A2 (en) * 2009-07-22 2011-01-27 Reshape Medical, Inc. Retrieval mechanisms for implantable medical devices
WO2011011743A2 (en) 2009-07-23 2011-01-27 Reshape Medical, Inc. Deflation and removal of implantable medical devices
US9604038B2 (en) 2009-07-23 2017-03-28 Reshape Medical, Inc. Inflation and deflation mechanisms for inflatable medical devices
EP2480279A4 (en) 2009-09-24 2017-11-15 Reshape Medical, Inc. Normalization and stabilization of balloon surfaces for deflation
EP2533846B1 (en) 2010-02-08 2018-08-22 ReShape Medical LLC Materials and methods for improved intragastric balloon devices
US9622896B2 (en) 2010-02-08 2017-04-18 Reshape Medical, Inc. Enhanced aspiration processes and mechanisms for instragastric devices
MX2012009112A (en) * 2010-02-09 2013-02-27 Bard Inc C R Deflation indicator for a medical device bolster.
US8758221B2 (en) 2010-02-24 2014-06-24 Apollo Endosurgery, Inc. Source reservoir with potential energy for remotely adjustable gastric banding system
WO2011106637A1 (en) 2010-02-25 2011-09-01 Reshape Medical, Inc. Improved and enhanced explant processes and mechanisms for intragastric devices
US8840541B2 (en) 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
WO2011127205A1 (en) 2010-04-06 2011-10-13 Reshape Medical , Inc. Inflation devices for intragastric devices with improved attachment and detachment and associated systems and methods
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US20110270025A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Remotely powered remotely adjustable gastric band system
US8517915B2 (en) 2010-06-10 2013-08-27 Allergan, Inc. Remotely adjustable gastric banding system
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
WO2012045030A2 (en) 2010-10-01 2012-04-05 Intrapace, Inc. Feedback systems and methods to enhance obstructive and other obesity treatments, optionally using multiple sensors
US8961393B2 (en) 2010-11-15 2015-02-24 Apollo Endosurgery, Inc. Gastric band devices and drive systems
US8963708B2 (en) 2011-01-13 2015-02-24 Sensurtec, Inc. Breach detection in solid structures
US8647358B2 (en) 2011-01-21 2014-02-11 Obalon Therapeutics Inc. Intragastric device
US8202291B1 (en) 2011-01-21 2012-06-19 Obalon Therapeutics, Inc. Intragastric device
HUE029644T2 (en) 2011-01-21 2017-02-28 Obalon Therapeutics Inc Intragastric device
US8292911B2 (en) 2011-01-21 2012-10-23 Obalon Therapeutics, Inc. Intragastric device
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
US8382775B1 (en) 2012-01-08 2013-02-26 Vibrynt, Inc. Methods, instruments and devices for extragastric reduction of stomach volume
US9314362B2 (en) 2012-01-08 2016-04-19 Vibrynt, Inc. Methods, instruments and devices for extragastric reduction of stomach volume
US10507127B2 (en) 2012-06-07 2019-12-17 Epitomee Medical Ltd. Expandable device
US9456916B2 (en) 2013-03-12 2016-10-04 Medibotics Llc Device for selectively reducing absorption of unhealthy food
US10137023B2 (en) 2012-09-14 2018-11-27 Medibotics Llc Colonnade (TM) expandable intragastric food flow lumen device
US10085866B2 (en) 2013-02-23 2018-10-02 Aspire Bariatrics, Inc. Apparatus and method for draining material from a stomach
US9067070B2 (en) 2013-03-12 2015-06-30 Medibotics Llc Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type
US9011365B2 (en) 2013-03-12 2015-04-21 Medibotics Llc Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food
EP2967818B1 (en) 2013-03-15 2018-05-16 Ez Off Weightloss, LLC System for gastric restriction and malabsorption
US9833350B2 (en) 2013-03-15 2017-12-05 Ez-Off Weightloss, Llc Anchorable size-varying gastric balloons for weight loss
US10219799B2 (en) 2013-08-05 2019-03-05 Endo-Tagss, Llc Transabdominal gastric device and method
CN105682727B (en) 2013-08-05 2019-06-21 恩多-塔格斯有限责任公司 Stomach operation system and method through abdomen
KR20160094397A (en) 2013-12-04 2016-08-09 오발론 테라퓨틱스 인코퍼레이티드 Systems and methods for locating and/or characterizing intragastric devices
AU2014358675B2 (en) 2013-12-05 2019-10-03 Epitomee Medical Ltd Retentive devices and systems for in-situ release of pharmaceutical active agents
US9895248B2 (en) 2014-10-09 2018-02-20 Obalon Therapeutics, Inc. Ultrasonic systems and methods for locating and/or characterizing intragastric devices
EP3223898B1 (en) * 2014-11-26 2020-05-27 EZ-OFF Weightloss, LLC Anchorable size-varying gastric balloons for weight loss
CN107921263A (en) * 2015-06-28 2018-04-17 亚龙·伊兰 GI irritation device and application thereof
FR3042401A1 (en) * 2015-10-16 2017-04-21 Marc Augustin INFLATABLE BALLOON FOR MEDICAL USE
US10335303B2 (en) 2015-12-07 2019-07-02 Obalon Therapeutics, Inc. Intragastric device
US10537453B2 (en) 2015-12-16 2020-01-21 Obalon Therapeutics, Inc. Intragastric device with expandable portions
EP3439728A4 (en) * 2016-04-04 2019-12-04 Innoventions Ltd. Drug delivery apparatus and method
US10350100B2 (en) 2016-04-12 2019-07-16 Obalon Therapeutics, Inc. System for detecting an intragastric balloon
US10813781B2 (en) 2016-10-04 2020-10-27 Ez-Off Weight Loss, Llc Sleeve-anchorable gastric balloon for weight loss
WO2018085079A1 (en) 2016-11-04 2018-05-11 Obalon Therapeutics, Inc. Pressure control system for intragastric device
CN108158705A (en) * 2017-12-18 2018-06-15 常州至善医疗科技有限公司 A kind of connection and release structure for balloon system
US11864952B2 (en) * 2018-10-29 2024-01-09 Hakim Said Tissue expander
US20220339021A1 (en) * 2019-09-25 2022-10-27 Simovations Inc. Percutaneous transabdominal port for hollow viscera

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1282881A (en) * 1917-07-07 1918-10-29 John T Landis Pneumatic dilator.
US1690995A (en) * 1927-12-28 1928-11-06 Monte Lloyd Corp Anorectal dilator
US4133315A (en) * 1976-12-27 1979-01-09 Berman Edward J Method and apparatus for reducing obesity
US4246893A (en) * 1978-07-05 1981-01-27 Daniel Berson Inflatable gastric device for treating obesity
US4899747A (en) * 1981-12-10 1990-02-13 Garren Lloyd R Method and appartus for treating obesity
US4416267A (en) * 1981-12-10 1983-11-22 Garren Lloyd R Method and apparatus for treating obesity
US4607618A (en) * 1983-02-23 1986-08-26 Angelchik Jean P Method for treatment of morbid obesity
US4648383A (en) * 1985-01-11 1987-03-10 Angelchik Jean P Peroral apparatus for morbid obesity treatment
US4723547A (en) * 1985-05-07 1988-02-09 C. R. Bard, Inc. Anti-obesity balloon placement system
US4694827A (en) * 1986-01-14 1987-09-22 Weiner Brian C Inflatable gastric device for treating obesity and method of using the same
US4762130A (en) * 1987-01-15 1988-08-09 Thomas J. Fogarty Catheter with corkscrew-like balloon
US4823808A (en) * 1987-07-06 1989-04-25 Clegg Charles T Method for control of obesity, overweight and eating disorders
US5340315A (en) * 1991-06-27 1994-08-23 Abbott Laboratories Method of treating obesity
US5234454A (en) * 1991-08-05 1993-08-10 Akron City Hospital Percutaneous intragastric balloon catheter and method for controlling body weight therewith
ES2098563T3 (en) * 1991-11-19 1997-05-01 Origin Medsystems Inc INFLATABLE ENDOSCOPIC RETRACTOR DEVICES TO SEPARATE LAYERS OF TISSUES.
US5259399A (en) * 1992-03-02 1993-11-09 Alan Brown Device and method of causing weight loss using removable variable volume intragastric bladder
US5327914A (en) * 1992-09-02 1994-07-12 Shlain Leonard M Method and devices for use in surgical gastroplastic procedure

Also Published As

Publication number Publication date
EP1032451A1 (en) 2000-09-06
AU1374299A (en) 1999-06-07
WO1999025418A1 (en) 1999-05-27
US5993473A (en) 1999-11-30
KR20010032290A (en) 2001-04-16
EP1032451A4 (en) 2004-10-27
JP2001523491A (en) 2001-11-27

Similar Documents

Publication Publication Date Title
US5993473A (en) Expandable body device for the gastric cavity and method
US9345604B2 (en) Percutaneous intragastric balloon device and method
US7488336B2 (en) Single control gastric band
US7172613B2 (en) Intragastric device for treating morbid obesity
US3854469A (en) Epiurethral valve
CA2646134C (en) Extragastric implantable devices for treatment of obesity
US4592339A (en) Gastric banding device
US8900116B2 (en) Inflatable stomal implant
US20080109027A1 (en) Method and system for gastric volume control
US20050197714A1 (en) System, system devices, and methods for regulating nutrient absorption and caloric intake
EP3023081A1 (en) Intragastric implants with multiple fluid chambers
EP0167602A1 (en) Elastomeric prosthetic sphincter
AU2857301A (en) Gastroplasty ring that can be loosened
JP2012510866A (en) Gastric restriction device with a fillable chamber and ablation means for treating obesity
US4584990A (en) Prosthetic sphincter having a diametric occlusion geometry
US20160113798A1 (en) Elevating Stomach Stimulation Device
WO1997017909A1 (en) Method and device for controlling urinary incontinence
RU2285499C2 (en) Device for test reduction of space of stomach
CA1232408A (en) Elastomeric prosthetic sphincter

Legal Events

Date Code Title Description
FZDE Discontinued