CA2311445A1 - Method for immobilizing mediator molecule on inorganic and metal implant material - Google Patents

Method for immobilizing mediator molecule on inorganic and metal implant material Download PDF

Info

Publication number
CA2311445A1
CA2311445A1 CA002311445A CA2311445A CA2311445A1 CA 2311445 A1 CA2311445 A1 CA 2311445A1 CA 002311445 A CA002311445 A CA 002311445A CA 2311445 A CA2311445 A CA 2311445A CA 2311445 A1 CA2311445 A1 CA 2311445A1
Authority
CA
Canada
Prior art keywords
implant material
molecule
mediator
anchor
inorganic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002311445A
Other languages
French (fr)
Other versions
CA2311445C (en
Inventor
Herbert Peter Jennissen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphoplant GmbH
Original Assignee
Herbert Peter Jennissen
Efmt Entwicklungs-Und Forschungszentrum Fur Mikrotherapie Ggmbh
Morphoplant Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Herbert Peter Jennissen, Efmt Entwicklungs-Und Forschungszentrum Fur Mikrotherapie Ggmbh, Morphoplant Gmbh filed Critical Herbert Peter Jennissen
Priority to CA2603280A priority Critical patent/CA2603280C/en
Publication of CA2311445A1 publication Critical patent/CA2311445A1/en
Application granted granted Critical
Publication of CA2311445C publication Critical patent/CA2311445C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier

Abstract

A mediator molecule is immobilized on the surface of a metallic or ceramic implant material. An anchor molecule such as a dialdehyde having a functional group that covalently binds the mediator molecule is covalently bound to the surface, and the mediator molecule is coupled to the functional group of the anchor molecule. The implant material may be composed of titanium, titanium alloy, aluminum, stainless steel or hydroxylapatite. Oxide units on the surface of the implant material can be increased preferably by treating with hot chromic-sulphuric acid for 0.5 to 3 hours at a temperature between 100 to 250° C. prior to binding the anchor molecule. Also, prior to binding the anchor molecule, the surface of the implant material can be activated by reacting with a silane derivative. Mediator molecules include BMP protein, ubiquitin and antibiotics, and the implant material may be an artificial joint or coronary vessel support such as a stent
CA002311445A 1997-11-24 1998-11-24 Method for immobilizing mediator molecule on inorganic and metal implant material Expired - Lifetime CA2311445C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2603280A CA2603280C (en) 1997-11-24 1998-11-24 Method for immobilizing mediator molecule on inorganic and metal implant material

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19752032 1997-11-24
DE19752032.4 1997-11-24
PCT/DE1998/003463 WO1999026674A2 (en) 1997-11-24 1998-11-24 Method for immobilizing mediator molecule on inorganic and metal implant material

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2603280A Division CA2603280C (en) 1997-11-24 1998-11-24 Method for immobilizing mediator molecule on inorganic and metal implant material

Publications (2)

Publication Number Publication Date
CA2311445A1 true CA2311445A1 (en) 1999-06-03
CA2311445C CA2311445C (en) 2008-10-21

Family

ID=7849669

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002311445A Expired - Lifetime CA2311445C (en) 1997-11-24 1998-11-24 Method for immobilizing mediator molecule on inorganic and metal implant material

Country Status (8)

Country Link
US (3) US6635269B1 (en)
EP (1) EP1035879B1 (en)
AT (1) ATE242647T1 (en)
AU (1) AU749139B2 (en)
CA (1) CA2311445C (en)
DE (2) DE59808721D1 (en)
ES (1) ES2201571T3 (en)
WO (1) WO1999026674A2 (en)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
US8172897B2 (en) 1997-04-15 2012-05-08 Advanced Cardiovascular Systems, Inc. Polymer and metal composite implantable medical devices
US10028851B2 (en) 1997-04-15 2018-07-24 Advanced Cardiovascular Systems, Inc. Coatings for controlling erosion of a substrate of an implantable medical device
DE59808721D1 (en) * 1997-11-24 2003-07-17 Efmt Entwicklungs Und Forschun METHOD FOR IMMOBILIZING MEDIATOR MOLECULES ON INORGANIC AND METAL IMPLANT MATERIALS
DE19935523C2 (en) * 1999-07-28 2002-10-10 Stefan Endres Procedure for mediator synthesis capacity determination
DE10037850A1 (en) * 2000-08-01 2002-02-21 Herbert P Jennissen Process for the production of bioactive implant surfaces
DE10059986C2 (en) * 2000-11-30 2003-02-13 Martin Wiemann Process for the non-covalent immobilization of heat-resistant biomolecules on implant materials
AU2002248484A1 (en) * 2001-02-21 2002-09-12 Drexel University Muscle-polymer constructs for bone tissue engineering
DE10119096A1 (en) * 2001-04-19 2002-10-24 Keramed Medizintechnik Gmbh New biologically functionalized coatings, useful for e.g. accelerating osteo-integration of implants, e.g. dental or joint implants, comprise resorbable calcium-phosphorus phase containing adhesion and/or signal proteins
GB0122393D0 (en) * 2001-09-17 2001-11-07 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility
US7285304B1 (en) 2003-06-25 2007-10-23 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US7989018B2 (en) 2001-09-17 2011-08-02 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US6863683B2 (en) 2001-09-19 2005-03-08 Abbott Laboratoris Vascular Entities Limited Cold-molding process for loading a stent onto a stent delivery system
DE10200161A1 (en) * 2002-01-04 2003-07-24 Herbert P Jennissen Method for producing models of biological molecules, especially for use in the production of implants or prostheses, whereby the models are used on the surface of the implants so that they resemble biological molecules
US7758881B2 (en) 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US8435550B2 (en) 2002-12-16 2013-05-07 Abbot Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US20060286140A1 (en) * 2003-09-15 2006-12-21 Eric Wickstrom Implants with attached silylated therapeutic agents
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US8568469B1 (en) 2004-06-28 2013-10-29 Advanced Cardiovascular Systems, Inc. Stent locking element and a method of securing a stent on a delivery system
US8241554B1 (en) 2004-06-29 2012-08-14 Advanced Cardiovascular Systems, Inc. Method of forming a stent pattern on a tube
DE102004031258A1 (en) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Protein hybrids with polyhydroxyaromatic amino acid epitopes
US7971333B2 (en) 2006-05-30 2011-07-05 Advanced Cardiovascular Systems, Inc. Manufacturing process for polymetric stents
US8778256B1 (en) 2004-09-30 2014-07-15 Advanced Cardiovascular Systems, Inc. Deformation of a polymer tube in the fabrication of a medical article
US8747879B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device to reduce chance of late inflammatory response
US7731890B2 (en) 2006-06-15 2010-06-08 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
US8747878B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device by controlling crystalline structure
US9283099B2 (en) 2004-08-25 2016-03-15 Advanced Cardiovascular Systems, Inc. Stent-catheter assembly with a releasable connection for stent retention
US7229471B2 (en) 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices
US7875233B2 (en) 2004-09-30 2011-01-25 Advanced Cardiovascular Systems, Inc. Method of fabricating a biaxially oriented implantable medical device
US8043553B1 (en) 2004-09-30 2011-10-25 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article
US8173062B1 (en) 2004-09-30 2012-05-08 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube in fabricating a medical article
GB0424560D0 (en) 2004-11-08 2004-12-08 Leuven K U Res & Dev Heart valve tissue engineering
US7381048B2 (en) 2005-04-12 2008-06-03 Advanced Cardiovascular Systems, Inc. Stents with profiles for gripping a balloon catheter and molds for fabricating stents
AU2006270221B2 (en) 2005-07-15 2012-01-19 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US20090062909A1 (en) 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
US7658880B2 (en) 2005-07-29 2010-02-09 Advanced Cardiovascular Systems, Inc. Polymeric stent polishing method and apparatus
US9248034B2 (en) 2005-08-23 2016-02-02 Advanced Cardiovascular Systems, Inc. Controlled disintegrating implantable medical devices
US8465808B2 (en) * 2005-10-05 2013-06-18 Duquesne University Of The Holy Spirit Process for depositing an organic acid on the surface of a metal composition
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
EP1880739B1 (en) 2005-12-23 2017-09-13 Herbert P. Prof. Dr. Jennissen Process for the immobilization of proteins on an implant
US20070156230A1 (en) 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US7951185B1 (en) 2006-01-06 2011-05-31 Advanced Cardiovascular Systems, Inc. Delivery of a stent at an elevated temperature
US7964210B2 (en) 2006-03-31 2011-06-21 Abbott Cardiovascular Systems Inc. Degradable polymeric implantable medical devices with a continuous phase and discrete phase
ES2540059T3 (en) 2006-04-26 2015-07-08 Micell Technologies, Inc. Coatings containing multiple drugs
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
EP1852443A1 (en) 2006-05-05 2007-11-07 Leukocare AG Biocompatible three dimensional matrix for the immobilization of biological substances
US7761968B2 (en) 2006-05-25 2010-07-27 Advanced Cardiovascular Systems, Inc. Method of crimping a polymeric stent
US20130325104A1 (en) 2006-05-26 2013-12-05 Abbott Cardiovascular Systems Inc. Stents With Radiopaque Markers
US7951194B2 (en) 2006-05-26 2011-05-31 Abbott Cardiovascular Sysetms Inc. Bioabsorbable stent with radiopaque coating
US7959940B2 (en) 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US8343530B2 (en) 2006-05-30 2013-01-01 Abbott Cardiovascular Systems Inc. Polymer-and polymer blend-bioceramic composite implantable medical devices
US7842737B2 (en) 2006-09-29 2010-11-30 Abbott Cardiovascular Systems Inc. Polymer blend-bioceramic composite implantable medical devices
US20070282434A1 (en) * 2006-05-30 2007-12-06 Yunbing Wang Copolymer-bioceramic composite implantable medical devices
US8486135B2 (en) 2006-06-01 2013-07-16 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from branched polymers
US8034287B2 (en) 2006-06-01 2011-10-11 Abbott Cardiovascular Systems Inc. Radiation sterilization of medical devices
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8535372B1 (en) 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
US8333000B2 (en) 2006-06-19 2012-12-18 Advanced Cardiovascular Systems, Inc. Methods for improving stent retention on a balloon catheter
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US9072820B2 (en) 2006-06-26 2015-07-07 Advanced Cardiovascular Systems, Inc. Polymer composite stent with polymer particles
US8128688B2 (en) 2006-06-27 2012-03-06 Abbott Cardiovascular Systems Inc. Carbon coating on an implantable device
US7794776B1 (en) 2006-06-29 2010-09-14 Abbott Cardiovascular Systems Inc. Modification of polymer stents with radiation
US7740791B2 (en) 2006-06-30 2010-06-22 Advanced Cardiovascular Systems, Inc. Method of fabricating a stent with features by blow molding
US7823263B2 (en) 2006-07-11 2010-11-02 Abbott Cardiovascular Systems Inc. Method of removing stent islands from a stent
US7757543B2 (en) 2006-07-13 2010-07-20 Advanced Cardiovascular Systems, Inc. Radio frequency identification monitoring of stents
US7998404B2 (en) 2006-07-13 2011-08-16 Advanced Cardiovascular Systems, Inc. Reduced temperature sterilization of stents
US7794495B2 (en) 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
US7886419B2 (en) 2006-07-18 2011-02-15 Advanced Cardiovascular Systems, Inc. Stent crimping apparatus and method
US8016879B2 (en) 2006-08-01 2011-09-13 Abbott Cardiovascular Systems Inc. Drug delivery after biodegradation of the stent scaffolding
US9173733B1 (en) 2006-08-21 2015-11-03 Abbott Cardiovascular Systems Inc. Tracheobronchial implantable medical device and methods of use
US20100178250A1 (en) * 2006-08-25 2010-07-15 Philadelphia Health & Education Corporation Method of Local Delivery of Bioactive and Diagnostic Agents Using Magnetizable Bone Cement
US7923022B2 (en) 2006-09-13 2011-04-12 Advanced Cardiovascular Systems, Inc. Degradable polymeric implantable medical devices with continuous phase and discrete phase
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US8099849B2 (en) 2006-12-13 2012-01-24 Abbott Cardiovascular Systems Inc. Optimizing fracture toughness of polymeric stent
DE102006060958A1 (en) * 2006-12-20 2008-06-26 Jennissen, Herbert P., Prof. Dr. Process for the preparation of a polymer matrix, implants made thereof and their use
US9737642B2 (en) * 2007-01-08 2017-08-22 Micell Technologies, Inc. Stents having biodegradable layers
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
DE102007007865A1 (en) 2007-02-14 2008-08-21 Jennissen, Herbert, Prof. Dr. Process for the preparation of storable implants with an ultrahydrophilic surface
US8262723B2 (en) 2007-04-09 2012-09-11 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from polymer blends with star-block copolymers
US8084077B2 (en) * 2007-05-25 2011-12-27 Abbott Laboratories One-step phosphorylcholine-linked polymer coating and drug loading of stent
AU2008256684B2 (en) 2007-05-25 2012-06-14 Micell Technologies, Inc. Polymer films for medical device coating
US7829008B2 (en) 2007-05-30 2010-11-09 Abbott Cardiovascular Systems Inc. Fabricating a stent from a blow molded tube
US7959857B2 (en) 2007-06-01 2011-06-14 Abbott Cardiovascular Systems Inc. Radiation sterilization of medical devices
US8293260B2 (en) 2007-06-05 2012-10-23 Abbott Cardiovascular Systems Inc. Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices
US8202528B2 (en) 2007-06-05 2012-06-19 Abbott Cardiovascular Systems Inc. Implantable medical devices with elastomeric block copolymer coatings
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US7901452B2 (en) 2007-06-27 2011-03-08 Abbott Cardiovascular Systems Inc. Method to fabricate a stent having selected morphology to reduce restenosis
US7955381B1 (en) 2007-06-29 2011-06-07 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
DE102007051914A1 (en) * 2007-10-29 2009-05-07 Herbert Prof. Dr. Jennissen Process for the preparation of particles loaded with growth factors and the particles thus obtained
CN105688276A (en) 2008-02-29 2016-06-22 史密夫和内修有限公司 Gradient coating for biomedical applications
JP5788179B2 (en) 2008-02-29 2015-09-30 スミス アンド ネフュー インコーポレーテッド Coating and coating method
CA2721832C (en) 2008-04-17 2018-08-07 Micell Technologies, Inc. Stents having bioabsorbable layers
JP2011528275A (en) 2008-07-17 2011-11-17 ミセル テクノロジーズ，インク． Drug delivery medical device
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
DE102008053892A1 (en) * 2008-10-30 2010-05-06 Fachhochschule Gelsenkirchen Medical implant with biofunctionalized surface
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
WO2010075590A2 (en) * 2008-12-26 2010-07-01 Battelle Memorial Institute Medical implants and methods of making medical implants
DE102009011991A1 (en) * 2009-03-05 2010-09-09 Peter Hildebrandt Flat surgical implant for treatment of e.g. hernia, has planar support designed as web, grid or net, where bioactive substances develop anti-inflammatory effect and/or cell-growth promoting effect in contact with muscle or connective tissue
CN102481195B (en) 2009-04-01 2015-03-25 米歇尔技术公司 Drug delivery medical device
EP3366326A1 (en) 2009-04-17 2018-08-29 Micell Technologies, Inc. Stents having controlled elution
US8568471B2 (en) 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
US8808353B2 (en) 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile
WO2011097103A1 (en) * 2010-02-02 2011-08-11 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
WO2011133655A1 (en) 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
US9428588B2 (en) 2010-11-26 2016-08-30 National Institute For Materials Science Bio-hybrid material, production method therefor, and stent
WO2012166819A1 (en) 2011-05-31 2012-12-06 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US8726483B2 (en) 2011-07-29 2014-05-20 Abbott Cardiovascular Systems Inc. Methods for uniform crimping and deployment of a polymer scaffold
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
JP5976486B2 (en) * 2011-10-20 2016-08-23 医療法人メディカル・ライフクォリティ Target surface treatment method
AU2014248508B2 (en) 2013-03-12 2018-11-08 Micell Technologies, Inc. Bioabsorbable biomedical implants
JP2016519965A (en) 2013-05-15 2016-07-11 マイセル・テクノロジーズ，インコーポレイテッド Bioabsorbable biomedical implant
GB201310894D0 (en) * 2013-06-19 2013-07-31 Univ Singapore Surface modification of medical or veterinary devices
US9999527B2 (en) 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers
US9700443B2 (en) 2015-06-12 2017-07-11 Abbott Cardiovascular Systems Inc. Methods for attaching a radiopaque marker to a scaffold
WO2018095578A1 (en) * 2016-11-25 2018-05-31 Stimos Gmbh Material for a bone implant and method for producing the same

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB387806A (en) * 1930-12-17 1933-02-16 Robert Secrest Dunham Improvements in or relating to the surface treatment of aluminium or aluminium alloys
US2375210A (en) * 1941-01-03 1945-05-08 Batcheller Clements Alloy steel printing plate
US3519538A (en) * 1968-09-05 1970-07-07 Corning Glass Works Chemically coupled enzymes
US4002602A (en) * 1974-03-11 1977-01-11 Gideon Goldstein Ubiquitous immunopoietic polypeptide (UBIP) and methods
US5092944A (en) * 1976-05-07 1992-03-03 The United States Of America As Represented By The Secretary Of The Navy High energy cast explosives based on dinitropropylacrylate
JPS5548392A (en) * 1978-02-17 1980-04-07 Toyo Jozo Co Ltd Novel immobilizing material combined with biologically active substance, its preparation, device comprising it, method, and preparation of support
US4168191A (en) * 1978-06-29 1979-09-18 The United States Of America As Represented By The United States Department Of Energy Thermally stable, plastic-bonded explosives
US4190647A (en) * 1979-01-26 1980-02-26 Sloan-Kettering Institute For Cancer Research Polypeptides and methods
CA1130228A (en) * 1980-05-21 1982-08-24 Chiang-Chang Liao Support matrix for amino-containing biologically active substances
US4543220A (en) * 1984-04-16 1985-09-24 The United States Of America As Represented By The Secretary Of The Army Process for unitary shaped-charge structure
WO1990009798A1 (en) * 1989-02-24 1990-09-07 Immunotherapeutics, Inc. Immobilized cytokines
US5330911A (en) * 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5547526A (en) * 1990-03-06 1996-08-20 Daimler-Benz Aerospace Ag Pressable explosive granular product and pressed explosive charge
WO1992000047A1 (en) * 1990-06-22 1992-01-09 Case Western Reserve University Process for controlling cell growth on surfaces
KR940004638B1 (en) * 1991-03-06 1994-05-27 국방과학연구소 Composite powder of condensed type using the adhesive agent with ethylene acetic vinyl resin
US5306307A (en) * 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
EP0717630A1 (en) * 1994-07-08 1996-06-26 SULZER Medizinaltechnik AG Method of manufacturing implant materials
US5750921A (en) * 1997-07-07 1998-05-12 Chan; May L. Waste-free method of making molding powder
DE59808721D1 (en) * 1997-11-24 2003-07-17 Efmt Entwicklungs Und Forschun METHOD FOR IMMOBILIZING MEDIATOR MOLECULES ON INORGANIC AND METAL IMPLANT MATERIALS

Also Published As

Publication number Publication date
AU2408099A (en) 1999-06-15
CA2311445C (en) 2008-10-21
ES2201571T3 (en) 2004-03-16
DE59808721D1 (en) 2003-07-17
WO1999026674A2 (en) 1999-06-03
ATE242647T1 (en) 2003-06-15
US20040074568A1 (en) 2004-04-22
EP1035879A2 (en) 2000-09-20
EP1035879B1 (en) 2003-06-11
US20080107702A1 (en) 2008-05-08
DE19881727D2 (en) 2001-01-04
US7255872B2 (en) 2007-08-14
AU749139B2 (en) 2002-06-20
US6635269B1 (en) 2003-10-21
WO1999026674A3 (en) 1999-09-16

Similar Documents

Publication Publication Date Title
CA2311445A1 (en) Method for immobilizing mediator molecule on inorganic and metal implant material
KR101013999B1 (en) Membrane and implant immobilized osteogenic enhancing peptides on the surface
WO1999037337A3 (en) Prostheses with associated growth factors
CA2150036A1 (en) A material for a bone substitute and the manufacturing method thereof
EP1443112A3 (en) Macrophage activating factors derived from cloned vitamin D binding protein
WO1991005036A3 (en) Surfaces having desirable cell adhesive effects
Puleo Retention of enzymatic activity immobilized on silanized Co‐Cr‐Mo and Ti‐6Al‐4V
CA2118036A1 (en) Novel bioactive coatings and their preparation and use
WO1999016907A3 (en) Reagent and method for attaching target molecules to a surface
WO2003065881A3 (en) Medical device with coating that promotes endothelial cell adherence and differentiation
Puleo Activity of enzyme immobilized on silanized Co‐Cr‐Mo
EP1378522A3 (en) Methods of enhancing bioactivity of chemokines
Hayakawa et al. Direct attachment of fibronectin to tresyl chloride‐activated titanium
CA2295040A1 (en) Method for coating stents with dna and expression of recombinant genes from dna coated stent in vivo
Mikulec et al. Use of p‐nitrophenyl chloroformate chemistry to immobilize protein on orthopedic biomaterials
KR100630903B1 (en) Membrane and implant immobilized osteogenic enhancing peptides on the surface
GB1534412A (en) Immobilisation of proteins
KR101234361B1 (en) Fusion protein using for bone and teeth regeneration
GB9312315D0 (en) Leukocyte adhesion assay
CA2603280A1 (en) Method for immobilizing mediator molecule on inorganic and metal implant material
Kurimoto et al. Thiolated dermal bovine collagen as a novel support for bioactive substances–conjugation with lysozyme
AU771873B2 (en) Method for the application of an oxide layer on metallic implant materials
Juergensen et al. Biological adhesive composition and method of promoting adhesion between tissue surfaces
IL129533A0 (en) Enzymatic process for the preparation of cephalosporanic 7beta-(4-carboxybutanamide) acid by means of the modified enzyme d-aminoacid oxidase of trgonopsis variabilis produced in escherichia coli
JPS62235568A (en) Carrier biochemically activated by antibody covalent-bonded with surface

Legal Events

Date Code Title Description
EEER Examination request