CA2312102A1 - Integrated fluid manipulation cartridge - Google Patents

Integrated fluid manipulation cartridge Download PDF

Info

Publication number
CA2312102A1
CA2312102A1 CA002312102A CA2312102A CA2312102A1 CA 2312102 A1 CA2312102 A1 CA 2312102A1 CA 002312102 A CA002312102 A CA 002312102A CA 2312102 A CA2312102 A CA 2312102A CA 2312102 A1 CA2312102 A1 CA 2312102A1
Authority
CA
Canada
Prior art keywords
sample
cartridge
component
flow path
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002312102A
Other languages
French (fr)
Other versions
CA2312102C (en
Inventor
Lee Allan Christel
Gregory T.A. Kovacs
Wiiliam A. Mcmillan
M. Allen Northrup
Kurt E. Petersen
Farzad Pourahmadi
Jesus Ching
Ronald Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cepheid
Original Assignee
Cepheid
Lee Allan Christel
Gregory T.A. Kovacs
Wiiliam A. Mcmillan
M. Allen Northrup
Kurt E. Petersen
Farzad Pourahmadi
Jesus Ching
Ronald Chang
Mcmillan, William A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepheid, Lee Allan Christel, Gregory T.A. Kovacs, Wiiliam A. Mcmillan, M. Allen Northrup, Kurt E. Petersen, Farzad Pourahmadi, Jesus Ching, Ronald Chang, Mcmillan, William A. filed Critical Cepheid
Publication of CA2312102A1 publication Critical patent/CA2312102A1/en
Application granted granted Critical
Publication of CA2312102C publication Critical patent/CA2312102C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432—Photolithographic masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
    • G01F1/708—Measuring the time taken to traverse a fixed distance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

A cartridge (101) for separating a desired analyte from a fluid sample includes a sample port (103) and a sample flow path extending from the port through the body of the cartridge. The sample flow path includes at least one flow-through component (122), e.g., filter paper or a microfabricated chip, for capturing the desired analyte from the sample as the sample flows through the cartridge. The cartridge also includes an elution flow path for carrying elution fluid through the component (122) to release captured analyte from the component into the elution fluid. The elution flow path diverges from the sample flow path after passing through the component (122). Flow controllers (41 A
and 41B) direct the remaining fluid sample into a waste chamber (139) after the sample flows through the component (122) and direct the elution fluid and eluted analyte into a reagent chamber (141) and reaction chamber (143). The continuous-flow design of the cartridge permits the rapid processing of a fluid sample that is larger in volume than any interactive region within the cartridge, allowing increased sensitivity in the detection of low copy concentrations of analytes, such as nucleic acid.
CA002312102A 1997-12-24 1998-12-24 Integrated fluid manipulation cartridge Expired - Lifetime CA2312102C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99818897A 1997-12-24 1997-12-24
US11545498A 1998-07-14 1998-07-14
US09/115,454 1998-07-14
US08/998,188 1998-07-14
PCT/US1998/027632 WO1999033559A1 (en) 1997-12-24 1998-12-24 Integrated fluid manipulation cartridge

Publications (2)

Publication Number Publication Date
CA2312102A1 true CA2312102A1 (en) 1999-07-08
CA2312102C CA2312102C (en) 2007-09-04

Family

ID=26813217

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002312102A Expired - Lifetime CA2312102C (en) 1997-12-24 1998-12-24 Integrated fluid manipulation cartridge

Country Status (10)

Country Link
US (3) US6440725B1 (en)
EP (2) EP1042061A1 (en)
JP (3) JP4209589B2 (en)
AT (1) ATE400358T1 (en)
AU (1) AU758407B2 (en)
CA (1) CA2312102C (en)
DE (1) DE69839709D1 (en)
DK (1) DK1179585T3 (en)
ES (1) ES2309022T3 (en)
WO (1) WO1999033559A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017382B2 (en) 2002-03-05 2011-09-13 Abbott Point Of Care Inc. Apparatus and methods for analyte measurement and immunoassay

Families Citing this family (646)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6440725B1 (en) * 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
US6660228B1 (en) 1998-03-02 2003-12-09 Cepheid Apparatus for performing heat-exchanging, chemical reactions
US20060029926A1 (en) * 1998-05-06 2006-02-09 Metrika, Inc. Blocking compositions for immunoassays
JP4321738B2 (en) 1998-06-24 2009-08-26 チェン アンド チェン エルエルシー Liquid sample test system
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6780617B2 (en) * 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
EP1125121B1 (en) * 1998-10-28 2007-12-12 Covaris, Inc. Apparatus and methods for controlling sonic treatment
US7687039B2 (en) 1998-10-28 2010-03-30 Covaris, Inc. Methods and systems for modulating acoustic energy delivery
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US6948843B2 (en) * 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US7914994B2 (en) * 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US7214544B2 (en) * 1999-03-02 2007-05-08 Qualigen, Inc. Semi-continuous blood separation using magnetic beads
TW496775B (en) * 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US20040200909A1 (en) * 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US9073053B2 (en) * 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US8815521B2 (en) 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
ATE278771T1 (en) * 1999-05-28 2004-10-15 Cepheid APPARATUS AND METHOD FOR ANALYZING LIQUID SAMPLES
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6878540B2 (en) * 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US6692697B1 (en) * 1999-07-30 2004-02-17 Texas Instruments Incorporated Versatile flow cell front-end for optically-based integrated sensors
US7329388B2 (en) 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
GB2357288A (en) * 1999-12-13 2001-06-20 Ortho Clinical Diagnostics Solid phase carrier coated with a polymer for adsorbing macromolecules
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
JP2001188061A (en) * 1999-12-28 2001-07-10 Shimadzu Corp Microchip for analysis
US6403037B1 (en) 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
DE60032113T2 (en) * 2000-02-11 2007-06-28 Stmicroelectronics S.R.L., Agrate Brianza Integrated device for microfluidic temperature control and its manufacturing method
JP3442338B2 (en) 2000-03-17 2003-09-02 株式会社日立製作所 DNA analyzer, DNA base sequencer, DNA base sequence determination method, and reaction module
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
WO2001077641A1 (en) * 2000-04-06 2001-10-18 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
WO2001087768A2 (en) * 2000-05-15 2001-11-22 Tecan Trading Ag Use of vapor-deposited conformal coatings in microfluidic structures
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
DE60023464T2 (en) * 2000-06-05 2006-07-20 Stmicroelectronics S.R.L., Agrate Brianza Process for the production of integrated chemical microreactors made of semiconductor material and integrated microreactor
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US6374684B1 (en) 2000-08-25 2002-04-23 Cepheid Fluid control and processing system
JP3993372B2 (en) 2000-09-13 2007-10-17 独立行政法人理化学研究所 Reactor manufacturing method
US6613224B1 (en) * 2000-10-06 2003-09-02 Waters Investments Limited Liquid separation column smart cartridge
US20020155033A1 (en) * 2000-10-06 2002-10-24 Protasis Corporation Fluid Separate conduit cartridge
EP1328342A4 (en) * 2000-10-10 2006-03-15 Aviva Biosciences Corp An integrated biochip system for sample preparation and analysis
EP1331999A2 (en) * 2000-11-03 2003-08-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20090118139A1 (en) * 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US20050221385A1 (en) * 2000-11-07 2005-10-06 Caliper Life Sciences, Inc. Pressure based mobility shift assays
US7105304B1 (en) * 2000-11-07 2006-09-12 Caliper Life Sciences, Inc. Pressure-based mobility shift assays
US6623700B1 (en) * 2000-11-22 2003-09-23 Xerox Corporation Level sense and control system for biofluid drop ejection devices
WO2002052045A1 (en) * 2000-12-26 2002-07-04 Aviva Biosciences Active and biocompatible platforms prepared by polymerization of surface coating films
US20020098122A1 (en) * 2001-01-22 2002-07-25 Angad Singh Active disposable microfluidic system with externally actuated micropump
US6692700B2 (en) * 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
ITMI20010434A1 (en) * 2001-03-02 2002-09-02 Oglio Stefano Dall DISPOSABLE STERILIZABLE SAMPLING UNIT FOR DETERMINATIONS IN MICROBIOLOGY AND CHEMICAL-CLINICS
US7192557B2 (en) * 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US20020160518A1 (en) * 2001-04-03 2002-10-31 Hayenga Jon W. Microfluidic sedimentation
DE10117772C2 (en) * 2001-04-09 2003-04-03 Advalytix Ag Mixing device and mixing method for mixing small amounts of liquid
GB2374560B (en) * 2001-04-17 2005-04-06 Rawson Francis F H Processing vessel
US6727479B2 (en) * 2001-04-23 2004-04-27 Stmicroelectronics S.R.L. Integrated device based upon semiconductor technology, in particular chemical microreactor
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US6981522B2 (en) 2001-06-07 2006-01-03 Nanostream, Inc. Microfluidic devices with distributing inputs
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US7014747B2 (en) 2001-06-20 2006-03-21 Sandia Corporation Dielectrophoretic systems without embedded electrodes
WO2003004162A1 (en) * 2001-07-02 2003-01-16 Gene Logic, Inc. Flow-thru chip cartridge, chip holder, system & method thereof
US20030108949A1 (en) * 2001-07-03 2003-06-12 Gang Bao Filtration-based microarray chip
WO2003033740A2 (en) * 2001-07-10 2003-04-24 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid
EP1277438A1 (en) * 2001-07-10 2003-01-22 Agilent Technologies, Inc. (a Delaware corporation) System for point of care diagnosis and/or analysis
EP1427531B1 (en) * 2001-09-11 2016-10-19 Iquum, Inc. Sample vessels
DE10146545A1 (en) * 2001-09-21 2003-04-10 Merck Patent Gmbh microcomponent
US7344894B2 (en) * 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
ATE521891T1 (en) * 2001-10-29 2011-09-15 Arkray Inc TEST APPARATUS
US7767437B2 (en) * 2001-11-02 2010-08-03 Genefluidics, Inc. System for detection of a component in a liquid
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
FR2832507B1 (en) * 2001-11-20 2004-02-20 Stago Diagnostica METHOD OF DETECTING ANALYTE (S) USING COLLOIDAL MAGNETIC PARTICLES
WO2003052427A1 (en) * 2001-12-14 2003-06-26 Arkray, Inc. Sample measuring device
US6739576B2 (en) 2001-12-20 2004-05-25 Nanostream, Inc. Microfluidic flow control device with floating element
US20030116552A1 (en) * 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
JP3721334B2 (en) * 2002-02-01 2005-11-30 富士写真フイルム株式会社 Receptor-ligand association reaction method and reactor used therefor
WO2003068402A1 (en) 2002-02-13 2003-08-21 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
DE10206464A1 (en) * 2002-02-16 2003-08-28 Micronas Gmbh Method for producing a sensor or actuator arrangement and sensor or actuator arrangement
AU2003216002A1 (en) * 2002-03-31 2003-10-13 Gyros Ab Efficient mmicrofluidic devices
US7052480B2 (en) 2002-04-10 2006-05-30 Baxter International Inc. Access disconnection systems and methods
US10155082B2 (en) 2002-04-10 2018-12-18 Baxter International Inc. Enhanced signal detection for access disconnection systems
US7022098B2 (en) 2002-04-10 2006-04-04 Baxter International Inc. Access disconnection systems and methods
US20040254513A1 (en) * 2002-04-10 2004-12-16 Sherwin Shang Conductive polymer materials and applications thereof including monitoring and providing effective therapy
JP2005532043A (en) * 2002-04-11 2005-10-27 シークエノム， インコーポレイテッド Method and apparatus for performing chemical reactions on a solid support
DE10216947B4 (en) * 2002-04-17 2007-10-04 Ehrfeld Mikrotechnik Bts Gmbh Method for homogenizing emulsions
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
JP4095886B2 (en) * 2002-05-08 2008-06-04 株式会社日立ハイテクノロジーズ Chemical analysis device and genetic diagnosis device
JP4106977B2 (en) 2002-06-21 2008-06-25 株式会社日立製作所 Analysis chip and analyzer
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing
US20040126783A1 (en) * 2002-07-10 2004-07-01 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid from a sample
US7452507B2 (en) * 2002-08-02 2008-11-18 Sandia Corporation Portable apparatus for separating sample and detecting target analytes
JP2004081019A (en) * 2002-08-23 2004-03-18 Jsr Corp Apparatus for examining cell reaction and method for examining cell reaction
US20040038385A1 (en) * 2002-08-26 2004-02-26 Langlois Richard G. System for autonomous monitoring of bioagents
CN1331575C (en) * 2002-09-09 2007-08-15 塞通诺米公司 Implementation of microfluidic components in a microfluidic system
US6878271B2 (en) * 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US7455770B2 (en) * 2002-09-09 2008-11-25 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
ITTO20020808A1 (en) * 2002-09-17 2004-03-18 St Microelectronics Srl INTEGRATED DNA ANALYSIS DEVICE.
ITTO20020809A1 (en) * 2002-09-17 2004-03-18 St Microelectronics Srl MICROPUMP, IN PARTICULAR FOR AN INTEGRATED DNA ANALYSIS DEVICE.
JP3725109B2 (en) * 2002-09-19 2005-12-07 財団法人生産技術研究奨励会 Microfluidic device
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US7143900B2 (en) * 2002-10-28 2006-12-05 Hewlett-Packard Development Company, L.P. Separation device and method of making the same
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7010964B2 (en) 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
EP1420251B1 (en) * 2002-11-12 2013-01-09 Panasonic Corporation Specific coupling reaction measuring method
FR2846957B1 (en) * 2002-11-13 2005-09-30 Commissariat Energie Atomique MICRO-SYSTEM FILLING MICROBALLS AND PROCESS FOR OBTAINING THE SAME
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
US7175810B2 (en) * 2002-11-15 2007-02-13 Eksigent Technologies Processing of particles
WO2004046305A2 (en) * 2002-11-18 2004-06-03 Agency For Science, Technology And Research Method and system for cell and/or nucleic acid molecules isolation
US7842234B2 (en) * 2002-12-02 2010-11-30 Epocal Inc. Diagnostic devices incorporating fluidics and methods of manufacture
CA2772050C (en) * 2002-12-26 2016-09-06 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
KR20050118668A (en) * 2003-01-21 2005-12-19 마이크로닉스 인코포레이티드. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
EP1603674B1 (en) 2003-02-05 2016-01-06 Iquum, Inc. Sample processing
WO2004076056A2 (en) * 2003-02-26 2004-09-10 Lake Shore Cryotronics Inc. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
US8501402B2 (en) * 2003-03-24 2013-08-06 Boehringer Ingelheim Rcv Gmbh & Co Kg Methods and devices for producing biomolecules
GB0307999D0 (en) * 2003-04-07 2003-05-14 Glaxo Group Ltd A system
DE10319045A1 (en) * 2003-04-25 2004-12-09 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Device and method for processing liquids containing biopolymers
JP4836795B2 (en) * 2003-05-19 2011-12-14 ブランデイズ ユニバーシティー Nucleic acid processing method, kit, and apparatus
US7170594B2 (en) * 2003-05-28 2007-01-30 Smiths Detection, Inc. Device for polymerase chain reactions
ES2220227B1 (en) 2003-05-30 2006-02-16 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" METHOD AND APPARATUS FOR THE DETECTION OF SUBSTANCES OR ANALYTICS FROM THE ANALYSIS OF ONE OR SEVERAL SAMPLES.
EP1633481A1 (en) * 2003-06-06 2006-03-15 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
US7648835B2 (en) * 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
WO2005029030A2 (en) 2003-06-10 2005-03-31 University Of Louisville Research Foundation, Inc. Micro scale flow through sorbent plate collection device
US20040259076A1 (en) * 2003-06-23 2004-12-23 Accella Scientific, Inc. Nano and micro-technology virus detection method and device
US20050013106A1 (en) 2003-07-17 2005-01-20 Takiar Hem P. Peripheral card with hidden test pins
WO2005010808A2 (en) 2003-07-17 2005-02-03 Sandisk Corporation Memory card with raised portion
US7416132B2 (en) * 2003-07-17 2008-08-26 Sandisk Corporation Memory card with and without enclosure
EP2402089A1 (en) 2003-07-31 2012-01-04 Handylab, Inc. Processing particle-containing samples
WO2005028635A2 (en) * 2003-09-19 2005-03-31 Microfluidic Systems Inc. Microfluidic differential extraction cartridge
US7541166B2 (en) 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
US7524464B2 (en) 2003-09-26 2009-04-28 Ahn Chong H Smart disposable plastic lab-on-a-chip for point-of-care testing
SE0302649D0 (en) * 2003-10-04 2003-10-04 Gyros Ab Compact dispenser system
US7032605B1 (en) 2003-10-15 2006-04-25 Douglas B. Dority Dual piston rotary valve
US8007724B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having at least one auxiliary buffer passage
EP1706735B1 (en) 2003-11-07 2017-01-04 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
DE10353985A1 (en) * 2003-11-19 2005-06-23 Olympus Biosystems Gmbh Apparatus for manipulation and analysis of micro-objects, useful particularly for cells or their components, is constructed as a fluidics microsystem and/or microchip
WO2005055804A2 (en) * 2003-12-02 2005-06-23 Musc Foundation For Research Development Methods and compositions for diagnosing epithelial cell cancer
US7328628B2 (en) 2003-12-08 2008-02-12 Covaris, Inc. Apparatus and methods for sample preparation
US7476360B2 (en) 2003-12-09 2009-01-13 Genefluidics, Inc. Cartridge for use with electrochemical sensor
US7322254B2 (en) * 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
FR2863626B1 (en) 2003-12-15 2006-08-04 Commissariat Energie Atomique METHOD AND DEVICE FOR DIVIDING A BIOLOGICAL SAMPLE BY MAGNETIC EFFECT
CA2549367A1 (en) * 2003-12-23 2005-07-21 Fastraq, Inc. Point of care diagnostic platform
US20050142571A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US20050142570A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US20050142565A1 (en) * 2003-12-30 2005-06-30 Agency For Science, Technology And Research Nucleic acid purification chip
US7384791B2 (en) * 2004-01-21 2008-06-10 Hewlett-Packard Development Company, L.P. Method of analyzing blood
SG10201405756WA (en) * 2004-01-25 2014-11-27 Fluidigm Corp Crystal forming devices and systems and methods for making and using the same
GB2416030B (en) * 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
FR2865806B1 (en) * 2004-01-30 2007-02-02 Commissariat Energie Atomique ON-CHIP LABORATORY COMPRISING A MICRO-FLUIDIC NETWORK AND A COPLANAR ELECTRONEBULATING NOSE
ATE520340T1 (en) * 2004-02-03 2011-09-15 Sysmex Corp ANALYZER, CARTRIDGE, CARTRIDGE KIT
WO2005084254A2 (en) * 2004-02-27 2005-09-15 Musc Foundation For Research Development Enhanced detection of rna using a panel of truncated gene-specific primers for reverse transcription
US8101431B2 (en) * 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US7160425B2 (en) * 2004-03-25 2007-01-09 Hewlett-Packard Development Company, L.P. Cell transporter for a biodevice
US7390388B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells on a biodevice
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
US20050244837A1 (en) * 2004-04-28 2005-11-03 Cepheid Method and device for sample preparation control
DE102004021780B4 (en) * 2004-04-30 2008-10-02 Siemens Ag Method and device for DNA isolation with dry reagents
DE102004021822B3 (en) * 2004-04-30 2005-11-17 Siemens Ag Method and arrangement for DNA amplification by means of PCR using dry reagents
ES2553097T3 (en) * 2004-05-03 2015-12-04 Handylab, Inc. Processing of samples containing polynucleotides
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP4373947B2 (en) * 2004-05-04 2009-11-25 ミリポア・コーポレイション Method for counting and identifying microorganisms
JP3952036B2 (en) * 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 Microfluidic device, test solution test method and test system
DE602005016402D1 (en) 2004-05-24 2009-10-15 Genvault Corp STABLE STORAGE OF PROTEIN AND STABLE STORAGE OF NUCLEIC ACID IN RECYCLABLE FORM
US7311386B2 (en) 2004-06-30 2007-12-25 Lexmark Interntional, Inc. Die attach methods and apparatus for micro-fluid ejection device
US7043838B2 (en) 2004-06-30 2006-05-16 Lexmark International, Inc. Process for manufacturing a micro-fluid ejection device
WO2006085948A2 (en) * 2004-07-01 2006-08-17 Cornell Research Foundation, Inc. Real-time pcr detection of microorganisms using an integrated microfluidics platform
ITBO20040420A1 (en) 2004-07-07 2004-10-07 Type S R L METAL CUTTING AND FORMING MACHINE
CA2571642A1 (en) * 2004-07-09 2006-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N Identification of markers in lung and breast cancer
US8329437B1 (en) 2004-07-29 2012-12-11 E.I. Spectra, Llc Disposable particle counter cartridge
JP4661125B2 (en) * 2004-08-04 2011-03-30 日立電線株式会社 Component separation element and manufacturing method thereof
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
US8053214B2 (en) 2004-09-09 2011-11-08 Microfluidic Systems, Inc. Apparatus and method of extracting and optically analyzing an analyte from a fluid-based sample
US7988935B2 (en) 2004-09-09 2011-08-02 Microfluidic Systems, Inc. Handheld and portable microfluidic device to automatically prepare nucleic acids for analysis
CN102759466A (en) * 2004-09-15 2012-10-31 英特基因有限公司 Microfluidic devices
KR20070085275A (en) * 2004-09-20 2007-08-27 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Multiple mode multiplex reaction quenching method
US20080193961A1 (en) * 2004-09-29 2008-08-14 Easley Christopher J Localized Control of Thermal Properties on Microdevices and Applications Thereof
JP4621846B2 (en) * 2004-09-30 2011-01-26 アークレイ株式会社 Analysis tool
CN100565207C (en) 2004-10-01 2009-12-02 株式会社日立高新技术 Chemical analysis device
JPWO2006038643A1 (en) * 2004-10-06 2008-08-07 ユニバーサル・バイオ・リサーチ株式会社 Reaction container and reaction control device
WO2006044458A2 (en) 2004-10-13 2006-04-27 University Of Virginia Patent Foundation Electrostatic actuation for management of flow
DE102004050575B3 (en) * 2004-10-15 2006-01-05 Siemens Ag Method for the combined isolation of magnetic beads from a liquid sample and subsequent thermal cycling for the PCR and associated assembly
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
US7785868B2 (en) 2004-12-02 2010-08-31 Microfluidic Systems, Inc. Apparatus to automatically lyse a sample
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
CA2588753C (en) 2004-12-03 2014-02-18 Cytonome, Inc. Unitary cartridge for particle processing
US20070141576A1 (en) * 2004-12-13 2007-06-21 Bbk Bio Corporpation Biological chip and use thereof
WO2006069305A2 (en) * 2004-12-22 2006-06-29 University Of Virginia Patent Foundation The use of microwaves for thermal and non-thermal applications in micro and nanoscale devices
JP5165383B2 (en) * 2004-12-23 2013-03-21 アイ−スタツト・コーポレイシヨン Molecular diagnostic system and method
JP2008527312A (en) * 2004-12-31 2008-07-24 メムズフロウ エイピーエス Generation of pulsating pressure waves for cell lysis, for example
JP4361879B2 (en) 2005-01-07 2009-11-11 株式会社日立ハイテクノロジーズ Chemical analysis apparatus and chemical analysis cartridge
CN101031802B (en) * 2005-01-07 2012-11-07 积水化学工业株式会社 Detection device using cartridge
WO2006076567A2 (en) * 2005-01-13 2006-07-20 Micronics, Inc. Microfluidic rare cell detection device
JP4422623B2 (en) 2005-01-17 2010-02-24 株式会社日立ハイテクノロジーズ Chemical analysis apparatus and chemical analysis cartridge
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
EP1838442B1 (en) 2005-01-18 2013-09-11 Biocept, Inc. Cell separation using microchannel having patterned posts
US20060166223A1 (en) * 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
US20070017812A1 (en) * 2005-03-30 2007-01-25 Luc Bousse Optimized Sample Injection Structures in Microfluidic Separations
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
EP1712284B1 (en) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Cell separation method using hydrophobic solid supports
JP2006300548A (en) * 2005-04-15 2006-11-02 Hitachi Software Eng Co Ltd Inspection chip and inspection chip system
US8394608B2 (en) * 2005-05-09 2013-03-12 Biofire Diagnostics, Inc. Self-contained biological analysis
US20060264779A1 (en) 2005-05-09 2006-11-23 Kemp Timothy M Fluidic medical devices and uses thereof
US8206974B2 (en) 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
US10816563B2 (en) 2005-05-25 2020-10-27 Boehringer Ingelheim Vetmedica Gmbh System for operating a system for the integrated and automated analysis of DNA or protein
EP1883474B1 (en) 2005-05-25 2021-03-31 Boehringer Ingelheim Vetmedica GmbH System for the integrated and automated analysis of dna or protein and method for operating said type of system
AU2006309284B2 (en) 2005-05-31 2012-08-02 Board Of Regents, The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
CA2610875A1 (en) 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
JP4870946B2 (en) * 2005-06-17 2012-02-08 凸版印刷株式会社 Reaction vessel and reaction method
ES2373686T3 (en) * 2005-06-23 2012-02-07 Biocartis Sa CARTRIDGE, SYSTEM AND PROCEDURE FOR AUTOMATED MEDICAL DIAGNOSTICS.
WO2007002480A2 (en) * 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
ITBO20050481A1 (en) 2005-07-19 2007-01-20 Silicon Biosystems S R L METHOD AND APPARATUS FOR THE HANDLING AND / OR IDENTIFICATION OF PARTICLES
US7757561B2 (en) * 2005-08-01 2010-07-20 Covaris, Inc. Methods and systems for processing samples using acoustic energy
WO2007030240A2 (en) * 2005-08-01 2007-03-15 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
TW200712495A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus and method for detecting an analyte
TW200712489A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus assembly and method for detecting an analyte
TW200712487A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus and method for detecting an analyte
TW200714898A (en) 2005-08-02 2007-04-16 3M Innovative Properties Co Apparatus and method for detecting an analyte
KR100714988B1 (en) * 2005-08-09 2007-05-09 삼성전자주식회사 Method for DNA purification using bare surface of SiO2 structure,and Purification Apparatus thereby
US7618588B2 (en) 2005-08-10 2009-11-17 Microfluidic Systems, Inc. Disposable integrated heater and tube assembly for thermally-driven chemical reactions
AU2006283177B2 (en) * 2005-08-23 2011-11-17 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
CN101317086B (en) * 2005-10-04 2013-08-14 海德威技术公司 Microfluidic detection of analytes
WO2007041671A2 (en) * 2005-10-04 2007-04-12 University Of Virginia Patent Foundation Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof
WO2007149111A2 (en) * 2005-10-06 2007-12-27 Massachusetts Institute Of Technology Continuous biomolecule separation in a nanofilter
WO2007044917A2 (en) * 2005-10-11 2007-04-19 Handylab, Inc. Polynucleotide sample preparation device
US8916375B2 (en) * 2005-10-12 2014-12-23 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) * 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US8372340B2 (en) 2005-10-19 2013-02-12 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
ITBO20050646A1 (en) 2005-10-26 2007-04-27 Silicon Biosystem S R L METHOD AND APPARATUS FOR CHARACTERIZATION AND COUNTING OF PARTICLES
US20070141605A1 (en) * 2005-11-21 2007-06-21 Applera Corporation Portable preparation, analysis, and detection apparatus for nucleic acid processing
DE102005059536B4 (en) * 2005-12-13 2008-08-28 Siemens Ag Method and biochip for studying a biological sample
CA2634735A1 (en) 2005-12-29 2007-07-12 I-Stat Corporation Molecular diagnostics amplification system and methods
US8084270B2 (en) * 2006-01-25 2011-12-27 Koninklijke Philips Electronics N.V. Device for analyzing fluids
US8263360B2 (en) * 2006-01-30 2012-09-11 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Hydrophilic IR transparent membrane, spectroscopic sample holder comprising same and method of using same
JP4906362B2 (en) * 2006-01-30 2012-03-28 株式会社日立ハイテクノロジーズ Chemical analysis pretreatment equipment
US9452429B2 (en) 2006-02-02 2016-09-27 E. I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
US8171778B2 (en) * 2006-05-05 2012-05-08 E I Spectra, LLC Thin film particle sensor
US20110189714A1 (en) * 2010-02-03 2011-08-04 Ayliffe Harold E Microfluidic cell sorter and method
US8616048B2 (en) * 2006-02-02 2013-12-31 E I Spectra, LLC Reusable thin film particle sensor
US9293311B1 (en) 2006-02-02 2016-03-22 E. I. Spectra, Llc Microfluidic interrogation device
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc Microfluidic devices
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
WO2007106557A2 (en) 2006-03-14 2007-09-20 University Of Southern California Mems device for delivery of therapeutic agents
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8741230B2 (en) * 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2001990B1 (en) 2006-03-24 2016-06-29 Handylab, Inc. Integrated system for processing microfluidic samples, and method of using same
ITTO20060226A1 (en) 2006-03-27 2007-09-28 Silicon Biosystem S P A METHOD AND APPARATUS FOR PROCESSING AND OR ANALYSIS AND OR SELECTION OF PARTICLES, IN PARTICULAR BIOLOGICAL PARTICLES
US20100120132A1 (en) * 2006-03-31 2010-05-13 Intel Corporation Bioassays by direct optical detection of nanoparticles
JP4685691B2 (en) * 2006-04-13 2011-05-18 株式会社日立ソリューションズ Inspection chip and inspection chip system
CA2646309C (en) 2006-04-21 2016-07-26 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
US7705339B2 (en) * 2006-04-25 2010-04-27 University Of South Florida Portable reactor for real-time nucleic acid amplification and detection comprising a reaction chamber formed from a flexible printed circuit board
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
JP5627886B2 (en) * 2006-05-16 2014-11-19 フルイディウム コーポレーション PCR-free sample preparation and detection system for rapid biological analysis and identification
KR100785016B1 (en) * 2006-05-22 2007-12-12 삼성전자주식회사 Method and apparatus for the concentration and amplification of nucleic acids in a single micro chamber
JP4759451B2 (en) * 2006-06-16 2011-08-31 株式会社日立ソリューションズ Pretreatment chip for biological material and pretreatment chip system
DE102006028101B4 (en) * 2006-06-19 2014-02-13 Siemens Aktiengesellschaft Method for analyzing amplified nucleic acids
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US7549349B2 (en) * 2006-06-22 2009-06-23 Evogen, Inc. Sample cartridge for air-sampling device
US20100240022A1 (en) * 2006-06-23 2010-09-23 Mcneely Michael R Reagent preparation and valving design for liquid testing
KR101269741B1 (en) * 2006-07-04 2013-05-30 쓰리엠 이노베이티브 프로퍼티즈 캄파니 Electromagnetic wave shielding gasket having elasticity and adhesiveness
US8187557B2 (en) 2006-07-13 2012-05-29 Cepheid Reagent reservoir system for analytical instruments
EP1878802A1 (en) 2006-07-14 2008-01-16 Roche Diagnostics GmbH Disposable device for analysing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus
EP1878496A1 (en) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Apparatus for performing nucleic acid analysis
US7858363B2 (en) * 2006-07-22 2010-12-28 Zymo Research Corporation Plasmid DNA isolation
US8252160B2 (en) * 2006-07-28 2012-08-28 Hewlett-Packard Development Company, L.P. Prevention of fluid delivered to reservoir from wicking into channels within microfluidic device
JP2008051803A (en) * 2006-07-28 2008-03-06 Sharp Corp Microchannel device for analysis
WO2008016691A2 (en) * 2006-08-01 2008-02-07 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
JP2008048735A (en) 2006-08-21 2008-03-06 Samsung Electronics Co Ltd Method for separating microorganism with non-planar solid support and apparatus for separating the same
US8158411B2 (en) 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
US20080069732A1 (en) * 2006-09-20 2008-03-20 Robert Yi Diagnostic test system
GB0618966D0 (en) * 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
WO2008133640A2 (en) * 2006-10-11 2008-11-06 Arcxis Biotechnologies, Inc. Disposable micropurification cards, methods, and systems thereof
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
CN101578520B (en) 2006-10-18 2015-09-16 哈佛学院院长等 Based on formed pattern porous medium cross flow and through biometric apparatus, and preparation method thereof and using method
CN101568636A (en) * 2006-11-02 2009-10-28 威腾技术公司 Cartridge for conducting diagnostic assays
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
US9102911B2 (en) 2009-05-15 2015-08-11 Biofire Diagnostics, Llc High density self-contained biological analysis
EP1925359A1 (en) 2006-11-22 2008-05-28 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy to form particles and particulates
ITMI20062272A1 (en) * 2006-11-27 2008-05-28 Genedia S R L REACTOR FOR BIOCHEMICAL PROCESSES PARTICULARLY EXTRACTION PURIFICATION ENRICHMENT SEDIMENTATION
US20080121591A1 (en) * 2006-11-29 2008-05-29 Canon U.S. Life Sciences, Inc. Device for nucleic acid preparation
US7993525B2 (en) * 2006-12-29 2011-08-09 Intel Corporation Device and method for particle complex handling
US8338166B2 (en) * 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
US10001496B2 (en) * 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
NL1033317C2 (en) * 2007-02-01 2008-08-04 C2V B V Device for capillary chromatography and method for manufacturing such a device.
US8367397B2 (en) * 2007-02-15 2013-02-05 Honeywell International Inc. Active biochip for nucleic acid analysis
WO2008101196A1 (en) * 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
US20090011417A1 (en) * 2007-03-07 2009-01-08 George Maltezos Testing Device
AU2008236691B2 (en) 2007-04-04 2014-08-07 Ande Corporation Integrated nucleic acid analysis
DE102007020444A1 (en) * 2007-04-27 2008-11-06 Bayer Materialscience Ag Process for the oxidation of a hydrogen chloride-containing gas mixture
FR2917095B1 (en) * 2007-06-07 2009-07-17 Biomerieux Sa DEVICE FOR LYING MICROORGANISMS PRESENT IN AN ENVIRONMENTAL OR CLINICAL SAMPLE AND EXTRACTING NUCLEIC ACIDS FROM SAID MICROORGANISMS FOR ANALYSIS.
JP5282088B2 (en) 2007-06-21 2013-09-04 ジェン−プロウブ インコーポレイテッド Equipment and containers used for processing execution
JP5433139B2 (en) * 2007-06-29 2014-03-05 株式会社東芝 Microchemical analyzer, measuring method thereof, and microcassette
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
NZ582786A (en) * 2007-07-23 2012-09-28 Clondiag Gmbh Assays for nucleic acids
US8088341B2 (en) * 2007-07-25 2012-01-03 University Of Louisville Research Foundation, Inc. Analyte collection devices and methods
US20090030342A1 (en) * 2007-07-27 2009-01-29 3M Innovative Properties Company Apparatus and method for releasing a sample of material
JP5852781B2 (en) * 2007-07-31 2016-02-03 マイクロニクス， インコーポレイテッド Hygienic swab collection system, microfluidic assay device and method for diagnostic assays
GB0715171D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
GB0715170D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
EP2178640A1 (en) * 2007-08-03 2010-04-28 Enigma Diagnostics Limited Reaction vessel
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
ITBO20070588A1 (en) 2007-08-13 2009-02-14 Silicon Biosystems Spa METHOD TO BOND A SILICON LAYER TO A METHACRYLIC POLYMER SUBSTRATE
US20110126929A1 (en) * 2007-08-15 2011-06-02 Massachusetts Institute Of Technology Microstructures For Fluidic Ballasting and Flow Control
US8308926B2 (en) 2007-08-20 2012-11-13 Purdue Research Foundation Microfluidic pumping based on dielectrophoresis
US8015887B2 (en) * 2007-09-29 2011-09-13 E I Spectra, LLC Instrumented pipette tip
CN104502579B (en) 2007-10-02 2018-04-13 赛拉诺斯知识产权有限责任公司 Modular point-of-care devices and its application
ITTO20070771A1 (en) 2007-10-29 2009-04-30 Silicon Biosystems Spa METHOD AND APPARATUS FOR IDENTIFICATION AND HANDLING OF PARTICLES
EP2056114A1 (en) * 2007-10-29 2009-05-06 Koninklijke Philips Electronics N.V. Automatic detection of infectious diseases
US20100288941A1 (en) * 2007-11-27 2010-11-18 Ayliffe Harold E Fluorescence-based pipette instrument
US8178045B2 (en) * 2007-12-17 2012-05-15 University Of Louisville Research Foundation, Inc. Interchangeable preconcentrator connector assembly
JP5542691B2 (en) 2007-12-20 2014-07-09 ユニバーシティ オブ サザン カリフォルニア Devices and methods for delivering therapeutic agents
WO2009089466A2 (en) 2008-01-09 2009-07-16 Keck Graduate Institute System, apparatus and method for material preparation and/or handling
WO2009098485A1 (en) * 2008-02-07 2009-08-13 Forensic Sciences Service Ltd Improvements in and relating to analysis
EP2250286A1 (en) 2008-02-15 2010-11-17 Life Technologies Corporation Methods and compositions for shearing of polymers by sonication
WO2009115950A1 (en) * 2008-03-17 2009-09-24 Koninklijke Philips Electronics N.V. Biosensor device having reduced electrical power consumption
AU2009228014B2 (en) * 2008-03-27 2014-10-02 President And Fellows Of Harvard College Cotton thread as a low-cost multi-assay diagnostic platform
CA2719320A1 (en) 2008-03-27 2009-10-01 President And Fellows Of Harvard College Three-dimensional microfluidic devices
US8921118B2 (en) * 2008-03-27 2014-12-30 President And Fellows Of Harvard College Paper-based microfluidic systems
CN101978272B (en) * 2008-03-27 2015-02-04 哈佛学院院长等 Paper-based cellular arrays
JP5303028B2 (en) 2008-04-07 2013-10-02 イーアイ・スペクトラ・エルエルシー Manufacturing method of microfluidic sensor
US8961902B2 (en) 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
CN102202708B (en) 2008-05-08 2015-01-21 迷你泵有限责任公司 Drug-delivery pumps and methods of manufacture
EP2163239A1 (en) 2008-05-27 2010-03-17 Qiagen GmbH Products containing bioparticles, method for their manufacture
KR101102532B1 (en) * 2008-07-10 2012-01-03 삼성전자주식회사 Cartridge containing reagent therein, microfluidic device having the cartridge, manufacturing method of the microfluidic device, biochemistry analysis method using microfluidic device
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8114043B2 (en) 2008-07-25 2012-02-14 Baxter International Inc. Electromagnetic induction access disconnect sensor
WO2010014950A1 (en) * 2008-07-31 2010-02-04 University Of Louisville Rasearch Foundation, Inc. Large volume analyte preconcentrator
WO2010025302A2 (en) 2008-08-27 2010-03-04 Life Technologies Corporation Apparatus for and method of processing biological samples
US11235323B2 (en) * 2008-08-27 2022-02-01 Life Technologies Corporation Apparatus for and method of processing biological samples
US8133451B2 (en) * 2008-08-28 2012-03-13 Microfluidic Systems, Inc. Sample preparation apparatus
JP2012501681A (en) 2008-09-12 2012-01-26 ジェンボールト コーポレイション Matrix and media for storage and stabilization of biomolecules
US20100104485A1 (en) * 2008-10-28 2010-04-29 Microfluidic Systems, Inc. Flow-through thermal cycling device
IT1391619B1 (en) 2008-11-04 2012-01-11 Silicon Biosystems Spa METHOD FOR THE IDENTIFICATION, SELECTION AND ANALYSIS OF TUMOR CELLS
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
FR2938062B1 (en) * 2008-11-05 2014-02-28 Biomerieux Sa DEVICE FOR PREPARING AND / OR PROCESSING A BIOLOGICAL SAMPLE
FR2938063B1 (en) 2008-11-05 2014-09-19 Commissariat Energie Atomique DEVICE FOR PREPARING AND / OR PROCESSING A BIOLOGICAL SAMPLE
GB0901593D0 (en) 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
CA2751455C (en) 2009-02-03 2019-03-12 Netbio, Inc. Nucleic acid purification
US20100267092A1 (en) * 2009-02-09 2010-10-21 Frederic Zenhausern Components
US9739771B2 (en) * 2009-02-27 2017-08-22 Yale University Physiologic sample preparation for nanosensors
CA2754577C (en) 2009-03-06 2018-07-10 President And Fellows Of Harvard College Microfluidic, electrochemical devices
KR20100102926A (en) * 2009-03-12 2010-09-27 삼성전자주식회사 Filter unit for purifying target molecule and microfluidic device using the same
PT2408562T (en) 2009-03-17 2018-06-06 Menarini Silicon Biosystems Spa Microfluidic device for isolation of cells
ITBO20090154A1 (en) * 2009-03-17 2010-09-18 Silicon Biosystems Spa MICROFLUID SYSTEM
ITBO20090155A1 (en) * 2009-03-17 2010-09-18 Silicon Biosystems Spa METHOD FOR INSULATING PARTICLES
ITBO20090152A1 (en) * 2009-03-17 2010-09-18 Silicon Biosystems Spa MICROFLUIDIC DEVICE
US8448532B2 (en) * 2009-03-18 2013-05-28 The United States Of America As Represented By The Secretary Of The Navy Actively cooled vapor preconcentrator
JP2012521558A (en) * 2009-03-23 2012-09-13 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Manipulation of magnetic particles in biological samples
CN102483410A (en) * 2009-03-25 2012-05-30 莱泽尔诊断公司 Apparatus and methods for analyzing fluid variables
SG174567A1 (en) * 2009-03-25 2011-10-28 Univ Nanyang Tech Apparatus and method for detection of organisms
US9110073B2 (en) 2009-03-31 2015-08-18 Hitachi High-Technologies Corporation Liquid chromatograph, liquid chromatograph column and filter for liquid chromatograph column
US8709356B2 (en) * 2009-04-10 2014-04-29 Canon U.S. Life Sciences, Inc. Systems and methods for minimization or elimination of diffusion effects in a microfluidic system
RU2549443C2 (en) 2009-04-14 2015-04-27 Биокартис Нв Cavitation induced by high-intensity focused ultrasound with reduced power threshold
AU2010237532B2 (en) 2009-04-15 2014-11-20 Biocartis Nv Optical detection system for monitoring rtPCR reaction
ES2677010T3 (en) 2009-04-15 2018-07-27 Biocartis Nv Bioanalytical sample chamber protection
WO2010127464A1 (en) 2009-05-06 2010-11-11 Biocartis Sa Device for cutting a sample carrier
US20100300882A1 (en) * 2009-05-26 2010-12-02 General Electric Company Devices and methods for in-line sample preparation of materials
DE102009040151B4 (en) * 2009-05-26 2013-09-12 Analytik Jena Ag Arrangement for the detection of chemiluminescence on gases
KR20120031218A (en) 2009-06-05 2012-03-30 인터젠엑스 인크. Universal sample preparation system and use in an integrated analysis system
JP2012529908A (en) 2009-06-15 2012-11-29 ネットバイオ・インコーポレーテッド Improved method for quantification of forensic DNA
WO2010151705A2 (en) 2009-06-26 2010-12-29 Claremont Biosolutions Llc Capture and elution of bio-analytes via beads that are used to disrupt specimens
JP2011010616A (en) * 2009-07-03 2011-01-20 Olympus Corp Container for treating adipose tissue
EP4060331A1 (en) * 2009-07-27 2022-09-21 Meso Scale Technologies, LLC Assay information management methods and devices
EP2459999A1 (en) * 2009-07-28 2012-06-06 Yeda Research and Development Co. Ltd. Ultrasound assisted immunoassay
WO2011014946A1 (en) * 2009-08-02 2011-02-10 Samad Talebpour Cell concentration, capture and lysis devices and methods of use thereof
EP2311563A1 (en) * 2009-08-07 2011-04-20 F. Hoffmann-La Roche AG Processing units and methods for the processing of liquid samples
US20110039267A1 (en) * 2009-08-13 2011-02-17 Cha-Mei Tang Sample Preparation And Detection Of Analytes Using Silica Beads
DE102009029305A1 (en) * 2009-09-09 2011-03-10 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Analyzer for the automated determination of a measured variable of a liquid sample
FR2950358B1 (en) 2009-09-18 2015-09-11 Biomerieux Sa SIMPLIFIED NUCLEIC ACID AMPLIFICATION DEVICE AND METHOD FOR IMPLEMENTING THE SAME
US8664377B2 (en) * 2009-09-30 2014-03-04 Samsung Electronics Co., Ltd. Method and apparatus for isolating nucleic acids
US8862448B2 (en) 2009-10-19 2014-10-14 Theranos, Inc. Integrated health data capture and analysis system
GB0919159D0 (en) * 2009-11-02 2009-12-16 Sec Dep For Environment Food A Device and apparatus
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
US8569691B2 (en) 2009-11-24 2013-10-29 University Of Louisville Research Foundation Preconcentrator for analysis instruments
WO2011071772A2 (en) 2009-12-07 2011-06-16 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
KR101155085B1 (en) * 2009-12-18 2012-06-11 광주과학기술원 Device for cell lysis and method for producing the same
FR2955508B1 (en) * 2010-01-25 2012-03-30 Corning Inc MICROREACTORS WITH PLANAR MICROFLUIDIC DEVICE AND ULTRASONIC APPLICATION SYSTEM; IMPLEMENTING CHEMICAL REACTIONS IN THEIR BREAST
US8438903B2 (en) * 2010-01-27 2013-05-14 International Business Machines Corporation Molecule detection device formed in a semiconductor structure
CA2788113A1 (en) 2010-02-03 2011-08-11 President And Fellows Of Harvard College Devices and methods for multiplexed assays
JP5691187B2 (en) * 2010-02-10 2015-04-01 ソニー株式会社 Microchip for nucleic acid amplification reaction and method for producing the same
BR112012020251A2 (en) * 2010-02-12 2016-05-03 Univ Northwestern analysis device for sample acquisition, treatment and reaction
AU2015221472B2 (en) * 2010-02-23 2017-01-19 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
JP5308390B2 (en) * 2010-03-31 2013-10-09 富士フイルム株式会社 Test substance detection method and test substance detection apparatus
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
FR2959312B1 (en) 2010-04-23 2023-01-20 Biomerieux Sa DEVICE FOR PREPARING AND/OR PROCESSING A BIOLOGICAL SAMPLE
EP2565616B1 (en) * 2010-04-28 2020-08-05 Panasonic Intellectual Property Management Co., Ltd. Chemical sensor
BR112012029726A2 (en) * 2010-05-27 2017-09-26 Koninl Philips Electronics Nv method for operating an ultrasonic transducer, ultrasonic transducer for selective generation of ultrasonic waves and heat, and sample analysis system
US9132422B2 (en) 2010-06-03 2015-09-15 Spinomix, S.A. Fluidic interfacing system and assembly
US20110312712A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Genetic analysis loc for pcr amplification of nucleic acids from whole blood
WO2012044387A2 (en) * 2010-07-06 2012-04-05 T2 Biosystems, Inc. Methods and compositions for detection of analytes
ITBO20100503A1 (en) * 2010-08-04 2012-02-05 Silicon Biosystems Spa MICROFLUID SYSTEM
ITBO20100504A1 (en) * 2010-08-04 2012-02-05 Silicon Biosystems Spa MICROFLUID SYSTEM
GB201013153D0 (en) 2010-08-04 2010-09-22 Touchlight Genetics Ltd Primer for production of closed linear DNA
EP2601307A4 (en) 2010-08-06 2014-01-01 Capitalbio Corp Microarray-based assay integrated with particles for analyzing molecular interactions
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
CN102375069A (en) * 2010-08-26 2012-03-14 南京神州英诺华医疗科技有限公司 Novel automatic treatment instrument for respiratory tract specimen
US8459121B2 (en) 2010-10-28 2013-06-11 Covaris, Inc. Method and system for acoustically treating material
KR101776215B1 (en) * 2010-10-29 2017-09-08 삼성전자 주식회사 Micro-device for disrupting cells and method of disrupting cells using the same
US8986986B2 (en) * 2010-10-29 2015-03-24 Samsung Electronics Co., Ltd. Cell lysis device and methods of lysing cells or viruses
IT1403518B1 (en) * 2010-12-22 2013-10-31 Silicon Biosystems Spa MICROFLUID DEVICE FOR PARTICLE HANDLING
US8709359B2 (en) 2011-01-05 2014-04-29 Covaris, Inc. Sample holder and method for treating sample material
EP2666008B1 (en) 2011-01-21 2021-08-11 Labrador Diagnostics LLC Systems and methods for sample use maximization
US8718948B2 (en) 2011-02-24 2014-05-06 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
PT3270141T (en) 2011-03-08 2020-08-28 Univ Laval Fluidic centripetal device
JP5637300B2 (en) * 2011-03-28 2014-12-10 学校法人加計学園 Sample solution concentration measuring method and sample solution concentration measuring apparatus
JP5931347B2 (en) * 2011-04-12 2016-06-08 株式会社東芝 Automatic analyzer
BR112013026451B1 (en) 2011-04-15 2021-02-09 Becton, Dickinson And Company system and method to perform molecular diagnostic tests on several samples in parallel and simultaneously amplification in real time in plurality of amplification reaction chambers
WO2012151473A2 (en) 2011-05-04 2012-11-08 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
CN103547370A (en) 2011-05-18 2014-01-29 3M创新有限公司 Systems and methods for volumetric metering on a sample processing device
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
ES2870874T3 (en) 2011-05-18 2021-10-27 Diasorin S P A Systems and methods for detecting the presence of a selected volume of material in a sample processing device
EP2709760B1 (en) 2011-05-18 2019-06-05 DiaSorin S.p.A. Systems and methods for valving on a sample processing device
EP2726838A4 (en) * 2011-07-01 2015-05-06 Univ Singapore A system and method for detecting one or more analytes in a fluid
CA2842720C (en) 2011-07-25 2023-10-10 Qvella Corporation Methods and devices for electrical sample preparation
US9670538B2 (en) * 2011-08-05 2017-06-06 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
US8599009B2 (en) 2011-08-16 2013-12-03 Elwha Llc Systematic distillation of status data relating to regimen compliance
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9632102B2 (en) * 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
EP2761305B1 (en) 2011-09-30 2017-08-16 Becton, Dickinson and Company Unitized reagent strip
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US9150598B2 (en) 2011-10-05 2015-10-06 The Regents Of The University Of California Masking apertures enabling automation and solution exchange in sessile bilayers
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
ITTO20110990A1 (en) 2011-10-28 2013-04-29 Silicon Biosystems Spa METHOD AND APPARATUS FOR OPTICAL ANALYSIS OF LOW TEMPERATURE PARTICLES
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
US9050593B2 (en) 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
ITBO20110766A1 (en) 2011-12-28 2013-06-29 Silicon Biosystems Spa DEVICES, EQUIPMENT, KITS AND METHOD FOR THE TREATMENT OF A BIOLOGICAL SAMPLE
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11648561B2 (en) 2012-02-13 2023-05-16 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US9339812B2 (en) 2012-02-13 2016-05-17 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US8804105B2 (en) 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
ES2619032T3 (en) 2012-04-20 2017-06-22 Cepheid Bladder Cancer Screening Methods
JP6197030B2 (en) 2012-04-27 2017-09-13 セフェィド Device having different processing modules
US9063121B2 (en) 2012-05-09 2015-06-23 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
TWI512261B (en) 2012-06-22 2015-12-11 Panasonic Corp Microfluidic device
DE102012107651A1 (en) * 2012-08-21 2014-02-27 Astrium Gmbh Method for carrying out a biochemical analysis, in particular in space
EP2705899A1 (en) 2012-09-07 2014-03-12 Fluigent A microfluidic system comprising a homogenizing component
DE102012109026A1 (en) * 2012-09-25 2014-03-27 Eads Deutschland Gmbh Detection device and detection method for the automatic determination of biomass
WO2014052487A1 (en) 2012-09-28 2014-04-03 Cepheid Two-primer pcr for microrna multiplex assay
EP2906269B1 (en) 2012-10-11 2018-01-03 Magnolia Medical Technologies, Inc. System for delivering a fluid to a patient with reduced contamination
US20150285794A1 (en) * 2012-10-19 2015-10-08 Ecole Polytechnique Federale De Lausanne (Epfl) High-throughput nanoimmunoassay chip
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
US9957553B2 (en) 2012-10-24 2018-05-01 Genmark Diagnostics, Inc. Integrated multiplex target analysis
JP2013019911A (en) * 2012-10-25 2013-01-31 Seiko Instruments Inc Micro fluid device
DK2912174T3 (en) 2012-10-25 2019-08-26 Neumodx Molecular Inc METHOD AND MATERIALS FOR INSULATING NUCLEIC ACID MATERIALS
US9987576B2 (en) 2012-12-10 2018-06-05 University Of Virginia Patent Foundation Frequency-based filtering of mechanical actuation using fluidic device
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US20140206007A1 (en) * 2013-01-18 2014-07-24 The Johns Hopkins University Electromagnetically actuated droplet microfluidic chip and system
EP2964786B1 (en) 2013-03-06 2018-12-19 Cepheid Methods of detecting bladder cancer
KR102094496B1 (en) 2013-03-11 2020-03-30 큐 헬스 인코퍼레이티드 Systems and methods for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
EP2969218A2 (en) * 2013-03-15 2016-01-20 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
CN105228748B (en) 2013-03-15 2017-10-10 金马克诊断股份有限公司 System, method and apparatus for manipulating deformable fluid container
CN111366434A (en) * 2013-03-15 2020-07-03 赛拉诺斯知识产权有限责任公司 Automated assay device for disrupting cells in a sample
US9359632B2 (en) 2013-03-15 2016-06-07 Theranos, Inc. Devices, systems and methods for sample preparation
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US20150028876A1 (en) * 2013-07-24 2015-01-29 Nathan McLaughlin Method and apparatus for testing a lighting device under temperature
KR20150016036A (en) * 2013-08-02 2015-02-11 삼성전자주식회사 Method for amplifying nucleic acids
JP6295578B2 (en) * 2013-09-30 2018-03-20 凸版印刷株式会社 Reaction vessel, nucleic acid analyzer, and nucleic acid analysis method
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
CN110560187B (en) 2013-11-18 2022-01-11 尹特根埃克斯有限公司 Cartridge and instrument for sample analysis
US9283560B2 (en) * 2013-11-22 2016-03-15 Sharp Kabushiki Kaisha Passive microfluidic metering device
CA2931609A1 (en) * 2013-12-04 2015-06-11 Pocared Diagnostics Ltd. Filter arrangement with slider valve and method for using the same
DE102014200505A1 (en) 2014-01-14 2015-07-16 Robert Bosch Gmbh Container and device for the digestion and / or homogenization of a fluid and method for digesting and / or homogenizing a fluid
DE102014200501A1 (en) 2014-01-14 2015-07-16 Robert Bosch Gmbh Digestion device and method for disrupting a cell containing biological sample and method for producing a disruption device
WO2015138343A1 (en) 2014-03-10 2015-09-17 Click Diagnostics, Inc. Cartridge-based thermocycler
EP3116651B1 (en) * 2014-03-11 2020-04-22 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making it
PT3594360T (en) 2014-04-24 2021-08-19 Lucira Health Inc Colorimetric detection of nucleic acid amplification
BR112016022867A2 (en) 2014-04-25 2018-07-03 Hewlett Packard Development Co diagnostic cassette.
DE102014207775A1 (en) 2014-04-25 2015-10-29 Robert Bosch Gmbh Method and microfluidic system for processing organic cells and manufacturing method for producing a microfluidic system for processing organic cells
DE102014207774B4 (en) * 2014-04-25 2015-12-31 Robert Bosch Gmbh Method and device for purifying biological molecules
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
EP3151965B1 (en) 2014-06-04 2021-02-24 Edan Instruments, Inc. Sample collection and analysis devices
PT3158317T (en) * 2014-06-18 2019-12-10 Zoetis Denmark Aps A microfluidic detection system
KR102238956B1 (en) * 2014-06-24 2021-04-13 삼성전자주식회사 Fluid Analysis Sheet, Fluid Analysis Cartridge Having the Same and Method of Manufacturing the Fluid Analysis Cartridge
US10596492B2 (en) * 2014-07-09 2020-03-24 Sudhin Biopharma Particle settling devices
US20190210042A1 (en) * 2014-07-09 2019-07-11 Sudhin Biopharma Particle setting devices
US20160041156A1 (en) * 2014-08-11 2016-02-11 OncoGenesis Inc. Integrated Device for Measuring Multiple Analytes
AU2014403832B2 (en) 2014-08-22 2021-11-04 Cepheid Methods of detecting influenza
GB201415789D0 (en) 2014-09-05 2014-10-22 Touchlight Genetics Ltd Synthesis of DNA
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
EP3552690A1 (en) 2014-10-22 2019-10-16 IntegenX Inc. Systems and methods for sample preparation, processing and analysis
WO2016069853A2 (en) 2014-10-30 2016-05-06 Cepheid Methods of detecting ebola
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
EP3223945B1 (en) * 2014-11-26 2019-04-03 IMEC vzw Compact glass-based fluid analysis device and method to fabricate
WO2016087957A1 (en) * 2014-12-05 2016-06-09 Diasys Diagnostics India Private Limited Multiplexed microfluidic device
PT3234188T (en) 2014-12-15 2020-01-16 Cepheid Exponential base-greater-than-2 nucleic acid amplification
CN105806685B (en) * 2014-12-29 2020-05-05 徕卡显微系统(上海)有限公司 Embedding machine with movable distributor
CN204330461U (en) * 2014-12-29 2015-05-13 徕卡显微系统(上海)有限公司 Embedding machine
MX2017008618A (en) 2014-12-31 2018-03-23 Click Diagnostics Inc Devices and methods for molecular diagnostic testing.
WO2016128570A1 (en) * 2015-02-13 2016-08-18 Espci Paper device for genetic diagnosis
US9861982B2 (en) * 2015-03-09 2018-01-09 Emd Millipore Corporation Connectors for pneumatic devices in microfluidic systems
JP6834947B2 (en) * 2015-04-28 2021-02-24 パナソニック株式会社 Chemical Concentrator
AU2016266805B2 (en) 2015-05-27 2022-05-19 Qiagen Gmbh Composition and method for disrupting tissue material
US10077999B2 (en) * 2015-07-14 2018-09-18 Cytochip Inc. Volume sensing in fluidic cartridge
CN113791203A (en) 2015-06-12 2021-12-14 芯易诊有限公司 Method for analyzing biological samples
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
ES2842205T3 (en) * 2015-06-15 2021-07-13 Cepheid Integration of DNA purification and methylation measurement and joint measurement of mutations and / or mRNA expression levels in an automated reaction cartridge
CA2933515A1 (en) * 2015-06-19 2016-12-19 The Governing Council Of The University Of Toronto Amplification of nanoparticle based assay
US20160367918A1 (en) * 2015-06-22 2016-12-22 Fuji Electric Co., Ltd. Filter system
EP3112869A1 (en) * 2015-06-30 2017-01-04 IMEC vzw Sensor device
US10775370B2 (en) 2015-07-17 2020-09-15 Stat-Diagnostica & Innovation, S.L. Fluidic system for performing assays
KR102604091B1 (en) 2015-07-17 2023-11-22 큐 헬스 인코퍼레이티드 Systems and methods for enhanced detection and quantitation of analytes
CN108124451B (en) 2015-07-24 2022-09-09 塞弗德公司 Compositions and methods for extracting DNA and RNA from tissue samples
US11071982B2 (en) * 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
WO2017087707A1 (en) * 2015-11-18 2017-05-26 Beckman Coulter, Inc. Filtering device for analyzing instrument
EP3429752A4 (en) 2016-03-14 2019-10-30 Lucira Health, Inc. Systems and methods for performing biological assays
CA3015376C (en) 2016-03-14 2023-11-14 Diassess Inc. Devices and methods for biological assay sample preparation and delivery
JP2019509740A (en) * 2016-03-14 2019-04-11 ディアスセス インコーポレイテッド Selectively vented biological assay devices and related methods
WO2017185067A1 (en) 2016-04-22 2017-10-26 Click Diagnostics, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
US10774393B2 (en) 2016-05-20 2020-09-15 Roche Molecular Systems, Inc. Cell surface marker depletion in a sample processing device
CN109477111B (en) 2016-06-07 2023-12-15 塞弗德公司 Thermostable polymerase inhibitor compositions and methods
WO2018005710A1 (en) 2016-06-29 2018-01-04 Click Diagnostics, Inc. Devices and methods for the detection of molecules using a flow cell
USD800331S1 (en) 2016-06-29 2017-10-17 Click Diagnostics, Inc. Molecular diagnostic device
USD800913S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Detection window for molecular diagnostic device
USD800914S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Status indicator for molecular diagnostic device
EP3481968A4 (en) * 2016-07-08 2019-12-18 California Institute of Technology Methods and devices for performing flow-through capture of low-concentration analytes
US11440009B2 (en) 2016-07-15 2022-09-13 Hewlett-Packard Development Company, L.P. Plurality of filters
WO2018048488A1 (en) * 2016-09-08 2018-03-15 Hemex Health, Inc. Diagnostics systems and methods
US10349589B2 (en) 2016-09-08 2019-07-16 Hemex Health, Inc. Diagnostics systems and methods
JP7146743B2 (en) * 2016-09-23 2022-10-04 アルヴェオ テクノロジーズ インコーポレイテッド Methods and compositions for detecting analytes
US10751714B2 (en) 2016-10-07 2020-08-25 Boehringer Ingelheim Vetmedica Gmbh Cartridge for testing a sample
CN109803761B (en) 2016-10-07 2022-09-13 勃林格殷格翰维特梅迪卡有限公司 Analysis device and method for detecting sample
WO2018065102A1 (en) 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Method and analysis system for testing a sample
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
CN106568982B (en) * 2016-10-31 2018-05-29 浙江大学 A kind of device and its application method for being formed and being screened for two-dimentional droplet array
KR102103582B1 (en) * 2016-11-29 2020-04-23 삼육대학교산학협력단 Microfluidic chip comprising silica nano particles and method for preparing the same
CA3046636A1 (en) * 2016-12-12 2018-06-21 Cepheid Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
TWI611171B (en) 2016-12-14 2018-01-11 財團法人工業技術研究院 Biological sample processing device
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
CN108654138B (en) * 2017-04-01 2023-06-16 四川大学 Centrifugal force micro-fluid extraction device and extraction method thereof
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
US11602750B2 (en) 2017-05-30 2023-03-14 Roche Molecular Systems, Inc. Customizable sample processing device
CA3070832A1 (en) 2017-08-02 2019-02-07 Pocared Diagnostics Ltd. Processor filter arrangement that includes method and apparatus to remove waste fluid through a filter
CA3074105A1 (en) 2017-09-12 2019-03-21 Magnolia Medical Technologies, Inc. Fluid control devices and methods of using the same
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
DE102017008908A1 (en) 2017-09-22 2019-03-28 Friz Biochem Gesellschaft Für Bioanalytik Mbh Portable container for tuberculosis preanalytics
US11491487B2 (en) 2017-10-23 2022-11-08 Cytochip Inc. Devices and methods for measuring analytes and target particles
JP7319973B2 (en) 2017-10-31 2023-08-02 エフ． ホフマン－ラ ロシュ アーゲー Improved magnetic particles and uses thereof
WO2019094784A1 (en) 2017-11-09 2019-05-16 Click Diagnostics, Inc. Portable molecular diagnostic device and methods for the detection of target viruses
CN109868205A (en) * 2017-12-05 2019-06-11 台达电子国际（新加坡）私人有限公司 Biological sample processing unit and its biological sample processing method
WO2019121850A1 (en) 2017-12-19 2019-06-27 F. Hoffmann-La Roche Ag Method of making a frangible seal in a sample processing device
AU2019239860A1 (en) * 2018-03-21 2020-09-03 Precision Planting Llc Reagent cartridge
CN112020385B (en) 2018-04-18 2023-01-06 苏德新生物制药公司 Particle settling device
WO2020023934A1 (en) * 2018-07-27 2020-01-30 Zepto Life Technology, LLC System and method for processing analyte signals in gmr-based detection of biomarkers
JP2020024202A (en) * 2018-08-06 2020-02-13 積水化学工業株式会社 Analysis tool and cleaning method
WO2020092134A1 (en) 2018-10-29 2020-05-07 Cepheid Exponential base-3 nucleic acid amplification with reduced amplification time using nested overlapping primers
FR3088340B1 (en) 2018-11-12 2021-01-22 Commissariat Energie Atomique AUTOMATED SYSTEM FOR THE PREPARATION, DETECTION AND ANALYSIS OF A FLUIDIC SAMPLE
CN109406238B (en) * 2018-12-07 2023-10-17 郑州机械研究所有限公司 Multifunctional clamp for preparing metallographic specimen and metallographic specimen preparation method
USD907232S1 (en) 2018-12-21 2021-01-05 Lucira Health, Inc. Medical testing device
WO2020139210A1 (en) * 2018-12-28 2020-07-02 Mikro Biyosistemler Elektronik Sanayi Ve Ticaret A.S. A method of microfluidic particle separation enhancement and the device thereof
EP3908403A1 (en) 2019-01-10 2021-11-17 Instrumentation Laboratory Company Ultrasound lysing of whole blood
GB201902810D0 (en) * 2019-03-01 2019-04-17 Vidya Holdings Ltd Disposition of reagents in assay device
JP2022523951A (en) 2019-03-11 2022-04-27 マグノリア メディカル テクノロジーズ，インコーポレイテッド Fluid control device and how to use it
US11740203B2 (en) 2019-06-25 2023-08-29 Hemex Health, Inc. Diagnostics systems and methods
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
US11254979B2 (en) 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
US11352675B2 (en) 2020-01-03 2022-06-07 Visby Medical, Inc. Devices and methods for antibiotic susceptability testing
IL296581A (en) 2020-03-19 2022-11-01 Sudhin Biopharma Particle settling devices
CN115701914A (en) * 2020-04-06 2023-02-14 沙新创新控股有限公司 Cell lysis system and method
WO2021205151A2 (en) * 2020-04-06 2021-10-14 Shaheen Innovations Holding Limited Cell lysis systems and methods
US20230140317A1 (en) * 2020-04-23 2023-05-04 Hewlett-Packard Development Company, L.P. Measuring deformability of a cell
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
CA3180786A1 (en) * 2020-06-01 2021-05-28 Imad Lahoud An infectious disease screening system
EP3919176A1 (en) * 2020-06-01 2021-12-08 Shaheen Innovations Holding Limited Assay devices for infectious disease screening
JP2023527574A (en) 2020-06-01 2023-06-29 シャヒーン イノベーションズ ホールディング リミテッド Infectious disease test device
EP3919175A1 (en) * 2020-06-01 2021-12-08 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
CA3183566A1 (en) 2020-06-26 2021-12-30 Victor Chu Methods of detecting sars-cov-2, influenza, and rsv
US11904314B2 (en) * 2020-07-30 2024-02-20 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
EP4226158A1 (en) 2020-10-06 2023-08-16 Cepheid Methods of diagnosing tuberculosis and differentiating between active and latent tuberculosis
US20220298572A1 (en) 2021-03-16 2022-09-22 Cepheid Compositions and methods for discriminating bacterial and viral infections in a human subject
WO2022251508A1 (en) * 2021-05-28 2022-12-01 Proof Diagnostics Reaction cartridge
CN113686843A (en) * 2021-07-19 2021-11-23 清华大学深圳国际研究生院 Colorimetric reaction micro-fluidic rapid detection equipment based on ultrasonic pyrolysis
CN117106887A (en) 2021-10-22 2023-11-24 塞弗德公司 Compositions and methods for diagnosing and treating tuberculosis
WO2023177748A1 (en) * 2022-03-15 2023-09-21 Cepheid Unitary cartridge body and associated components and methods of manufacture
CN115141739A (en) * 2022-09-06 2022-10-04 至美时代生物智能科技(北京)有限公司 Air microorganism sampling and detection integrated device and sampling and detection method

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB938163A (en) 1960-09-20 1963-10-02 Boots Pure Drug Co Ltd Improvements in or relating to particle size reduction or cellular disruption
US3799742A (en) 1971-12-20 1974-03-26 C Coleman Miniaturized integrated analytical test container
US4231990A (en) 1977-08-31 1980-11-04 S.A. Anarec Apparatus for the treatment of fluids
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
SE8102316L (en) 1981-04-10 1982-10-11 Pharmacia Diagnostics Ab DEVICE FOR PERFORMANCE OF ANALYSIS
AU570439B2 (en) 1983-03-28 1988-03-17 Compression Labs, Inc. A combined intraframe and interframe transform coding system
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
AU604684B2 (en) * 1986-03-20 1991-01-03 Gen-Probe Incorporated Method for releasing RNA and DNA from cells
GB2191110B (en) 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US4789628A (en) 1986-06-16 1988-12-06 Vxr, Inc. Devices for carrying out ligand/anti-ligand assays, methods of using such devices and diagnostic reagents and kits incorporating such devices
US4915812A (en) 1986-06-20 1990-04-10 Molecular Devices Corporation Zero volume cell
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
CH667599A5 (en) 1986-12-11 1988-10-31 Battelle Memorial Institute ENCLOSURE FOR CONTAINING A LIQUID MEDIUM.
US4918025A (en) 1987-03-03 1990-04-17 Pb Diagnostic Systems, Inc. Self contained immunoassay element
US4855240A (en) 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
AU1983588A (en) * 1987-06-23 1989-01-19 Norman G. Anderson Centrifugal fast chromatograph
US4908318A (en) 1987-09-04 1990-03-13 Integrated Genetics, Inc. Nucleic acid extraction methods
US4923978A (en) 1987-12-28 1990-05-08 E. I. Du Pont De Nemours & Company Process for purifying nucleic acids
WO1989006280A1 (en) * 1988-01-04 1989-07-13 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
US4921952A (en) 1988-01-21 1990-05-01 The United States Of America As Represented By The United States Department Of Energy Nucleic acid isolation process
JPH0721485B2 (en) * 1988-03-11 1995-03-08 ダイソー株式会社 Flow analysis method of chloride ion in caustic.
SE8801299L (en) 1988-04-08 1989-10-09 Bertil Hoeoek MICROMECHANICAL ONE-WAY VALVE
US4983523A (en) 1988-04-08 1991-01-08 Gene-Trak Systems Methods for preparing sample nucleic acids for hybridization
US5374533A (en) 1988-05-10 1994-12-20 Tetjin Limited Method for determining chondrocalcin
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
FR2634892B1 (en) 1988-07-28 1990-09-14 Guigan Jean DEVICE FOR PERFORMING BIOLOGICAL ANALYSIS BY IMMUNO-ENZYMATIC DETECTION OF ANTIBODIES OR ANTIGENS IN A SERUM
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US5207988A (en) 1989-07-06 1993-05-04 The Cleveland Clinic Foundation Apparatus for detecting and quantifying clot lysis and establishing optimum medication and dosages
US5124444A (en) 1989-07-24 1992-06-23 Microprobe Corporation Lactam-containing compositions and methods useful for the extraction of nucleic acids
US5231015A (en) 1989-10-18 1993-07-27 Eastman Kodak Company Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme
AU642444B2 (en) * 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5143084A (en) 1990-05-24 1992-09-01 Spacelabs, Inc. Disposable cartridge for sampling and analyzing body fluids
CA2084342A1 (en) 1990-06-15 1991-12-16 Rich T. Smethers Self-contained assay assembly and apparatus
US5114858A (en) 1990-06-26 1992-05-19 E. I. Du Pont De Nemours And Company Cellular component extraction process in a disposable filtration vessel
DE4126436A1 (en) 1990-09-17 1992-03-19 Abion Ohg DISPOSABLE REACTION TUBE FOR SOLID-PHASE IMMUNAL ANALYTICS AND METHOD FOR MEASURING COMPONENTS DETERMINABLE BY IMMUNE REACTIONS
US5652141A (en) 1990-10-26 1997-07-29 Oiagen Gmbh Device and process for isolating nucleic acids from cell suspension
DE4034036C2 (en) * 1990-10-26 1994-03-03 Diagen Inst Molekularbio Device and method for isolating nucleic acids from cell suspensions
US5654179A (en) * 1990-11-14 1997-08-05 Hri Research, Inc. Nucleic acid preparation methods
US5352777A (en) 1990-12-26 1994-10-04 Pioneer Hi-Bred International, Inc. DNA isolation from animal cells
SE9100392D0 (en) 1991-02-08 1991-02-08 Pharmacia Biosensor Ab A METHOD OF PRODUCING A SEALING MEANS IN A MICROFLUIDIC STRUCTURE AND A MICROFLUIDIC STRUCTURE COMPRISING SUCH SEALING MEANS
US5264184A (en) 1991-03-19 1993-11-23 Minnesota Mining And Manufacturing Company Device and a method for separating liquid samples
US5422241A (en) 1991-07-03 1995-06-06 Ambion, Inc. Methods for the recovery of nucleic acids from reaction mixtures
US5155018A (en) 1991-07-10 1992-10-13 Hahnemann University Process and kit for isolating and purifying RNA from biological sources
US5329000A (en) 1991-10-31 1994-07-12 Becton, Dickinson And Company Purification of DNA with silicon tetrahydrazide
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
DE69324716T2 (en) 1992-02-13 1999-09-09 Becton Dickinson Co Celite hydrate and purification of DNA
US5223219A (en) 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5409586A (en) 1992-08-26 1995-04-25 Hitachi, Ltd. Method for analyzing nucleic acid or protein and apparatus therefor
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5422271A (en) 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5798215A (en) 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
US5399486A (en) 1993-02-18 1995-03-21 Biocircuits Corporation Disposable unit in diagnostic assays
US5503985A (en) 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
GB9314249D0 (en) * 1993-07-09 1993-08-18 Proofname Ltd Purification method and apparatus
JP3035352B2 (en) 1993-08-24 2000-04-24 メトリカ・インコーポレーテッド New disposable electronic test device
US5438127A (en) 1993-09-27 1995-08-01 Becton Dickinson And Company DNA purification by solid phase extraction using a PCl3 modified glass fiber membrane
US5438129A (en) 1993-09-27 1995-08-01 Becton Dickinson And Company DNA purification by solid phase extraction using partially fluorinated aluminum hydroxide adsorbant
ES2325393T3 (en) 1993-10-28 2009-09-03 Houston Advanced Research Center POROUS FLOW EQUIPMENT THROUGH MICROFABRICATED FOR THE DIFFERENTIATED DETECTION OF UNION REACTIONS.
US5976824A (en) 1993-11-24 1999-11-02 Abbott Laboratories Method and apparatus for collecting a cell sample from a liquid specimen
DE69422604T2 (en) 1994-03-08 2000-06-08 Zeptosens Ag Witterwil Apparatus and method that combine bioaffinity assay and electrophoretic separation
DE69527585T2 (en) * 1994-06-08 2003-04-03 Affymetrix Inc Method and device for packaging chips
US5580435A (en) 1994-06-10 1996-12-03 The Board Of Trustees Of The Leland Stanford Junior University System for detecting components of a sample in electrophoretic separation
DE4420732A1 (en) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Device for the treatment of nucleic acids from a sample
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5641400A (en) 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
WO1996028538A1 (en) 1995-03-10 1996-09-19 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
JP3477918B2 (en) * 1995-05-29 2003-12-10 株式会社島津製作所 Capillary electrophoresis chip
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
WO1997003348A1 (en) 1995-07-13 1997-01-30 Immunological Associates Of Denver Self-contained device integrating nucleic acid extraction, amplification and detection
DK0760393T3 (en) * 1995-08-17 2003-09-29 Hoffmann La Roche chromatography
WO1997010056A2 (en) 1995-09-12 1997-03-20 Becton Dickinson And Company Device and method for dna amplification and assay
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
EP0885039A1 (en) * 1996-03-06 1998-12-23 Akzo Nobel N.V. Automated nucleic acid extraction from samples
US5707860A (en) 1996-03-12 1998-01-13 Becton Dickinson And Company Vehicle for delivery of particles to a sample
US5846727A (en) 1996-06-06 1998-12-08 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Microsystem for rapid DNA sequencing
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
EP0909385B1 (en) 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Method of transporting fluid samples within a microfluidic channel
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
WO1998011989A1 (en) * 1996-09-18 1998-03-26 Promega Corporation Improved filtration system and method
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US5882903A (en) 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
EP1030733A4 (en) 1997-02-05 2000-08-30 California Inst Of Techn Microfluidic sub-millisecond mixers
AP9901660A0 (en) 1997-02-28 1999-09-30 Burstein Lab Inc Laboratory in a disk.
US5939259A (en) 1997-04-09 1999-08-17 Schleicher & Schuell, Inc. Methods and devices for collecting and storing clinical samples for genetic analysis
AU727083B2 (en) 1997-04-25 2000-11-30 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
US5786182A (en) 1997-05-02 1998-07-28 Biomerieux Vitek, Inc. Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use
US6156273A (en) 1997-05-27 2000-12-05 Purdue Research Corporation Separation columns and methods for manufacturing the improved separation columns
US5922288A (en) 1997-05-29 1999-07-13 Herst; C. V. Taylor Device for isolating a component of a physiological sample
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
CA2301309A1 (en) * 1997-08-13 1999-02-25 Cepheid Microstructures for the manipulation of fluid samples
US6440725B1 (en) * 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6261848B1 (en) * 1998-05-08 2001-07-17 The Johns Hopkins University Miniature immuno-optical rapid analyte sensor platform
US6100084A (en) 1998-11-05 2000-08-08 The Regents Of The University Of California Micro-sonicator for spore lysis
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6878540B2 (en) * 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017382B2 (en) 2002-03-05 2011-09-13 Abbott Point Of Care Inc. Apparatus and methods for analyte measurement and immunoassay
US8222024B2 (en) 2002-03-05 2012-07-17 Abbott Point Of Care Inc. Apparatus and methods for analyte measurement and immunoassay
US8642322B2 (en) 2002-03-05 2014-02-04 Abbott Point Of Care Inc. Apparatus and methods for analyte measurement immunoassay
US8679827B2 (en) 2002-03-05 2014-03-25 Abbott Point Of Care Inc. Apparatus and methods for analyte measurement and immunoassay

Also Published As

Publication number Publication date
DK1179585T3 (en) 2008-11-10
US6440725B1 (en) 2002-08-27
US20050194316A1 (en) 2005-09-08
EP1042061A1 (en) 2000-10-11
US6893879B2 (en) 2005-05-17
JP4522480B2 (en) 2010-08-11
ES2309022T3 (en) 2008-12-16
EP1179585A3 (en) 2002-03-13
ATE400358T1 (en) 2008-07-15
DE69839709D1 (en) 2008-08-21
JP2009236933A (en) 2009-10-15
US20020042125A1 (en) 2002-04-11
JP2009014736A (en) 2009-01-22
JP4209589B2 (en) 2009-01-14
CA2312102C (en) 2007-09-04
JP4399507B2 (en) 2010-01-20
AU758407B2 (en) 2003-03-20
WO1999033559A1 (en) 1999-07-08
EP1179585A2 (en) 2002-02-13
US7569346B2 (en) 2009-08-04
AU1947299A (en) 1999-07-19
JP2001527220A (en) 2001-12-25
EP1179585B1 (en) 2008-07-09

Similar Documents

Publication Publication Date Title
CA2312102A1 (en) Integrated fluid manipulation cartridge
CA2047038A1 (en) Self-metering fluid analysis device
WO2000073412A3 (en) Apparatus and method for analyzing a fluid sample
Mopper et al. Determination of sugars in unconcentrated seawater and other natural waters by liquid chromatography and pulsed amperometric detection.
EP0198413A3 (en) Rapid assay processor
WO1999009042A3 (en) Microstructures for the manipulation of fluid samples
EP0345782A3 (en) Fluid analysis with particulate reagent suspension
AU2684488A (en) Test device and method for colored particle immunoassay
WO1993022055A3 (en) Fluid handling in microfabricated analytical devices
WO2002022266A3 (en) Fluid cartridge and method
WO2001032828A3 (en) Biological fluid processing
Liu et al. Automatic on-line preconcentration system for graphite furnace atomic absorption spectrometry for the determination of trace metals in sea water
CA1087971A (en) Alcohol retainer cartridge and method for using same
Michalski Application of ion chromatography in clinical studies and pharmaceutical industry
WO2002059599A3 (en) System and method for in vitro analysis of therapeutic agents
JP2007333706A (en) Cartridge type detection device
AU603733B2 (en) Analysis of gold
CA2285282C (en) Detection of low level hydrophobic analytes in environmental samples
EP1329705A3 (en) Pipette- and cartridge-comprising set and related application methods
Yan et al. Determination of (ultra) trace amounts of lead in biological materials by on-line coupling flow injection microcolumn separation and preconcentration to electrothermal atomic absorption spectrometry using a macrocycle immobilized silica gel sorbent
Milner et al. Determination of uric acid in biological fluids by high-pressure liquid chromatography
ATE74789T1 (en) DEVICE FOR FILTERING A REAGENT FEED.
JPS56169596A (en) Biochemical analysis using immobilized enzyme column
Frenzel Highly sensitive semi-quantitative field test for the determination of chromium (VI) in aqueous samples
Martinotti et al. In-flow speciation of copper, zinc, lead and cadmium in fresh waters by diffential-pulse anodic stripping voltammetry: Part I. Optimization of filtration and enrichment steps

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20181224