CA2315469A1 - Method and apparatus for the transdermal administration of a substance - Google Patents

Method and apparatus for the transdermal administration of a substance Download PDF

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Publication number
CA2315469A1
CA2315469A1 CA002315469A CA2315469A CA2315469A1 CA 2315469 A1 CA2315469 A1 CA 2315469A1 CA 002315469 A CA002315469 A CA 002315469A CA 2315469 A CA2315469 A CA 2315469A CA 2315469 A1 CA2315469 A1 CA 2315469A1
Authority
CA
Canada
Prior art keywords
housing
pharmaceutical agent
microneedles
substance
microns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002315469A
Other languages
French (fr)
Other versions
CA2315469C (en
Inventor
Zeil B. Rosenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of CA2315469A1 publication Critical patent/CA2315469A1/en
Application granted granted Critical
Publication of CA2315469C publication Critical patent/CA2315469C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen

Abstract

A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5-250 microns and generally about 50-100 microns.
CA002315469A 1999-09-22 2000-08-10 Method and apparatus for the transdermal administration of a substance Expired - Lifetime CA2315469C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/401,452 1999-09-22
US09/401,452 US6623457B1 (en) 1999-09-22 1999-09-22 Method and apparatus for the transdermal administration of a substance

Publications (2)

Publication Number Publication Date
CA2315469A1 true CA2315469A1 (en) 2001-03-22
CA2315469C CA2315469C (en) 2009-04-21

Family

ID=23587826

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002315469A Expired - Lifetime CA2315469C (en) 1999-09-22 2000-08-10 Method and apparatus for the transdermal administration of a substance

Country Status (9)

Country Link
US (4) US6623457B1 (en)
EP (1) EP1086718B1 (en)
JP (1) JP2001149485A (en)
AT (1) ATE346644T1 (en)
AU (1) AU778234B2 (en)
CA (1) CA2315469C (en)
DE (1) DE60032082T2 (en)
ES (1) ES2273639T3 (en)
SG (1) SG92728A1 (en)

Families Citing this family (300)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6641591B1 (en) 1999-08-26 2003-11-04 John H. Shadduck Instruments and techniques for controlled removal of epidermal layers
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US6494865B1 (en) * 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
CA2396767A1 (en) * 1999-12-30 2001-07-12 Redeon, Inc. Stacked microneedle systems
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US7473244B2 (en) * 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
WO2002028471A1 (en) 2000-10-05 2002-04-11 Thomas Marsoner Medical injection device
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
WO2002045771A2 (en) * 2000-11-09 2002-06-13 Biovalve Technologies, Inc. Microneedle adapter
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US7850663B2 (en) 2001-01-12 2010-12-14 Becton, Dickinson And Company Medicament microdevice delivery system, cartridge and method of use
DE60239594D1 (en) * 2001-02-23 2011-05-12 Glaxosmithkline Biolog Sa INFLUENZA VACCINE COMPOSITIONS FOR INTRADERMAL ADMINISTRATION
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
EP1381423A1 (en) * 2001-04-13 2004-01-21 Becton, Dickinson and Company Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
AU2007203302B2 (en) * 2001-04-20 2010-07-01 Alza Corporation Microprojection array immunization patch and method
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
MXPA03009603A (en) * 2001-04-20 2004-12-06 Johnson & Johnson Microprojection array having a beneficial agent containing coating.
EP1381344A4 (en) * 2001-04-27 2008-06-11 Glaxosmithkline Biolog Sa Novel vaccine
CN1253220C (en) * 2001-06-29 2006-04-26 贝克顿迪肯森公司 Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
DE60223844T2 (en) * 2001-12-20 2008-08-28 Alza Corp., Mountain View MICROPROPERTIES FOR THROUGHPING THE SKIN WITH PILLAR DEPTH CONTROL
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
WO2003094995A1 (en) 2002-05-06 2003-11-20 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
KR20120087197A (en) 2002-07-19 2012-08-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Microneedle device, method of using microneedle device and method of delivering microneedle device
BR0313890A (en) * 2002-08-30 2005-07-26 Becton Dickinson Co Pharmacokinetic control method of immunomodulatory compounds
US20040051019A1 (en) 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
EP1590034B1 (en) * 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
DK200201823A (en) 2002-11-26 2004-05-27 Maersk Medical As Connection piece for a hose connection
WO2004101023A2 (en) * 2003-05-06 2004-11-25 Becton Dickinson And Company A method for altering insulin pharmacokinetics
AU2004245051B2 (en) * 2003-06-02 2010-10-07 Becton, Dickinson And Company Medicament microdevice delivery system with a cartridge
US20060127465A1 (en) * 2003-06-10 2006-06-15 Shinya Maenosono Pad base for transdermal administration and needle
JP2005021678A (en) * 2003-06-10 2005-01-27 Medorekkusu:Kk Pad base for percutaneous admistration and its manufacturing method
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
WO2005007020A2 (en) 2003-07-03 2005-01-27 Corium International, Inc. Wound dressing, ingredient delivery device and iv hold-down, and method relating to same
US7766902B2 (en) 2003-08-13 2010-08-03 Wisconsin Alumni Research Foundation Microfluidic device for drug delivery
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
JP2007508914A (en) * 2003-10-24 2007-04-12 アルザ・コーポレーシヨン Apparatus and method for facilitating transdermal drug delivery
EP1706171A1 (en) * 2003-12-29 2006-10-04 3M Innovative Properties Company Medical devices and kits including same
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
CA2560784A1 (en) 2004-03-26 2005-10-06 Unomedical A/S Infusion set
US20050251095A1 (en) * 2004-05-07 2005-11-10 Giap Brandon C Improved medication injection device
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2005123173A1 (en) * 2004-06-10 2005-12-29 3M Innovative Properties Company Patch application device and kit
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
ATE490037T1 (en) 2004-08-16 2010-12-15 Functional Microstructures Ltd METHOD FOR PRODUCING A MICRONEEDLE OR A MICROIMPLANT
AR050608A1 (en) * 2004-08-19 2006-11-08 Alza Corp APPARATUS AND METHOD FOR TRANSDERMAL ADMINISTRATION OF VASCULAR ENDOTELIAL GROWTH FACTORS
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
US9174035B2 (en) 2004-11-18 2015-11-03 3M Innovative Properties Company Microneedle array applicator and retainer
BRPI0517749A (en) 2004-11-18 2008-10-21 3M Innovative Properties Co application device for applying a micro-needle device to a skin surface, and method for using an application device
JP5015787B2 (en) 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー Contact coating method of microneedle array
KR101224257B1 (en) * 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Masking method for coating a microneedle array
US20080307849A1 (en) * 2004-11-26 2008-12-18 Agency For Science, Technology And Research Method And Apparatus For Forming Microstructures
MX2007006840A (en) 2004-12-10 2007-08-14 Unomedical As Cannula inserter.
WO2006064271A1 (en) * 2004-12-17 2006-06-22 Functional Microstructures Limited Microneedle device for transdermal transport of fluid
JP2008529750A (en) * 2005-02-16 2008-08-07 アルザ コーポレイション Microprojection array with improved biocompatibility
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
ATE555824T1 (en) 2005-04-11 2012-05-15 Infotonics Technology Ct Inc BLOOD MONITORING SYSTEMS AND METHODS THEREOF
WO2006115502A1 (en) * 2005-04-25 2006-11-02 Giap, Brandon, C. Improved medication injection device
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
EP1904158B1 (en) * 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
JP5144510B2 (en) 2005-06-27 2013-02-13 スリーエム イノベイティブ プロパティズ カンパニー Microneedle array application device
ATE477833T1 (en) * 2005-06-27 2010-09-15 3M Innovative Properties Co MICRONEEDLE CARTRIDGE ASSEMBLY
WO2007008824A2 (en) * 2005-07-11 2007-01-18 Infotonics Technology Center, Inc. Minimally invasive allergy testing system
CN101242869B (en) * 2005-09-02 2010-05-26 Iomai公司 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
PT1762259E (en) 2005-09-12 2010-12-10 Unomedical As Inserter for an infusion set with a first and second spring units
GB0520757D0 (en) * 2005-10-12 2005-11-23 Vuppalapati Gunasekar Delivery device
US20070087029A1 (en) * 2005-10-14 2007-04-19 Pakala Syamasundar V Localized delivery to the lymphatic system
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
KR20080081959A (en) * 2005-12-08 2008-09-10 나노패스 테크놀러지스 엘티디. Microneedle adapter for dosed drug delivery devices
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
ES2327963T3 (en) 2005-12-23 2009-11-05 Unomedical A/S INJECTION DEVICE.
US8048089B2 (en) 2005-12-30 2011-11-01 Edge Systems Corporation Apparatus and methods for treating the skin
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
WO2007098771A2 (en) 2006-02-28 2007-09-07 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
US10172644B2 (en) 2006-03-29 2019-01-08 Edge Systems Llc Devices, systems and methods for treating the skin
US9566088B2 (en) 2006-03-29 2017-02-14 Edge Systems Llc Devices, systems and methods for treating the skin
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US20070265570A1 (en) * 2006-04-27 2007-11-15 Gerut Zachary E Device and method for treating skin prior to performing surgery
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
US20070276425A1 (en) * 2006-05-29 2007-11-29 Stanley Kim Painless Blood Sampling Lancet with Bundled Multiple Thin Needles
US20070282246A1 (en) * 2006-06-05 2007-12-06 Mit, Llp Iontosonic-microneedle biosensor apparatus and methods
KR20090026760A (en) 2006-06-07 2009-03-13 우노메디컬 에이/에스 Inserter
KR20090028701A (en) 2006-06-09 2009-03-19 우노메디컬 에이/에스 Mounting pad
WO2008007374A2 (en) * 2006-07-12 2008-01-17 Nanopass Technologies Ltd. Microneedle devices with controlled uncapping
US8012566B2 (en) * 2006-07-12 2011-09-06 Hewlett-Packard Development Company, L.P. Microneedles formed by electroplating and selectively releasing temperature sensitive layers
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
KR100886633B1 (en) * 2006-07-14 2009-03-04 호남석유화학 주식회사 Skin pricking micro projection apparatus having reservoir space of materials for transdermal delivery in front side
JP2008029710A (en) * 2006-07-31 2008-02-14 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai Microneedle type patch and its manufacturing method
WO2008014791A1 (en) 2006-08-02 2008-02-07 Unomedical A/S Cannula and delivery device
JP2010505471A (en) 2006-10-02 2010-02-25 エムキネティクス， インコーポレイテッド Method and apparatus for magnetic induction therapy
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
EP1917990A1 (en) 2006-10-31 2008-05-07 Unomedical A/S Infusion set
US20080114340A1 (en) * 2006-11-01 2008-05-15 Biotex, Inc. System and method for reducing photon scatter in dermal tissue
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US8523926B2 (en) * 2007-01-19 2013-09-03 Joseph Neev Devices and methods for generation of subsurface microdisruptions for biomedical applications
US10588694B1 (en) 2007-01-19 2020-03-17 Joseph Neev Devices and methods for generation of subsurface micro-disruptions for biomedical applications
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
CN101754770B (en) * 2007-06-14 2015-05-20 克鲁塞尔瑞士股份公司 Intradermal influenza vaccine
JP2010530266A (en) 2007-06-20 2010-09-09 ウノメディカル アクティーゼルスカブ Catheter and catheter manufacturing method and apparatus
CN101808685A (en) 2007-07-03 2010-08-18 优诺医疗有限公司 Inserter having bistable equilibrium states
WO2009008988A1 (en) * 2007-07-09 2009-01-15 Apogee Technology, Inc. Immunostimulating polyphosphazene compounds for intradermal immunization
US8486003B2 (en) 2007-07-10 2013-07-16 Unomedical A/S Inserter having two springs
WO2009010396A1 (en) 2007-07-18 2009-01-22 Unomedical A/S Insertion device with pivoting action
US8647356B2 (en) * 2007-07-21 2014-02-11 Stanley I. Kim Lancet system
US8328720B2 (en) 2007-08-10 2012-12-11 Infotonics Technology Center, Inc. MEMS interstitial prothrombin time test
JP5223278B2 (en) * 2007-09-27 2013-06-26 凸版印刷株式会社 Microneedle manufacturing method
ES2612061T3 (en) * 2007-09-28 2017-05-11 The Queen's University Of Belfast Device and delivery method
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
EP2240099B1 (en) 2008-01-04 2018-02-21 Edge Systems LLC Apparatus for treating the skin
US8814836B2 (en) 2008-01-29 2014-08-26 Edge Systems Llc Devices, systems and methods for treating the skin using time-release substances
WO2009097451A1 (en) 2008-01-29 2009-08-06 Edge Systems Corporation Apparatus and method for treating the skin
US10898643B2 (en) 2008-02-13 2021-01-26 Unomedical A/S Sealing between a cannula part and a fluid path
WO2009103759A1 (en) 2008-02-20 2009-08-27 Unomedical A/S Insertion device with horizontally moving part
US9408971B2 (en) * 2008-03-31 2016-08-09 Covidien Lp Self-capping syringe assembly with one-way valve
WO2009130926A1 (en) * 2008-04-22 2009-10-29 南部化成株式会社 Endermic method, needle organizer and endermic injector device
US10543123B2 (en) 2008-04-28 2020-01-28 Joseph Neev Devices and methods for generation of subsurface micro-disruptions for opthalmic surgery and opthalmic applications
JP5476062B2 (en) * 2008-07-25 2014-04-23 南部化成株式会社 Transdermal device
US8795259B2 (en) 2008-08-01 2014-08-05 Wisconsin Alumni Research Foundation Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow
US8986250B2 (en) 2008-08-01 2015-03-24 Wisconsin Alumni Research Foundation Drug delivery platform utilizing hydrogel pumping mechanism
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8721583B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9040087B2 (en) 2008-10-31 2015-05-26 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8409376B2 (en) 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8545857B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8762067B2 (en) 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US8551505B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8731842B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9056047B2 (en) 2008-10-31 2015-06-16 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8256233B2 (en) 2008-10-31 2012-09-04 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8603494B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8603495B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US8545855B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
EP2347788A4 (en) 2008-11-17 2012-05-16 Yoichi Inaba Simple device for treating trichophytosis unguium
CN105999538A (en) * 2008-11-18 2016-10-12 3M创新有限公司 Hollow microneedle array and method
AU2009331635A1 (en) 2008-12-22 2011-06-23 Unomedical A/S Medical device comprising adhesive pad
FI20095433A0 (en) * 2009-04-20 2009-04-20 Valtion Teknillinen micro-needle
EP2459252B1 (en) 2009-07-30 2013-08-21 Unomedical A/S Inserter device with horizontal moving part
BR112012002804A2 (en) 2009-08-07 2016-05-31 Unomedical As sensor device and one or more cannulas
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US8409147B2 (en) * 2009-08-22 2013-04-02 Joseph Wayne Kraft Rapid local anesthesia linear injection device
US8088108B2 (en) * 2009-08-22 2012-01-03 Joseph Wayne Kraft Rapid local anesthesia injection cone
US10159825B2 (en) * 2009-09-17 2018-12-25 Zipline Medical, Inc. Rapid closing surgical closure device
CN102811671B (en) * 2009-09-17 2016-08-03 锡普莱恩医疗有限公司 Quick-make surgical closure device
EP2493551A4 (en) 2009-10-26 2013-04-17 Emkinetics Inc Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
DE102009046581A1 (en) * 2009-11-10 2011-05-12 Robert Bosch Gmbh Manufacturing method for a porous microneedle array and corresponding porous microneedle array and corresponding substrate composite
CN102770156B (en) 2009-12-16 2016-01-20 克洛恩泰克制药股份公司 Codon optimized hepatitis B virus core antigen (HBCAG)
CA2689400C (en) * 2009-12-30 2023-01-10 Kenneth W. Adams Therapeutic agent delivery apparatus and process
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US8328757B2 (en) * 2010-01-08 2012-12-11 Wisconsin Alumni Research Foundation Bladder arrangement for microneedle-based drug delivery device
US9327105B2 (en) 2010-03-26 2016-05-03 Itrace Biomedical Inc. Active transdermal drug delivery system and the method thereof
KR20130018783A (en) 2010-03-30 2013-02-25 우노메디컬 에이/에스 Medical device
US8439945B2 (en) 2010-05-03 2013-05-14 Zipline Medical, Inc. Methods for biopsying tissue
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
WO2011159623A1 (en) 2010-06-14 2011-12-22 Zipline Medical, Inc. Methods and apparatus for inhibiting scar formation
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
EP2433663A1 (en) 2010-09-27 2012-03-28 Unomedical A/S Insertion system
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
EP2436412A1 (en) 2010-10-04 2012-04-04 Unomedical A/S A sprinkler cannula
US10441767B2 (en) 2010-10-27 2019-10-15 Asti Corporation Jig for microneedle array placement and microneedle array device
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US20120135526A1 (en) * 2010-11-23 2012-05-31 Kenneth Greenberg Low-pressure biolistic barrels
US10244981B2 (en) 2011-03-30 2019-04-02 SensiVida Medical Technologies, Inc. Skin test image analysis apparatuses and methods thereof
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
EP2720740A1 (en) 2011-06-15 2014-04-23 ChronTech Pharma AB Injection needle and device
WO2013009690A2 (en) 2011-07-09 2013-01-17 The Regents Of The University Of California Leukemia stem cell targeting ligands and methods of use
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9700245B2 (en) 2011-09-23 2017-07-11 Itrace Biomedical Inc. Transdermal analyte extraction and detection system and the method thereof
CA2850624A1 (en) 2011-10-03 2013-04-11 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
EP2763723B1 (en) 2011-10-05 2016-04-13 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2578190A1 (en) * 2011-10-07 2013-04-10 Sanofi-Aventis Deutschland GmbH Intraocular injection device
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
US9050086B2 (en) 2011-11-01 2015-06-09 Zipline Medical, Inc. Surgical incision and closure apparatus
US10123801B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Means to prevent wound dressings from adhering to closure device
US10123800B2 (en) 2011-11-01 2018-11-13 Zipline Medical, Inc. Surgical incision and closure apparatus with integrated force distribution
US8323313B1 (en) 2011-11-01 2012-12-04 Zipline Medical, Inc. Surgical incision and closure apparatus with integrated force distribution
US9561034B2 (en) 2011-11-01 2017-02-07 Zipline Medical, Inc. Surgical incision and closure apparatus
KR20140102759A (en) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013138118A1 (en) 2012-03-14 2013-09-19 The Regents Of The University Of California Treatment of inflammatory disorders in non-human mammals
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
CA2868398A1 (en) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
KR20140143216A (en) * 2012-04-03 2014-12-15 테라젝트, 인코포레이티드 Soluble microneedle arrays for buccal delivery of vaccines
WO2013171907A1 (en) * 2012-05-18 2013-11-21 大勝 明 Injection needle and kit preparation
KR200466758Y1 (en) 2012-06-01 2013-05-07 인싸이토(주) Percutaneous injection module
JP5903016B2 (en) 2012-06-27 2016-04-13 コスメディ製薬株式会社 Protective release sheet for microneedle patch
JP6418544B2 (en) * 2012-06-27 2018-11-07 コスメディ製薬株式会社 Protective release sheet for microneedle patch
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
JP6144355B2 (en) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． Chemically modified mRNA
CN105073178B (en) 2012-12-21 2019-07-30 考里安国际公司 Microarray and its application method for therapeutic agent delivering
US10179239B2 (en) 2013-01-15 2019-01-15 Itrace Biomedical Inc. Personalized pain management treatments
US9710607B2 (en) 2013-01-15 2017-07-18 Itrace Biomedical Inc. Portable electronic therapy device and the method thereof
WO2014126101A1 (en) 2013-02-13 2014-08-21 久光製薬株式会社 Microneedle array
EP2961469A4 (en) 2013-02-28 2016-10-26 Kimberly Clark Co Drug delivery device
CA2901568C (en) 2013-02-28 2021-02-16 Kimberly-Clark Worldwide, Inc. Transdermal drug delivery device
WO2014164314A1 (en) 2013-03-12 2014-10-09 Corium International, Inc. Microprojection applicators
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
JP2016512754A (en) 2013-03-15 2016-05-09 コリウム インターナショナル， インコーポレイテッド Microarray, method of use and manufacturing for delivery of therapeutic agents
US10238812B2 (en) 2013-03-15 2019-03-26 Edge Systems Llc Skin treatment systems and methods using needles
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP2967633B1 (en) 2013-03-15 2018-04-25 Edge Systems LLC Devices for treating the skin
RU2720808C2 (en) 2013-09-03 2020-05-13 Джорджия Тек Рисёч Корпорейшн Thermostable vaccines and microneedles
JP2016538829A (en) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Polynucleotide encoding low density lipoprotein receptor
JP2017502762A (en) 2014-01-05 2017-01-26 ジップライン メディカル， インコーポレイテッドＺｉｐｌｉｎｅ Ｍｅｄｉｃａｌ， Ｉｎｃ． Wound closure device with equipment
US20160279401A1 (en) * 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
CN106163594B (en) * 2014-04-14 2019-10-25 凸版印刷株式会社 Injection device
AU2015253262B2 (en) 2014-04-30 2019-11-28 Sorrento Therapeutics, Inc. Controller portion of transdermal drug delivery apparatus and methods
AU2015253258B9 (en) 2014-04-30 2019-09-05 Sorrento Therapeutics, Inc. Receptacle portion of transdermal drug delivery apparatus and methods
US10232160B2 (en) 2014-04-30 2019-03-19 Sorrento Therapeutics, Inc. Transdermal drug delivery apparatus and methods
KR101724655B1 (en) * 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 Micro-needle patch and menufacturing method thereof
US9987427B1 (en) * 2014-06-24 2018-06-05 National Technology & Engineering Solutions Of Sandia, Llc Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof
WO2016014464A1 (en) 2014-07-21 2016-01-28 The Cleveland Clinic Foundation Convection enhanced delivery device and system
US9968765B2 (en) 2014-07-21 2018-05-15 The Cleveland Clinic Foundation Convection enhanced delivery device and system
KR101636775B1 (en) * 2014-08-19 2016-07-08 아주대학교산학협력단 Apparatus and method of regional anesthesia
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JP5931155B2 (en) * 2014-09-30 2016-06-08 日本写真印刷株式会社 Package of microneedle sheet and method for manufacturing the same
JP6906885B2 (en) 2014-11-14 2021-07-21 ロレアル Microneedle sheet to reduce wrinkles
US10179229B2 (en) 2014-12-23 2019-01-15 Edge Systems Llc Devices and methods for treating the skin using a porous member
EP3795204B1 (en) 2014-12-23 2023-10-25 HydraFacial LLC Device for treating the skin using a rollerball
CN104922791B (en) * 2015-05-26 2018-10-26 上海交通大学 Non-invasive acupuncture patch and preparation method thereof
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP4197517A1 (en) 2015-07-08 2023-06-21 HydraFacial LLC Devices, systems and methods for promoting hair growth
JP2019513070A (en) 2016-03-01 2019-05-23 キトテック メディカル， インコーポレイテッド Microstructure-based systems, devices and methods for wound closure
WO2018081795A1 (en) 2016-10-31 2018-05-03 Zipline Medical, Inc. Systems and methods for monitoring physical therapy of the knee and other joints
KR102539625B1 (en) * 2016-12-22 2023-06-05 오하이오 스테이트 이노베이션 파운데이션 Interpenetrating microstructures for cargo delivery based on nanochannels
US11241563B2 (en) * 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
CA3053641A1 (en) 2017-02-17 2018-08-23 Allergan, Inc. Microneedle array with active ingredient
CN109394236B (en) * 2017-08-17 2022-04-01 李泉 Blood sampling device and control equipment thereof
WO2019033362A1 (en) * 2017-08-17 2019-02-21 深圳华迈兴微医疗科技有限公司 Blood collection device and control apparatus therefor
WO2019059265A1 (en) * 2017-09-20 2019-03-28 シンクランド株式会社 Method for manufacture of microneedle and microneedle
TWI657842B (en) * 2017-10-27 2019-05-01 研能科技股份有限公司 Liquid supplying device for human insulin injection
TWI666036B (en) * 2017-10-27 2019-07-21 研能科技股份有限公司 Wearable liquid supplying device for human insulin injection
CA3101595A1 (en) 2018-06-29 2020-01-02 Johnson & Johnson Consumer Inc. Three-dimensional microfluidics devices for the delivery of actives
GB2574074B (en) 2018-07-27 2020-05-20 Mclaren Applied Tech Ltd Time synchronisation
GB2588236B (en) 2019-10-18 2024-03-20 Mclaren Applied Ltd Gyroscope bias estimation
JP2022554188A (en) * 2019-10-24 2022-12-28 ジャニーン ホプキンス Applicator device and method of use
US20230134699A1 (en) * 2020-04-09 2023-05-04 Carnegie Mellon University Hybrid microneedle arrays
CN112869871B (en) * 2021-01-11 2022-10-14 杭州维纳安可医疗科技有限责任公司 Ablation device, control method, device, system and storage medium thereof
CN117813128A (en) * 2021-01-22 2024-04-02 索伦托药业有限公司 Device for delivering coronavirus vaccine by microlitres-grade lymph
US20220330860A1 (en) 2021-04-14 2022-10-20 Neoenta LLC Dermal patch system
KR102577073B1 (en) * 2021-04-27 2023-09-11 주식회사 이엘홀딩스 Tattoo patch with micro needle
USD1016615S1 (en) 2021-09-10 2024-03-05 Hydrafacial Llc Container for a skin treatment device
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US11510602B1 (en) 2021-11-08 2022-11-29 Satio, Inc. Dermal patch for collecting a physiological sample
WO2023159181A1 (en) 2022-02-18 2023-08-24 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
WO2023193010A1 (en) 2022-04-01 2023-10-05 The Regents Of The University Of California Methods of improving cancer immunotherapy
US20230346666A1 (en) 2022-04-29 2023-11-02 Colgate-Palmolive Company Personal Care Composition

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1699012A (en) * 1927-11-22 1929-01-15 Joseph S Naylor Stock and poultry marker
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
FR1584474A (en) 1968-02-20 1969-12-26
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (en) 1972-02-14 1973-08-13 Ici Ltd DRESSINGS
DE2513467C3 (en) * 1975-03-26 1979-10-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen Device for infusing liquids into the human or animal body
IT1202218B (en) * 1985-05-21 1989-02-02 Mario Aluigi MULTI-NEEDLE JUNCTION PLATES FOR MESOTHERAPY USE AND RELATED POINT-SAVING CASES
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
EP0750518B1 (en) * 1994-02-28 2002-01-02 Novo Nordisk A/S Needle unit
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (en) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
US6230051B1 (en) 1996-06-18 2001-05-08 Alza Corporation Device for enhancing transdermal agent delivery or sampling
DE69722414T2 (en) 1996-07-03 2004-05-19 Altea Therapeutics Corp. MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOSA
CA2241615A1 (en) 1997-06-26 1998-12-26 An-Go-Gen Inc. Catheters
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO2000035530A1 (en) * 1998-12-18 2000-06-22 Minimed Inc. Insertion sets with micro-piercing members for use with medical devices and methods of using the same
CA2376128C (en) * 1999-06-04 2009-01-06 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance

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