CA2316976A1 - Osmotic delivery system with membrane plug retention mechanism - Google Patents

Osmotic delivery system with membrane plug retention mechanism Download PDF

Info

Publication number
CA2316976A1
CA2316976A1 CA002316976A CA2316976A CA2316976A1 CA 2316976 A1 CA2316976 A1 CA 2316976A1 CA 002316976 A CA002316976 A CA 002316976A CA 2316976 A CA2316976 A CA 2316976A CA 2316976 A1 CA2316976 A1 CA 2316976A1
Authority
CA
Canada
Prior art keywords
membrane plug
membrane
delivery system
capsule
osmotic delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002316976A
Other languages
French (fr)
Other versions
CA2316976C (en
Inventor
Rupal Ayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Alza Corporation
Rupal Ayer
Intarcia Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation, Rupal Ayer, Intarcia Therapeutics, Inc. filed Critical Alza Corporation
Publication of CA2316976A1 publication Critical patent/CA2316976A1/en
Application granted granted Critical
Publication of CA2316976C publication Critical patent/CA2316976C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

An osmotic delivery system has a membrane plug retention mechanism which can also be used to control the delivery rate of a beneficial agent from the osmotic delivery system. The osmotic delivery device includes an implant capsule containing a beneficial agent and an osmotic agent. Holes are formed along a side wall of the implant capsule at an open end of the capsule. When the membrane plug is inserted into the open end of the capsule the membrane material swells into the holes in the capsule side wall creating a large frictional force which prevents expulsion of the membrane plug. A beneficial agent delivery rate of the osmotic delivery system is controllable by varying the size and number of the holes to change the amount of exposed surface area of the membrane plug. An increase in the surface area of the membrane plug exposed to the exterior environment causes a corresponding increase in the liquid permeation rate of the membrane and thus, increases the beneficial agent delivery rate.
CA002316976A 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism Expired - Fee Related CA2316976C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6898797P 1997-12-29 1997-12-29
US60/068,987 1997-12-29
PCT/US1998/026654 WO1999033446A1 (en) 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism

Publications (2)

Publication Number Publication Date
CA2316976A1 true CA2316976A1 (en) 1999-07-08
CA2316976C CA2316976C (en) 2009-02-17

Family

ID=22085978

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002316976A Expired - Fee Related CA2316976C (en) 1997-12-29 1998-12-15 Osmotic delivery system with membrane plug retention mechanism

Country Status (13)

Country Link
US (5) US6270787B1 (en)
EP (1) EP1041968B1 (en)
JP (1) JP4173635B2 (en)
AR (1) AR014194A1 (en)
AT (1) ATE260640T1 (en)
AU (1) AU1828599A (en)
CA (1) CA2316976C (en)
DE (1) DE69822208T2 (en)
ES (1) ES2217613T3 (en)
HK (1) HK1031332A1 (en)
TW (1) TW446552B (en)
WO (1) WO1999033446A1 (en)
ZA (1) ZA9811880B (en)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
AU1828599A (en) * 1997-12-29 1999-07-19 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
ATE234603T1 (en) * 1998-12-31 2003-04-15 Alza Corp OSMOTIC ADMINISTRATION SYSTEM WITH SPACE-SAVING PISTONS
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
ES2248156T3 (en) * 1999-12-21 2006-03-16 Alza Corporation VALVE FOR OSMOTIC DEVICES.
US7163688B2 (en) 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
AU2003213719A1 (en) * 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
JP2005533782A (en) * 2002-06-17 2005-11-10 アルザ コーポレイション An osmotic delivery system having an engine with fast extruding force and zero order including an osmotic agent dispersed in a fluid vehicle
AU2003243699B2 (en) * 2002-06-21 2009-01-15 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
AU2003256308B2 (en) 2002-06-26 2008-07-03 Intarcia Therapeutics, Inc. Minimally compliant, volume efficient piston for osmotic drug delivery systems
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
JP2006512370A (en) * 2002-12-19 2006-04-13 アルザ・コーポレーション A stable non-aqueous single phase gel and its formulation for delivery from an implantable device
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP2339328A3 (en) 2002-12-30 2011-07-13 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of celecoxib
AU2003272270A1 (en) 2003-02-28 2004-09-28 The Regents Of The University Of Michigan Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
KR20050120767A (en) * 2003-03-31 2005-12-23 알자 코포레이션 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
RU2005133427A (en) 2003-03-31 2006-04-27 Алза Корпорейшн (Us) WATERLESS SINGLE-PHASE CARRIERS AND DRUGS USING SUCH CARRIERS
AR043809A1 (en) 2003-03-31 2005-08-17 Alza Corp OSMOTIC PUMP WITH MEDIUM TO DISSIP INTERNAL PRESSURE
WO2004091278A2 (en) * 2003-04-11 2004-10-28 Transform Pharmaceuticals, Inc. Gabapentin compositions
WO2005000786A1 (en) 2003-05-23 2005-01-06 Transform Pharmaceuticals, Inc. Sertraline compositions
MXPA06003453A (en) * 2003-09-26 2006-08-31 Johnson & Johnson Oros push-stick for controlled delivery of active agents.
NZ546183A (en) 2003-09-26 2011-04-29 Alza Corp Controlled release formulations exhibiting an ascending rate of release
JP5563731B2 (en) * 2003-09-26 2014-07-30 アルザ・コーポレーシヨン Controlled release formulation of opioid and non-opioid analgesics
NZ546148A (en) 2003-09-26 2009-05-31 Alza Corp Drug coating providing high drug loading and methods for providing the same
CN1859900A (en) * 2003-09-30 2006-11-08 阿尔萨公司 Osmotically driven active agent delivery device providing an ascending release profile
US7407499B2 (en) 2003-10-31 2008-08-05 Intarcia Therapeutics, Inc. Osmotic pump with self-retaining, fast-start membrane plug
US20050113410A1 (en) * 2003-11-03 2005-05-26 Mark Tawa Pharmaceutical salts of zafirlukast
MXPA06003065A (en) * 2003-11-06 2006-05-31 Alza Corp Modular imbibition rate reducer for use with implantable osmotic pump.
CA2546601A1 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
US20060004037A1 (en) * 2004-03-25 2006-01-05 Transform Pharmaceuticals, Inc. Novel tricyclic compounds and related methods of treatment
KR20070012392A (en) * 2004-03-31 2007-01-25 코닌클리케 필립스 일렉트로닉스 엔.브이. Method and system for transferring budgets in a technique for restrained budget use
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
JP5017103B2 (en) * 2004-06-17 2012-09-05 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド Pharmaceutical co-crystal composition and related methods of use
JP2008510558A (en) 2004-08-27 2008-04-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Electronically and remotely controlled pills and systems for administering at least one drug
US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US8779175B2 (en) * 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20060160783A1 (en) * 2004-12-30 2006-07-20 Transform Pharmaceuticals, Inc. Novel omeprazole forms and related methods
WO2006084141A2 (en) * 2005-02-03 2006-08-10 Intarcia Therapeutics, Inc Suspension formulation of interferon
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20070005043A1 (en) * 2005-06-30 2007-01-04 Alza Corporation Osmotic Intraosseous Drug Delivery System
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US7931620B2 (en) * 2006-02-01 2011-04-26 Roche Diagnostics International Ag Self-sealing connection for housing shells of an administering device
JP2009535552A (en) * 2006-04-28 2009-10-01 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Osmotic pump having at least one chargeable material
DE602007009377D1 (en) * 2006-05-30 2010-11-04 Intarcia Therapeutics Inc SECONDARY FLOW MODULATOR WITH AN INTERNAL CHANNEL FOR AN OSMOTIC OUTPUT SYSTEM
KR101200728B1 (en) 2006-08-09 2012-11-13 인타르시아 세라퓨틱스 인코포레이티드 Osmotic delivery system and piston assemblies
US9114133B2 (en) 2006-08-25 2015-08-25 U.S. Dept. Of Veterans Affairs Method of improving diastolic dysfunction
US8617143B2 (en) * 2006-12-07 2013-12-31 The Regents Of The University Of California Therapeutic agent delivery systems and devices
JP5322951B2 (en) 2007-02-09 2013-10-23 リガンド・ファーマシューティカルズ・インコーポレイテッド Novel antagonist of glucagon receptor
AU2008244523B2 (en) * 2007-04-23 2012-02-16 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
JP2010534721A (en) * 2007-07-27 2010-11-11 ディポメド，インコーポレイティド Pulse type gastric retentive preparation
JP5572549B2 (en) 2007-08-13 2014-08-13 リガンド・ファーマシューティカルズ・インコーポレイテッド Novel activator of glucokinase
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
EP2240155B1 (en) * 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
KR101599089B1 (en) 2008-08-13 2016-03-02 메타베이시스 테라퓨틱스, 인크. Glucagon antagonists
KR101419583B1 (en) * 2008-10-15 2014-07-25 인타르시아 세라퓨틱스 인코포레이티드 Highly concentrated drug particles, formulations, suspensions and uses thereof
KR20120006040A (en) 2009-04-07 2012-01-17 코닌클리케 필립스 일렉트로닉스 엔.브이. Modular ingestible drug delivery capsule
US10046109B2 (en) 2009-08-12 2018-08-14 Progenity, Inc. Drug delivery device with compressible drug reservoir
SI2462246T1 (en) 2009-09-28 2018-01-31 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
EP2556082B1 (en) 2010-04-08 2017-02-22 Emory University Substituted androst-4-ene diones
SG10201606408SA (en) 2010-08-30 2016-09-29 Sinusys Corp Devices and methods for dilating a paranasal sinus opening and for treating sinusitis
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
WO2012129237A2 (en) 2011-03-20 2012-09-27 Trustees Of Boston University Therapeutic agent for emphysema and copd
EP2688559B1 (en) * 2011-03-24 2018-05-09 STOCO 10 GmbH Swallowable medication capsule
ITFI20110114A1 (en) 2011-05-31 2012-12-01 Scuola Superiore Di Studi Universit Arie Di Perfe ROBOTIC PLATFORM FOR MINING-INVASIVE SURGERY
WO2013003697A1 (en) 2011-06-30 2013-01-03 Trustees Of Boston University Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
US20130090633A1 (en) * 2011-10-07 2013-04-11 University Of Southern California Osmotic patch pump
TWI615155B (en) * 2011-11-01 2018-02-21 拜耳股份有限公司 Osmotically active vaginal delivery system
WO2013130468A1 (en) 2012-02-29 2013-09-06 SinuSys Corporation Devices and methods for dilating a paranasal sinus opening and for treating sinusitis
US9737364B2 (en) 2012-05-14 2017-08-22 Vanderbilt University Local magnetic actuation of surgical devices
ES2592404T3 (en) 2012-05-21 2016-11-30 Bayer Pharma Aktiengesellschaft Benzothienopyrimidines substituted
US9826904B2 (en) 2012-09-14 2017-11-28 Vanderbilt University System and method for detecting tissue surface properties
US20140081169A1 (en) * 2012-09-17 2014-03-20 Vanderbilt University System and method of tetherless insufflation in colon capsule endoscopy
TW201412740A (en) 2012-09-20 2014-04-01 Bayer Pharma AG Substituted pyrrolopyrimidinylamino-benzothiazolones
CN102871982B (en) 2012-10-16 2014-09-10 中国科学院上海药物研究所 Medicine osmotic pump preparation
WO2014113697A1 (en) 2013-01-17 2014-07-24 Vanderbilt University Real-time pose and magnetic force detection for wireless magnetic capsule
US9687263B2 (en) 2013-05-30 2017-06-27 SinuSys Corporation Devices and methods for inserting a sinus dilator
CA2924141C (en) 2013-08-22 2022-06-07 The General Hospital Corporation 5-amino 4-cyano substituted oxazole and thiazole derivatives as inhibitors of human 12/15-lipoxygenase
JP2017519000A (en) 2014-06-12 2017-07-13 リガンド・ファーマシューティカルズ・インコーポレイテッド Glucagon antagonist
WO2016040451A1 (en) 2014-09-09 2016-03-17 Vanderbilt University Hydro-jet endoscopic capsule and methods for gastric cancer screening in low resource settings
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
KR20240042548A (en) 2015-06-03 2024-04-02 인타르시아 세라퓨틱스 인코포레이티드 Implant placement and removal systems
SG11201803353PA (en) 2015-11-05 2018-05-30 Massachusetts Gen Hospital Intrathecal delivery of nucleic acid sequences encoding abcd1 for treatment of adrenomyeloneuropathy
MA53353A (en) 2016-05-16 2021-06-09 Intarcia Therapeutics Inc GLUCAGON RECEPTOR SELECTIVE POLYPEPTIDES AND METHODS FOR THEIR USE
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
AU2017345724B2 (en) 2016-10-20 2024-04-18 Peptron, Inc. Methods of delivering a neuroprotective polypeptide to the central nervous system
EP3565580B1 (en) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel
EP3592376A1 (en) 2017-03-08 2020-01-15 Intarcia Therapeutics, Inc Apparatus and methods for administration of a nauseogenic compound from a drug delivery device
US11122965B2 (en) 2017-10-09 2021-09-21 Vanderbilt University Robotic capsule system with magnetic actuation and localization
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
MX2021004185A (en) 2018-10-11 2021-09-08 Intarcia Therapeutics Inc Human amylin analog polypeptides and methods of use.
US20200155466A1 (en) * 2018-11-21 2020-05-21 II Don S. Houtz Oral Medicine Delivery Capsule
CN109589491B (en) * 2019-01-29 2024-01-09 上海安翰医疗技术有限公司 Automatic drug delivery device
CN115666621A (en) 2020-01-13 2023-01-31 度勒科特公司 Sustained release drug delivery systems with reduced impurities and related methods

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732865A (en) 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3929132A (en) * 1973-04-10 1975-12-30 Alza Corp Osmotic dispenser
US3995632A (en) 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
US3916889A (en) 1973-09-28 1975-11-04 Sandoz Ag Patient ventilator apparatus
US3888249A (en) * 1973-11-02 1975-06-10 David L Spencer Arterial infusion catheter
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4111202A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4203439A (en) 1976-11-22 1980-05-20 Alza Corporation Osmotic system with volume amplifier for increasing amount of agent delivered therefrom
US4243030A (en) 1978-08-18 1981-01-06 Massachusetts Institute Of Technology Implantable programmed microinfusion apparatus
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4340054A (en) 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4552561A (en) 1982-12-23 1985-11-12 Alza Corporation Body mounted pump housing and pump assembly employing the same
US4639244A (en) 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US4874388A (en) 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5151093A (en) 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
GB9027422D0 (en) 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5223265A (en) 1992-01-10 1993-06-29 Alza Corporation Osmotic device with delayed activation of drug delivery
US5456679A (en) 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5308348A (en) 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
CA2193806A1 (en) * 1994-06-22 1995-12-28 Michael Cardamone Controlled release device and method
US5731001A (en) * 1995-06-07 1998-03-24 Magruder; Judy A. Locking couplings for osmotic delivery devices
ATE284202T1 (en) 1996-02-02 2004-12-15 Alza Corp IMPLANTABLE DELAYED RELEASE SYSTEM
AU1828599A (en) * 1997-12-29 1999-07-19 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
AR013256A1 (en) * 1997-12-30 2000-12-13 Intarcia Therapeutics Inc ADMINISTRATION ARRANGEMENT FOR A CONTROLLED ADMINISTRATION OF A CHARITY AGENT, METHOD FOR FORMING AN ADMINISTRATION ARRANGEMENT, METHOD FOR MAKING AN ADMINISTRATION ARRANGEMENT AND METHOD OF CONTROLLING A SPEED OF FREEDOM.

Also Published As

Publication number Publication date
US20040243106A1 (en) 2004-12-02
DE69822208D1 (en) 2004-04-08
US20010021822A1 (en) 2001-09-13
AU1828599A (en) 1999-07-19
WO1999033446A1 (en) 1999-07-08
US20050048097A1 (en) 2005-03-03
US6976981B2 (en) 2005-12-20
EP1041968A1 (en) 2000-10-11
CA2316976C (en) 2009-02-17
ZA9811880B (en) 1999-06-29
AR014194A1 (en) 2001-02-07
US6899887B2 (en) 2005-05-31
JP2001526939A (en) 2001-12-25
JP4173635B2 (en) 2008-10-29
US6270787B1 (en) 2001-08-07
EP1041968B1 (en) 2004-03-03
TW446552B (en) 2001-07-21
US20010022974A1 (en) 2001-09-20
DE69822208T2 (en) 2005-04-28
HK1031332A1 (en) 2001-06-15
ES2217613T3 (en) 2004-11-01
ATE260640T1 (en) 2004-03-15

Similar Documents

Publication Publication Date Title
CA2316976A1 (en) Osmotic delivery system with membrane plug retention mechanism
CA2316886A1 (en) Beneficial agent delivery system with membrane plug
HK1039054A1 (en) Controlled release tablet comprising a hypoglycemic drug and an antihyperglycemic drug.
CA2297801A1 (en) Osmotic delivery system with semipermeable plug
CA2324493A1 (en) Controlled release oral tablet having a unitary core
CA2031393A1 (en) Tablets with controlled-rate release of active substances
CA2024942A1 (en) Implantable delivery dispenser
CA2029383A1 (en) Swelling modulated polymeric drug delivery device
CA2193481A1 (en) Colonic drug delivery composition
EP1652516A3 (en) Osmotic controlled delivery of active agents
CA2373746A1 (en) Insecticidal liquid bait station
CA2158689A1 (en) Medical devices containing triggerable disintegration agents
AU1017988A (en) Tablet for pharmaceutical use able to release active substances at successive times
AU3293189A (en) Dispensers for powdered medication
EP0747292A4 (en) Discharge container
AU4089189A (en) The use of asymmetric membranes in delivery devices
CA2199249A1 (en) Laminated tablet with pointed core
AU1560692A (en) Capsule
EP0064845A3 (en) Endodontic filling system
CA2345005A1 (en) Container for intravenous administration
AU1671799A (en) Medicament preparation in the form of a tablet or pellet for acid-labile active substances
WO2001077551A3 (en) Pressure relief device for a sealed system
CA2300935A1 (en) Composition, device and method of using
CA2023152A1 (en) Composite material for use in medicine
CA1268807A (en) Deferred-action battery

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20121217