CA2328945A1 - Softgel-compatible composition containing retinol - Google Patents

Softgel-compatible composition containing retinol Download PDF

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Publication number
CA2328945A1
CA2328945A1 CA002328945A CA2328945A CA2328945A1 CA 2328945 A1 CA2328945 A1 CA 2328945A1 CA 002328945 A CA002328945 A CA 002328945A CA 2328945 A CA2328945 A CA 2328945A CA 2328945 A1 CA2328945 A1 CA 2328945A1
Authority
CA
Canada
Prior art keywords
softgel
composition containing
compatible composition
containing retinol
compatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002328945A
Other languages
French (fr)
Other versions
CA2328945C (en
Inventor
Marie A. Rinaldi
Paul C. Tutschek
Subhash J. Saxena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catalent Pharma Solutions Inc
Heron Therapeutics LLC
Original Assignee
Advanced Polymer Systems, Inc.
Marie A. Rinaldi
Paul C. Tutschek
Subhash J. Saxena
R.P. Scherer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/062,138 external-priority patent/US5891470A/en
Application filed by Advanced Polymer Systems, Inc., Marie A. Rinaldi, Paul C. Tutschek, Subhash J. Saxena, R.P. Scherer Corporation filed Critical Advanced Polymer Systems, Inc.
Publication of CA2328945A1 publication Critical patent/CA2328945A1/en
Application granted granted Critical
Publication of CA2328945C publication Critical patent/CA2328945C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Abstract

A softgel-compatible composition containing retinol comprises retinol-impregnated microparticles. The composition may include an optionally thickened silicone oil, or may include an emulsion comprising a silicone oil. Ascorbic acid may be present as ascorbic acid-impregnated microparticles and/or within the emulsion. Such compositions are compatible with softgels, and may also be used in other dispensing containers, such as sachets, tubes, and airless pumps.
CA002328945A 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol Expired - Lifetime CA2328945C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/062,138 US5891470A (en) 1998-04-17 1998-04-17 Softgel formulation containing retinol
US09/062,138 1998-04-17
US09/272,893 US6228894B1 (en) 1998-04-17 1999-03-19 Softgel-compatible composition containing retinol
US09/272,893 1999-03-19
PCT/US1999/008559 WO1999053904A2 (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol

Publications (2)

Publication Number Publication Date
CA2328945A1 true CA2328945A1 (en) 1999-10-28
CA2328945C CA2328945C (en) 2007-07-03

Family

ID=26741915

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002328945A Expired - Lifetime CA2328945C (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol

Country Status (11)

Country Link
US (1) US6228894B1 (en)
EP (1) EP1071404B1 (en)
JP (1) JP4338894B2 (en)
AT (1) ATE252376T1 (en)
AU (1) AU765268B2 (en)
BR (1) BR9910129A (en)
CA (1) CA2328945C (en)
DE (1) DE69912262T2 (en)
ES (1) ES2211075T3 (en)
MX (1) MXPA00010116A (en)
WO (1) WO1999053904A2 (en)

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Publication number Priority date Publication date Assignee Title
BR9803936A (en) * 1998-09-08 2000-04-04 Cosmeticos Natural Ind Com Process and composition to increase the action of vitamin A on an individual's cellular activity and use of vitamin C.
US6468516B1 (en) * 1999-03-19 2002-10-22 Warner-Lambert Company Composition and manufacture of topical pharmaceutical and cosmetic semi-solid post-foaming dosage forms in a pouch
AU2001257534A1 (en) * 2000-05-05 2001-11-20 R.P. Scherer Technologies, Inc. Oil-in-water emulsion formulation containing hydroquinone and retinol
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
JP2003104827A (en) * 2001-09-28 2003-04-09 Kose Corp Cosmetic
US20030232091A1 (en) * 2002-06-17 2003-12-18 Adi Shefer Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
AU2002358337A1 (en) * 2002-12-18 2004-07-09 Coreana Cosmetics Co., Ltd. Novel retinol derivative and cosmetic composition comprising the same
US20050031699A1 (en) 2003-06-26 2005-02-10 L'oreal Porous particles loaded with cosmetically or pharmaceutically active compounds
US8920918B2 (en) * 2005-10-31 2014-12-30 Kee Action Sports Technology Holdings, Llc Oil and polyethylene glycol fill material for use in paintball shells
PE20081482A1 (en) * 2006-12-20 2008-12-23 Novartis Ag GELATINE CAPSULES CONTAINING AN ACID
AU2009210455B2 (en) * 2008-02-01 2014-01-23 Amcol International Corporation Improved skin brightening compositions
FR2931661B1 (en) * 2008-05-30 2010-07-30 Galderma Res & Dev NOVEL DEPIGMENTING COMPOSITIONS IN THE FORM OF AN ANHYDROUS VASELIN - FREE AND ELASTOMER - FREE COMPOSITION COMPRISING A SOLUBILIZED PHENOLIC DERIVATIVE AND A RETINOID.
FR2931662B1 (en) * 2008-05-30 2010-07-30 Galderma Res & Dev NOVEL DEPIGMENTING COMPOSITIONS IN THE FORM OF AN ANHYDROUS VASELIN - FREE AND ELASTOMER - FREE COMPOSITION COMPRISING A SOLUBILIZED PHENOLIC DERIVATIVE.
US8529920B2 (en) 2008-09-12 2013-09-10 Amcol International Corporation Low pH retinoid topical compositions
US20100064927A1 (en) * 2008-09-17 2010-03-18 Aldo Perrone Starch-based paintball fill material
US9180112B2 (en) * 2010-03-23 2015-11-10 Ermis Labs, LLC Dermal compositions containing gorgonian extract
KR101080186B1 (en) * 2010-06-21 2011-11-07 주식회사 필라이트솔루션 Improved led lamp
WO2015115072A1 (en) * 2014-01-31 2015-08-06 富士カプセル株式会社 Capsule formulation
DE102018201522A1 (en) * 2018-02-01 2019-08-01 Beiersdorf Ag Cosmetic product comprising a dispenser and an anhydrous cosmetic preparation

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US4369180A (en) 1981-09-10 1983-01-18 Randolph C. Karrh Cosmetic facial preparation containing aloe vera
US4826828A (en) 1985-04-22 1989-05-02 Avon Products, Inc. Composition and method for reducing wrinkles
US4690825A (en) 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen
US5145675A (en) 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
JP2622955B2 (en) 1986-07-29 1997-06-25 エイボン プロダクツ インコ−ポレイテツド Anhydrous cosmetics
ZA886284B (en) * 1987-08-31 1990-04-25 Advanced Polymer Systems Inc Controlled release formulations
ZA892859B (en) 1988-04-22 1989-12-27 Advanced Polymer Systems Inc Porous particles in preparations involving immiscible phases
US4873091A (en) 1988-05-23 1989-10-10 Advanced Polymer Systems, Inc. Controlled release formulating employing resilient microbeads
US5055300A (en) 1988-06-17 1991-10-08 Basic Bio Systems, Inc. Time release protein
US5073365A (en) 1989-06-01 1991-12-17 Advanced Polymer Systems Clinical and personal care articles enhanced by lubricants and adjuvants
JP3014780B2 (en) 1990-01-29 2000-02-28 ジヨンソン・アンド・ジヨンソン・コンシユーマー・プロダクツ・インコーポレーテツド Skin care composition
US5559149A (en) 1990-01-29 1996-09-24 Johnson & Johnson Consumer Products, Inc. Skin care compositions containing retinoids
US5082661A (en) 1990-09-26 1992-01-21 Elizabeth Arden Co., Division Of Conopco, Inc. Odorless cosmetic compositions in gelatin capsules
ES2120417T5 (en) 1991-06-27 2009-04-01 JOHNSON & JOHNSON CONSUMER COMPANIES, INC. STABILIZING COMPOSITIONS OF TREATMENT FOR SKIN, CONTAINING RETINOIDS.
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US5516793A (en) * 1993-04-26 1996-05-14 Avon Products, Inc. Use of ascorbic acid to reduce irritation of topically applied active ingredients
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US6194452B1 (en) 1997-11-07 2001-02-27 Howard Murad Stable pharmaceutical compositions including ascorbic acid and methods of using same
US5891470A (en) * 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol

Also Published As

Publication number Publication date
WO1999053904A3 (en) 1999-12-23
EP1071404B1 (en) 2003-10-22
JP4338894B2 (en) 2009-10-07
CA2328945C (en) 2007-07-03
JP2002512184A (en) 2002-04-23
DE69912262T2 (en) 2004-08-26
MXPA00010116A (en) 2002-08-06
AU3653299A (en) 1999-11-08
WO1999053904A2 (en) 1999-10-28
EP1071404A2 (en) 2001-01-31
ES2211075T3 (en) 2004-07-01
BR9910129A (en) 2001-01-09
AU765268B2 (en) 2003-09-11
ATE252376T1 (en) 2003-11-15
DE69912262D1 (en) 2003-11-27
US6228894B1 (en) 2001-05-08

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EEER Examination request
MKEX Expiry

Effective date: 20190416