CA2329103A1 - Dialyzers for blood treatment and processes for production thereof - Google Patents

Dialyzers for blood treatment and processes for production thereof Download PDF

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Publication number
CA2329103A1
CA2329103A1 CA002329103A CA2329103A CA2329103A1 CA 2329103 A1 CA2329103 A1 CA 2329103A1 CA 002329103 A CA002329103 A CA 002329103A CA 2329103 A CA2329103 A CA 2329103A CA 2329103 A1 CA2329103 A1 CA 2329103A1
Authority
CA
Canada
Prior art keywords
semipermeable membrane
dialyzer
dry
hydrophilic polymer
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002329103A
Other languages
French (fr)
Other versions
CA2329103C (en
Inventor
Hidetoshi Kozawa
Hidekazu Nakashima
Shigehisa Wada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP36296299A external-priority patent/JP4211169B2/en
Priority claimed from JP36296199A external-priority patent/JP4061798B2/en
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of CA2329103A1 publication Critical patent/CA2329103A1/en
Application granted granted Critical
Publication of CA2329103C publication Critical patent/CA2329103C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0233—Manufacturing thereof forming the bundle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0088—Physical treatment with compounds, e.g. swelling, coating or impregnation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/009—After-treatment of organic or inorganic membranes with wave-energy, particle-radiation or plasma
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0095—Drying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B01D69/084—Undulated fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/36—Hydrophilic membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/38—Hydrophobic membranes

Abstract

The present invention relates to a dialyzer for blood treatment having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any of the following requirements: (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m2; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. The invention also relates to a process for producing a dialyzer having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere to the inside of the dialyzer, and then irradiating the semipermeable membrane with gamma-ray in the inert gas atmosphere. The invention further relates to a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone being filled with dry mist. The dialyzer includes a dry-type semipermeable membrane having less change in performance before and after drying and high water permeability and dialyzing performance, is light-weight, easy to handle, and exhibits a reduced elution of a hydrophilic polymer.
CA002329103A 1999-12-21 2000-12-20 Dialyzers for blood treatment and processes for production thereof Expired - Lifetime CA2329103C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP362962/99 1999-12-21
JP362961/99 1999-12-21
JP36296299A JP4211169B2 (en) 1999-12-21 1999-12-21 Dialysis machine for blood treatment
JP362960/99 1999-12-21
JP36296099A JP4211168B2 (en) 1999-12-21 1999-12-21 Dialyzer manufacturing method and sterilization method
JP36296199A JP4061798B2 (en) 1999-12-21 1999-12-21 Semipermeable membrane for blood treatment and dialyzer for blood treatment using the same

Publications (2)

Publication Number Publication Date
CA2329103A1 true CA2329103A1 (en) 2001-06-21
CA2329103C CA2329103C (en) 2009-06-09

Family

ID=27341673

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002329103A Expired - Lifetime CA2329103C (en) 1999-12-21 2000-12-20 Dialyzers for blood treatment and processes for production thereof

Country Status (10)

Country Link
US (2) US6605218B2 (en)
EP (1) EP1110563B1 (en)
JP (1) JP4211168B2 (en)
KR (1) KR100701115B1 (en)
CN (2) CN1240446C (en)
AT (1) ATE359858T1 (en)
CA (1) CA2329103C (en)
DE (1) DE60034416T2 (en)
ES (1) ES2285998T3 (en)
TW (1) TW467750B (en)

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CN103842003A (en) * 2011-11-04 2014-06-04 旭化成医疗株式会社 Separation membrane for use in treatment of blood, and blood treatment device having said membrane integrated therein

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JP3580314B1 (en) * 2003-12-09 2004-10-20 東洋紡績株式会社 Polysulfone-based selectively permeable hollow fiber membrane bundle and method for producing the same
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JP3636199B1 (en) * 2004-03-23 2005-04-06 東洋紡績株式会社 Polysulfone-based permselective hollow fiber membrane bundle, method for producing the same and blood purifier
JP4501530B2 (en) * 2004-05-19 2010-07-14 東洋紡績株式会社 Highly permeable hollow fiber membrane blood purifier
US20080000830A1 (en) * 2004-08-10 2008-01-03 Kimihiro Mabuchi Highly Water Permeable Hollow Fiber Membrane Type Blood Purifier and Process for Manufacturing the Same
JP4731875B2 (en) 2004-10-15 2011-07-27 東洋紡績株式会社 Blood purifier sterilization method and blood purifier package
JP4885437B2 (en) * 2004-10-15 2012-02-29 東洋紡績株式会社 Blood purifier and blood purifier package
US9067178B2 (en) * 2004-12-22 2015-06-30 Nipro Corporation Blood purifier package and process for manufacturing the same
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JP4483651B2 (en) * 2005-03-28 2010-06-16 東洋紡績株式会社 Sterilization method of blood purification module
JP3772909B1 (en) * 2005-04-04 2006-05-10 東洋紡績株式会社 Blood purifier
JP5110645B2 (en) * 2005-08-10 2012-12-26 旭化成メディカル株式会社 Hollow fiber membrane blood purification device
US20080035568A1 (en) * 2005-10-03 2008-02-14 Zhongping Huang Apparatus and Method for Filtering Fluids
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JP4596171B2 (en) * 2006-04-28 2010-12-08 東洋紡績株式会社 Blood purifier
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TWI374038B (en) * 2007-05-25 2012-10-11 Asahi Kasei Medical Co Ltd A polysulphone-based membrane for the blood treatment and its manufacturing method
CN102089070A (en) * 2008-06-10 2011-06-08 水技术国际公司 Preparation of high performance ultra filtration hollow fiber membrane
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CN110079887B (en) 2011-02-04 2021-12-24 弗雷塞尼斯医疗保健控股公司 Performance enhancing additives for fiber formation and polysulfone fibers
US20150174312A1 (en) * 2012-06-11 2015-06-25 Asahi Kasei Medical Co., Ltd. Separation membrane for blood treatment and blood treatment device having same membrane incorporated therein
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CN103842003B (en) * 2011-11-04 2016-10-26 旭化成医疗株式会社 Blood treatment separates film and is provided with the blood processor of this film

Also Published As

Publication number Publication date
DE60034416D1 (en) 2007-05-31
CN1240446C (en) 2006-02-08
US6605218B2 (en) 2003-08-12
KR20010070309A (en) 2001-07-25
US20050072731A1 (en) 2005-04-07
TW467750B (en) 2001-12-11
CA2329103C (en) 2009-06-09
JP4211168B2 (en) 2009-01-21
JP2001170167A (en) 2001-06-26
US20010004976A1 (en) 2001-06-28
EP1110563B1 (en) 2007-04-18
ES2285998T3 (en) 2007-12-01
CN1611272A (en) 2005-05-04
DE60034416T2 (en) 2008-01-03
US6960297B2 (en) 2005-11-01
CN1300629A (en) 2001-06-27
ATE359858T1 (en) 2007-05-15
EP1110563A3 (en) 2004-05-19
CN100453126C (en) 2009-01-21
EP1110563A2 (en) 2001-06-27
KR100701115B1 (en) 2007-03-29

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Effective date: 20201221