CA2334702A1 - Pharmaceutical compositions and uses for androst-5-ene-3.beta.,17.beta.-diol - Google Patents
Pharmaceutical compositions and uses for androst-5-ene-3.beta.,17.beta.-diol Download PDFInfo
- Publication number
- CA2334702A1 CA2334702A1 CA002334702A CA2334702A CA2334702A1 CA 2334702 A1 CA2334702 A1 CA 2334702A1 CA 002334702 A CA002334702 A CA 002334702A CA 2334702 A CA2334702 A CA 2334702A CA 2334702 A1 CA2334702 A1 CA 2334702A1
- Authority
- CA
- Canada
- Prior art keywords
- beta
- androst
- ene
- diol
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Androst-5-ene-3.beta.,17.beta.-diol is used to treat or reduce the likelihood of acquiring osteoporosis or menopausal symptoms, or other diseases affected by estrogen receptor activity, and for conditions which respond well to DHEA treatment, but where a higher ratio of estrogenic to androgenic effects is desired. Combination therapies are included, as are kits and pharmaceutical compositions for providing the active ingredients of claimed methods and combinations.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9628698A | 1998-06-11 | 1998-06-11 | |
US09/096,286 | 1998-06-11 | ||
PCT/CA1999/000537 WO1999063973A2 (en) | 1998-06-11 | 1999-06-10 | PHARMACEUTICAL COMPOSITIONS AND USES FOR ANDROST-5-ENE-3β,17β-DIOL |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2334702A1 true CA2334702A1 (en) | 1999-12-16 |
CA2334702C CA2334702C (en) | 2005-10-18 |
Family
ID=22256669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002334702A Expired - Fee Related CA2334702C (en) | 1998-06-11 | 1999-06-10 | Pharmaceutical compositions and uses for androst-5-ene-3.beta.,17.beta.-diol |
Country Status (23)
Country | Link |
---|---|
US (12) | US6432940B1 (en) |
EP (2) | EP1731157A3 (en) |
JP (1) | JP2002517432A (en) |
KR (3) | KR20060098400A (en) |
CN (3) | CN1243550C (en) |
AR (1) | AR018660A1 (en) |
AU (1) | AU4127499A (en) |
BR (1) | BR9911115A (en) |
CA (1) | CA2334702C (en) |
HK (2) | HK1037329A1 (en) |
HU (1) | HUP0102483A3 (en) |
ID (1) | ID27922A (en) |
IL (2) | IL140225A0 (en) |
MX (1) | MXPA00012304A (en) |
MY (1) | MY131522A (en) |
NO (1) | NO20006286L (en) |
NZ (1) | NZ536787A (en) |
PL (1) | PL345955A1 (en) |
RU (1) | RU2221569C2 (en) |
TR (2) | TR200100063T2 (en) |
TW (2) | TWI263499B (en) |
WO (1) | WO1999063973A2 (en) |
ZA (1) | ZA200007299B (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465445B1 (en) * | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
KR20060098400A (en) * | 1998-06-11 | 2006-09-18 | 앙도르쉐르슈 인코포레이티드 | PHARMACEUTICAL COMPOSITIONS AND USES FOR ANDROST-5-ENE-3β,17β-DIOL |
US6667299B1 (en) * | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
US20060079492A1 (en) * | 1999-10-25 | 2006-04-13 | Ahlem Clarence N | Compositions and treatment methods |
MXPA01012769A (en) | 1999-06-11 | 2003-06-24 | Watson Pharmaceuticals Inc | Administration of non-oral androgenic steroids to women. |
JP4790178B2 (en) | 1999-07-06 | 2011-10-12 | アンドルシェルシュ・インコーポレイテッド | Method for treating and / or suppressing weight gain |
DK1955700T3 (en) * | 1999-09-30 | 2011-05-23 | Harbor Biosciences Inc | Therapeutic treatment of androgen receptor-related disorders |
WO2001026651A2 (en) * | 1999-10-14 | 2001-04-19 | Endorecherche, Inc. | Selective estrogen receptor modulators in the treatment or reduction of the risk of acquiring hypertension, cardiovascular diseases, and insulin resistance |
FR2803750B1 (en) * | 2000-01-17 | 2004-04-02 | Assist Publ Hopitaux De Paris | ORAL USE OF DEHYDROEPIANDROSTERONE, ITS BIOLOGICAL PRECURSORS AND ITS METABOLIC DERIVATIVES AS AN ANTI-ATROPHYANT |
AU2001241779A1 (en) * | 2000-02-25 | 2001-09-03 | Hollis-Eden Pharmaceuticals, Inc. | Method of treatment of prostate cancer |
DE10039199A1 (en) * | 2000-08-10 | 2002-02-21 | Schering Ag | Combination preparations from an ERß selective estrogen and a SERM or antiestrogen |
FR2825277B1 (en) * | 2001-05-30 | 2004-10-15 | Oreal | COSMETIC AND / OR DERMATOLOGICAL AND / OR PHARMACEUTICAL COMPOSITION CONTAINING AT LEAST ONE ENZIME 3, B-HSD IHNIBITOR COMPOUND |
DE10151363A1 (en) * | 2001-10-17 | 2003-05-08 | Schering Ag | Use of estrogen receptor beta agonists to prepare medicaments for producing somatotropic and organotropic effects on the CNS, circulatory, skeletal and immune system in aging men and women |
AU2003206442A1 (en) * | 2002-02-21 | 2003-09-09 | Pantarhei Bioscience B.V. | Estrogenic component for treating decreased libido in women |
AU2003224561A1 (en) * | 2002-04-23 | 2003-11-10 | Sahltech I Goteborg Ab | Use of dhea for treatment of female hypopituitarism |
AU2003278744B2 (en) * | 2002-08-28 | 2010-07-29 | Harbor Biosciences, Inc. | Therapeutic treatment methods |
US20050101581A1 (en) * | 2002-08-28 | 2005-05-12 | Reading Christopher L. | Therapeutic treatment methods 2 |
GB0302572D0 (en) | 2003-02-05 | 2003-03-12 | Astrazeneca Ab | Method of treatment |
US20080032959A1 (en) * | 2004-06-23 | 2008-02-07 | Alves Stephen E | Estrogen Receptor Modulators |
RS20070166A (en) * | 2004-10-20 | 2008-09-29 | Endorecherche Inc., | Sex steroid precursors alone or in combination with a selective estrogen receptor modulator... |
EA200700983A1 (en) * | 2004-11-01 | 2008-04-28 | Эндорешерш, Инк. | APPLICATION OF ANDROGENS TO REDUCE THE PROBABILITY OF PURCHASING OR TREATING THE AGING OF THE SKIN |
EP1967202A1 (en) * | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
US8268806B2 (en) | 2007-08-10 | 2012-09-18 | Endorecherche, Inc. | Pharmaceutical compositions |
CA2697160A1 (en) * | 2007-08-21 | 2009-02-26 | Harbor Biosciences, Inc. | Stabilized therapeutic compositions and formulations |
EP2053055A1 (en) * | 2007-10-24 | 2009-04-29 | Bayer Schering Pharma Aktiengesellschaft | 11.beta.-fluoro-3-acetoxyestra-3,5-diene-17-one and method for its manufacture |
JP2010109894A (en) * | 2008-10-31 | 2010-05-13 | Fujitsu Ltd | Acoustic wave filter, duplexer, communication module, and communication apparatus |
AU2014201406B2 (en) * | 2009-06-16 | 2016-08-11 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
US20100317635A1 (en) | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
KR20220061258A (en) | 2010-06-16 | 2022-05-12 | 앙도르쉐르슈 인코포레이티드 | Methods of treating or preventing estrogen-related diseases |
US20130178747A1 (en) * | 2012-01-10 | 2013-07-11 | Peter J. Muran | Breast cancer precursor evaluation system and proactive breast wellness program |
CN105037532B (en) * | 2015-07-27 | 2018-02-09 | 苏州博源医疗科技有限公司 | 17 ketosteroid immunogenes, antibody and detection reagent and preparation method |
CN111830169B (en) * | 2020-07-24 | 2022-07-12 | 中山大学 | Compound for diagnosing polycystic ovarian syndrome and application thereof |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US424954A (en) * | 1890-04-08 | Table-knife | ||
US279982A (en) * | 1883-06-26 | Thomas beid | ||
US816689A (en) * | 1904-07-07 | 1906-04-03 | Charles M Stevenson | Merry-go-round. |
CH203260A (en) | 1936-11-24 | 1939-02-28 | Dreiding Boris | Means for the local production of heat. |
US2185187A (en) * | 1938-05-23 | 1940-01-02 | Vlieg Gerard A De | Rotary cutter |
FR672M (en) * | 1960-08-31 | 1961-07-17 | ||
US3797444A (en) | 1971-04-19 | 1974-03-19 | H Stubbs | Towing guide |
US3742951A (en) | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
US4139617A (en) * | 1974-05-13 | 1979-02-13 | Richardson-Merrell Inc. | 19-Oxygenated-androst-5-enes for the enhancement of libido |
US4040401A (en) | 1974-11-05 | 1977-08-09 | Ethyl Corporation | Spark vacuum advance control |
US4064654A (en) | 1975-03-20 | 1977-12-27 | H. G. Olson & Co., Inc. | Sealed closures with weather stripping |
JPS53144014A (en) | 1977-05-20 | 1978-12-15 | Masaya Koyama | Automatic sprayer |
DE3333240A1 (en) | 1983-09-12 | 1985-03-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | MEDIUM FOR TRANSDERMAL APPLICATION OF MEDICINAL PRODUCTS |
US4634694A (en) | 1984-01-14 | 1987-01-06 | Akzo N.V. | Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives |
US4725439A (en) | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
US4624665A (en) | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
US4568343A (en) | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
US5155045A (en) * | 1985-01-25 | 1992-10-13 | Trustees Of The University Of Penn. | Use of male essence to alter female endocrine response |
US4666441A (en) | 1985-12-17 | 1987-05-19 | Ciba-Geigy Corporation | Multicompartmentalized transdermal patches |
IE60941B1 (en) | 1986-07-10 | 1994-09-07 | Elan Transdermal Ltd | Transdermal drug delivery device |
US4816258A (en) | 1987-02-26 | 1989-03-28 | Alza Corporation | Transdermal contraceptive formulations |
US5887216A (en) * | 1997-03-19 | 1999-03-23 | Ricoh Company, Ltd. | Method and system to diagnos a business office device based on operating parameters set by a user |
US5686465A (en) * | 1988-10-31 | 1997-11-11 | Endorecherche Inc. | Sex steroid activity inhibitors |
CA2004203A1 (en) | 1988-12-01 | 1990-06-01 | Sharad K. Govil | Compositions for transdermal delivery of estradiol |
US5461042A (en) * | 1988-12-30 | 1995-10-24 | Loria; Roger M. | Regulation of the immune system |
DE69032648T2 (en) * | 1989-07-07 | 1999-04-08 | Endorecherche Inc | Androgen derivatives to inhibit the activity of sex steroids |
US5116828A (en) * | 1989-10-26 | 1992-05-26 | Nippon Zoki Pharmaceutical Co., Ltd. | Pharmaceutical composition for treatment of osteoporosis |
US5641768A (en) * | 1989-11-17 | 1997-06-24 | Loria; Roger M. | 5-androstene 3β, 17β diol for treatment |
US5071644A (en) | 1990-08-07 | 1991-12-10 | Mediventures, Inc. | Topical drug delivery with thermo-irreversible gels |
US5506223A (en) * | 1990-08-29 | 1996-04-09 | Humanetics Corporation | Δ5-androstenes useful for promoting weight maintenance or weight loss and treatment process |
US5183815A (en) * | 1991-01-22 | 1993-02-02 | Merck & Co., Inc. | Bone acting agents |
US5206008A (en) | 1991-04-15 | 1993-04-27 | Virginia Commonwealth University | Enhancement of immune response |
ZA924811B (en) * | 1991-06-28 | 1993-12-29 | Endorecherche Inc | Controlled release systems and low dose androgens |
EP0627921B1 (en) * | 1992-02-24 | 2000-05-31 | East Carolina University | Method of inhibiting carcinogenesis by treatment with dehydroepiandrosterone and analogs thereof |
FR2696934B1 (en) * | 1992-10-20 | 1995-06-02 | Conservatoire Nal Arts Metiers | Derivatives of natural hydroxyl 3B steroids having properties of triggering and stimulating immunity, composition containing them and process for obtaining them. |
US5776923A (en) | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
IL108371A (en) | 1993-01-19 | 2009-09-01 | Endorech Inc | Use of sex steroid precursors to prepare medicaments for treatment of vaginal atrophy |
US5387583A (en) * | 1993-04-20 | 1995-02-07 | Loria; Roger M. | Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof |
US5571933A (en) * | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
ES2098193B1 (en) * | 1995-07-21 | 1997-12-01 | Gomez Jesus Calderon | NEW PHARMACEUTICAL FORMULATION OF DEHYDROEPIANDROSTERONE FOR TOPIC PERCUTANEOUS APPLICATION. |
US5828688A (en) * | 1995-10-26 | 1998-10-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method and apparatus for linewidth reduction in distributed feedback or distributed bragg reflector semiconductor lasers using vertical emission |
US6653331B2 (en) * | 1996-07-03 | 2003-11-25 | Pharmacia & Upjohn Company | Targeted drug delivery using sulfonamide derivatives |
US5770226A (en) * | 1996-07-10 | 1998-06-23 | Wake Forest University | Combined pharmaceutical estrogen-androgen-progestin oral contraceptive |
US6139873A (en) * | 1996-07-10 | 2000-10-31 | Cedars-Sinai Medical Center | Combined pharmaceutical estrogen-androgen-progestin |
IT1292129B1 (en) * | 1997-06-11 | 1999-01-25 | Sunnimex Ltd | USEFUL MEDICATION FOR REDUCE FAT MASS AND INCREASE LEAN MASS IN WOMEN IN MENOPAUSE AND IN BOTH SEXES IN |
US6117429A (en) * | 1997-08-11 | 2000-09-12 | Weider Nutrition International, Inc | Compositions and treatments for reducing potential unwanted side effects associated with long-term administration of androgenic testosterone precursors |
US5877216A (en) * | 1997-10-28 | 1999-03-02 | Vivus, Incorporated | Treatment of female sexual dysfunction |
CA2306837C (en) * | 1997-10-28 | 2007-05-08 | Asivi, Llc. | Treatment of female sexual dysfunction |
KR20060098400A (en) * | 1998-06-11 | 2006-09-18 | 앙도르쉐르슈 인코포레이티드 | PHARMACEUTICAL COMPOSITIONS AND USES FOR ANDROST-5-ENE-3β,17β-DIOL |
US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
US6284262B1 (en) * | 1999-01-26 | 2001-09-04 | Virgil A. Place | Compact dosage unit for buccal administration of a pharmacologically active agent |
US6117446A (en) * | 1999-01-26 | 2000-09-12 | Place; Virgil A. | Drug dosage unit for buccal administration of steroidal active agents |
JP4790178B2 (en) * | 1999-07-06 | 2011-10-12 | アンドルシェルシュ・インコーポレイテッド | Method for treating and / or suppressing weight gain |
US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US20020107230A1 (en) * | 2000-12-22 | 2002-08-08 | Waldon R. Forrest | Methods and formulations for the treatment of female sexual dysfunction |
WO2002092102A2 (en) * | 2001-05-16 | 2002-11-21 | Endeavor Pharmaceuticals | Treatment of conditions relating to hormone deficiencies by administration of progestins |
-
1999
- 1999-06-10 KR KR1020067016679A patent/KR20060098400A/en not_active Application Discontinuation
- 1999-06-10 PL PL99345955A patent/PL345955A1/en not_active IP Right Cessation
- 1999-06-10 BR BR9911115-2A patent/BR9911115A/en not_active Application Discontinuation
- 1999-06-10 EP EP06018947A patent/EP1731157A3/en not_active Withdrawn
- 1999-06-10 CN CNB998086371A patent/CN1243550C/en not_active Expired - Fee Related
- 1999-06-10 MX MXPA00012304A patent/MXPA00012304A/en not_active Application Discontinuation
- 1999-06-10 HU HU0102483A patent/HUP0102483A3/en unknown
- 1999-06-10 CA CA002334702A patent/CA2334702C/en not_active Expired - Fee Related
- 1999-06-10 NZ NZ536787A patent/NZ536787A/en unknown
- 1999-06-10 EP EP99924625A patent/EP1083904A2/en not_active Ceased
- 1999-06-10 RU RU2001101492/15A patent/RU2221569C2/en not_active IP Right Cessation
- 1999-06-10 CN CNB2004100826380A patent/CN100377711C/en not_active Expired - Fee Related
- 1999-06-10 AU AU41274/99A patent/AU4127499A/en not_active Abandoned
- 1999-06-10 KR KR1020007014057A patent/KR100679735B1/en not_active IP Right Cessation
- 1999-06-10 AR ARP990102786A patent/AR018660A1/en unknown
- 1999-06-10 WO PCT/CA1999/000537 patent/WO1999063973A2/en active IP Right Grant
- 1999-06-10 TR TR2001/00063T patent/TR200100063T2/en unknown
- 1999-06-10 IL IL14022599A patent/IL140225A0/en unknown
- 1999-06-10 JP JP2000553042A patent/JP2002517432A/en active Pending
- 1999-06-10 KR KR1020067016678A patent/KR20060098399A/en not_active Application Discontinuation
- 1999-06-10 ID IDW20010063A patent/ID27922A/en unknown
- 1999-06-10 TR TR2001/02867T patent/TR200102867T2/xx unknown
- 1999-06-10 CN CNA2006100840974A patent/CN1879630A/en active Pending
- 1999-06-11 TW TW088109823A patent/TWI263499B/en not_active IP Right Cessation
- 1999-06-11 MY MYPI99002408A patent/MY131522A/en unknown
- 1999-06-11 TW TW095106594A patent/TWI283579B/en not_active IP Right Cessation
- 1999-06-11 US US09/332,356 patent/US6432940B1/en not_active Expired - Fee Related
-
2000
- 2000-12-08 ZA ZA200007299A patent/ZA200007299B/en unknown
- 2000-12-11 NO NO20006286A patent/NO20006286L/en not_active Application Discontinuation
-
2001
- 2001-11-21 HK HK01108194A patent/HK1037329A1/en not_active IP Right Cessation
- 2001-11-21 HK HK05109960A patent/HK1078004A1/en not_active IP Right Cessation
-
2002
- 2002-06-10 US US10/166,427 patent/US6995150B2/en not_active Expired - Fee Related
- 2002-06-10 US US10/166,428 patent/US20020187964A1/en not_active Abandoned
- 2002-06-10 US US10/166,463 patent/US6964955B2/en not_active Expired - Fee Related
- 2002-06-10 US US10/166,506 patent/US20020187967A1/en not_active Abandoned
- 2002-06-10 US US10/167,727 patent/US20020187968A1/en not_active Abandoned
- 2002-06-10 US US10/166,505 patent/US20020187966A1/en not_active Abandoned
- 2002-06-10 US US10/166,423 patent/US20020187973A1/en not_active Abandoned
- 2002-06-10 US US10/167,729 patent/US20020187969A1/en not_active Abandoned
- 2002-06-10 US US10/166,424 patent/US6884795B2/en not_active Expired - Fee Related
- 2002-06-10 US US10/170,083 patent/US20020187970A1/en not_active Abandoned
-
2006
- 2006-05-17 IL IL175723A patent/IL175723A0/en unknown
-
2007
- 2007-04-11 US US11/734,165 patent/US20080161277A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2334702A1 (en) | Pharmaceutical compositions and uses for androst-5-ene-3.beta.,17.beta.-diol | |
YATES et al. | Sex difference in rate of ring A reduction of Δ4-3-keto-steroids in vitro by rat liver | |
Santen et al. | Use of aromatase inhibitors in breast carcinoma. | |
YU54602A (en) | Drospirenone for hormone replacement therapy | |
HUT60139A (en) | Process for producing pharmaceutical composition suitable for treating prostate cancer connected with androgen | |
CA2467222A1 (en) | Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy | |
ATE245992T1 (en) | PROGESTAGEN-FREE FORMULATIONS OF GNRH AND ESTROGEN FOR THE TREATMENT OF BENIGAN GYNECOLOGICAL DISORDERS | |
AU5513194A (en) | Combination therapy for treatment of estrogen sensitive diseases | |
CA2205897A1 (en) | Compositions and methods for contraception and for treatment of benign gynecological disorders | |
MY126960A (en) | Administration of non-oral androgenic steroids to women | |
Kloosterboer et al. | Pros and cons of existing treatment modalities in osteoporosis: a comparison between tibolone, SERMs and estrogen (±progestogen) treatments | |
UA92348C2 (en) | 17b-HSD1 AND STS INHIBITORS | |
WO2001003687A2 (en) | Method and compositions for inhibiting biosynthesis or bioactivity of endogenous steroid sex hormones in humans | |
WO2005047303A3 (en) | NOVEL 17β HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | |
ATE271386T1 (en) | ORAL SINGLE STAGE CONTRACEPTION METHOD AND COMBINATION PRODUCT CONTAINING PROGESTEN AND ESTROGEN | |
AP2001002054A0 (en) | Use of biogenic estrogen sulfamates for hormone replacement therapy. | |
CA2504697A1 (en) | Methods for treating migraine | |
AU723713B2 (en) | Steroid compounds having contraceptive and anti-osteoporosis activity | |
UA85203C2 (en) | 17β HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | |
Ward et al. | Hydroxylation of steroids by the isolated rat adrenal | |
GR3025872T3 (en) | Orally active derivatives of 1,3,5(10)-estratriene | |
WO1999045886A3 (en) | New contraceptive kit for monotherapy | |
ZA965891B (en) | Tnf receptor and steroid hormone in a combined therapy | |
Weidenfeld et al. | Inhibition of prostaglandin synthesis in brain of rat by dexamethasone: lack of effect of dexamethasone phosphate ester and various hormonal steroids | |
CA2163878A1 (en) | Agents containing a compound with an anti-androgen effect and a compound with a competitive, progesterone-antagonistic effect |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |