CA2337113A1 - Methods and devices for reducing the mineral content of vascular calcified lesions - Google Patents

Methods and devices for reducing the mineral content of vascular calcified lesions Download PDF

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Publication number
CA2337113A1
CA2337113A1 CA002337113A CA2337113A CA2337113A1 CA 2337113 A1 CA2337113 A1 CA 2337113A1 CA 002337113 A CA002337113 A CA 002337113A CA 2337113 A CA2337113 A CA 2337113A CA 2337113 A1 CA2337113 A1 CA 2337113A1
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CA
Canada
Prior art keywords
lesion
methods
devices
mineral content
vascular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002337113A
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French (fr)
Other versions
CA2337113C (en
Inventor
Brent R. Constantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corazon Technologies Inc
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Corazon Technologies, Inc.
Brent R. Constantz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/118,193 external-priority patent/US6394096B1/en
Application filed by Corazon Technologies, Inc., Brent R. Constantz filed Critical Corazon Technologies, Inc.
Publication of CA2337113A1 publication Critical patent/CA2337113A1/en
Application granted granted Critical
Publication of CA2337113C publication Critical patent/CA2337113C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22065—Functions of balloons
    • A61B2017/22067—Blocking; Occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22098—Decalcification of valves

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Methods, and devices are provided for at least reducing the mineral content of a vascular calcified lesion (14), i.e. a calcified lesion (14) present on the vascular tissue (12) of a host. In the subject methods, the local environment of the lesion (14) is maintained at a sub-physiologic pH for a period of time sufficient for the mineral content of the lesion to be reduced, e.g.
by flushing the lesion (14) with a fluid capable of locally increasing the proton concentration in the region of the lesion (14). Also provided are systems and kits for practicing the subject methods.
The subject methods, and devices find particular use in the treatment of vascular diseases associated with the presence of calcified lesions (14) an vascular tissue (12).
CA002337113A 1998-07-15 1999-07-14 Methods and devices for reducing the mineral content of vascular calcified lesions Expired - Fee Related CA2337113C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/118,193 US6394096B1 (en) 1998-07-15 1998-07-15 Method and apparatus for treatment of cardiovascular tissue mineralization
US09/118,193 1998-07-15
US09/195,291 US6387071B1 (en) 1998-07-15 1998-11-18 Methods and devices for reducing the mineral content of vascular calcified lesions
US09/195,291 1998-11-18
PCT/US1999/015918 WO2000003651A1 (en) 1998-07-15 1999-07-14 Methods and devices for reducing the mineral content of vascular calcified lesions

Publications (2)

Publication Number Publication Date
CA2337113A1 true CA2337113A1 (en) 2000-01-27
CA2337113C CA2337113C (en) 2009-06-23

Family

ID=26816067

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002337113A Expired - Fee Related CA2337113C (en) 1998-07-15 1999-07-14 Methods and devices for reducing the mineral content of vascular calcified lesions

Country Status (5)

Country Link
US (4) US6379345B1 (en)
EP (1) EP1100392B1 (en)
AU (1) AU5101699A (en)
CA (1) CA2337113C (en)
WO (1) WO2000003651A1 (en)

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US6622732B2 (en) 2003-09-23
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US20060161099A1 (en) 2006-07-20
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US20030018297A1 (en) 2003-01-23
US6379345B1 (en) 2002-04-30

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