CA2340248A1 - Apparatus for delivering a substance having one or more needles driven at high velocity - Google Patents
Apparatus for delivering a substance having one or more needles driven at high velocity Download PDFInfo
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- CA2340248A1 CA2340248A1 CA002340248A CA2340248A CA2340248A1 CA 2340248 A1 CA2340248 A1 CA 2340248A1 CA 002340248 A CA002340248 A CA 002340248A CA 2340248 A CA2340248 A CA 2340248A CA 2340248 A1 CA2340248 A1 CA 2340248A1
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- Prior art keywords
- needle
- skin
- substance
- syringe
- tip
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0076—Tattooing apparatus
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K11/00—Marking of animals
- A01K11/005—Branding or tattooing devices for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3286—Needle tip design, e.g. for improved penetration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/422—Desensitising skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31531—Microsyringes, e.g. having piston bore diameter close or equal to needle shaft diameter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
- A61M5/3291—Shafts with additional lateral openings
Abstract
An apparatus for delivering a substance to a surface, such as the skin of a human being, animal or other organic matter has a needle. Also provided is means for supplying the substance to the tip of the needle in use, and driving means for driving the needle, in use, at a velocity in the range of 1 metre per second to 100 metres per second in order to penetrate the surface and deliver the substance thereto.
Description
WO 00/09184 PCTlGB99/02680 APPARATUS FOR DELIVERING A SUBSTANCE HAVING ONE OR MORE NEEDLES DRIVEN AT HIGH
VELOCITY
This invention relates to improvements in devices for delivery of substances such as drugs, vaccines, fluorescent or magnetic material, and dyes into a surface, such as the skin of a human being, animal or other organic matter. The substance may be a solution, particulate fluid, or a paste, for example.
Numerous such apparatus have been proposed in the past. A simple hypodermic syringe is the most well known, although other mechanical arrangements, such as a standard tattooing machine which are manually operated are well known.
In order to improve the injection of substances mechanically driven needles are also in use. US Patents 5401242, 5054339, 4671277 disclose mechanically operated systems which inject substances such as drugs, vaccines, pigment etc. into the skin. A
problem with this type of system is that their use can cause considerable pain to the person or animal to which they are being applied and can, in extreme circumstances, such as that of a standard tattooing machine, damage the skin to such an extent that recovery takes several days. This last point has prevented tattooing machines being used for drug delivery US Patent 5681283 discloses the use of a system in which needles are injected into the skin using elastic bands at a higher velocity with the intention of making the injection "painless".
US Patent 5564436 discloses a pneumatically operated automatic rotating cassette with a plurality of stylets so that the higher velocity can reduce the pain of the of needle entry.
Many of these devices have disadvantages in that they are unable to dispense accurate amounts of a substance, particularly when small volumes or multiple doses are required, and in that they are unable to deliver the substance reliably to a desired depth.
Also these devices are often difficult for an unskilled operator to use, and are not viable for self administration applications. Furthermore, these apparatus are often unable to deliver substances without reliably ensuring that no substance is left on the surface of the skin, meaning that they often cannot be employed to deliver valuable or potentially toxic substances.
Also these devices use needle acceleration and velocity which is insufficient to obtain needle entry which is pain and blood free.
VELOCITY
This invention relates to improvements in devices for delivery of substances such as drugs, vaccines, fluorescent or magnetic material, and dyes into a surface, such as the skin of a human being, animal or other organic matter. The substance may be a solution, particulate fluid, or a paste, for example.
Numerous such apparatus have been proposed in the past. A simple hypodermic syringe is the most well known, although other mechanical arrangements, such as a standard tattooing machine which are manually operated are well known.
In order to improve the injection of substances mechanically driven needles are also in use. US Patents 5401242, 5054339, 4671277 disclose mechanically operated systems which inject substances such as drugs, vaccines, pigment etc. into the skin. A
problem with this type of system is that their use can cause considerable pain to the person or animal to which they are being applied and can, in extreme circumstances, such as that of a standard tattooing machine, damage the skin to such an extent that recovery takes several days. This last point has prevented tattooing machines being used for drug delivery US Patent 5681283 discloses the use of a system in which needles are injected into the skin using elastic bands at a higher velocity with the intention of making the injection "painless".
US Patent 5564436 discloses a pneumatically operated automatic rotating cassette with a plurality of stylets so that the higher velocity can reduce the pain of the of needle entry.
Many of these devices have disadvantages in that they are unable to dispense accurate amounts of a substance, particularly when small volumes or multiple doses are required, and in that they are unable to deliver the substance reliably to a desired depth.
Also these devices are often difficult for an unskilled operator to use, and are not viable for self administration applications. Furthermore, these apparatus are often unable to deliver substances without reliably ensuring that no substance is left on the surface of the skin, meaning that they often cannot be employed to deliver valuable or potentially toxic substances.
Also these devices use needle acceleration and velocity which is insufficient to obtain needle entry which is pain and blood free.
Also these devices are prone to permit significant levels of lateral or transaxial movement of the needle during penetration of the skin casing extra damage and trauma. This becomes more significant as the acceleration and velocity increases.
Also these devices require needles which have cutting edges and are substantially cutting rather than parting in action causing tissue damage, bleeding, bruising etc.
The present invention is directed towards overcoming the above and other problems.
According to the present invention there is provided an apparatus for delivering a substance to a surface, such as the skin of a human being, animal or other organic matter, the apparatus comprising:
a needle;
means for supplying the substance to the tip of the needle in use;
and means for driving the needle, in use, at a velocity in the range of 1 metre per second to 100 metres per second at the time when the needle first contacts the skin in order to penetrate the skin and deliver the substance thereto.
Preferably the driving means drives the needle at a velocity of at 5 to 50 metres per sec, more preferably 6 to 35 metres per sec. at the time when the needle first contacts the skin.
By driving the needle at very high velocity, as opposed to a normal tattooing machine which operates at approximately 0.6 metres per second, an auto-injector or a lancet which operates at 0.5 to 4 metres per sec., it has been determined that the amount of pain experienced by the recipient of the substance is reduced considerably.
Although high speed has been stated to reduce the pain of injection the very high speeds of the present invention have not previously been disclosed.
The use of ultra high speeds e.g. in excess of 100 metres per second has been found to cause bruising and increase in pain and it is very surprising that the use of velocities in the range specified in the invention gives an improved reduction in pain.
In addition the use of ultra high velocities requires greater energy and increases safety problems and generates a lot of noise which can be disconcerting to a user, particularly in self administration, and also imposes a great deal of wear on the equipment with consequent increase risk of failure.
It is preferred that when the needle enters the surface it is moving at or near its maximum velocity and it is brought to a very rapid stop e.g. by there being a stopping means incorporated in the driving means and this also aids in controlling the depth of penetration. This use of a stopping means to bring the needle to a sudden stop enables more effective injection and enables the substance being injected to be injected at a shallow depth in the skin when required. The sudden stop also has the advantage that the momentum of the substance being injected can be used to facilitate the injection of the substance.
The needle driving means may include one or more of a leaf spring and stop arrangement, a bistable spring or diaphragm arrangement. The needle driving means may include a mechanically hydraulic, pneumatic or electromechanically driven drive mechanism.
There are different types of injections, for example the needle can be driven through the skin to inject a substance into the subcutaneous layer e.g. to a depth of 10 to 12 mm, such as in injections of vaccines, insulin, etc. or the needle can be driven deeper to penetrate muscle for intramuscular injection, or the needle can be driven only a small distance into the skin, and the apparatus of the present invention can be used for these and a wide range of other types of injections.
For use in some injections there is preferably a means whereby a series of injections take place sequentially and rapidly one after the other with preferably only a small amount of the substance injected with each penetration of the needle, in this way the total amount of substance to be injected is injected in a series of small amounts with less risk of bruising etc. due to deeper penetration of the needle. The rate of injection of the needle can be up to 50 times a second or higher and the driving means mechanism incorporates a means to drive the needle repeatedly a small distance into the skin.
The diameter of the needles may be in the range of 10 to 1000 microns or more, and may be arranged so that they form 1 to 5000 holes per square centimetre. With such a needle arrangement the needles may be designed to penetrate to a depth of 10 microns upwards e.g. 30 microns and upwards, dependent upon the substance being delivered and the surface to which the substance is being applied. The needle may contain one or more edges but, preferably is substantially non-cutting with smooth tapered, bevelled or radiused surfaces for example a pencil tip point.
When a rapid series of injections which penetrate a small distance into the skin are required the driving means can be motorised to generate a rapid succession of small injections.
When an injection which penetrates a controlled depth into the surface is required a preferred driving means is pneumatically operated and comprises a block slidably mounted in a conduit so that application of a pneumatic force at one end of the conduit will generate a pulse of air which will propel the block at speed down the conduit, so that it will strike an end piece which forms part of, or is connected to the needle.
Also these devices require needles which have cutting edges and are substantially cutting rather than parting in action causing tissue damage, bleeding, bruising etc.
The present invention is directed towards overcoming the above and other problems.
According to the present invention there is provided an apparatus for delivering a substance to a surface, such as the skin of a human being, animal or other organic matter, the apparatus comprising:
a needle;
means for supplying the substance to the tip of the needle in use;
and means for driving the needle, in use, at a velocity in the range of 1 metre per second to 100 metres per second at the time when the needle first contacts the skin in order to penetrate the skin and deliver the substance thereto.
Preferably the driving means drives the needle at a velocity of at 5 to 50 metres per sec, more preferably 6 to 35 metres per sec. at the time when the needle first contacts the skin.
By driving the needle at very high velocity, as opposed to a normal tattooing machine which operates at approximately 0.6 metres per second, an auto-injector or a lancet which operates at 0.5 to 4 metres per sec., it has been determined that the amount of pain experienced by the recipient of the substance is reduced considerably.
Although high speed has been stated to reduce the pain of injection the very high speeds of the present invention have not previously been disclosed.
The use of ultra high speeds e.g. in excess of 100 metres per second has been found to cause bruising and increase in pain and it is very surprising that the use of velocities in the range specified in the invention gives an improved reduction in pain.
In addition the use of ultra high velocities requires greater energy and increases safety problems and generates a lot of noise which can be disconcerting to a user, particularly in self administration, and also imposes a great deal of wear on the equipment with consequent increase risk of failure.
It is preferred that when the needle enters the surface it is moving at or near its maximum velocity and it is brought to a very rapid stop e.g. by there being a stopping means incorporated in the driving means and this also aids in controlling the depth of penetration. This use of a stopping means to bring the needle to a sudden stop enables more effective injection and enables the substance being injected to be injected at a shallow depth in the skin when required. The sudden stop also has the advantage that the momentum of the substance being injected can be used to facilitate the injection of the substance.
The needle driving means may include one or more of a leaf spring and stop arrangement, a bistable spring or diaphragm arrangement. The needle driving means may include a mechanically hydraulic, pneumatic or electromechanically driven drive mechanism.
There are different types of injections, for example the needle can be driven through the skin to inject a substance into the subcutaneous layer e.g. to a depth of 10 to 12 mm, such as in injections of vaccines, insulin, etc. or the needle can be driven deeper to penetrate muscle for intramuscular injection, or the needle can be driven only a small distance into the skin, and the apparatus of the present invention can be used for these and a wide range of other types of injections.
For use in some injections there is preferably a means whereby a series of injections take place sequentially and rapidly one after the other with preferably only a small amount of the substance injected with each penetration of the needle, in this way the total amount of substance to be injected is injected in a series of small amounts with less risk of bruising etc. due to deeper penetration of the needle. The rate of injection of the needle can be up to 50 times a second or higher and the driving means mechanism incorporates a means to drive the needle repeatedly a small distance into the skin.
The diameter of the needles may be in the range of 10 to 1000 microns or more, and may be arranged so that they form 1 to 5000 holes per square centimetre. With such a needle arrangement the needles may be designed to penetrate to a depth of 10 microns upwards e.g. 30 microns and upwards, dependent upon the substance being delivered and the surface to which the substance is being applied. The needle may contain one or more edges but, preferably is substantially non-cutting with smooth tapered, bevelled or radiused surfaces for example a pencil tip point.
When a rapid series of injections which penetrate a small distance into the skin are required the driving means can be motorised to generate a rapid succession of small injections.
When an injection which penetrates a controlled depth into the surface is required a preferred driving means is pneumatically operated and comprises a block slidably mounted in a conduit so that application of a pneumatic force at one end of the conduit will generate a pulse of air which will propel the block at speed down the conduit, so that it will strike an end piece which forms part of, or is connected to the needle.
Preferably the block can be returned to its original position by reduction of pressure in the conduit. In this way a series of pulsed impulses can be applied to the end piece with the block being withdrawn back down the conduit between pulses.
The end piece which is struck can be the end of the needle suitably reinforced if need be, or it can be an end piece or the like attached to or forming part of the end of the needle. The end piece will normally have a flat end which is struck for ease of operation although this is not essential The pneumatic force can be applied by a means which generates a pulse of air down the conduit which sends the block down the conduit at the required velocity, reversal of the pressure will cause the block to be sucked back up the conduit.
Suitable means include hand held bellows, a piston with a spring return or a motorised means.
The bellows can, for example be in the form of a sealed rubber chamber connected to the conduit. Another means of operating is by means of a pen injector which can be conveniently carried and used as required.
If a rapid series of injections are required e.g. in which the needle penetrates only a small distance into the skin, a motorised means can be used to generate the pulse of 2 0 air and subsequent reversal of pressure.
In another embodiment of the invention there is provided a means whereby the needle is driven into the skin in one or more steps by applying a blow to the needle e.g. as described above, so that the needle penetrates a controlled distance into the skin and optionally another blow or blows can be applied to the needle to drive the needle in further in if desired.
If a plurality of blows are required this can be carried out as described above and/or there can a two or more blocks slidably mounted within the conduit so that a plurality of blows impact on the plate.
Optionally there can be a needle guide which can fit around the needle to assist in the location and positioning of the needle and keeps the needle exactly on line during the injection and reduces any risk of the needle bending. In addition the guide can help guard against needle stick injury when the needle is withdrawn and can serve as a depth control.
In one embodiment of the invention the substance to be injected is contained in a reservoir fluidically connected to the needle and there are means to accelerate the needle independently without accelerating the reservoir. This means that there is less mass to be accelerated to the requisite velocity and so it is easier to attain this velocity and also to stop the needle. The acceleration of the needle is preferably 1 to 20,OOOg.
The end piece which is struck can be the end of the needle suitably reinforced if need be, or it can be an end piece or the like attached to or forming part of the end of the needle. The end piece will normally have a flat end which is struck for ease of operation although this is not essential The pneumatic force can be applied by a means which generates a pulse of air down the conduit which sends the block down the conduit at the required velocity, reversal of the pressure will cause the block to be sucked back up the conduit.
Suitable means include hand held bellows, a piston with a spring return or a motorised means.
The bellows can, for example be in the form of a sealed rubber chamber connected to the conduit. Another means of operating is by means of a pen injector which can be conveniently carried and used as required.
If a rapid series of injections are required e.g. in which the needle penetrates only a small distance into the skin, a motorised means can be used to generate the pulse of 2 0 air and subsequent reversal of pressure.
In another embodiment of the invention there is provided a means whereby the needle is driven into the skin in one or more steps by applying a blow to the needle e.g. as described above, so that the needle penetrates a controlled distance into the skin and optionally another blow or blows can be applied to the needle to drive the needle in further in if desired.
If a plurality of blows are required this can be carried out as described above and/or there can a two or more blocks slidably mounted within the conduit so that a plurality of blows impact on the plate.
Optionally there can be a needle guide which can fit around the needle to assist in the location and positioning of the needle and keeps the needle exactly on line during the injection and reduces any risk of the needle bending. In addition the guide can help guard against needle stick injury when the needle is withdrawn and can serve as a depth control.
In one embodiment of the invention the substance to be injected is contained in a reservoir fluidically connected to the needle and there are means to accelerate the needle independently without accelerating the reservoir. This means that there is less mass to be accelerated to the requisite velocity and so it is easier to attain this velocity and also to stop the needle. The acceleration of the needle is preferably 1 to 20,OOOg.
The mass of the needle and associated moving parts is preferably 0.01 to 2.Sgrm, more preferably 0.1 to 2grms and most preferably 0.3 to 1 grm., this also means that the needle and other connected components have less kinetic energy and this reduces the risk of bruising etc. This is different to other techniques of injection, such as the injection of animals with tranquillising darts, when the needle penetrates the surface and forms part of, or is rigidly connected directly to a chamber containing the substance to be injected.
The needle can be separate and adjacent to a syringe containing the substance to be delivered with one end of the needle flexibly connected to the end of the syringe by for example a flexible tube or by a coiled length of the needle so that rapid movement of the needle is not significantly inhibited by connection to the syringe. The needle is driven by the driving means until it has penetrated to the required depth and then the syringe is operated to inject the substance contained in the syringe through the needle into the surface.
In another embodiment a syringe has a piston operating in the normal way with the needle projecting through the end of the syringe and having an extension projecting through the piston so the end of the extension can be struck by a driving means to drive the needle into a surface, there being a connection means between the syringe and the needle whereby the substance in the syringe can pass through the needle from the syringe as the piston is depressed. In use the needle is placed against the surface and the end of the extension is struck as referred to above to drive the needle into the surface and then, when it has been driven into the required depth, the piston is depressed to inject the substance in the syringe into the surface.
Preferably the needle is driven into the skin of the user by applying one or more impacts to the needle to drive the needle into the skin to the desired controlled depth and then the substance to be delivered is applied through the needle; the pneumatically driven method referred to above is especially suitable for this.
It has been found that, with the apparatus of the invention a needle used for at least some applications can be blunter i.e. it has a rounded or conical tip and has no, or less sharp, cutting surfaces than typical hypodermic or lancet needles and this structure can cause less cutting of capillaries and bleeding. This is thought to be due to the blunter needle, when driven at the speeds of the present invention, forces the components of the skin such as capillaries, cells etc. apart rather than cutting them as would be done with sharper needles. This reduces the risk and incidence of pain and bruising and the possible formation of unsightly fibroids and the like. For some people such as haemophiliacs this is a great advantage.
This advantage was surprising and contrary to what would otherwise be thought.
The needle can be separate and adjacent to a syringe containing the substance to be delivered with one end of the needle flexibly connected to the end of the syringe by for example a flexible tube or by a coiled length of the needle so that rapid movement of the needle is not significantly inhibited by connection to the syringe. The needle is driven by the driving means until it has penetrated to the required depth and then the syringe is operated to inject the substance contained in the syringe through the needle into the surface.
In another embodiment a syringe has a piston operating in the normal way with the needle projecting through the end of the syringe and having an extension projecting through the piston so the end of the extension can be struck by a driving means to drive the needle into a surface, there being a connection means between the syringe and the needle whereby the substance in the syringe can pass through the needle from the syringe as the piston is depressed. In use the needle is placed against the surface and the end of the extension is struck as referred to above to drive the needle into the surface and then, when it has been driven into the required depth, the piston is depressed to inject the substance in the syringe into the surface.
Preferably the needle is driven into the skin of the user by applying one or more impacts to the needle to drive the needle into the skin to the desired controlled depth and then the substance to be delivered is applied through the needle; the pneumatically driven method referred to above is especially suitable for this.
It has been found that, with the apparatus of the invention a needle used for at least some applications can be blunter i.e. it has a rounded or conical tip and has no, or less sharp, cutting surfaces than typical hypodermic or lancet needles and this structure can cause less cutting of capillaries and bleeding. This is thought to be due to the blunter needle, when driven at the speeds of the present invention, forces the components of the skin such as capillaries, cells etc. apart rather than cutting them as would be done with sharper needles. This reduces the risk and incidence of pain and bruising and the possible formation of unsightly fibroids and the like. For some people such as haemophiliacs this is a great advantage.
This advantage was surprising and contrary to what would otherwise be thought.
For persons who have to have frequent injections such as diabetics, who need to inject insulin on a regular basis, the reduction of bruising, bleeding etc. is also a great advantage and this embodiment is particularly applicable for use with such people.
After injection the needle can then be withdrawn from the surface and it has been found that, in at least some applications, a relatively slow withdrawal of the needle can reduce the risk of bruising to the skin.
For other applications, faster withdrawal of the needle is beneficial and can be achieved by a compressed spring for example.
It has been determined that with the present invention, the substance is delivered such that little residue is left on the surface of the skin.
A needle which can be used in the present invention has a sharpened tip and substance retaining core, the tip having at least one aperture formed therein, the at least one aperture connecting the core of the needle with the exterior of the tip of the needle and having a cross-sectional area smaller than the core, so that, in use, the needle can be driven into the skin in order to deliver the substance from the core to the skin without the aperture pulling out skin/tissue during its removal.
By providing a needle which does not have apertures of such shape, orientation or location which draws up skin upon removal of the needle damage to the skin by the apparatus is reduced significantly. Furthermore, blockage of the apertures and contamination of the substance supply by withdrawn skin particles is reduced significantly.
Plural apertures may be provided.
The one or more apertures may have a circular cross-section, or may, alternatively, have a slot or a cross shaped cross-section.
The needle may be hollow in order to provide the substance supplying core and preferably the needle has a hole in a recess so that the sides of the needle aperture do not press against the skin. Alternatively, the needle may be formed from a solid sharpened member. The needle is preferably slidably retained with a housing, the housing may define the core. With the latter arrangement, the one or more apertures may be provided within the sharpened member, between the sharpened member and the housing or a combination thereof. The grooves may define the core, in the case of a solid needle member.
If the needle is provided by a central sharpened member and surrounding housing, the housing may be arranged to surround the needle to prevent lateral movement thereof, hence reducing damage to the skin. The housing can also serve to prevent needle stick injury after use.
With such an arrangement, the housing may be angled to control the angle of entry of needle to a skin, or may be arranged so that the angle of entry can be controlled either manually or automatically.
The one or more needles may be retained on a flexible pad which is placed or attached adjacent to the skin prior to insertion of the needle;
The flexible pad may include a substance reservoir in fluid communication with the one or more substance retaining cores or apertures in the skin. As the needle penetrates the reservoir in the pad it and then enters the skin it causes the substance in the pad to be injected into the skin.
The needle can be struck by the device described above causing rapid acceleration to penetrate the skin painlessly.
According to another aspect of the present invention there is also provided an apparatus for delivering a substance to the skin of a human being, animal or other organic matter, the apparatus comprising:
a needle;
a chamber surrounding the needle for retaining, in use, the substance to be delivered;
and a membrane defining one wall of the chamber, the relative positions of the needle and membrane being such that, in use, the needle can be driven through the membrane and into and out of the skin to thereby deliver the substance.
The needle may be any one of the configurations described above. The membrane may be formed from an elastomer, such as silicone rubber.
The needle may be driven through the membrane by a high velocity driving mechanism of the type described above. Alternatively, it may be driven through the membrane by a user-generated force. The membrane may be arranged to be attached, in use, to the skin.
The provision of a chamber partly defined by a membrane ensures that the substances kept sterile and out of contact with the environment prior to use.
Furthermore, the employment of a membrane prevents needle-stick injury both before and after needle deployment. In addition, it minimises spillage of the substance.
With any of the above arrangements means may be provided for detecting the depth of penetration of the skin by the needle, and the depth of penetration may be able to be controlled either by the user or automatically in response to detection of penetration depth. The penetration depth may be detected by applying a voltage WO 00!09184 PCT/GB99/02680 _ g _ potential to and measurement of the resulting current flowing through the skin between two needles, or the needle, skin and a detection point placed on the skin.
The invention is illustrated by example in the following non limiting examples.
Example 1 Single Needle Penetration A tube and pneumatic drive was used to accelerate a block at 0.4g to a velocity of 5 -metres per sec. To strike a radius tip 28 gauge needle assembly weighing 0.2g adjacent to the skin. The needle contained a lateral hole adjacent to the tip and was driven lOmm into the skin of the arm with no pain, was able to deliver a small quantity of sterile saline to the skin and left no blood or bruising on withdrawal.
For comparison an injection device was tested which fired a 29 gauge bevel tip hypodermic needle at 4 metres per sec. into the skin of the arm to a depth of 11 mm.
There was significant pain, some bleeding after withdrawal of the needle and bruising developed around the penetration sight taking S days to disappear.
Example 2 Multiple Shallow Micro Injections A shuttle weighing 0.9g comprising a needle with a tip aperture as described in fig.
below attached to a micro-syringe containing a dye was accelerated to 5 to 15 metres per sec. Towards the skin of the arm of a male volunteer. The needle penetrated to 0.3mm before stopping rapidly at the end stop. The momentum of the fluid and piston in the micro-syringe created a short pressure pulse to deliver a small quantity of dye to the skin. The cycle was repeated a number of times in rapid succession. The injections were painless and did not bleed.
Further examples of the present invention will now be described with reference to the accompanying drawings, in which:
Figures lA and 1B are schematic diagrams of a first example of the present invention;
Figures 2A to 2D are schematic side cross-sectional views of a second example of the present invention, Figures 3A and 3B are further schematic side cross-sectional views of the second example of the present invention;
_ g _ Figures 4A and 4B are schematic side cross-sectional views of a third example of the present invention;
Figure 5 is a schematic side cross-sectional view of a fourth example of the present invention;
Figures 6A and 6B are schematic side cross-sectional views of a fifth example of the present invention;
Figure 7 is a view of sixth example of the invention Figure 8 is a view of a seventh example of the invention and Figure 9 is a graph showing the velocity versus time of a needle driven by an example of the present invention.
Refernng to Fig. 1 A, a first example of the present invention has a needle 1 attached to a drive mechanism 2. The drive mechanism 2 comprises a lever 3 and spring 4.
The spring 4 is, in this example a leaf spring, although 20 alternative spring arrangements may be provided. The spring 4 is attached to a magnetic drive member S. The magnetic drive member 5 is moved about a pivot axis 6 by a combination of a spring 7 and solenoid 8. In use, the drive member S is driven into engagement with the lever 3 by the generation of a magnetic field by the solenoid 8. The magnetic field is then cut off and the drive member 5 is drawn out of engagement with the lever 3 by force generated in the spring 7. In such a manner the drive member 5 can be driven into and out of engagement with the lever 3 in a pulsed manner. The engagement of the drive member 5 with the lever 3 urges the tip line of the needle 1 into skin 10 to which a substance is to be applied.
The lever 3 acts to increase the velocity with which the needle moves given the driving velocity of the drive member 5.
The spring 4 is provided to increase yet further the velocity of the needle.
In use, the needle 1 is driven in and out of the skin 10 at high velocity, a substance (not shown), which may either be liquid or particulate, is provided to the tip 9 of the needle 1 in a manner of the type described below or in another well known manner. Withdrawal of the needle generates a vacuum in the hole created by the needle's departure, and the substance is drawn into the generated hole. This arrangement has the advantage that no pump is required to supply substance to the needle tip.
Figure 9 shows an example velocity profile of an example of the present invention.
As can be seen from Figure 9, the needle is initially accelerated to a high velocity for skin penetration. At point A the needle hits the skin, and at point B the needle hits an end stop, causing the needle 1 to decelerate rapidly. Upon withdrawal (point C) there is initial high acceleration to counter limiting friction with the skin and in order to ensure minimum damage to the skin, this is then followed by a phase D to ensure optimum substance delivery. It will be noted that the cycle is asymmetric, but this is not essential. In some embodiments where the substance is applied under external pressure e.g. from a syringe, the withdrawal acceleration should occur after the substance delivery phase D. in some embodiments the acceleration C is much lower acceleration.
Fig. 1 B is a schematic diagram, in which features corresponding to those in figure 1 A
are numbered identically. In. this arrangement, a motor and cam arrangement 11 acts against a leaf spring 4 to generate a reciprocating motion in the needle 1.
With the arrangements of both figures 1 A and 1 B the drive mechanism is arranged such that the needle is driven towards the skin 10 at a velocity of at least 1 metre per second and preferably much higher, so that the pain felt by a recipient of the substance is minimised. Also, the withdrawal is controlled to optimise substance delivery, as discussed above.
Figs. 2A to 2D show needle arrangements which may be employed with the example of Figs. 1 A and 1 B, or may be employed in more conventional needle driving apparatus.
Referring to figure 2A, the needle 1 has a sharp tip 20 and is of hollow construction.
Formed in the sharp tip 7 is an aperture 21, which in figure 2A is a slot, and which in figure 2B and figure 2C is a cruciform. The aperture 21 in each of the examples of figures 2A to 2C passes from the core of the needle to the exterior. In use, the tip 20 of the needle 1 is driven into the skin and, during withdrawal of the needle 1, the partial vacuum created in the aperture formed by the tip 20 and needle 1 draws a substance 22 from the core of the needle 1 out into the skin. An important feature of all of the aperture 10 configurations shown in figures 2A to 2D is that the shape, orientation, and cross-sectional area of the aperture or apertures 21 are small enough that they do not draw a core of skin through them upon entry of the needle 1 into the skin, and do not draw skin out upon removal, but allow flow 15 of substance 22 during withdrawal.
Figure 2D shows the employment of plural apertures 21, which may be either circular or slot-like.
The needles shown in any of the figures may be formed by any well known forming, turning, laser machining, or moulding technique. The diameter of the needles may be in the range of 10 to 1000 microns, and may be arranged so that there are 1 to holes per square centimetre. With such a needle arrangement the needles may be designed to penetrate to a depth of 10 microns upwards e.g. 30 microns and upwards, dependent upon the substance being delivered and the surface to which the substance is being applied.
Figures 3A and 3B show alternative examples to the arrangement shown in figures 2A to 2B. In these examples, the needle 1 comprises a housing 30 in which a substance 22 to be delivered is retained. Slidably retained within the housing 30 with a member 31 which has a sharpened tip 20. The member 31 is driven in the same manner as the previous example, and has an aperture or apertures 21 formed in it.
This example operates in a manner similar to that of the examples in figures 2A to 2D, in that the substance 22 is drawn into skin 10 via apertures 21 during withdrawal of the needle.
Figures 4A and 4B show a further example of the present invention. Referring to figure 4A, a needle 1, driven in the same manner as the earlier examples, is retained within a housing 30 which contains a substance 22 to be delivered into skin 10. A
substance 22 is retained in the housing 30 by a septum 40 which, in use, engages with the surface of the skin. The septum 40 is preferably an elastomer, such as silicone rubber. As can be seen from figure 4B, in use, the needle 1 is driven through the septum 40 and into the skin 10. As with previous examples, withdrawal of the needle 1 creates a partial vacuum in the hole generated by the needle l, drawing substance 22 into the skin 10. Because the septum 40 is an elastomer, withdrawal of the needle 1 back up into the housing 30 enables the septum 40 to close and seal in the substance 22, preventing contamination of the substance 22 by skin debris and the external atmosphere, as well as protecting a user from needle-stick injury.
Figure 5 shows a further example of the present invention which also employs a septum 40. In this example, an array of needles 1 is provided. It will be appreciated that, in the previous examples, an array of needles, rather than a single needle 1, could be employed using the same principles. In the example of figure S, a housing 30 defines a substance retaining core in which substance 22 is held prior to delivery.
The septum 40 may have an adhesive formed thereon so that the apparatus of this example can be attached to the skin 10 and activated at regular intervals. In this example, a user applies pressure to the upper surface 41 of the housing 30, urging one or more needles 1 to pass through the septum into the skin 10. As user force is removed, the needle or needles 1 pass back up through the septum 40, the septum 40 sealing itself after substance 22 has been drawn through into the skin 10.
Figures 6A and 6B show further examples of the present invention in which the housing 30 has a convex skin engaging surface 42. The operation of examples of these figures is generally the same as previous examples, although the skin engaging surface 42 is arranged to stretch the skin prior to insertion of needle 1.
This reduces the damage caused to the skin 10 by the needle 1, by controlling more precisely needle entry and reducing the possibility of lateral movement of the needle during deployment.
The arrangement of figure 6B has a skin engaging surface 42 which is arranged so that the angle of deployment of the needle 1 can be altered, either manually or mechanically by the apparatus. The ability to alter the angle of entry is useful to gain multiple holes through a single surface puncture to increase the local dose whilst minimising skin damage/infection risk when the apparatus is to be drawn across the surface of the skin, so that damage to the skin 10 is minimised.
Referring to Figure 7 a syringe 50 has a piston 51 mounted within it which can be depressed by handle 52. There is an outlet 54 from the syringe so that, when piston 51 is depressed, a substance in the body of the syringe 53 is forced out through the outlet 54. Attached to the outlet by a Luer connector 55 is one end of needle 63. The needle 63 is flexible and fixed to a holder 56 and mounted in a sliding flexible tube.
The needle can b a zig-zag shape or coiled as shown in figs. &a and 7b.
Attached to holder 56 is a striker plate 58 which is the end piece of the needle 63 and which is slidably mounted within conduit 59, there is a block 60 positioned in the conduit.
The end A of the conduit 59 is connected to pneumatic pump or the like so that air under pressure can enter the conduit and propel the block 60 down the conduit to strike plate 58. Reversal of the direction of the air in the conduit will cause the block 60 to be sucked back to the end of the conduit.
In use the substance to be injected is placed in the syringe 50 and the block 60 is at the end of conduit 59 remote from the needle 57. The needle 57 is placed against the surface to be injected and a pulse of high pressure air is sent down conduit 59 so to propel block 60 at the required high speed i.e. above 1 metre per sec, down conduit 59 to strike plate 58. The needle is then driven into the surface and, by having three blocks three impacts are made on the plate 58 and the needle penetrates in three steps. When the needle has penetrated the surface the piston 51 in the syringe 50 is depressed and the substance in the syringe is injected into the surface.
Referring to Figure 8 a syringe 74 has a needle 77 attached to one end and the needle has openings at 73 whereby a substance in the syringe can enter the needle. An extension 78 to the needle 77 passes through the piston 75 and terminates in a striker plate 79. The striker plate is positioned in conduit 80 down which blocks can be propelled pneumatically to strike plate 79.
In use the syringe is filled with the substance to be injected and the needle 77 is placed against the surface, a block or blocks are propelled down conduit 80 in a similar way to that described for Figure 7 and strike plate 79 and so drive the needle into the surface. When the needle has penetrated the surface to the required depth the piston 75 is depressed and the substance injected into the surface.
It will be appreciated that all of the embodiments of the present invention can be arranged to deliver many different substances into skin. The substance may be a traditional tattoo dye, a temporary dye, a drug, a gene therapy substance, a particulate substance, a vaccine, nutrients, carriers, diagnostic material, water, saline for example.
In all the examples of the present invention, there may be provided an end stop on the needle to prevent excessive entry of the needle into the skin for reasons of safety or depth control. This stop control enables the needle to be brought to a stop very rapidly and this aids the injection of the substance into the surface.
There may also be provided electrical or mechanical control of the depth of entry which is capable of adjustment by an operator. The control of depth of penetration may alternatively be automatic, and such arrangement might be provided by measuring a current passing through needle, the skin, and a conductive detecting element positioned oh the skin, the value of the current being proportional to the depth of entry of the needle 1. The applied voltage may be pulsed with a variety of waveforms in order to reduce perceived pain, when required.
After injection the needle can then be withdrawn from the surface and it has been found that, in at least some applications, a relatively slow withdrawal of the needle can reduce the risk of bruising to the skin.
For other applications, faster withdrawal of the needle is beneficial and can be achieved by a compressed spring for example.
It has been determined that with the present invention, the substance is delivered such that little residue is left on the surface of the skin.
A needle which can be used in the present invention has a sharpened tip and substance retaining core, the tip having at least one aperture formed therein, the at least one aperture connecting the core of the needle with the exterior of the tip of the needle and having a cross-sectional area smaller than the core, so that, in use, the needle can be driven into the skin in order to deliver the substance from the core to the skin without the aperture pulling out skin/tissue during its removal.
By providing a needle which does not have apertures of such shape, orientation or location which draws up skin upon removal of the needle damage to the skin by the apparatus is reduced significantly. Furthermore, blockage of the apertures and contamination of the substance supply by withdrawn skin particles is reduced significantly.
Plural apertures may be provided.
The one or more apertures may have a circular cross-section, or may, alternatively, have a slot or a cross shaped cross-section.
The needle may be hollow in order to provide the substance supplying core and preferably the needle has a hole in a recess so that the sides of the needle aperture do not press against the skin. Alternatively, the needle may be formed from a solid sharpened member. The needle is preferably slidably retained with a housing, the housing may define the core. With the latter arrangement, the one or more apertures may be provided within the sharpened member, between the sharpened member and the housing or a combination thereof. The grooves may define the core, in the case of a solid needle member.
If the needle is provided by a central sharpened member and surrounding housing, the housing may be arranged to surround the needle to prevent lateral movement thereof, hence reducing damage to the skin. The housing can also serve to prevent needle stick injury after use.
With such an arrangement, the housing may be angled to control the angle of entry of needle to a skin, or may be arranged so that the angle of entry can be controlled either manually or automatically.
The one or more needles may be retained on a flexible pad which is placed or attached adjacent to the skin prior to insertion of the needle;
The flexible pad may include a substance reservoir in fluid communication with the one or more substance retaining cores or apertures in the skin. As the needle penetrates the reservoir in the pad it and then enters the skin it causes the substance in the pad to be injected into the skin.
The needle can be struck by the device described above causing rapid acceleration to penetrate the skin painlessly.
According to another aspect of the present invention there is also provided an apparatus for delivering a substance to the skin of a human being, animal or other organic matter, the apparatus comprising:
a needle;
a chamber surrounding the needle for retaining, in use, the substance to be delivered;
and a membrane defining one wall of the chamber, the relative positions of the needle and membrane being such that, in use, the needle can be driven through the membrane and into and out of the skin to thereby deliver the substance.
The needle may be any one of the configurations described above. The membrane may be formed from an elastomer, such as silicone rubber.
The needle may be driven through the membrane by a high velocity driving mechanism of the type described above. Alternatively, it may be driven through the membrane by a user-generated force. The membrane may be arranged to be attached, in use, to the skin.
The provision of a chamber partly defined by a membrane ensures that the substances kept sterile and out of contact with the environment prior to use.
Furthermore, the employment of a membrane prevents needle-stick injury both before and after needle deployment. In addition, it minimises spillage of the substance.
With any of the above arrangements means may be provided for detecting the depth of penetration of the skin by the needle, and the depth of penetration may be able to be controlled either by the user or automatically in response to detection of penetration depth. The penetration depth may be detected by applying a voltage WO 00!09184 PCT/GB99/02680 _ g _ potential to and measurement of the resulting current flowing through the skin between two needles, or the needle, skin and a detection point placed on the skin.
The invention is illustrated by example in the following non limiting examples.
Example 1 Single Needle Penetration A tube and pneumatic drive was used to accelerate a block at 0.4g to a velocity of 5 -metres per sec. To strike a radius tip 28 gauge needle assembly weighing 0.2g adjacent to the skin. The needle contained a lateral hole adjacent to the tip and was driven lOmm into the skin of the arm with no pain, was able to deliver a small quantity of sterile saline to the skin and left no blood or bruising on withdrawal.
For comparison an injection device was tested which fired a 29 gauge bevel tip hypodermic needle at 4 metres per sec. into the skin of the arm to a depth of 11 mm.
There was significant pain, some bleeding after withdrawal of the needle and bruising developed around the penetration sight taking S days to disappear.
Example 2 Multiple Shallow Micro Injections A shuttle weighing 0.9g comprising a needle with a tip aperture as described in fig.
below attached to a micro-syringe containing a dye was accelerated to 5 to 15 metres per sec. Towards the skin of the arm of a male volunteer. The needle penetrated to 0.3mm before stopping rapidly at the end stop. The momentum of the fluid and piston in the micro-syringe created a short pressure pulse to deliver a small quantity of dye to the skin. The cycle was repeated a number of times in rapid succession. The injections were painless and did not bleed.
Further examples of the present invention will now be described with reference to the accompanying drawings, in which:
Figures lA and 1B are schematic diagrams of a first example of the present invention;
Figures 2A to 2D are schematic side cross-sectional views of a second example of the present invention, Figures 3A and 3B are further schematic side cross-sectional views of the second example of the present invention;
_ g _ Figures 4A and 4B are schematic side cross-sectional views of a third example of the present invention;
Figure 5 is a schematic side cross-sectional view of a fourth example of the present invention;
Figures 6A and 6B are schematic side cross-sectional views of a fifth example of the present invention;
Figure 7 is a view of sixth example of the invention Figure 8 is a view of a seventh example of the invention and Figure 9 is a graph showing the velocity versus time of a needle driven by an example of the present invention.
Refernng to Fig. 1 A, a first example of the present invention has a needle 1 attached to a drive mechanism 2. The drive mechanism 2 comprises a lever 3 and spring 4.
The spring 4 is, in this example a leaf spring, although 20 alternative spring arrangements may be provided. The spring 4 is attached to a magnetic drive member S. The magnetic drive member 5 is moved about a pivot axis 6 by a combination of a spring 7 and solenoid 8. In use, the drive member S is driven into engagement with the lever 3 by the generation of a magnetic field by the solenoid 8. The magnetic field is then cut off and the drive member 5 is drawn out of engagement with the lever 3 by force generated in the spring 7. In such a manner the drive member 5 can be driven into and out of engagement with the lever 3 in a pulsed manner. The engagement of the drive member 5 with the lever 3 urges the tip line of the needle 1 into skin 10 to which a substance is to be applied.
The lever 3 acts to increase the velocity with which the needle moves given the driving velocity of the drive member 5.
The spring 4 is provided to increase yet further the velocity of the needle.
In use, the needle 1 is driven in and out of the skin 10 at high velocity, a substance (not shown), which may either be liquid or particulate, is provided to the tip 9 of the needle 1 in a manner of the type described below or in another well known manner. Withdrawal of the needle generates a vacuum in the hole created by the needle's departure, and the substance is drawn into the generated hole. This arrangement has the advantage that no pump is required to supply substance to the needle tip.
Figure 9 shows an example velocity profile of an example of the present invention.
As can be seen from Figure 9, the needle is initially accelerated to a high velocity for skin penetration. At point A the needle hits the skin, and at point B the needle hits an end stop, causing the needle 1 to decelerate rapidly. Upon withdrawal (point C) there is initial high acceleration to counter limiting friction with the skin and in order to ensure minimum damage to the skin, this is then followed by a phase D to ensure optimum substance delivery. It will be noted that the cycle is asymmetric, but this is not essential. In some embodiments where the substance is applied under external pressure e.g. from a syringe, the withdrawal acceleration should occur after the substance delivery phase D. in some embodiments the acceleration C is much lower acceleration.
Fig. 1 B is a schematic diagram, in which features corresponding to those in figure 1 A
are numbered identically. In. this arrangement, a motor and cam arrangement 11 acts against a leaf spring 4 to generate a reciprocating motion in the needle 1.
With the arrangements of both figures 1 A and 1 B the drive mechanism is arranged such that the needle is driven towards the skin 10 at a velocity of at least 1 metre per second and preferably much higher, so that the pain felt by a recipient of the substance is minimised. Also, the withdrawal is controlled to optimise substance delivery, as discussed above.
Figs. 2A to 2D show needle arrangements which may be employed with the example of Figs. 1 A and 1 B, or may be employed in more conventional needle driving apparatus.
Referring to figure 2A, the needle 1 has a sharp tip 20 and is of hollow construction.
Formed in the sharp tip 7 is an aperture 21, which in figure 2A is a slot, and which in figure 2B and figure 2C is a cruciform. The aperture 21 in each of the examples of figures 2A to 2C passes from the core of the needle to the exterior. In use, the tip 20 of the needle 1 is driven into the skin and, during withdrawal of the needle 1, the partial vacuum created in the aperture formed by the tip 20 and needle 1 draws a substance 22 from the core of the needle 1 out into the skin. An important feature of all of the aperture 10 configurations shown in figures 2A to 2D is that the shape, orientation, and cross-sectional area of the aperture or apertures 21 are small enough that they do not draw a core of skin through them upon entry of the needle 1 into the skin, and do not draw skin out upon removal, but allow flow 15 of substance 22 during withdrawal.
Figure 2D shows the employment of plural apertures 21, which may be either circular or slot-like.
The needles shown in any of the figures may be formed by any well known forming, turning, laser machining, or moulding technique. The diameter of the needles may be in the range of 10 to 1000 microns, and may be arranged so that there are 1 to holes per square centimetre. With such a needle arrangement the needles may be designed to penetrate to a depth of 10 microns upwards e.g. 30 microns and upwards, dependent upon the substance being delivered and the surface to which the substance is being applied.
Figures 3A and 3B show alternative examples to the arrangement shown in figures 2A to 2B. In these examples, the needle 1 comprises a housing 30 in which a substance 22 to be delivered is retained. Slidably retained within the housing 30 with a member 31 which has a sharpened tip 20. The member 31 is driven in the same manner as the previous example, and has an aperture or apertures 21 formed in it.
This example operates in a manner similar to that of the examples in figures 2A to 2D, in that the substance 22 is drawn into skin 10 via apertures 21 during withdrawal of the needle.
Figures 4A and 4B show a further example of the present invention. Referring to figure 4A, a needle 1, driven in the same manner as the earlier examples, is retained within a housing 30 which contains a substance 22 to be delivered into skin 10. A
substance 22 is retained in the housing 30 by a septum 40 which, in use, engages with the surface of the skin. The septum 40 is preferably an elastomer, such as silicone rubber. As can be seen from figure 4B, in use, the needle 1 is driven through the septum 40 and into the skin 10. As with previous examples, withdrawal of the needle 1 creates a partial vacuum in the hole generated by the needle l, drawing substance 22 into the skin 10. Because the septum 40 is an elastomer, withdrawal of the needle 1 back up into the housing 30 enables the septum 40 to close and seal in the substance 22, preventing contamination of the substance 22 by skin debris and the external atmosphere, as well as protecting a user from needle-stick injury.
Figure 5 shows a further example of the present invention which also employs a septum 40. In this example, an array of needles 1 is provided. It will be appreciated that, in the previous examples, an array of needles, rather than a single needle 1, could be employed using the same principles. In the example of figure S, a housing 30 defines a substance retaining core in which substance 22 is held prior to delivery.
The septum 40 may have an adhesive formed thereon so that the apparatus of this example can be attached to the skin 10 and activated at regular intervals. In this example, a user applies pressure to the upper surface 41 of the housing 30, urging one or more needles 1 to pass through the septum into the skin 10. As user force is removed, the needle or needles 1 pass back up through the septum 40, the septum 40 sealing itself after substance 22 has been drawn through into the skin 10.
Figures 6A and 6B show further examples of the present invention in which the housing 30 has a convex skin engaging surface 42. The operation of examples of these figures is generally the same as previous examples, although the skin engaging surface 42 is arranged to stretch the skin prior to insertion of needle 1.
This reduces the damage caused to the skin 10 by the needle 1, by controlling more precisely needle entry and reducing the possibility of lateral movement of the needle during deployment.
The arrangement of figure 6B has a skin engaging surface 42 which is arranged so that the angle of deployment of the needle 1 can be altered, either manually or mechanically by the apparatus. The ability to alter the angle of entry is useful to gain multiple holes through a single surface puncture to increase the local dose whilst minimising skin damage/infection risk when the apparatus is to be drawn across the surface of the skin, so that damage to the skin 10 is minimised.
Referring to Figure 7 a syringe 50 has a piston 51 mounted within it which can be depressed by handle 52. There is an outlet 54 from the syringe so that, when piston 51 is depressed, a substance in the body of the syringe 53 is forced out through the outlet 54. Attached to the outlet by a Luer connector 55 is one end of needle 63. The needle 63 is flexible and fixed to a holder 56 and mounted in a sliding flexible tube.
The needle can b a zig-zag shape or coiled as shown in figs. &a and 7b.
Attached to holder 56 is a striker plate 58 which is the end piece of the needle 63 and which is slidably mounted within conduit 59, there is a block 60 positioned in the conduit.
The end A of the conduit 59 is connected to pneumatic pump or the like so that air under pressure can enter the conduit and propel the block 60 down the conduit to strike plate 58. Reversal of the direction of the air in the conduit will cause the block 60 to be sucked back to the end of the conduit.
In use the substance to be injected is placed in the syringe 50 and the block 60 is at the end of conduit 59 remote from the needle 57. The needle 57 is placed against the surface to be injected and a pulse of high pressure air is sent down conduit 59 so to propel block 60 at the required high speed i.e. above 1 metre per sec, down conduit 59 to strike plate 58. The needle is then driven into the surface and, by having three blocks three impacts are made on the plate 58 and the needle penetrates in three steps. When the needle has penetrated the surface the piston 51 in the syringe 50 is depressed and the substance in the syringe is injected into the surface.
Referring to Figure 8 a syringe 74 has a needle 77 attached to one end and the needle has openings at 73 whereby a substance in the syringe can enter the needle. An extension 78 to the needle 77 passes through the piston 75 and terminates in a striker plate 79. The striker plate is positioned in conduit 80 down which blocks can be propelled pneumatically to strike plate 79.
In use the syringe is filled with the substance to be injected and the needle 77 is placed against the surface, a block or blocks are propelled down conduit 80 in a similar way to that described for Figure 7 and strike plate 79 and so drive the needle into the surface. When the needle has penetrated the surface to the required depth the piston 75 is depressed and the substance injected into the surface.
It will be appreciated that all of the embodiments of the present invention can be arranged to deliver many different substances into skin. The substance may be a traditional tattoo dye, a temporary dye, a drug, a gene therapy substance, a particulate substance, a vaccine, nutrients, carriers, diagnostic material, water, saline for example.
In all the examples of the present invention, there may be provided an end stop on the needle to prevent excessive entry of the needle into the skin for reasons of safety or depth control. This stop control enables the needle to be brought to a stop very rapidly and this aids the injection of the substance into the surface.
There may also be provided electrical or mechanical control of the depth of entry which is capable of adjustment by an operator. The control of depth of penetration may alternatively be automatic, and such arrangement might be provided by measuring a current passing through needle, the skin, and a conductive detecting element positioned oh the skin, the value of the current being proportional to the depth of entry of the needle 1. The applied voltage may be pulsed with a variety of waveforms in order to reduce perceived pain, when required.
Claims (52)
1. An apparatus for delivering a substance to a surface, such as the skin of a human being, animal or other organic matter, the apparatus comprising:
one or more needles;
means for supplying the substance to the tip of the needle in use;
and driving means for driving the needle, in use, at a velocity in the range of 1 metre per second to 100 metres per second at the time when the needle first contacts the skin in order to penetrate the surface and deliver the substance thereto.
one or more needles;
means for supplying the substance to the tip of the needle in use;
and driving means for driving the needle, in use, at a velocity in the range of 1 metre per second to 100 metres per second at the time when the needle first contacts the skin in order to penetrate the surface and deliver the substance thereto.
2. An apparatus according to claim 1, wherein the needle driving means drives the needle at a velocity in the range of 5 to 50 metres per sec. at the time when the needle first contacts the skin.
3. An apparatus according to claim 1, wherein the needle driving means drives the needle at a velocity in the range of 6 to 35 metres per sec. at the time when the needle first contacts the skin.
4. An apparatus according to claim 1, 2 or 3, wherein the needle driving means includes one or more of a leaf spring and stop arrangement, a bistable spring and diaphragm arrangement.
5. An apparatus as claimed in any one of claims 1 to 4 in which there is a stopping means incorporated in the driving means adapted to bring the needle to a rapid stop at a pre-determined depth of penetration.
6. An apparatus according to any of claims 1 to 5, wherein the driving means is arranged to withdraw the needle from the surface with rapid acceleration.
7. An apparatus according to any of claims 1 to 6, wherein the driving means mechanism incorporates a means to drive the needle repeatedly a small distance into the skin.
8. An apparatus according to any of claims 1 to 7, wherein the diameter of the one or more needles is in the range of 10 to 1000 microns or more, and are arranged so that they form 1 to 5000 holes per square centimetre.
9. An apparatus as claimed in any one of claims 1 to 8 in which, in use, the majority of the energy for penetration after contact with the surface comes from the momentum of the needle and associated moving parts and not from the continued force of the driving means.
10. An apparatus as claimed in any one of claims 1 to 9 in which there are means to drive the needle independently of a reservoir containing the substance to be injected and the needle is fluidically connected to the reservoir.
11. An apparatus as claimed in claim 10 in which the needle driving means is pneumatically operated
12. An apparatus as claimed in claim 11 in which the driving means comprises a block slidably mounted in a conduit and a pneumatic means adapted to drive the block along the conduit, there being an end piece which forms part of, or is connected to the needle so that the block driven down the conduit will strike the end piece.
13. An apparatus as claimed in claim 12 in which there are means to strike the needle a plurality of times and to return the block to its original position by reduction of pressure in the conduit.
14. An apparatus as claimed in claim 12 or 13 in which the pneumatic force is applied by a means which generates a pulse of air which sends the block down the conduit at the required velocity.
15. An apparatus as claimed in claim 12 or 13 in which the pneumatic force is applied by a piston with a spring return, a bellows or by a motorised means.
16. An apparatus as claimed in any one of claims 12 to 15 in which there are a plurality of blocks slidably mounted within the conduit.
17. Apparatus as claimed in any one of claims 1 to 16 in which the substance to be delivered is fed under normal, manual or mechanical pressure to the needle by means of a syringe or a compressible sack.
18. An apparatus as claimed in any one of claims 12 to 17 in which the needle is separate and adjacent to a syringe containing the substance to be injected with one end of the needle fluidically connected to the end of the syringe.
19. An apparatus as claimed in any one of claims 12 to 18 in which there is a syringe having a piston slidably mounted within it and the needle projecting through the end of the syringe which needle having an extension projecting through the piston so the end of the extension can be struck by a driving means to drive the needle into a surface, there being a connection means between the syringe and the needle whereby the substance in the syringe can pass through the needle from the syringe as the piston is depressed.
20. An apparatus as claimed in any one of claims 10 to 19 in which the mass of the needle and associated moving parts is 0.01 to 2.5grm.
21. An apparatus as claimed in any one of claims 10 to 20 in which the mass of the needle and associated moving parts is 0.1 to 2grms.
22. An apparatus as claimed in any one of claims 10 to 20 in which the mass of the needle and associated moving parts is 0.3 to 1grm.
23. An apparatus as claimed in any one of claims 10 to 20 in which the means for driving the needle, in use can accelerate the needle at 1 to 20,000g.
24. An apparatus as claimed in any one of the preceding claims in which the needle has substantially non-cutting tip with substantially no sharpened edges or blades with smooth, tapered, radiused or bevelled edges or surfaces.
25. An apparatus as claimed in any one of the preceding claims in which the needle has a sharpened tip substantially non-cutting tip and substance retaining core, the tip having at least one aperture formed therein, the at least one aperture connecting the core of the needle with the exterior of the tip of the needle and having a cross-sectional area smaller than the core so that, in use, the needle can be driven into the skin in order to deliver the substance from the core to the skin without the aperture pulling out skin during its removal.
26. An apparatus as claimed in claim 25 in which the tip of the needle is conical or pencil tip.
27. An apparatus according to claim 25 or 26 wherein at least one aperture is directly adjacent to the tip to allow injections to a shallow depth below lmm.
28. An apparatus according to claim 25 or 26 wherein plural apertures are provided.
29. An apparatus according to claim 27 or claim 28, wherein the one or more apertures have a circular cross-section.
30. An apparatus according to claim 25, 26 or 27, wherein the one or more apertures are slots.
31. An apparatus according to claim 25, 26 or claim 27, wherein the one or more apertures have a cross shaped cross-section.
32. An apparatus according to any of claims 25 to 31, wherein the needle is hollow in order to provide the substance supplying core.
33. An apparatus according to any of claims 25 to 31, wherein the needle is formed from a solid sharpened member.
34. An apparatus according to any of claims 10 to 33, wherein the needle is slidably retained with a housing, the housing defining the substance retaining core.
35. An apparatus according to claim 34, wherein the housing is angled to control the angle of entry of the needle to the surface.
36. An apparatus of any of claims 25 to 35, wherein arranged so that the angle of entry of the needle can be controlled either manually or automatically.
37. An apparatus according to any of claims 25 to 36, wherein the at least one needle is retained on a flexible pad which includes a substance reservoir which, in use, is placed adjacent to the skin so the needle penetrates the wall of the pad and then skin there being a fluidic connection between the reservoir and the skin aperture and a means to retain the needle adjacent to the skin on one wall of the pad.
38. An apparatus according to claim 37, wherein the flexible pad includes a substance reservoir in fluid communication with the or each substance supplying cores.
39. An apparatus as claimed in any one of the preceding claims in which there is a needle guide to restrict transaxial or lateral movement of the needle and which can protect the needle and prevent needle stick injury after use.
40. An apparatus as claimed in claim 39 in which the needle guide restricts the transaxial or lateral movement of the needle to below +/-2 degrees.
41. An apparatus as claimed in claim 39 in which the needle guide restricts the transaxial or lateral movement of the needle to below +/-0.5 degrees.
42. An apparatus as claimed in claim 39 in which the needle guide restricts the transaxial or lateral movement of the needle to below +/- 0.1 degree.
43. An apparatus as claimed in any one of claims to 25 to 41 in combination with an apparatus as claimed in any one of claims 1 to 24.
44. An apparatus for delivering a substance to the skin of a human being, animal or other organic matter, the apparatus comprising:
a needle;
a chamber surrounding the needle for retaining, in use, the substance to be delivered;
and a membrane defining one wall of the chamber, the relative positions of the needle and membrane being such that, in use, the needle can be driven through the membrane and into the skin to thereby deliver the substance.
a needle;
a chamber surrounding the needle for retaining, in use, the substance to be delivered;
and a membrane defining one wall of the chamber, the relative positions of the needle and membrane being such that, in use, the needle can be driven through the membrane and into the skin to thereby deliver the substance.
45. An apparatus according to claim 44, wherein the membrane is formed from an elastomer.
46. An apparatus according to claim 44 or 45, wherein the needle is driven through the membrane by a user-generated force.
47. An apparatus according to claim 44 or 45, wherein the membrane may be arranged to be attached, in use, to the skin.
48. An apparatus according to any one of claims 44 to 47 wherein the needle is driven by an apparatus as claimed in any one of claims 1 to 24
49. An apparatus according to any of the preceding claims further comprising means provided for detecting the depth of penetration of the skin by the needle,
50. An apparatus according to claim 49, wherein the depth of penetration is able to be controlled either by the user or automatically in response to detection of penetration depth.
51. An apparatus according to any one of claims 49 or 50, wherein the penetration depth is detected by applying a voltage potential to and measurement of the resulting current flowing through the skin between two needles, or the needle, skin and a detection point placed on the skin.
52. A method of delivering a substance by employing an apparatus according to any of the preceding claims.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9817662.1A GB9817662D0 (en) | 1998-08-13 | 1998-08-13 | Substance delivery |
GB9817662.1 | 1998-08-13 | ||
PCT/GB1999/002680 WO2000009184A1 (en) | 1998-08-13 | 1999-08-13 | Apparatus for delivering a substance having one or more needles driven at high velocity |
Publications (1)
Publication Number | Publication Date |
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CA2340248A1 true CA2340248A1 (en) | 2000-02-24 |
Family
ID=10837211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002340248A Abandoned CA2340248A1 (en) | 1998-08-13 | 1999-08-13 | Apparatus for delivering a substance having one or more needles driven at high velocity |
Country Status (15)
Country | Link |
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US (1) | US6890319B1 (en) |
EP (1) | EP1104315B1 (en) |
JP (1) | JP2002522170A (en) |
KR (1) | KR20010074821A (en) |
CN (1) | CN1312728A (en) |
AT (1) | ATE282445T1 (en) |
AU (1) | AU766222B2 (en) |
BR (1) | BR9914309A (en) |
CA (1) | CA2340248A1 (en) |
DE (1) | DE69922014T2 (en) |
GB (1) | GB9817662D0 (en) |
IL (1) | IL141209A0 (en) |
NO (1) | NO20010546L (en) |
NZ (1) | NZ509816A (en) |
WO (1) | WO2000009184A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9629991B1 (en) | 2016-06-08 | 2017-04-25 | Eclipse Aesthetics, LLC | Disposable radio frequency needle cartridges having absorbing containment barriers |
US9636491B1 (en) | 2016-06-08 | 2017-05-02 | Eclipse Aesthetics, LLC | Disposable needle cartridges having absorbing contaminant barriers |
US10220195B2 (en) | 2016-06-08 | 2019-03-05 | Eclipse Medcorp, Llc | Radio frequency needling device for use with disposable needle cartridges |
Families Citing this family (199)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
GB9919218D0 (en) * | 1999-08-13 | 1999-10-20 | Imprint Pharm Ltd | Injection means |
AU2001245472A1 (en) * | 2000-03-09 | 2001-09-17 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier andproduction techniques for such systems |
US7419481B2 (en) | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
CN1250171C (en) * | 2000-10-13 | 2006-04-12 | 阿尔扎公司 | Apparatus and method for piercing skin with microtrusions |
JP4198985B2 (en) * | 2000-10-13 | 2008-12-17 | アルザ・コーポレーシヨン | Microblade array impact applicator. |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
EP1404234B1 (en) | 2001-06-12 | 2011-02-09 | Pelikan Technologies Inc. | Apparatus for improving success rate of blood yield from a fingerstick |
ES2336081T3 (en) | 2001-06-12 | 2010-04-08 | Pelikan Technologies Inc. | SELF-OPTIMIZATION PUNCTURE DEVICE WITH MEANS OF ADAPTATION TO TEMPORARY VARIATIONS IN CUTANEOUS PROPERTIES. |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
JP4272051B2 (en) | 2001-06-12 | 2009-06-03 | ペリカン テクノロジーズ インコーポレイテッド | Blood sampling apparatus and method |
DE60238119D1 (en) | 2001-06-12 | 2010-12-09 | Pelikan Technologies Inc | ELECTRIC ACTUATOR ELEMENT FOR A LANZETTE |
WO2002100254A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US6881203B2 (en) * | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
EP1462134A4 (en) | 2001-12-13 | 2010-03-31 | Panasonic Corp | Administration instrument for medical use |
US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
US20030161815A1 (en) | 2002-02-12 | 2003-08-28 | Intercytex Limited | Cell delivery system |
US6912417B1 (en) | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
EP1501402A4 (en) * | 2002-04-19 | 2008-07-02 | Pelikan Technologies Inc | Device and method for variable speed lancet |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7547287B2 (en) * | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
KR20120087197A (en) | 2002-07-19 | 2012-08-06 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Microneedle device, method of using microneedle device and method of delivering microneedle device |
US20040143213A1 (en) * | 2002-11-12 | 2004-07-22 | Collegium Pharmaceutical, Inc. | Inertial drug delivery system |
EP1563061B1 (en) | 2002-11-14 | 2012-06-20 | Aderans Research Institute, Inc. | Cultivation of hair inductive cells |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7052652B2 (en) | 2003-03-24 | 2006-05-30 | Rosedale Medical, Inc. | Analyte concentration detection devices and methods |
DK1633235T3 (en) | 2003-06-06 | 2014-08-18 | Sanofi Aventis Deutschland | Apparatus for sampling body fluid and detecting analyte |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US20050049549A1 (en) * | 2003-08-04 | 2005-03-03 | Wong Patrick S.L. | Method and device for enhancing transdermal agent flux |
TWI233341B (en) * | 2003-09-26 | 2005-06-01 | Cheng-Kun Chen | Improved structure of tattooing needle and eyebrow lining needle |
EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | Method and apparatus for an improved sample capture device |
EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | Method and apparatus for a variable user interface |
EP1706171A1 (en) * | 2003-12-29 | 2006-10-04 | 3M Innovative Properties Company | Medical devices and kits including same |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
EP3466483A1 (en) * | 2004-03-08 | 2019-04-10 | Ichor Medical Systems Inc. | Improved apparatus for electrically mediated delivery of therapeutic agents |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
GB2414409B (en) | 2004-05-28 | 2009-11-18 | Cilag Ag Int | Injection device |
GB2414401B (en) | 2004-05-28 | 2009-06-17 | Cilag Ag Int | Injection device |
GB2414399B (en) | 2004-05-28 | 2008-12-31 | Cilag Ag Int | Injection device |
GB2414400B (en) | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
GB2414403B (en) * | 2004-05-28 | 2009-01-07 | Cilag Ag Int | Injection device |
GB2414405B (en) * | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
GB2414406B (en) | 2004-05-28 | 2009-03-18 | Cilag Ag Int | Injection device |
GB2414402B (en) * | 2004-05-28 | 2009-04-22 | Cilag Ag Int | Injection device |
GB2414404B (en) | 2004-05-28 | 2009-06-03 | Cilag Ag Int | Injection device |
GB2414775B (en) | 2004-05-28 | 2008-05-21 | Cilag Ag Int | Releasable coupling and injection device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
WO2005123173A1 (en) * | 2004-06-10 | 2005-12-29 | 3M Innovative Properties Company | Patch application device and kit |
BRPI0517749A (en) | 2004-11-18 | 2008-10-21 | 3M Innovative Properties Co | application device for applying a micro-needle device to a skin surface, and method for using an application device |
US9174035B2 (en) | 2004-11-18 | 2015-11-03 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
GB2424836B (en) | 2005-04-06 | 2010-09-22 | Cilag Ag Int | Injection device (bayonet cap removal) |
GB2424835B (en) | 2005-04-06 | 2010-06-09 | Cilag Ag Int | Injection device (modified trigger) |
GB2424838B (en) | 2005-04-06 | 2011-02-23 | Cilag Ag Int | Injection device (adaptable drive) |
GB2425062B (en) | 2005-04-06 | 2010-07-21 | Cilag Ag Int | Injection device |
GB2427826B (en) | 2005-04-06 | 2010-08-25 | Cilag Ag Int | Injection device comprising a locking mechanism associated with integrally formed biasing means |
WO2006108185A1 (en) | 2005-04-07 | 2006-10-12 | 3M Innovative Properties Company | System and method for tool feedback sensing |
US20060281187A1 (en) | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
EP1904158B1 (en) * | 2005-06-24 | 2013-07-24 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
JP5144510B2 (en) | 2005-06-27 | 2013-02-13 | スリーエム イノベイティブ プロパティズ カンパニー | Microneedle array application device |
BRPI0614477A2 (en) * | 2005-08-01 | 2011-03-29 | Hawk Medical Technologies Ltd | use of salicylic acid for eradication of pigmentation in a skin area, eradication apparatus and method of using a skin piercing apparatus |
DE602005018480D1 (en) | 2005-08-30 | 2010-02-04 | Cilag Gmbh Int | Needle device for a prefilled syringe |
US20070066934A1 (en) * | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
US20070185432A1 (en) * | 2005-09-19 | 2007-08-09 | Transport Pharmaceuticals, Inc. | Electrokinetic system and method for delivering methotrexate |
US20110098656A1 (en) | 2005-09-27 | 2011-04-28 | Burnell Rosie L | Auto-injection device with needle protecting cap having outer and inner sleeves |
US8801631B2 (en) | 2005-09-30 | 2014-08-12 | Intuity Medical, Inc. | Devices and methods for facilitating fluid transport |
US8382681B2 (en) | 2005-09-30 | 2013-02-26 | Intuity Medical, Inc. | Fully integrated wearable or handheld monitor |
US7618429B2 (en) * | 2005-12-22 | 2009-11-17 | Spamedica International Srl | Skin rejuvination resurfacing method |
US7780635B2 (en) | 2006-02-09 | 2010-08-24 | Aderans Research Institute, Inc. | Apparatus and methods for delivering fluid and material to a subject |
WO2007124411A1 (en) * | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
GB2438591B (en) | 2006-06-01 | 2011-07-13 | Cilag Gmbh Int | Injection device |
GB2438590B (en) | 2006-06-01 | 2011-02-09 | Cilag Gmbh Int | Injection device |
GB2438593B (en) | 2006-06-01 | 2011-03-30 | Cilag Gmbh Int | Injection device (cap removal feature) |
EP1882492B1 (en) * | 2006-07-25 | 2008-10-22 | MT Derm GmbH | Device for the controlled penetration into an object and method of operating the same |
JP2008029710A (en) * | 2006-07-31 | 2008-02-14 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | Microneedle type patch and its manufacturing method |
JP4499080B2 (en) * | 2006-11-21 | 2010-07-07 | 株式会社 トップエレガンス | Solid needle to inject liquid |
US7922688B2 (en) | 2007-01-08 | 2011-04-12 | Restoration Robotics, Inc. | Automated delivery of a therapeutic or cosmetic substance to cutaneous, subcutaneous and intramuscular tissue regions |
US8036448B2 (en) | 2007-04-05 | 2011-10-11 | Restoration Robotics, Inc. | Methods and devices for tattoo application and removal |
ITMI20070990A1 (en) * | 2007-05-16 | 2008-11-17 | Aquila Luca Dell | PERFECTED TATTOO MACHINE, PARTICULARLY FOR THE PERFORMANCE OF ACUPUNTURE, TATTOOS AND THE LIKE. |
US8012120B2 (en) | 2007-09-13 | 2011-09-06 | Avant Medical Corp. | Device and method for the automatic initiation of an injection |
AU2009251688A1 (en) * | 2008-04-01 | 2009-12-03 | The General Hospital Corporation | Method and apparatus for cooling biological tissue |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
CA2724641C (en) | 2008-05-20 | 2020-03-24 | Avant Medical Corp. | Autoinjector system |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
CA2725264C (en) | 2008-05-30 | 2017-06-20 | Intuity Medical, Inc. | Body fluid sampling device -- sampling site interface |
US9636051B2 (en) | 2008-06-06 | 2017-05-02 | Intuity Medical, Inc. | Detection meter and mode of operation |
EP2299904B1 (en) | 2008-06-06 | 2019-09-11 | Intuity Medical, Inc. | Medical measurement method |
GB2461086B (en) | 2008-06-19 | 2012-12-05 | Cilag Gmbh Int | Injection device |
GB2461085B (en) | 2008-06-19 | 2012-08-29 | Cilag Gmbh Int | Injection device |
GB2461084B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Fluid transfer assembly |
GB2461087B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
GB2461089B (en) | 2008-06-19 | 2012-09-19 | Cilag Gmbh Int | Injection device |
US8652159B2 (en) * | 2008-07-29 | 2014-02-18 | Facet Technologies, Llc | Lancet |
KR101013581B1 (en) | 2008-08-06 | 2011-02-14 | 라종주 | Electric Skin Treatment Device |
GB0900930D0 (en) * | 2009-01-20 | 2009-03-04 | Future Injection Technologies Ltd | Injection device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
WO2011065981A1 (en) | 2009-11-30 | 2011-06-03 | Intuity Medical, Inc. | Calibration material delivery devices and methods |
EP2512552B1 (en) | 2009-12-16 | 2015-02-25 | Becton Dickinson and Company | Self-injection device |
DK2512551T3 (en) | 2009-12-16 | 2019-07-01 | Becton Dickinson Co | Self Injection Device |
JP5650241B2 (en) | 2009-12-16 | 2015-01-07 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Self injection device |
JP5650242B2 (en) | 2009-12-16 | 2015-01-07 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Self injection device |
DK2512560T3 (en) | 2009-12-16 | 2018-07-16 | Becton Dickinson Co | Even injector device |
JP5650243B2 (en) | 2009-12-16 | 2015-01-07 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Self injection device |
WO2011093674A2 (en) * | 2010-01-29 | 2011-08-04 | (주)유바이오메드 | Micro needle and micro needle device |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US10330667B2 (en) | 2010-06-25 | 2019-06-25 | Intuity Medical, Inc. | Analyte monitoring methods and systems |
EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
JP5843862B2 (en) | 2010-09-02 | 2016-01-13 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Self-injection device with needle cover with anti-start device |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
US8814831B2 (en) | 2010-11-30 | 2014-08-26 | Becton, Dickinson And Company | Ballistic microneedle infusion device |
JP6082901B2 (en) * | 2011-01-31 | 2017-02-22 | オリンパス株式会社 | Vaccine / adjuvant |
US9320536B2 (en) * | 2011-03-03 | 2016-04-26 | Jongju Na | Method, system, and apparatus for dermatological treatment |
US9999384B2 (en) | 2011-03-09 | 2018-06-19 | Becton, Dickinson And Company | Sleeve for removable lancet of lancing device |
EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
LT2699293T (en) | 2011-04-20 | 2019-04-25 | Amgen Inc. | Autoinjector apparatus |
BR112013032080B8 (en) | 2011-06-14 | 2022-11-08 | Viol Co Ltd | SKIN TREATMENT APPLIANCE |
JP6223337B2 (en) | 2011-08-03 | 2017-11-08 | インテュイティ メディカル インコーポレイテッド | Body fluid extraction measuring instrument |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CN103917200B (en) * | 2011-09-13 | 2016-03-30 | 恩克斯特拉公司 | For the system and method for prostate treatment |
CA2850624A1 (en) | 2011-10-03 | 2013-04-11 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
JP6265740B2 (en) | 2011-10-06 | 2018-01-24 | 久光製薬株式会社 | applicator |
DE102011119203A1 (en) * | 2011-11-16 | 2013-05-16 | Lts Lohmann Therapie-Systeme Ag | Cylinder-piston unit with short cannula |
DE102011119055B4 (en) | 2011-11-16 | 2013-08-14 | Lts Lohmann Therapie-Systeme Ag | Cylinder-piston unit with adhesive disk II |
DE102011119204B3 (en) | 2011-11-16 | 2012-10-31 | Lts Lohmann Therapie-Systeme Ag | Cylinder-piston-unit for use in needle-free injector utilized in medical engineering for injecting solution into skin of patient, has sealing body accommodated by drive body such that combination of bodies has function of piston |
DE102011119058B3 (en) | 2011-11-16 | 2012-11-08 | Lts Lohmann Therapie-Systeme Ag | Cylinder-piston unit with adhesive disk I |
KR20140102759A (en) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | Modified nucleoside, nucleotide, and nucleic acid compositions |
USD690004S1 (en) | 2012-03-16 | 2013-09-17 | Aderans Research Institute, Inc. | Holder for a device for delivering cellular material and physiologic fluids |
EP2829291A4 (en) * | 2012-03-22 | 2015-11-25 | Terumo Corp | Automatic injection device |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
CA2868398A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
JP6226862B2 (en) | 2012-04-05 | 2017-11-08 | 久光製薬株式会社 | Puncture device and manufacturing method thereof |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
USD808010S1 (en) | 2012-04-20 | 2018-01-16 | Amgen Inc. | Injection device |
US9731069B2 (en) | 2012-09-27 | 2017-08-15 | Becton, Dickinson And Company | Perpendicular infusion set and disposable inserter |
JP6144355B2 (en) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | Chemically modified mRNA |
EP2937111B1 (en) | 2012-12-21 | 2020-03-18 | Hisamitsu Pharmaceutical Co., Inc. | Applicator |
JP6336564B2 (en) | 2013-03-15 | 2018-06-06 | アムゲン・インコーポレーテッド | Drug cassette, auto-injector, and auto-injector system |
US10492990B2 (en) | 2013-03-15 | 2019-12-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
US9452281B2 (en) | 2013-04-30 | 2016-09-27 | Elwha Llc | Tattooing systems and methods |
GB2515039B (en) | 2013-06-11 | 2015-05-27 | Cilag Gmbh Int | Injection Device |
GB2515038A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Injection device |
GB2515032A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Guide for an injection device |
GB2517896B (en) | 2013-06-11 | 2015-07-08 | Cilag Gmbh Int | Injection device |
WO2014205412A1 (en) | 2013-06-21 | 2014-12-24 | Intuity Medical, Inc. | Analyte monitoring system with audible feedback |
JP2016538829A (en) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | Polynucleotide encoding low density lipoprotein receptor |
EP3067088B1 (en) | 2013-11-05 | 2019-09-04 | Hisamitsu Pharmaceutical Co., Inc. | Applicator |
EP2954912A1 (en) * | 2014-06-13 | 2015-12-16 | MT Derm GmbH | Module for a hand-held device for inserting a substance through the skin surface, article and assembly |
US11478583B2 (en) * | 2014-10-03 | 2022-10-25 | Enable Injections, Inc. | Medical fluid transfer and injection apparatus and method |
AU2015372441A1 (en) | 2014-12-23 | 2017-08-10 | Automed Pty Ltd | Delivery apparatus, system and associated methods |
EP3037125A1 (en) * | 2014-12-23 | 2016-06-29 | MT Derm GmbH | Handheld device for local punctuation of human or animal skin and method for operating |
EP3240589A4 (en) * | 2014-12-30 | 2018-08-22 | William Rassman | Automated measurement and control system for tattoo delivery |
WO2016147476A1 (en) * | 2015-03-18 | 2016-09-22 | 凸版印刷株式会社 | Drug administration device, and manufacturing method for drug administration device |
CA2989189A1 (en) * | 2015-06-15 | 2016-12-22 | The University Of Sydney | Insertion system and method |
WO2017038499A1 (en) | 2015-09-02 | 2017-03-09 | 久光製薬株式会社 | Applicator |
CN115161178A (en) | 2015-09-09 | 2022-10-11 | 集联健康有限公司 | Systems, methods, and devices for sample collection, stabilization, and preservation |
CN105771038B (en) * | 2016-03-17 | 2022-09-13 | 南京医科大学第一附属医院 | Accurate trace acupuncture point injection pen |
KR102535764B1 (en) | 2016-03-28 | 2023-05-30 | 아이커 메디칼 시스템스 인코포레이티드 | Apparatus for delivery of therapeutic agents |
CN105996979A (en) * | 2016-05-14 | 2016-10-12 | 广州多得医疗设备服务有限公司 | Piston-type single-pulse air generator |
CN105943365B (en) * | 2016-05-31 | 2018-04-17 | 张岩 | The painless needle treating instrument of electrical acupuncture and dyestuff |
EP3487460A1 (en) * | 2016-07-20 | 2019-05-29 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Device for controlled puncturing of an object |
JP2018134392A (en) | 2017-01-10 | 2018-08-30 | ドローブリッジ ヘルス,インコーポレイテッド | Device, system, and method for sample collection |
CA3099306A1 (en) | 2018-05-15 | 2019-11-21 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
WO2021016590A1 (en) | 2019-07-25 | 2021-01-28 | Blackdot, Inc. | Robotic tattooing systems and related technologies |
US11957542B2 (en) | 2020-04-30 | 2024-04-16 | Automed Patent Holdco, Llc | Sensing complete injection for animal injection device |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2634726A (en) | 1952-01-30 | 1953-04-14 | Ralph D Hanson | Hypodermic needle |
US2862495A (en) | 1955-05-06 | 1958-12-02 | Baxter Laboratories Inc | Hypodermic needle |
US3181336A (en) | 1961-11-15 | 1965-05-04 | Schofield Hubert Percival | Method of producing the pointed end of a hypodermic needle |
US3788315A (en) | 1971-04-20 | 1974-01-29 | S Laurens | Disposable cutaneous transjector |
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3840008A (en) | 1972-04-18 | 1974-10-08 | Surgical Corp | Safety hypodermic needle |
DE2434618A1 (en) | 1973-07-30 | 1975-02-13 | Yolan Ronai Guttman | INFILTRATION-PROOF NEEDLE FOR INTRAVENOESIS |
US3946732A (en) | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
US3957051A (en) | 1974-09-13 | 1976-05-18 | Medical Development Corporation | Pump-type syringe having double-acting piston construction |
DE2642896C3 (en) | 1976-09-24 | 1980-08-21 | 7800 Freiburg | Precision snapper for setting standard stab wounds in the skin for diagnostic purposes |
US4634431A (en) | 1976-11-12 | 1987-01-06 | Whitney Douglass G | Syringe injector |
US4188949A (en) | 1977-07-05 | 1980-02-19 | Becton, Dickinson & Company | Sequential injection syringe |
US4204438A (en) | 1978-06-02 | 1980-05-27 | Christopher Binaris | Tattooing device |
US4214490A (en) | 1978-06-12 | 1980-07-29 | Chizek Franklin J | Method and means for placing an identification mark on a hog |
US4193400A (en) | 1978-06-16 | 1980-03-18 | The Deseret Company | Intravenous needle assembly with air bleed plug |
US4286599A (en) | 1979-01-12 | 1981-09-01 | Geo. A. Hormel & Company | Marking device |
US4351335A (en) | 1979-04-16 | 1982-09-28 | Whitney Douglass G | Injection device and method |
US4257561A (en) | 1979-06-05 | 1981-03-24 | Ethyl Products Company | Child-resistant dispensing nozzle assembly |
NL7906689A (en) | 1979-09-06 | 1981-03-10 | Dawsonville Corp Nv | TATTOO. |
US4411657A (en) | 1980-05-19 | 1983-10-25 | Anibal Galindo | Hypodermic needle |
GB2109690B (en) | 1981-02-12 | 1985-02-20 | Robert Charles Turner | Dose metering plunger devices for use with syringes |
US4527561A (en) | 1981-03-23 | 1985-07-09 | Becton, Dickinson And Company | Automatic retractable lancet assembly |
US4383530A (en) | 1981-06-05 | 1983-05-17 | John Bruno | Hypodermic needle and method of making needles |
US4437361A (en) | 1982-01-07 | 1984-03-20 | Steckel Lester M | Tattooing gun |
US4447232A (en) | 1982-05-21 | 1984-05-08 | Repro-Med Systems, Inc. | Spring-operated liquid-dispensing device |
US4508106A (en) | 1983-02-14 | 1985-04-02 | Angres Clinic, Ltd. | Microsurgical method for applying permanent eyelid liner |
US4537593A (en) | 1983-06-06 | 1985-08-27 | Becton, Dickinson And Co. | Self-venting, non-coring needle assembly |
US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
DE3405671A1 (en) * | 1984-02-17 | 1985-08-22 | Sandoz AG, 8500 Nürnberg | Device for setting up and maintaining the gas pressure in a vaccination gun operated with a high-pressure gas |
US4613328A (en) * | 1984-10-22 | 1986-09-23 | Cecil Boyd | Bio-medical injector apparatus |
US4582060A (en) | 1984-11-20 | 1986-04-15 | Young Dental Manufacturing Company | Tattooing tool and needle assembly for use therein |
FI70951C (en) | 1984-11-29 | 1999-05-19 | Valmet Oy | A method for replacing fabrics and rolls in a press section of a papermaking machine, and a press section frame structure applying the method |
US4699612A (en) | 1985-04-01 | 1987-10-13 | Hamacher Edward N | Infusion needle |
US4666438A (en) | 1985-07-02 | 1987-05-19 | Raulerson J Daniel | Needle for membrane penetration |
US4838877A (en) | 1985-08-06 | 1989-06-13 | Massau Bruce A | Polymeric hypodermic device |
US4665912A (en) | 1985-08-09 | 1987-05-19 | Waters Instruments, Inc. | Skin marking device |
US4592744A (en) | 1985-08-14 | 1986-06-03 | The University Of Virginia Alumni Patents Foundation | Self-resheathing needle assembly |
US4671277A (en) | 1985-08-28 | 1987-06-09 | Coopervision, Inc. | Pigment dispenser and reservoir for a pigmentation system |
US4808170A (en) | 1985-12-16 | 1989-02-28 | Alcon Laboratories, Inc. | Hypotraumatic injection needle useful in ophthalmic surgery |
US4719825A (en) | 1986-03-24 | 1988-01-19 | Lahaye Peter G | Metering needle assembly |
US5076282A (en) | 1986-04-18 | 1991-12-31 | Henry Fishman | Allergy testing apparatus and method |
DE3622399A1 (en) | 1986-07-01 | 1988-02-04 | Eberhardt Schlueter | AUTOMATIC INJECTION DEVICE AND AMPOULE OR CARTRIDGE FOR AN INJECTION DEVICE |
US4710180A (en) | 1986-10-06 | 1987-12-01 | Johnson Gerald W | Lipoject needle |
US4781689A (en) | 1986-11-13 | 1988-11-01 | Andrew Sealfon | Spring-operated liquid-dispensing device |
US4931059A (en) | 1986-11-24 | 1990-06-05 | Markham Charles W | Needle/stylet combination |
ES2050000T3 (en) | 1987-07-10 | 1994-05-01 | Braun Melsungen Ag | CANNULA. |
US4842587A (en) | 1987-07-15 | 1989-06-27 | Poncy George W | No-prick hypodermic syringe |
US4771660A (en) | 1987-08-24 | 1988-09-20 | Harold Yacowitz | Needle holder |
US5060658A (en) | 1988-02-23 | 1991-10-29 | Vance Products Incorporated | Fine-needle aspiration cell sampling apparatus |
US4914988A (en) | 1988-08-17 | 1990-04-10 | Chang Meng Cheng | Eyebrow tattooing machine |
US4924879A (en) | 1988-10-07 | 1990-05-15 | Brien Walter J O | Blood lancet device |
US4895147A (en) | 1988-10-28 | 1990-01-23 | Sherwood Medical Company | Lancet injector |
US4862772A (en) | 1988-12-22 | 1989-09-05 | Piperato Richard A | Tamperproof, single use, disposable tattoo equipment |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US4990135A (en) | 1989-08-29 | 1991-02-05 | Truesdale Jr R Grant | Inoculator and needle therefor |
JPH0648975B2 (en) | 1989-10-02 | 1994-06-29 | 俊郎 樋口 | Micro injection device and injection control method thereof |
US5262128A (en) | 1989-10-23 | 1993-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Array-type multiple cell injector |
US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
US5054339A (en) | 1990-02-20 | 1991-10-08 | Harold Yacowitz | Tattooing assembly |
US5061250A (en) | 1990-08-28 | 1991-10-29 | Shields Jack W | Intravenous needle sheathing device |
US5515871A (en) | 1990-09-28 | 1996-05-14 | Sulzer Brothers Ltd. | Hollow needle for medical use and a laser method for manufacturing |
TW279133B (en) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
US5451210A (en) | 1991-04-29 | 1995-09-19 | Lifequest Medical, Inc. | System and method for rapid vascular drug delivery |
US5271744A (en) | 1991-04-29 | 1993-12-21 | George C. Kramer | System and method for rapid vascular drug delivery |
AU1926792A (en) * | 1991-05-13 | 1992-12-30 | Sti International Limited | Automatic injectors |
US5244120A (en) | 1992-08-19 | 1993-09-14 | Cp Packaging, Inc. | Dual chamber medicament dispenser |
AU4282793A (en) | 1992-04-10 | 1993-11-18 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A microneedle for injection of ocular blood vessels |
DE4212315A1 (en) | 1992-04-13 | 1993-10-14 | Boehringer Mannheim Gmbh | Blood lancet device for drawing blood for diagnostic purposes |
US5250067A (en) | 1992-11-30 | 1993-10-05 | Ala Gelfer | Body treatment pad having a multiple number of sharpened skin-penetration protuberances |
US5279552A (en) | 1993-01-11 | 1994-01-18 | Anton Magnet | Intradermal injection device |
US5401242A (en) | 1993-02-25 | 1995-03-28 | Yacowitz; Harold | Apparatus for injecting a substance into the skin |
US5454922A (en) | 1993-05-07 | 1995-10-03 | Ceramatec, Inc. | Fluid dispensing pump |
US5472449A (en) | 1993-07-26 | 1995-12-05 | Chou; Kuei C. | Permanent pigment applicator having a detachable needle coupler |
US5443492A (en) | 1994-02-02 | 1995-08-22 | Medtronic, Inc. | Medical electrical lead and introducer system for implantable pulse generator |
JP2551742B2 (en) | 1994-05-23 | 1996-11-06 | 三星電機株式会社 | Skin wound forming device for drug administration |
US5496304A (en) | 1994-07-20 | 1996-03-05 | University Of Utah Research Foundation | Surgical marking pen |
GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
EP0727187B1 (en) | 1995-02-15 | 2003-08-06 | Joseph Eldor | Multiple hole spinal needle |
US5681283A (en) * | 1995-02-27 | 1997-10-28 | Brownfield; Carroll James | Device for painless insertion of needle for needle injected medication |
US5807275A (en) | 1995-07-19 | 1998-09-15 | Medical Biopsy, Inc. | Biopsy needle |
US5564436A (en) | 1995-09-21 | 1996-10-15 | Hakky; Said I. | Automatic rotating cassette multiple biopsy device |
JPH0990546A (en) | 1995-09-21 | 1997-04-04 | Fuji Photo Film Co Ltd | Silver halide photographing sensitive material and hydroxamic acid compound used therefor |
US5716348A (en) | 1995-10-19 | 1998-02-10 | Meridian Medical Technologies, Inc. | Anti-coring needle |
GB9612724D0 (en) * | 1996-06-18 | 1996-08-21 | Owen Mumford Ltd | Improvements relating to injection devices |
US5752942A (en) | 1996-06-20 | 1998-05-19 | Becton Dickinson And Company | Five beveled point geometry for a hypodermic needle |
US5860957A (en) | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
US5911703A (en) | 1997-05-22 | 1999-06-15 | Avant Drug Delivery Systems, Inc. | Two-stage fluid medicament jet injector |
US6030404A (en) | 1997-09-06 | 2000-02-29 | Lawson; Alexis A. | Skin penetration apparatus including multiple needle configuration |
SE9803662D0 (en) * | 1998-10-26 | 1998-10-26 | Pharmacia & Upjohn Ab | autoinjector |
US6065371A (en) | 1998-12-09 | 2000-05-23 | Yacowitz; Harold | Dual needle injection device |
-
1998
- 1998-08-13 GB GBGB9817662.1A patent/GB9817662D0/en not_active Ceased
-
1999
- 1999-08-13 AU AU54317/99A patent/AU766222B2/en not_active Ceased
- 1999-08-13 EP EP99940320A patent/EP1104315B1/en not_active Expired - Lifetime
- 1999-08-13 CN CN99809613A patent/CN1312728A/en active Pending
- 1999-08-13 JP JP2000564685A patent/JP2002522170A/en not_active Withdrawn
- 1999-08-13 AT AT99940320T patent/ATE282445T1/en not_active IP Right Cessation
- 1999-08-13 BR BR9914309-7A patent/BR9914309A/en not_active Application Discontinuation
- 1999-08-13 US US09/762,887 patent/US6890319B1/en not_active Expired - Fee Related
- 1999-08-13 DE DE69922014T patent/DE69922014T2/en not_active Expired - Fee Related
- 1999-08-13 WO PCT/GB1999/002680 patent/WO2000009184A1/en active IP Right Grant
- 1999-08-13 NZ NZ509816A patent/NZ509816A/en unknown
- 1999-08-13 KR KR1020017001813A patent/KR20010074821A/en not_active Application Discontinuation
- 1999-08-13 IL IL14120999A patent/IL141209A0/en unknown
- 1999-08-13 CA CA002340248A patent/CA2340248A1/en not_active Abandoned
-
2001
- 2001-02-01 NO NO20010546A patent/NO20010546L/en unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9629991B1 (en) | 2016-06-08 | 2017-04-25 | Eclipse Aesthetics, LLC | Disposable radio frequency needle cartridges having absorbing containment barriers |
US9636491B1 (en) | 2016-06-08 | 2017-05-02 | Eclipse Aesthetics, LLC | Disposable needle cartridges having absorbing contaminant barriers |
US10220195B2 (en) | 2016-06-08 | 2019-03-05 | Eclipse Medcorp, Llc | Radio frequency needling device for use with disposable needle cartridges |
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DE69922014D1 (en) | 2004-12-23 |
KR20010074821A (en) | 2001-08-09 |
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US6890319B1 (en) | 2005-05-10 |
EP1104315A1 (en) | 2001-06-06 |
AU766222B2 (en) | 2003-10-09 |
NO20010546L (en) | 2001-03-14 |
AU5431799A (en) | 2000-03-06 |
ATE282445T1 (en) | 2004-12-15 |
IL141209A0 (en) | 2002-02-10 |
CN1312728A (en) | 2001-09-12 |
NO20010546D0 (en) | 2001-02-01 |
NZ509816A (en) | 2003-07-25 |
GB9817662D0 (en) | 1998-10-07 |
JP2002522170A (en) | 2002-07-23 |
EP1104315B1 (en) | 2004-11-17 |
DE69922014T2 (en) | 2005-03-17 |
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