CA2341235A1 - Conformal patch for administering light therapy to subcutaneous tumors - Google Patents

Conformal patch for administering light therapy to subcutaneous tumors Download PDF

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Publication number
CA2341235A1
CA2341235A1 CA002341235A CA2341235A CA2341235A1 CA 2341235 A1 CA2341235 A1 CA 2341235A1 CA 002341235 A CA002341235 A CA 002341235A CA 2341235 A CA2341235 A CA 2341235A CA 2341235 A1 CA2341235 A1 CA 2341235A1
Authority
CA
Canada
Prior art keywords
light
patch
flexible substrate
light therapy
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002341235A
Other languages
French (fr)
Other versions
CA2341235C (en
Inventor
James C. Chen
Brent Wiscombe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Light Sciences Oncology Inc
Original Assignee
Light Sciences Corporation
James C. Chen
Brent Wiscombe
Light Sciences Limited Partnership
Light Sciences, Llc
Light Sciences Oncology, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Light Sciences Corporation, James C. Chen, Brent Wiscombe, Light Sciences Limited Partnership, Light Sciences, Llc, Light Sciences Oncology, Inc. filed Critical Light Sciences Corporation
Publication of CA2341235A1 publication Critical patent/CA2341235A1/en
Application granted granted Critical
Publication of CA2341235C publication Critical patent/CA2341235C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Electrotherapy Devices (AREA)

Abstract

A flexible patch (10) provided with a plurality of light sources (16) mounted in spaced apart array on its undersurface, and covered with an optically transparent polymer material. The light sources (16) are energized with an electrical current supplied by a flexible polymer battery (44), which is preferably rechargeable. Electrical current is conveyed through a lead (42) that extends from the flexible battery to the flexible patch (10) and then through an electrical circuit that includes a plurality of conductive traces (12, 14) formed using a conductive ink applied to the surface of a flexible substrate that supports the light sources. The thickness of the flexible patch (16) at its maximum is less than 1.0 millimeters. The light sources (16) can be separatly grouped, the electrical current supplied to each group individually controlled to achieve a desired light intensity, and/or duration exposure to the light therapy over different portions of the undersurface (40) of the flexible patch (10) with different portions of the treatment site.

Claims (25)

1. A light therapy patch adapted to conform to a non-planar portion of a patient's body to which a light therapy is to be administered at a treatment site, comprising:
(a) a flexible substrate formed of a dielectric material, said substrate including a plurality of openings that extend therethrough, said openings providing ventilation paths for air and moisture to move through the flexible substrate;
(b) a power source for supplying an electrical current at a desired voltage;
(c) a plurality of flexible conductive traces applied to at least one surface of the flexible substrate, said flexible conductive traces defining an electrical circuit for conveying an electrical current provided by the power source to defined portions of said at least one surface; and (d) a plurality of light emitting sources mounted to the flexible substrate in a spaced-apart array and electrically coupled to the conductive traces to receive the electrical current, said electrical current energizing the plurality of light emitting sources so that they emit light to provide the light therapy at the treatment site.
2. The light therapy patch of Claim 1, wherein the plurality of conductive traces comprise a conductive fluid applied to said at least one surface of the flexible substrate, said conductive fluid setting to form the conductive traces.
3. The light therapy patch of Claim 1, further comprising an adhesive that is adapted to secure the flexible substrate to the non-planar portion of the patient's body, with the flexible substrate conforming thereto.
4. The light therapy patch of Claim 3, wherein the adhesive is applied to the non-planar portion of the patient's body before conforming the flexible substrate to said non-planar portion.
5. The light therapy patch of Claim 3, wherein the adhesive is disposed over a surface of the flexible substrate that is adapted to face toward the non-planar portion of the patient's body when the flexible substrate is conformed to said non-planar portion.
6. The light therapy patch of Claim 3, wherein the adhesive is adapted to adhere to tissue inside the patient's body, enabling the flexible substrate to be secured to administer the light therapy to an internal treatment site.
7. The light therapy patch of Claim 1, further comprising a light reflective layer disposed over a surface of the flexible substrate that faces outwardly when the flexible substrate is conformed to the non-planar portion of the patient's body, said light reflective layer serving to reflect light emitted by the plurality of light sources toward the treatment site.
8. The light therapy patch of Claim 1, further comprising an optically transparent coating applied over the plurality of light sources mounted on the flexible substrate to protect the plurality of light sources.
9. The light therapy patch of Claim 1, wherein the power source comprises a flexible polymeric battery.
10. The light therapy patch of Claim 9, further comprising a lead for connecting the flexible polymeric battery to said plurality of conductive traces, said flexible polymeric battery being carried separate from the flexible substrate by the patient during administration of the light therapy.
11. The light therapy patch of Claim 1, wherein the plurality of light emitting sources emit a broad spectrum light.
12. The light therapy patch of Claim 1, wherein the plurality of light emitting sources are selected from the group consisting of incandescent lights, halogen lights, fluorescent lights, electroluminescent lights, light emitting diodes, polymeric light emitting diodes, organic light emitting diodes, and metallic light emitting diodes.
13. The light therapy patch of Claim 1, wherein the electrical circuit comprises a plurality of parallel circuits conveying the electrical current to groups of the light sources.
14. The light therapy patch of Claim 13, further comprising a microcontroller coupled to the electrical circuit for separately controlling the electrical current supplied to the groups of light sources and thereby controlling the light administered to different regions of the treatment site by the groups of light sources.
15. A method for administering a light therapy to a treatment site, comprising the steps of:
(a) providing a vapor permeable patch on which are mounted an array of spaced-apart light sources, said vapor permeable patch being sufficiently flexible to conform to a substantially non-planar portion of a patient's body and including a plurality of openings;
(b) adhesively attaching and conforming the patch to the patient's body, adjacent to the treatment site; and (c) energizing the plurality of light sources to administer the light therapy to the treatment site.
16. The method of Claim 15, further comprising the step of providing an ambulatory power source that is coupled to the plurality of light sources on the vapor permeable patch.
17. The method of Claim 15, wherein the plurality of light sources are divided into a plurality of separate groups, further comprising the step of selectively controlling an electrical current supplied to the separate groups of the light sources to separately control an intensity of light administered to different regions of the treatment site.
18. The method of Claim 15, further comprising the step of applying an adhesive to a surface of the treatment site to adhere the vapor permeable patch thereto.
19. The method of Claim 15, wherein the plurality of light sources are covered by an optically transparent protective layer on the vapor permeable patch.
20. The method of Claim 15, wherein the vapor permeable patch includes an electrical circuit defined by a plurality of conductive traces that are applied to a surface of said patch.
21. The method of Claim 20, wherein the plurality of conductive traces are applied to said surface as a fluid.
22. The method of Claim 15, further comprising the step of reflecting light emitted by the plurality of light sources towards the treatment site.
23. The method of Claim 15, further comprising the step of administering the light therapy to the treatment site with the vapor permeable patch for an extended period of time, while the patient is ambulatory.
24. The method of Claim 15, further comprising the step of providing a coating on the vapor permeable patch having an index of refraction substantially equal to that of skin of the patient.
25. The method of Claim 15, further comprising the step of inserting the vapor permeable patch into the patient's body, said step of adhesively attaching and conforming occurring at an internal treatment site within the patient's body.
CA002341235A 1998-09-11 1999-08-20 Conformal patch for administering light therapy to subcutaneous tumors Expired - Fee Related CA2341235C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/151,844 1998-09-11
US09/151,844 US6096066A (en) 1998-09-11 1998-09-11 Conformal patch for administering light therapy to subcutaneous tumors
PCT/US1999/019015 WO2000015296A1 (en) 1998-09-11 1999-08-20 Conformal patch for administering light therapy to subcutaneous tumors

Publications (2)

Publication Number Publication Date
CA2341235A1 true CA2341235A1 (en) 2000-03-23
CA2341235C CA2341235C (en) 2009-12-15

Family

ID=22540462

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002341235A Expired - Fee Related CA2341235C (en) 1998-09-11 1999-08-20 Conformal patch for administering light therapy to subcutaneous tumors

Country Status (6)

Country Link
US (1) US6096066A (en)
EP (1) EP1109599A4 (en)
JP (1) JP2003526391A (en)
AU (1) AU750568B2 (en)
CA (1) CA2341235C (en)
WO (1) WO2000015296A1 (en)

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US6096066A (en) 2000-08-01
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EP1109599A1 (en) 2001-06-27
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CA2341235C (en) 2009-12-15
AU750568B2 (en) 2002-07-25

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