CA2342974A1 - Methods and compositions for inhibition of angiogenesis - Google Patents

Methods and compositions for inhibition of angiogenesis

Info

Publication number
CA2342974A1
CA2342974A1 CA002342974A CA2342974A CA2342974A1 CA 2342974 A1 CA2342974 A1 CA 2342974A1 CA 002342974 A CA002342974 A CA 002342974A CA 2342974 A CA2342974 A CA 2342974A CA 2342974 A1 CA2342974 A1 CA 2342974A1
Authority
CA
Canada
Prior art keywords
angiogenesis
inhibition
compositions
methods
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002342974A
Other languages
French (fr)
Other versions
CA2342974C (en
Inventor
Robert D'amato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Original Assignee
The Children's Medical Center Corporation
Robert D'amato
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26699202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2342974(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Children's Medical Center Corporation, Robert D'amato filed Critical The Children's Medical Center Corporation
Publication of CA2342974A1 publication Critical patent/CA2342974A1/en
Application granted granted Critical
Publication of CA2342974C publication Critical patent/CA2342974C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Abstract

The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.
CA002342974A 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis Expired - Lifetime CA2342974C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2504693A 1993-03-01 1993-03-01
US025,046 1993-03-01
US08/168,817 US5629327A (en) 1993-03-01 1993-12-15 Methods and compositions for inhibition of angiogenesis
US168,817 1993-12-15
CA002157288A CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002157288A Division CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Publications (2)

Publication Number Publication Date
CA2342974A1 true CA2342974A1 (en) 1994-09-15
CA2342974C CA2342974C (en) 2005-08-16

Family

ID=26699202

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002157288A Expired - Lifetime CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA002342974A Expired - Lifetime CA2342974C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis
CA2512926A Expired - Lifetime CA2512926C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002157288A Expired - Lifetime CA2157288C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2512926A Expired - Lifetime CA2512926C (en) 1993-03-01 1994-02-24 Methods and compositions for inhibition of angiogenesis

Country Status (20)

Country Link
US (18) US5629327A (en)
EP (4) EP1245229A3 (en)
JP (4) JPH08507767A (en)
KR (1) KR100506043B1 (en)
AT (2) ATE304356T1 (en)
AU (1) AU676722B2 (en)
BR (1) BR9400764A (en)
CA (3) CA2157288C (en)
CO (1) CO4230017A1 (en)
DE (3) DE69430796T2 (en)
DK (2) DK1264597T3 (en)
ES (2) ES2245711T3 (en)
FR (1) FR08C0036I2 (en)
HK (1) HK1052865A1 (en)
LU (1) LU91471I2 (en)
NL (1) NL300358I2 (en)
NZ (4) NZ262676A (en)
PE (1) PE10095A1 (en)
PT (1) PT688211E (en)
WO (1) WO1994020085A1 (en)

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US8143283B1 (en) * 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
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