CA2344816A1 - Medicinal aerosol formulation - Google Patents

Medicinal aerosol formulation Download PDF

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Publication number
CA2344816A1
CA2344816A1 CA002344816A CA2344816A CA2344816A1 CA 2344816 A1 CA2344816 A1 CA 2344816A1 CA 002344816 A CA002344816 A CA 002344816A CA 2344816 A CA2344816 A CA 2344816A CA 2344816 A1 CA2344816 A1 CA 2344816A1
Authority
CA
Canada
Prior art keywords
formulation
stabilizer
metered dose
foregoing
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002344816A
Other languages
French (fr)
Other versions
CA2344816C (en
Inventor
Akwete Adjei
Anthony J. Cutie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kos Life Sciences Inc
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Individual
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22567809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2344816(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2344816A1 publication Critical patent/CA2344816A1/en
Application granted granted Critical
Publication of CA2344816C publication Critical patent/CA2344816C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

This invention relates to a medicinal aerosol formulation and more particularly, to a medicinal aerosol formulation containing a particulate drug, a propellant, and stabilizing agent selected from an amino acid, an amino acid derivative and a mixture of the foregoing.

Claims (20)

1. A medicinal aerosol formulation, which comprises:
(a) a therapeutically effective amount of a particulate medicament;
(b) a propellant; and (c) a stabilizer selected from an amino acid, a derivative thereof, or a mixture of the foregoing.
2. The formulation as defined in claim 1 wherein said stabilizer is selected from the group consisting of glycin, glycine, alanine, valine, leucine, isoleucine, methionine, threonine, isovaline, phenylalanine, tyrosine, serine, histidine, tryptophan, proline, hydroxyproline, arginine, ornithine, asparagine, citrulline, aspartic acid, cysteine, glutamic acid, glutamine, lysine, hydroxylysine, N-acetyl-L-cysteine, phenylalanine, trans-4-hydroxy-L-proline, tyrosine, L-aspartyl-L-phenylalanine methylester and a mixture of any of the foregoing.
3. The formulation as defined in claim 1 wherein the medicament is selected from the group consisting of albuterol, atropine, beclomethasone, beclomethasone monopropionate, beclomethasone dipropionate, budesonide, cromolyn, epinephrine, ephedrine, fentanyl, flunisolide, formoterol, ipratropium bromide, isoproterenol, pirbuterol, prednisone, salmeterol, amiloride, fluticasone, fluticasone esters, (-)4-amino-3,5-dichloro-a-[[[6(2-pyridinyl)ethoxy] hexyl]
amino]
methyl]benzene-methanol and pharmaceutically acceptable salts, esters, hydrates and solvates of the foregoing.
4. The formulation as defined in claim 1, wherein said propellant is selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane or a mixture thereof.
5. The formulation as defined in claim 1 which further includes a cosolvent.
6. The formulation as defined in claim 5 wherein said cosolvent comprises ethanol.
7. The formulation as defined in claim 2 wherein said stabilizer is present in an amount effective to prevent settling, creaming or flocculation of the formulation for a time sufficient to allow reproducible dosing of the drug after agitation of the formulation.
8. The formulation as defined in claim 7 wherein said stabilizer is present in an amount ranging from about 0.000002% by weight to about 20% by weight based on the weight of the formulation.
9. A method of preparing a medicinal aerosol formulation according to claim 1, which comprises:
(a) combining (i) said medicament in an amount sufficient to provide a plurality of therapeutically effective doses, (ii) said propellant in an amount sufficient to propel a plurality of said therapeutically effective doses from an aerosol canister; and (iii) said stabilizer in an amount effective to stabilize the formulation; and (b) dispersing components (i), (ii) and (iii).
10. The method as defined in claim 9 wherein the medicinal aerosol formulation further comprises combining in step (a) a cosolvent and in step (b) dispersing components (i), (ii), (iii) with said cosolvent.
11. A method of treating in an animal a condition capable of treatment by oral or nasal inhalation, which comprises, administering a formulation according to claim 1 to said animal by oral or nasal inhalation.
12. A formulation according to claim 1 in an aerosol canister equipped with a metered dose valve.
13. A method of stabilizing a suspension aerosol formulation comprising a propellant and a particulate drug which comprises, incorporating into the formulation a stabilizer selected from the group consisting of a suitable amino acid, a derivative thereof, or any mixture of the foregoing, in an amount which is effective to prevent settling, creaming, or flocculation of the formulation for a time sufficient to allow reproducible dosing of the drug after agitation of the formulation.
14. A metered dose inhaler containing a medicinal aerosol formulation, the formulation comprising:
(a) a drug in particulate form in a therapeutically effective amount;
(b) a propellant; and (c) a suitable stabilizer selected from an amino acid, an amino acid derivative, or a mixture of the foregoing, present in an amount sufficient to stabilize the formulation to prevent settling, creaming or flocculation for a time sufficient to allow reproducible dosing of the drug after agitation of the formulation.
15. The metered dose inhaler as defined in claim 14 wherein the stabilizer is selected from the group consisting of glycin, glycine, alanine, valine, leucine, isoleucine, methionine, threonine, isovaline, serine, histidine, tryptophan, proline, hydroxyproline, arginine, ornithine, asparagine, citrulline, aspartic acid, cysteine, glutamic acid, glutamine, lysine, hydroxylysine, N-acetyl-L-cysteine, phenylalanine, trans-4-hydroxy-L-proline, tyrosine, L-aspartyl-L-phenylalanine methylester and a mixture of any of the foregoing.
16. The metered dose inhaler as defined in claim 15 wherein said stabilizer is present in an amount of 0.000002% by weight to about 20% by weight based on the weight of the medicinal aerosol formulation.
17. The metered dose inhaler as defined in claim 14 wherein the drug is selected from the group consisting of albuterol, atropine, beclomethasone, beclomethasone monopropionate, beclomethasone dipropionate, budesonide, cromolyn, epinephrine, ephedrine, fentanyl, flunisolide, formoterol, ipratropium bromide, isoproterenol, pirbuterol, prednisone, salmeterol, amiloride, fluticasone, an ester of fluticasone,(-)4-amino-3,5-dichloro-.alpha.-[[[6(2-pyridinyl)ethoxy]
hexyl] amino]
methyl]benzene-methanol and pharmaceutically acceptable hydrates, salts and solvates of the foregoing.
18. The metered dose inhaler as defined in claim 14 wherein the propellant is selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane or a mixture thereof.
19. The metered dose inhaler as defined in claim 14 wherein the medicinal aerosol formulation further comprises a cosolvent.
20. The metered dose inhaler as defined in claim 19 wherein said cosolvent comprises ethanol.
CA2344816A 1998-09-22 1999-09-17 Medicinal aerosol formulation Expired - Fee Related CA2344816C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09158369 US6136294C1 (en) 1998-09-22 1998-09-22 Amino acid stabilized medical aerosol formulation
US09/158,369 1998-09-22
PCT/US1999/021510 WO2000016814A1 (en) 1998-09-22 1999-09-17 Medicinal aerosol formulation

Publications (2)

Publication Number Publication Date
CA2344816A1 true CA2344816A1 (en) 2000-03-30
CA2344816C CA2344816C (en) 2011-05-24

Family

ID=22567809

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2344816A Expired - Fee Related CA2344816C (en) 1998-09-22 1999-09-17 Medicinal aerosol formulation

Country Status (15)

Country Link
US (1) US6136294C1 (en)
EP (2) EP1731140B1 (en)
JP (1) JP2002526459A (en)
CN (1) CN100337614C (en)
AT (2) ATE336268T1 (en)
AU (1) AU745554B2 (en)
CA (1) CA2344816C (en)
CY (1) CY1105538T1 (en)
DE (2) DE69932835T2 (en)
DK (1) DK1123120T3 (en)
ES (1) ES2267288T3 (en)
HK (2) HK1041835A1 (en)
MX (1) MXPA01002894A (en)
PT (1) PT1123120E (en)
WO (1) WO2000016814A1 (en)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
GB9807232D0 (en) 1998-04-03 1998-06-03 Univ Cardiff Aerosol composition
US6458338B1 (en) * 1998-09-22 2002-10-01 Aeropharm Technology Incorporated Amino acid stabilized medicinal aerosol formulations
US6261539B1 (en) * 1998-12-10 2001-07-17 Akwete Adjei Medicinal aerosol formulation
US6362225B1 (en) * 1999-01-21 2002-03-26 George Andreakos Target therapies for treating common viral infections
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
CN1440298A (en) * 2000-01-25 2003-09-03 气体药品技术公司 Medical aerosol formulation
US6585957B1 (en) * 2000-01-25 2003-07-01 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6540982B1 (en) * 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US6468507B1 (en) * 2000-05-01 2002-10-22 Aeropharm Technology, Inc. Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer
US6610272B1 (en) 2000-05-01 2003-08-26 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6565833B1 (en) * 2000-05-01 2003-05-20 Aeropharm Technology Incorporated Medicinal aerosol formulation
ME00220B (en) * 2000-05-22 2010-10-10 Chiesi Farm Spa Stable pharmaceutical solution formulations for pressurised metered dose inhalers
AU2001247123A1 (en) * 2000-07-19 2002-02-05 Aeropharm Technology, Inc. A medicinal aerosol formulation
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
NZ523958A (en) * 2000-08-05 2004-11-26 Glaxo Group Ltd 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derviative as anti-inflammatory agents
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6406681B1 (en) * 2000-08-21 2002-06-18 Aeropharm Technology, Inc. Method of treating a systemic disease
US6551578B2 (en) * 2001-02-15 2003-04-22 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US6485707B2 (en) * 2001-02-15 2002-11-26 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US6544497B2 (en) 2001-02-15 2003-04-08 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US6475468B2 (en) * 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
GB0105560D0 (en) * 2001-03-07 2001-04-25 Glaxo Group Ltd Pharmaceutical formulations
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
WO2002088167A1 (en) * 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
US20040248867A1 (en) * 2001-06-12 2004-12-09 Keith Biggadike Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives
AU2002337803A1 (en) * 2001-10-03 2003-04-14 Glaxo Group Limited Sustained release pharmaceutical compositions
US20030140920A1 (en) * 2001-10-26 2003-07-31 Dey L.P. Albuterol inhalation soultion, system, kit and method for relieving symptoms of pediatric asthma
JP2003221335A (en) 2001-10-26 2003-08-05 Dey Lp Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptom of chronic obstructive pulmonary disease
US20030191151A1 (en) * 2001-10-26 2003-10-09 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US20030203930A1 (en) * 2001-10-26 2003-10-30 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US6702997B2 (en) 2001-10-26 2004-03-09 Dey, L.P. Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
EP1458354A1 (en) * 2001-12-21 2004-09-22 3M Innovative Properties Company Medicinal aerosol formulations comprising ion pair complexes
CA2470520A1 (en) * 2001-12-21 2003-07-24 3M Innovative Properties Company Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient
AU2002364594A1 (en) * 2001-12-21 2003-07-30 3M Innovative Properties Company Medicinal aerosol compositions with an amide and/or ester containing excipient compound
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
WO2003070194A2 (en) * 2002-02-20 2003-08-28 Sepracor Inc. Amino acid and peptide-modified forms of glucocorticoids
WO2003075977A2 (en) * 2002-03-05 2003-09-18 Cleveland State University Agglomerated particles for aerosol drug delivery
US20030199594A1 (en) * 2002-04-23 2003-10-23 Rasik Shah Helium propellant composition for use with aerosols
US20050203217A1 (en) * 2002-04-30 2005-09-15 Pomrink Gregory J. Stabilizers for polymerizable biocompatible materials
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
CN1292748C (en) * 2003-03-05 2007-01-03 南昌弘益科技有限公司 Timepidium bromide inhalant powders and their preparing process
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
DE10333317A1 (en) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulation for protein medicines without the addition of human serum albumin (HSA)
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0614621D0 (en) * 2006-07-24 2006-08-30 3M Innovative Properties Co Metered dose dispensers
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
US8278355B2 (en) 2006-09-12 2012-10-02 Therexcell Pharma Inc. Isovaline for treatment of pain
GB0620700D0 (en) * 2006-10-19 2006-11-29 3M Innovative Properties Co Metered dose valves and dispensers
WO2009002521A2 (en) * 2007-06-25 2008-12-31 Amgen Inc. Compositions of specific binding agents to hepatocyte growth factor
DE102008007198A1 (en) 2008-02-01 2009-08-13 Infectopharm Arzneimittel Und Consilium Gmbh Oral or nasally administrable formulations containing epinephrine with improved properties
US20120076859A1 (en) * 2010-09-23 2012-03-29 Activaero Gmbh Targeted Lung Delivery of Citrulline and/or Another Nitric Oxide Precursor and a Method for Treatment of Pulmonary Deficiency of Nitric Oxide in Cystic Fibrosis and Other Pulmonary Diseases
AR086745A1 (en) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-DIAMINO-6-CHLORINE-N- (N- (4- (4- (2- (HEXIL (2,3,4,5,6-PENTAHYDROXIHEXIL)) AMINO) ETOXI) PHENYL) BUTIL) CARBAMIMIDOIL) PIRAZINA -2-CARBOXAMIDE
GB201118188D0 (en) 2011-10-21 2011-12-07 3M Innovative Properties Co Manufacture of medicinal aerosol canisters
GB201210580D0 (en) 2012-06-14 2012-08-01 3M Innovative Properties Co Metered dose dispensing valve
GB201221063D0 (en) 2012-11-23 2013-01-09 3M Innovative Properties Co Metered dose dispensing valve
WO2014099673A1 (en) 2012-12-17 2014-06-26 Parion Sciences, Inc. 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
KR102258469B1 (en) 2012-12-17 2021-05-31 패리온 사이언스 인코퍼레이티드 Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
CN106138014A (en) * 2015-03-25 2016-11-23 天津金耀集团有限公司 A kind of aerosol drug compositions containing glucocorticoid
CN106137964A (en) * 2015-03-25 2016-11-23 天津金耀集团有限公司 A kind of aerosol drug compositions containing beclometasone
CN106137965A (en) * 2015-03-25 2016-11-23 天津金耀集团有限公司 A kind of aerosol drug composition containing ciclesonide
CN105534961B (en) * 2015-12-30 2019-06-04 孙红娟 Tobramycin inhalation solution and preparation method thereof
CN110302158B (en) * 2018-03-27 2023-01-17 天津金耀集团有限公司 Tiotropium bromide aerosol composition and preparation method thereof
CN110302184B (en) * 2018-03-27 2023-01-17 天津金耀集团有限公司 Application of lysine in quaternary ammonium salt M receptor antagonist aerosol
CN110302157B (en) * 2018-03-27 2023-01-17 天津金耀集团有限公司 Ipratropium bromide aerosol composition and preparation method thereof
CN110742875B (en) * 2018-07-05 2022-09-30 北京盈科瑞创新药物研究有限公司 Pirfenidone solution preparation for inhalation and preparation method and application thereof
CN110755414A (en) * 2019-11-12 2020-02-07 南京华盖制药有限公司 Arformoterol tartrate aerosol and preparation method thereof
GB2614901A (en) * 2022-01-21 2023-07-26 Nanopharm Ltd Inhalable formulations

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE555319A (en) * 1956-03-21 1900-01-01
US2885427A (en) * 1956-11-15 1959-05-05 Dow Chemical Co Fluorination of trichloroethylene
US3261748A (en) * 1964-07-17 1966-07-19 Dow Chemical Co 1,1,1,2-tetrafluoroethane anesthetic
NL7708731A (en) * 1976-08-13 1978-02-15 Montedison Spa PROCESS FOR THE PREPARATION OF NEW DRIVER COMPOSITIONS FOR AEROSOLS.
US4129603A (en) * 1978-02-07 1978-12-12 Imperial Chemical Industries Limited Manufacture of halogenated compounds
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
CA2050905A1 (en) * 1989-02-23 1990-08-24 George R. Felt Therapeutic aerosol formulations
US5439670A (en) * 1989-11-28 1995-08-08 Riker Laboratories, Inc. Medicinal aerosol formulations
GB9001635D0 (en) * 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
US5126123A (en) * 1990-06-28 1992-06-30 Glaxo, Inc. Aerosol drug formulations
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
DE69231994T3 (en) * 1991-06-10 2010-01-21 Schering Corp. Chlorofluorocarbon-free aerosol formulations
NZ244439A (en) * 1991-09-25 1994-01-26 Fisons Plc Pressurised aerosol compositions comprising hydrofluoroalkane, dispersed
US5674471A (en) * 1991-12-12 1997-10-07 Glaxo Group Limited Aerosol formulations containing P134a and salbutamol
US5658549A (en) * 1991-12-12 1997-08-19 Glaxo Group Limited Aerosol formulations containing propellant 134a and fluticasone propionate
IL104068A (en) * 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
US5653962A (en) * 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
US5744123A (en) * 1991-12-12 1998-04-28 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
GB9202522D0 (en) * 1992-02-06 1992-03-25 Glaxo Group Ltd Medicaments
US5736124A (en) * 1991-12-12 1998-04-07 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicament
GB9202519D0 (en) * 1992-02-06 1992-03-25 Glaxo Group Ltd Medicaments
NZ263686A (en) * 1993-03-17 1997-09-22 Minnesota Mining & Mfg Medicinal aerosol with dispersing aid derived from a hydroxy acid, an amino acid and/or a mercapto acid
PT731688E (en) * 1993-12-02 2003-07-31 Abbott Lab FORMULATIONS OF AEROSOL DRUGS FOR USE WITH CFC-FREE PROPULSORS
CN1069192C (en) * 1994-04-21 2001-08-08 王世立 Aerosol preparation and preparation method thereof
MX9704550A (en) * 1994-12-22 1997-10-31 Astra Ab Aerosol drug formulations.
US6136346A (en) * 1995-04-14 2000-10-24 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility

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DE69932835T2 (en) 2007-02-01
EP1123120B1 (en) 2006-08-16
EP1731140A2 (en) 2006-12-13
AU745554B2 (en) 2002-03-21
ATE336268T1 (en) 2006-09-15
WO2000016814A1 (en) 2000-03-30
US6136294A (en) 2000-10-24
CA2344816C (en) 2011-05-24
ATE505184T1 (en) 2011-04-15
HK1097777A1 (en) 2007-07-06
CN100337614C (en) 2007-09-19
EP1731140B1 (en) 2011-04-13
DK1123120T3 (en) 2006-10-02
EP1123120A4 (en) 2003-07-23
HK1041835A1 (en) 2002-07-26
ES2267288T3 (en) 2007-03-01
EP1123120A1 (en) 2001-08-16
DE69943360D1 (en) 2011-05-26
AU5926799A (en) 2000-04-10
US6136294C1 (en) 2002-09-24
JP2002526459A (en) 2002-08-20
DE69932835D1 (en) 2006-09-28
CN1328473A (en) 2001-12-26
EP1731140A3 (en) 2007-06-27
PT1123120E (en) 2006-10-31
CY1105538T1 (en) 2010-07-28

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