CA2347026A1 - Method for displacement chromatography - Google Patents

Method for displacement chromatography Download PDF

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Publication number
CA2347026A1
CA2347026A1 CA002347026A CA2347026A CA2347026A1 CA 2347026 A1 CA2347026 A1 CA 2347026A1 CA 002347026 A CA002347026 A CA 002347026A CA 2347026 A CA2347026 A CA 2347026A CA 2347026 A1 CA2347026 A1 CA 2347026A1
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CA
Canada
Prior art keywords
sample
bed
chromatography
stationary phase
components
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Granted
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CA002347026A
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French (fr)
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CA2347026C (en
Inventor
Erik Agner
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Individual
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Individual
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Publication of CA2347026A1 publication Critical patent/CA2347026A1/en
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Publication of CA2347026C publication Critical patent/CA2347026C/en
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Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Abstract

A method of sample displacement chromatography separation which comprises applying a multicomponent sample to one end of a chromatography bed comprising stationary phase material having affinity for components of the sample, causing components of the sample to become distributed along the chromatography bed by passage over the bed of a non-eluting mobile solvent phase, and recovering a desired component of the sample from at least a portion of the chromatography bed, in which the sample components are applied to the chromatography bed in a non-homogeneous manner such that the concentration of at least one component with relatively low affinity for the stationary phase material is enhanced during an earlier part of sample application and/or the concentration of at least one component with relatively high affinity for the stationary phase material is enhanced during a later part of sample application.
CA002347026A 1998-10-20 1999-10-20 Method for displacement chromatography Expired - Lifetime CA2347026C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9822963.6A GB9822963D0 (en) 1998-10-20 1998-10-20 Improvements in or relating to chromatography
GB9822963.6 1998-10-20
PCT/GB1999/003463 WO2000023798A1 (en) 1998-10-20 1999-10-20 Method for displacement chromatography

Publications (2)

Publication Number Publication Date
CA2347026A1 true CA2347026A1 (en) 2000-04-27
CA2347026C CA2347026C (en) 2007-12-18

Family

ID=10840955

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002347026A Expired - Lifetime CA2347026C (en) 1998-10-20 1999-10-20 Method for displacement chromatography

Country Status (9)

Country Link
US (1) US6576134B1 (en)
EP (1) EP1123505B1 (en)
JP (1) JP4424854B2 (en)
AT (1) ATE304702T1 (en)
AU (1) AU6352099A (en)
CA (1) CA2347026C (en)
DE (1) DE69927280T2 (en)
GB (1) GB9822963D0 (en)
WO (1) WO2000023798A1 (en)

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Also Published As

Publication number Publication date
DE69927280T2 (en) 2006-07-06
ATE304702T1 (en) 2005-09-15
US6576134B1 (en) 2003-06-10
CA2347026C (en) 2007-12-18
EP1123505A1 (en) 2001-08-16
WO2000023798A1 (en) 2000-04-27
AU6352099A (en) 2000-05-08
GB9822963D0 (en) 1998-12-16
EP1123505B1 (en) 2005-09-14
DE69927280D1 (en) 2005-10-20
JP4424854B2 (en) 2010-03-03
JP2002527773A (en) 2002-08-27

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