CA2347618A1 - Blood processing systems and methods with sensors to detect contamination - Google Patents
Blood processing systems and methods with sensors to detect contamination Download PDFInfo
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- CA2347618A1 CA2347618A1 CA002347618A CA2347618A CA2347618A1 CA 2347618 A1 CA2347618 A1 CA 2347618A1 CA 002347618 A CA002347618 A CA 002347618A CA 2347618 A CA2347618 A CA 2347618A CA 2347618 A1 CA2347618 A1 CA 2347618A1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/30—Control equipment
- B01D21/34—Controlling the feed distribution; Controlling the liquid level ; Control of process parameters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0236—Multiple bag systems for separating or storing blood components with sampling means, e.g. sample bag or sampling port
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36222—Details related to the interface between cassette and machine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36222—Details related to the interface between cassette and machine
- A61M1/362227—Details related to the interface between cassette and machine the interface providing means for actuating on functional elements of the cassette, e.g. plungers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362261—Constructional details of cassettes, e.g. specific details on material or shape at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362262—Details of incorporated reservoirs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362265—Details of valves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362266—Means for adding solutions or substances to the blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
- A61M1/3646—Expelling the residual body fluid after use, e.g. back to the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0217—Separation of non-miscible liquids by centrifugal force
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/2444—Discharge mechanisms for the classified liquid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/245—Discharge mechanisms for the sediments
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/30—Control equipment
- B01D21/302—Active control mechanisms with external energy, e.g. with solenoid valve
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
- A61M1/362263—Details of incorporated filters
- A61M1/362264—Details of incorporated filters the filter being a blood filter
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- A—HUMAN NECESSITIES
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- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
- A61M2205/125—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
- A61M2205/128—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated valves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
- A61M2205/3393—Masses, volumes, levels of fluids in reservoirs, flow rates by weighing the reservoir
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/08—Mobile separation devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
Abstract
Blood processing systems and methods employ two sensors (334, 336), one (334) to detect a condition of plasma exiting a separation device (18) and another sensor (336) to detect a condition of a cellular component exiting the separation device (18). The first sensor (334) detects, e.g., contamination of the plasma due to the presence of unwanted cellular components. The second sensor (336) detects, e.g., dilution of the cellular component due to presence of plasma. Blood processing parameters are carried out based, at least in part, by conditions detected by one or both of the sensors (334, 336).
Claims (31)
1. A blood separation system comprising a device which, in use, operates to separate whole blood into red blood cells and plasma, a whole blood inlet line to convey a flow of whole blood into the device, a plasma collection line outside the device to convey a flow of plasma from the device, a red blood cell collection line outside the device to convey a flow of red blood cells from the device, a first sensing assembly including a first sensor in the plasma collection line operating to detect presence of at least one species of cellular blood component in the flow of plasma and generating a first output, a second sensing assembly including a second sensor in the red blood cell collection line operating to detect red blood cell hematocrit in the flow of red blood cells and generating a second output, and a controller operating to control flows in the plasma collection line and the red blood cell collection line based upon the first and second outputs.
2. A system according to claim 1 wherein the plasma collection line includes a plasma pump operable to provide variable flow rates, and wherein the controller operates the plasma pump based upon the first and second outputs.
3. A system according to claim 1 wherein the whole blood inlet line includes a whole blood pump operable to provide variable flow rates, and wherein the controller operates the whole blood pump based upon the first and second outputs.
4. A system according to claim 1 wherein the first sensor operates to detect platelets in the flow of plasma.
5. A system according to claim 1 wherein the first sensor operates to detect red blood cells in the flow of plasma.
6. A system according to claim 1 wherein, during separation of the whole blood, a buffy coat layer forms between the plasma and the red blood cells, and wherein the first sensor operates to detect an interface between the buffy coat layer and the plasma.
7. A system according to claim 1 wherein, during separation of the whole blood, a buffy coat layer forms between the plasma and the red blood cells, and wherein the first sensor operates to detect an interface between the buffy coat layer and the red blood cells.
8. A system according to claim 1 wherein the first sensor assembly operates the first sensor to differentiate between platelets and red blood cells in the flow of plasma.
9. A system according to claim 1 wherein the controller includes an input for selecting either a first blood collection protocol to collect plasma or a second blood collection protocol to collect red blood cells, and wherein the first sensor assembly operates the first sensor to detect plateletsin the flow of plasma when the first blood collection protocol is selected and operates the first sensor to detect red blood cells in the flow of plasma when the second blood collection protocol is selected.
10. A system according to claim 1 wherein, during separation of the whole blood, a buffy coat layer forms between the plasma and the red blood cells, wherein the controller includes an input for selecting a blood collection protocol to collect the buffy coat layer, and wherein, when the first blood collection protocol is selected, the first sensor assembly operates the first sensor to detect an interface between the buffy coat layer and the plasma and an interface between the buffy coat layer and the red blood cells.
11. A system according to claim 1 wherein the device includes a separation chamber constructed and arranged for rotation about an axis and includes a low-G spaced from the axis and toward which the plasma flows during rotation, and a high-G wall spaced from the axis a greater distance than the low-G wall and toward which the red blood cells flow during rotation, wherein the plasma collection line collects plasma along the low-G wall, and wherein the red blood cell collection line collects red blood cells along the high-G wall.
12. A system according to claim 11 wherein the plasma collection line includes a plasma pump operable to provide variable flow rates, and wherein the controller operates the plasma pump based upon the first and second outputs.
13. A system according to claim 1 wherein the controller includes an input for selecting different blood collection protocols, and wherein the first sensor assembly operates the first sensor to detect different cellular blood components according to the blood collection protocol selected.
14. A blood separation system comprising a device for separating whole blood -into red blood cells and plasma, a sensing assembly outside the device including a first sensor to sense.a characteristic of plasma and a second sensor adjacent to the first sensor to sense a characteristic of red blood cells, and a fluid circuit coupled to the device and including a plasma collection tube for conveying a flow of plasma from the device, a red blood cell collection tube for conveying a flow of red blood cells from the device, and a fixture movable into.releasable engagement with the sensing assembly and including a holder to hold the plasma collection tube and the red blood cell collection tube in adjacent sensing alignment with, respectively, the first sensor and the second sensor.
15. A system according to claim 14 wherein the fluid circuit includes a whole blood inlet tube for conveying a flow of whole blood into the device, wherein the holder also holds the whole blood inlet tube, whereby the fixture serves to gather and hold the whole blood inlet tube, the plasma collection tube, and the red blood cell collection tube in a bundle.
16. A system according to claim 14 wherein the fixture comprises an integral part of the fluid circuit.
17. A system according to claim 14 wherein the fixture is separately fabricated part of the fluid circuit.
18. A system according to claim 14 wherein the fixture directs the plasma and red blood cell collection tubes through a bend without substantial kinking.
19. A system according to claim 14 wherein the fluid circuit includes an umbilicus adjacent to the fixture.
20. A system according to claim 14 wherein the first sensor includes an incident light source and an optical sensor, and wherein the fixture maintains a predetermined distance between the plasma collection tube and the incident light source.
21. A system according to claim 20 wherein the first sensor is free of a mirror or a focusing lens.
22. A system according to claim 20 wherein the plasma collection tubing comprises transparent flexible tubing that interfaces directly with the first sensor and is free of an optical cuvette.
23. A system according to claim 14 wherein the second sensor includes an incident light source and an optical sensor, and wherein the fixture maintains a predetermined distance between the red blood cell collection tube and the incident light source.
24. A system according to claim 23 wherein the second sensor is free of a mirror or a focusing lens.
25. A system according to claim 23 wherein the red blood cell collection tubing comprises transparent flexible tubing that interfaces directly with the second sensor and is free of an optical cuvette.
26. A system according to claim 14 wherein the plasma collection tubing comprises transparent flexible tubing.
27. A system according to claim 14 wherein the red blood cell collection tubing comprises transparent flexible tubing.
28. A system according to claim 14 wherein the device includes a separation chamber constructed and arranged for rotation about an axis and includes a low-G spaced from the axis and toward which the plasma flow during rotation, and a high-G wall spaced from the axis a greater distance than the low-G wall and toward which the red blood cells flow during rotation, wherein the plasma collection line collects plasma along the low-G wall, and wherein the red blood cell collection line collects red blood cells along the high-G wall.
29. A blood separation method comprising the steps of separating blood into red blood cells and plasma in a device, conveying a flow of plasma from the device while sensing to detect a specified cellular blood component in the flow of plasma, conveying a flow of red blood cells from the device while sensing to detect red blood cell hematocrit in the flow of red blood cells, controlling flows in the plasma collection line and the red blood cell collection line based upon the sensing.
30. A blood separation method comprising the steps of separating whole blood into red blood cells and plasma, conveying a flow of plasma from the device while sensing to detect a characteristic of plasma in the flow of plasma, conveying a flow of red blood cells from the device while sensing to detect a characteristic of red blood cells in the flow of red blood cells, and controlling flows in the plasma collection line and the red blood cell collection line based upon the sensing.
31. A blood separation method comprising the steps of separating blood into red blood cells and plasma in a device, conveying a flow of plasma from the device while sensing to detect a specified cellular blood component in the flow of plasma, conveying a flow of red blood cells from the device while sensing to detect red blood cell hematocrit in the flow of red blood cells, and controlling flows in the plasma collection line and the red blood cell collection line based upon the sensing.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/390,492 US6348156B1 (en) | 1999-09-03 | 1999-09-03 | Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma |
US09/390,492 | 1999-09-03 | ||
PCT/US2000/023697 WO2001017652A1 (en) | 1999-09-03 | 2000-08-29 | Blood processing systems and methods with sensors to detect contamination |
Publications (2)
Publication Number | Publication Date |
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CA2347618A1 true CA2347618A1 (en) | 2001-03-15 |
CA2347618C CA2347618C (en) | 2010-02-23 |
Family
ID=23542683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2347618A Expired - Lifetime CA2347618C (en) | 1999-09-03 | 2000-08-29 | Blood processing systems and methods with sensors to detect contamination |
Country Status (13)
Country | Link |
---|---|
US (1) | US6348156B1 (en) |
EP (2) | EP1707226B1 (en) |
JP (1) | JP4251263B2 (en) |
CN (1) | CN1251784C (en) |
AT (2) | ATE334708T1 (en) |
AU (1) | AU775852B2 (en) |
BR (1) | BR0007061A (en) |
CA (1) | CA2347618C (en) |
DE (2) | DE60037547T2 (en) |
ES (2) | ES2299137T3 (en) |
IL (1) | IL142693A0 (en) |
NO (1) | NO20012171L (en) |
WO (1) | WO2001017652A1 (en) |
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- 2000-08-29 ES ES06076325T patent/ES2299137T3/en not_active Expired - Lifetime
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- 2000-08-29 EP EP00961406A patent/EP1128887B1/en not_active Expired - Lifetime
- 2000-08-29 WO PCT/US2000/023697 patent/WO2001017652A1/en active IP Right Grant
- 2000-08-29 ES ES00961406T patent/ES2269177T3/en not_active Expired - Lifetime
- 2000-08-29 CA CA2347618A patent/CA2347618C/en not_active Expired - Lifetime
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CN1321107A (en) | 2001-11-07 |
US6348156B1 (en) | 2002-02-19 |
EP1128887A1 (en) | 2001-09-05 |
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WO2001017652A1 (en) | 2001-03-15 |
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EP1707226A1 (en) | 2006-10-04 |
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DE60029744D1 (en) | 2006-09-14 |
DE60029744T2 (en) | 2007-08-09 |
DE60037547T2 (en) | 2008-04-30 |
ATE334708T1 (en) | 2006-08-15 |
EP1128887A4 (en) | 2004-09-08 |
NO20012171L (en) | 2001-06-26 |
NO20012171D0 (en) | 2001-05-02 |
EP1128887B1 (en) | 2006-08-02 |
JP4251263B2 (en) | 2009-04-08 |
BR0007061A (en) | 2001-07-31 |
DE60037547D1 (en) | 2008-01-31 |
CN1251784C (en) | 2006-04-19 |
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