CA2360533A1 - Compositions comprising cyanoacrylates and an opacifying agent - Google Patents

Compositions comprising cyanoacrylates and an opacifying agent Download PDF

Info

Publication number
CA2360533A1
CA2360533A1 CA002360533A CA2360533A CA2360533A1 CA 2360533 A1 CA2360533 A1 CA 2360533A1 CA 002360533 A CA002360533 A CA 002360533A CA 2360533 A CA2360533 A CA 2360533A CA 2360533 A1 CA2360533 A1 CA 2360533A1
Authority
CA
Canada
Prior art keywords
composition
tissue
useful
space
cyanoacrylates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002360533A
Other languages
French (fr)
Other versions
CA2360533C (en
Inventor
Robert E. Krall
Charles W. Kerber
Kimberly Knox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker NV Operations Ltd
Stryker Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2360533A1 publication Critical patent/CA2360533A1/en
Application granted granted Critical
Publication of CA2360533C publication Critical patent/CA2360533C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/242—Gold; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J4/00—Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; adhesives, based on monomers of macromolecular compounds of groups C09J183/00 - C09J183/16

Abstract

A composition comprising of a monomer component comprised of an alkyl cyanoacrylate and at least one inhibitor, and a second component comprised of a resultant aggregate structure formed from an alkyl cyanoacrylate monomer, an alkyl esterified fatty acid and an opacificant agent where said composition forms a resultant aggregate structure when said composition contacts an anionic environment. The composition is useful for filling an existing space, e.g., the lumen of a blood vessel, a space created by a transiently placed external device, e.g., a catheter or like device, a space created by a procedure, e.g., an excision or implantation of an object, e.g., a stent. The composition is also useful for adhering tissue to tissue, or adhering tissue to a device.
The composition has the property of polymerizing when it comes in contact with an anionic environment, or when it is deployed in situ in an existing space.
CA002360533A 1999-01-29 2000-01-28 Compositions comprising cyanoacrylates and an opacifying agent Expired - Fee Related CA2360533C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/241,368 1999-01-29
US09/241,368 US6476069B2 (en) 1997-09-11 1999-01-29 Compositions for creating embolic agents and uses thereof
PCT/US2000/002262 WO2000044287A1 (en) 1999-01-29 2000-01-28 Cyanoacrylates comprising inhibitors and an opacifying agent as adhesives

Publications (2)

Publication Number Publication Date
CA2360533A1 true CA2360533A1 (en) 2000-08-03
CA2360533C CA2360533C (en) 2009-04-14

Family

ID=22910444

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002360533A Expired - Fee Related CA2360533C (en) 1999-01-29 2000-01-28 Compositions comprising cyanoacrylates and an opacifying agent

Country Status (9)

Country Link
US (1) US6476069B2 (en)
EP (1) EP1154723B1 (en)
JP (2) JP4317663B2 (en)
AT (1) ATE381290T1 (en)
AU (2) AU778078B2 (en)
CA (1) CA2360533C (en)
DE (1) DE60037500T2 (en)
ES (1) ES2296607T3 (en)
WO (1) WO2000044287A1 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037366A (en) 1997-09-11 2000-03-14 Prohold Medical Technologies, Inc. Composition for creating vascular occlusions
US6538026B1 (en) * 1997-09-11 2003-03-25 Provasis Therapeutics, Inc. Compositions useful for remodeling body spaces
US7687053B2 (en) * 2001-08-20 2010-03-30 Boston Scientific Scimed, Inc. Embolic compositions with non-cyanoacrylate rheology modifying agents
US6695769B2 (en) 2001-09-25 2004-02-24 The Foundry, Inc. Passive ventricular support devices and methods of using them
US7060023B2 (en) 2001-09-25 2006-06-13 The Foundry Inc. Pericardium reinforcing devices and methods of using them
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7341716B2 (en) * 2002-04-12 2008-03-11 Boston Scientific Scimed, Inc. Occlusive composition
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
WO2005006991A2 (en) * 2003-07-18 2005-01-27 Chiroxia Limited Device and method for fallopian tube occlusion
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20050090804A1 (en) * 2003-10-22 2005-04-28 Trivascular, Inc. Endoluminal prosthesis endoleak management
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US20050197421A1 (en) * 2004-03-03 2005-09-08 Loomis Gary L. Process for preparation of cyanoacrylate compositions
US20050228433A1 (en) * 2004-03-16 2005-10-13 Weenna Bucay-Couto In situ implant and method of forming same
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US20050287216A1 (en) * 2004-06-29 2005-12-29 Loomis Gary L Medical imaging agents for injectable compositions
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
CN1318099C (en) * 2005-07-29 2007-05-30 商菁华 Adhesive
US20070078207A1 (en) * 2005-09-30 2007-04-05 Jonn Jerry Y Stabilizer cyanoacrylate formulations
JP2007126632A (en) * 2005-10-06 2007-05-24 Taoka Chem Co Ltd 2-cyanoacrylate-based adhesive composition
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US8092819B2 (en) * 2006-01-27 2012-01-10 Cook Medical Technologies LLC. Implantable medical device coated with a bioactive agent
US20070185229A1 (en) 2006-02-08 2007-08-09 Bristol-Myers Squibb Company Formulation for improving skin adhesive effectiveness
US20070237720A1 (en) * 2006-04-06 2007-10-11 Orlando Padilla Embolic prosthesis for treatment of vascular aneurysm
US8603138B2 (en) * 2006-10-04 2013-12-10 Ethicon Endo-Surgery, Inc. Use of an adhesive to treat intraluminal bleeding
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
CN101917927A (en) * 2007-11-12 2010-12-15 维勒医学有限公司 The single vial formulation of medical grade cyanoacrylate
US20090137981A1 (en) * 2007-11-26 2009-05-28 Valor Medical Methods of treating a blood vessel
US20090246262A1 (en) * 2008-03-28 2009-10-01 Valor Medical, Inc. Easily applied field dressing for wounds
EP2326255B1 (en) 2008-05-19 2020-05-06 Anaesthetic Care Limited Varicose vein treatment
US8177809B2 (en) 2008-09-04 2012-05-15 Curaseal Inc. Inflatable device for enteric fistula treatment
US20100080791A1 (en) * 2008-09-26 2010-04-01 Rousseau Robert A Composition and Method For Treating Tissue Defects
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
DE102009012187A1 (en) * 2009-02-26 2010-09-02 Aesculap Aktiengesellschaft Medical adhesive composition
JP6122424B2 (en) 2011-06-16 2017-04-26 キュラシール インコーポレイテッド Device for fistula treatment and related method
JP6127042B2 (en) 2011-06-17 2017-05-10 キュラシール インコーポレイテッド Device and method for fistula treatment
EP3459469A1 (en) 2017-09-23 2019-03-27 Universität Zürich Medical occluder device
CN110964131B (en) 2018-09-29 2022-11-22 诺维新材有限公司 Polymer containing polyhydroxy group, preparation method and application thereof
IT201900010053A1 (en) * 2019-06-25 2020-12-25 Permabond Eng Adhesives Ltd COMPOSITIONS OF CYANOACRYLIC ADHESIVES WITH IMPROVED RESISTANCE TO HIGH TEMPERATURES
EP4033999A2 (en) 2019-09-26 2022-08-03 Universität Zürich Left atrial appendage occlusion devices
KR102530540B1 (en) * 2020-08-19 2023-05-09 서울대학교산학협력단 Novel cyanoacrylate derivatives and composition for embolic material including the same
WO2024006429A1 (en) * 2022-06-29 2024-01-04 University Of Kansas Shelf stable adhesive compositions

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3559652A (en) 1968-08-05 1971-02-02 Minnesota Mining & Mfg Method of adhesively repairing body tissue with alkoxyalkyl 2-cyanoacrylate
US3692752A (en) 1968-10-31 1972-09-19 Matsumoto Seiyaku Kogyo Kk Adhesive composition containing {60 -cyanoacrylate as its main ingredient
US3728375A (en) 1971-05-12 1973-04-17 Eastman Kodak Co Cyanoacrylate adhesive compositions
US3995641A (en) 1975-04-23 1976-12-07 Ethicon, Inc. Surgical adhesives
US4182823A (en) 1978-08-18 1980-01-08 National Starch And Chemical Corporation Anionic polymerization inhibitor for cyanoacrylate adhesives
US4328170A (en) 1978-11-02 1982-05-04 Matsumoto Seiyaku Kogyo Kabushiki Kaisha Process for preparing an α-cyanoacrylate
JPS5647471A (en) 1979-09-28 1981-04-30 Japan Synthetic Rubber Co Ltd Instantaneous adhesive composition
JPS5853676B2 (en) 1979-12-24 1983-11-30 東亞合成株式会社 adhesive composition
US4359454A (en) 1980-12-16 1982-11-16 World Health Organization Method and composition containing MCA for female sterilization
US4713235A (en) 1981-05-26 1987-12-15 Crx Medical, Inc. Radiopaque cyanoacrylates
US5403591A (en) 1993-06-25 1995-04-04 Medlogic Global Corporation Methods for inhibiting skin ulceration by use of cyanoacrylate adhesives
US5759194A (en) 1993-09-28 1998-06-02 Hemodynamics, Inc. Vascular patch applicator
TW359683B (en) 1993-12-23 1999-06-01 Loctite Ireland Ltd Sterilized cyanoacrylate adhesive composition, and a method of making such composition
US5795331A (en) 1994-01-24 1998-08-18 Micro Therapeutics, Inc. Balloon catheter for occluding aneurysms of branch vessels
US5703267A (en) 1995-03-27 1997-12-30 Toagosei Co., Ltd. Process for producing 2-cyanoacrylic acid
US5981621A (en) * 1996-02-29 1999-11-09 Closure Medical Corporation Monomeric compositions effective as wound closure devices
US5888546A (en) 1995-08-28 1999-03-30 The Regents Of The University Of California Embolic material for endovascular occlusion of abnormal vasculature and method for using the same
US5702361A (en) 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
US5695480A (en) * 1996-07-29 1997-12-09 Micro Therapeutics, Inc. Embolizing compositions
US6037366A (en) * 1997-09-11 2000-03-14 Prohold Medical Technologies, Inc. Composition for creating vascular occlusions
US6174919B1 (en) 1998-02-18 2001-01-16 Closure Medical Corporation Cyanoacrylate compositions with vinyl terminated ester groups

Also Published As

Publication number Publication date
EP1154723B1 (en) 2007-12-19
EP1154723A1 (en) 2001-11-21
DE60037500D1 (en) 2008-01-31
JP2002535065A (en) 2002-10-22
JP2009148627A (en) 2009-07-09
CA2360533C (en) 2009-04-14
AU2635400A (en) 2000-08-18
DE60037500T2 (en) 2008-12-24
ES2296607T3 (en) 2008-05-01
US6476069B2 (en) 2002-11-05
AU2005200245A1 (en) 2005-03-17
JP4317663B2 (en) 2009-08-19
ATE381290T1 (en) 2008-01-15
US20020098150A1 (en) 2002-07-25
WO2000044287A1 (en) 2000-08-03
AU778078B2 (en) 2004-11-11

Similar Documents

Publication Publication Date Title
CA2360533A1 (en) Compositions comprising cyanoacrylates and an opacifying agent
CA2175285A1 (en) Biodegradable moldable surgical material
MXPA04004665A (en) Catheter injectable depot compositions and uses thereof.
DE69929588D1 (en) Gynecological embolization and kit for it
CA2247906A1 (en) Monomeric compositions effective as wound closure devices
CA2299242A1 (en) A pressure sensitive adhesive composition
ATE290889T1 (en) ABSORBABLE ADHESIVE COMPOSITIONS
WO2003041684A3 (en) Injectable depot compositions and uses thereof
EP2374484A3 (en) Methods for embolizing blood vessels
HK1077735A1 (en) Injectable depot compositions and uses thereof
EP0937468A3 (en) Adhesive composition for surgical use application
CA2519946A1 (en) Temporary embolization using inverse thermosensitive polymers
WO2004045372A3 (en) Cohesive demineralized bone compositions
WO2002051383A3 (en) Controlled release of anti-arrhythmic agents from a biodegradable polyethylene oxide hydrogel for local application to the heart
DE60011403D1 (en) BIOADHESIVE COMPOSITIONS
AU2002364334A1 (en) Use of charged amphiphilic statistic polymers for thickening phases comprising giant micelles of surfactants and aqueous compositions comprising same
CA2358773A1 (en) Improved controlled release compositions and method
AU2001290060A1 (en) Catheter with hydrophilic coating comprising an anthraquinone
EP1637131A4 (en) Cataplasm base and cataplasm using the same
EP0773028A4 (en) Percutaneously absorbable preparation
WO2001003666A3 (en) Liquid based vaso-occlusive compositions
CA2346266A1 (en) Non-stick soft confectionery composition and methods of making the same
CA2260920A1 (en) Concentrated fabric softening composition and highly unsaturated fabric softener compound therefor
AU2002228711A1 (en) Hydroxy-alkanoic acid ester monomer compositions and methods of making same
AU659603B2 (en) Improved reaction systems and/or polymer compositions for contact with living body tissue

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140128