CA2363414A1 - Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method - Google Patents
Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method Download PDFInfo
- Publication number
- CA2363414A1 CA2363414A1 CA002363414A CA2363414A CA2363414A1 CA 2363414 A1 CA2363414 A1 CA 2363414A1 CA 002363414 A CA002363414 A CA 002363414A CA 2363414 A CA2363414 A CA 2363414A CA 2363414 A1 CA2363414 A1 CA 2363414A1
- Authority
- CA
- Canada
- Prior art keywords
- electrospray
- liquid chromatography
- separation
- channel
- dispensing nozzle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
- H01J49/167—Capillaries and nozzles specially adapted therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
- G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
- H01J49/0018—Microminiaturised spectrometers, e.g. chip-integrated devices, MicroElectro-Mechanical Systems [MEMS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Plasma & Fusion (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device (100) comprises a substrate (102) defining a channel (104) between an entrance orifice (106) on an injection surface (108) and an exit orifice on an ejection surface (112), a nozzle (110) defined by a portion recessed from the ejection surface (112) surrounding the exit orifice, and an electrode (122) for application of an electric potential to the substrate (102) to optimize and generate droplets or an electrospray (62). A plurality of these electrospray devices (100) can be used in the fonn of an array of miniaturized nozzles. The liquid chromatography-electrospray device (160) comprises a separation substrate (162) defining an introduction channel (164) between an entrance orifice and a reservoir (166) and a separation channel (168) between the reservoir (166) and an exit orifice (170), the separation channel (168) being populated with separation posts (174) perpendicular to the fluid flow.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12297299P | 1999-03-02 | 1999-03-02 | |
US60/122,972 | 1999-03-02 | ||
US09/468,535 | 1999-12-20 | ||
US09/468,535 US6633031B1 (en) | 1999-03-02 | 1999-12-20 | Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method |
PCT/US2000/005123 WO2000052455A1 (en) | 1999-03-02 | 2000-02-29 | Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2363414A1 true CA2363414A1 (en) | 2000-09-08 |
CA2363414C CA2363414C (en) | 2008-02-05 |
Family
ID=26821070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002363414A Expired - Fee Related CA2363414C (en) | 1999-03-02 | 2000-02-29 | Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method |
Country Status (6)
Country | Link |
---|---|
US (5) | US6633031B1 (en) |
EP (2) | EP2169398A1 (en) |
JP (1) | JP2002538461A (en) |
AU (1) | AU3506100A (en) |
CA (1) | CA2363414C (en) |
WO (1) | WO2000052455A1 (en) |
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-
1999
- 1999-12-20 US US09/468,535 patent/US6633031B1/en not_active Expired - Lifetime
-
2000
- 2000-02-29 AU AU35061/00A patent/AU3506100A/en not_active Abandoned
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- 2000-02-29 EP EP00913655A patent/EP1163512A4/en not_active Withdrawn
- 2000-02-29 WO PCT/US2000/005123 patent/WO2000052455A1/en active Application Filing
- 2000-02-29 CA CA002363414A patent/CA2363414C/en not_active Expired - Fee Related
- 2000-02-29 JP JP2000602620A patent/JP2002538461A/en active Pending
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US20040041093A1 (en) | 2004-03-04 |
AU3506100A (en) | 2000-09-21 |
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CA2363414C (en) | 2008-02-05 |
US6768107B2 (en) | 2004-07-27 |
EP2169398A1 (en) | 2010-03-31 |
JP2002538461A (en) | 2002-11-12 |
US6633031B1 (en) | 2003-10-14 |
US6822231B2 (en) | 2004-11-23 |
US20040016878A1 (en) | 2004-01-29 |
WO2000052455A1 (en) | 2000-09-08 |
US20050006502A1 (en) | 2005-01-13 |
EP1163512A4 (en) | 2007-08-08 |
EP1163512A1 (en) | 2001-12-19 |
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