CA2363414A1 - Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method - Google Patents

Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method Download PDF

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Publication number
CA2363414A1
CA2363414A1 CA002363414A CA2363414A CA2363414A1 CA 2363414 A1 CA2363414 A1 CA 2363414A1 CA 002363414 A CA002363414 A CA 002363414A CA 2363414 A CA2363414 A CA 2363414A CA 2363414 A1 CA2363414 A1 CA 2363414A1
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CA
Canada
Prior art keywords
electrospray
liquid chromatography
separation
channel
dispensing nozzle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002363414A
Other languages
French (fr)
Other versions
CA2363414C (en
Inventor
Gary A. Schultz
Thomas N. Corso
James E. Moon
Timothy J. Davis
Gregory J. Galvin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rheonix Inc
Advion Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Publication of CA2363414A1 publication Critical patent/CA2363414A1/en
Application granted granted Critical
Publication of CA2363414C publication Critical patent/CA2363414C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
    • H01J49/0018—Microminiaturised spectrometers, e.g. chip-integrated devices, MicroElectro-Mechanical Systems [MEMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

Abstract

A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device (100) comprises a substrate (102) defining a channel (104) between an entrance orifice (106) on an injection surface (108) and an exit orifice on an ejection surface (112), a nozzle (110) defined by a portion recessed from the ejection surface (112) surrounding the exit orifice, and an electrode (122) for application of an electric potential to the substrate (102) to optimize and generate droplets or an electrospray (62). A plurality of these electrospray devices (100) can be used in the fonn of an array of miniaturized nozzles. The liquid chromatography-electrospray device (160) comprises a separation substrate (162) defining an introduction channel (164) between an entrance orifice and a reservoir (166) and a separation channel (168) between the reservoir (166) and an exit orifice (170), the separation channel (168) being populated with separation posts (174) perpendicular to the fluid flow.
CA002363414A 1999-03-02 2000-02-29 Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method Expired - Fee Related CA2363414C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12297299P 1999-03-02 1999-03-02
US09/468,535 1999-12-20
US60/122,972 1999-12-20
US09/468,535 US6633031B1 (en) 1999-03-02 1999-12-20 Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
PCT/US2000/005123 WO2000052455A1 (en) 1999-03-02 2000-02-29 Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method

Publications (2)

Publication Number Publication Date
CA2363414A1 true CA2363414A1 (en) 2000-09-08
CA2363414C CA2363414C (en) 2008-02-05

Family

ID=26821070

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002363414A Expired - Fee Related CA2363414C (en) 1999-03-02 2000-02-29 Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method

Country Status (6)

Country Link
US (5) US6633031B1 (en)
EP (2) EP1163512A4 (en)
JP (1) JP2002538461A (en)
AU (1) AU3506100A (en)
CA (1) CA2363414C (en)
WO (1) WO2000052455A1 (en)

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US20030189167A1 (en) 2003-10-09
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US6768107B2 (en) 2004-07-27
US20040041093A1 (en) 2004-03-04
US6787766B2 (en) 2004-09-07
US6633031B1 (en) 2003-10-14
US6822231B2 (en) 2004-11-23
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AU3506100A (en) 2000-09-21
US20050006502A1 (en) 2005-01-13

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