CA2370539A1 - System and method for notating polymers - Google Patents
System and method for notating polymers Download PDFInfo
- Publication number
- CA2370539A1 CA2370539A1 CA002370539A CA2370539A CA2370539A1 CA 2370539 A1 CA2370539 A1 CA 2370539A1 CA 002370539 A CA002370539 A CA 002370539A CA 2370539 A CA2370539 A CA 2370539A CA 2370539 A1 CA2370539 A1 CA 2370539A1
- Authority
- CA
- Canada
- Prior art keywords
- polymer
- properties
- computer
- data structure
- chemical units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
- G16B50/30—Data warehousing; Computing architectures
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
- G16B50/40—Encryption of genetic data
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S707/00—Data processing: database and file management or data structures
- Y10S707/99931—Database or file accessing
- Y10S707/99933—Query processing, i.e. searching
- Y10S707/99936—Pattern matching access
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S707/00—Data processing: database and file management or data structures
- Y10S707/99941—Database schema or data structure
- Y10S707/99943—Generating database or data structure, e.g. via user interface
Abstract
A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. In one embodiment, the fields are capable of storing binary values.
The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. A computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence. The polymer is represented by a second data structure, tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the polymer. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction. The invention also involves a notational system referred to as Property Encoded Nomenclature.
The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. A computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence. The polymer is represented by a second data structure, tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the polymer. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction. The invention also involves a notational system referred to as Property Encoded Nomenclature.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2643162A CA2643162C (en) | 1999-04-23 | 2000-04-24 | Polymer identification, compositional analysis and sequencing, based on property comparison |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13074799P | 1999-04-23 | 1999-04-23 | |
US13079299P | 1999-04-23 | 1999-04-23 | |
US60/130,747 | 1999-04-23 | ||
US60/130,792 | 1999-04-23 | ||
US15994099P | 1999-10-14 | 1999-10-14 | |
US15993999P | 1999-10-14 | 1999-10-14 | |
US60/159,939 | 1999-10-14 | ||
US60/159,940 | 1999-10-14 | ||
PCT/US2000/010990 WO2000065521A2 (en) | 1999-04-23 | 2000-04-24 | System and method for polymer notation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2643162A Division CA2643162C (en) | 1999-04-23 | 2000-04-24 | Polymer identification, compositional analysis and sequencing, based on property comparison |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2370539A1 true CA2370539A1 (en) | 2000-11-02 |
CA2370539C CA2370539C (en) | 2009-01-06 |
Family
ID=27494876
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002370539A Expired - Lifetime CA2370539C (en) | 1999-04-23 | 2000-04-24 | System and method for notating polymers |
CA2643162A Expired - Lifetime CA2643162C (en) | 1999-04-23 | 2000-04-24 | Polymer identification, compositional analysis and sequencing, based on property comparison |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2643162A Expired - Lifetime CA2643162C (en) | 1999-04-23 | 2000-04-24 | Polymer identification, compositional analysis and sequencing, based on property comparison |
Country Status (5)
Country | Link |
---|---|
US (8) | US7412332B1 (en) |
EP (1) | EP1190364A2 (en) |
JP (1) | JP4824170B2 (en) |
CA (2) | CA2370539C (en) |
WO (1) | WO2000065521A2 (en) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
WO2000012726A2 (en) * | 1998-08-27 | 2000-03-09 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase i and ii |
CA2370539C (en) * | 1999-04-23 | 2009-01-06 | Massachusetts Institute Of Technology | System and method for notating polymers |
WO2001066772A2 (en) * | 2000-03-08 | 2001-09-13 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
DK1319183T3 (en) | 2000-09-12 | 2009-05-18 | Massachusetts Inst Technology | Methods and products related to low molecular weight heparin |
CA2423469A1 (en) * | 2000-10-18 | 2002-04-25 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
US7226739B2 (en) * | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
US20040214228A9 (en) * | 2001-09-14 | 2004-10-28 | Ganesh Venkataraman | Methods of evaluating glycomolecules for enhanced activities |
CA2459040A1 (en) * | 2001-09-14 | 2003-03-27 | Mimeon, Inc. | Methods of making glycolmolecules with enhanced activities and uses thereof |
WO2003078960A2 (en) | 2002-03-11 | 2003-09-25 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
EP1345167A1 (en) * | 2002-03-12 | 2003-09-17 | BRITISH TELECOMMUNICATIONS public limited company | Method of combinatorial multimodal optimisation |
WO2004069152A2 (en) * | 2002-05-03 | 2004-08-19 | Massachusetts Institute Of Technology | Δ4,5 glycuronidase and uses thereof |
CA2486456C (en) * | 2002-05-20 | 2012-07-17 | Massachusetts Institute Of Technology | Method for sequence determination using nmr |
DE60334220D1 (en) * | 2002-06-03 | 2010-10-28 | Massachusetts Inst Technology | Rationally Constructed Lyases Derived from Chondroitinase B. |
US20040147033A1 (en) * | 2002-12-20 | 2004-07-29 | Zachary Shriver | Glycan markers for diagnosing and monitoring disease |
JP4606712B2 (en) * | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | 2-O sulfatase compositions and related methods |
WO2005026720A1 (en) * | 2003-09-04 | 2005-03-24 | Parivid Llc | Methods and apparatus for characterizing polymeric mixtures |
US20050178959A1 (en) * | 2004-02-18 | 2005-08-18 | Viorica Lopez-Avila | Methods and compositions for assessing a sample by maldi mass spectrometry |
US7507570B2 (en) | 2004-03-10 | 2009-03-24 | Massachusetts Institute Of Technology | Recombinant chondroitinase ABC I and uses thereof |
US20060127950A1 (en) | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
US20060057638A1 (en) * | 2004-04-15 | 2006-03-16 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
EP1768687A2 (en) * | 2004-06-29 | 2007-04-04 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
US20060154894A1 (en) * | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
US20060264713A1 (en) * | 2005-05-20 | 2006-11-23 | Christoph Pedain | Disease and therapy dissemination representation |
GB0514552D0 (en) * | 2005-07-15 | 2005-08-24 | Nonlinear Dynamics Ltd | A method of analysing representations of separation patterns |
GB0514553D0 (en) * | 2005-07-15 | 2005-08-24 | Nonlinear Dynamics Ltd | A method of analysing a representation of a separation pattern |
US20070041979A1 (en) * | 2005-08-19 | 2007-02-22 | Raju T S | Proteolysis resistant antibody preparations |
US7767420B2 (en) | 2005-11-03 | 2010-08-03 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
WO2007120478A2 (en) * | 2006-04-03 | 2007-10-25 | Massachusetts Institute Of Technology | Glycomic patterns for the detection of disease |
US7756657B2 (en) * | 2006-11-14 | 2010-07-13 | Abb Inc. | System for storing and presenting sensor and spectrum data for batch processes |
US7301339B1 (en) * | 2006-12-26 | 2007-11-27 | Schlumberger Technology Corporation | Estimating the concentration of a substance in a sample using NMR |
WO2008085912A1 (en) | 2007-01-05 | 2008-07-17 | Massachusetts Institute Of Technology | Compositions of and methods of using sulfatases from flavobacterium heparinum |
US8069127B2 (en) * | 2007-04-26 | 2011-11-29 | 21 Ct, Inc. | Method and system for solving an optimization problem with dynamic constraints |
US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
CN101785003A (en) * | 2007-06-15 | 2010-07-21 | 新加坡科技研究局 | System and method for representing n-linked glycan structures |
US8093056B2 (en) * | 2007-06-29 | 2012-01-10 | Schlumberger Technology Corporation | Method and apparatus for analyzing a hydrocarbon mixture using nuclear magnetic resonance measurements |
US20100049445A1 (en) * | 2008-06-20 | 2010-02-25 | Eureka Genomics Corporation | Method and apparatus for sequencing data samples |
US8673267B2 (en) | 2009-03-02 | 2014-03-18 | Massachusetts Institute Of Technology | Methods and products for in vivo enzyme profiling |
US8063374B2 (en) * | 2009-09-22 | 2011-11-22 | California Polytechnic Corporation | Systems and methods for determining recycled thermoplastic content |
WO2011090948A1 (en) | 2010-01-19 | 2011-07-28 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
CA2794697A1 (en) | 2010-04-07 | 2011-10-13 | Momenta Pharmaceuticals, Inc. | High mannose glycans |
US20140166875A1 (en) | 2010-09-02 | 2014-06-19 | Wayne State University | Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry |
WO2012058248A2 (en) * | 2010-10-25 | 2012-05-03 | Wayne State University | Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum |
WO2012115952A1 (en) | 2011-02-21 | 2012-08-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
EP2686671A4 (en) | 2011-03-12 | 2015-06-24 | Momenta Pharmaceuticals Inc | N-acetylhexosamine-containing n-glycans in glycoprotein products |
EP2686000B1 (en) | 2011-03-15 | 2021-05-05 | Massachusetts Institute of Technology | Multiplexed detection with isotope-coded reporters |
WO2013177385A1 (en) | 2012-05-23 | 2013-11-28 | The Johns Hopkins University | Mass spectrometry imaging of glycans from tissue sections and improved analyte detection methods |
US9695244B2 (en) | 2012-06-01 | 2017-07-04 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab |
US10450361B2 (en) | 2013-03-15 | 2019-10-22 | Momenta Pharmaceuticals, Inc. | Methods related to CTLA4-Fc fusion proteins |
EP2996772B1 (en) | 2013-05-13 | 2018-12-19 | Momenta Pharmaceuticals, Inc. | Methods for the treatment of neurodegeneration |
EP3004374B1 (en) | 2013-06-07 | 2020-08-12 | Massachusetts Institute of Technology | Affinity-based detection of ligand-encoded synthetic biomarkers |
WO2015057622A1 (en) | 2013-10-16 | 2015-04-23 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
CN104572622B (en) * | 2015-01-05 | 2018-01-02 | 武汉传神信息技术有限公司 | A kind of screening technique of term |
US10381108B2 (en) * | 2015-09-16 | 2019-08-13 | Charles Jianping Zhou | Web search and information aggregation by way of molecular network |
US11448643B2 (en) | 2016-04-08 | 2022-09-20 | Massachusetts Institute Of Technology | Methods to specifically profile protease activity at lymph nodes |
EP3452407A4 (en) | 2016-05-05 | 2019-11-13 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
KR102115390B1 (en) * | 2016-07-26 | 2020-05-27 | 주식회사 엘지화학 | Method for measuring a modified ratio of a polymer |
WO2018187688A1 (en) | 2017-04-07 | 2018-10-11 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
DE102018000650A1 (en) * | 2018-01-27 | 2019-08-01 | Friedrich-Schiller-Universität Jena | Method for the determination of impurities in polyalkylene ethers or polyalkyleneamines and its use |
WO2019173332A1 (en) | 2018-03-05 | 2019-09-12 | Massachusetts Institute Of Technology | Inhalable nanosensors with volatile reporters and uses thereof |
US11835522B2 (en) | 2019-01-17 | 2023-12-05 | Massachusetts Institute Of Technology | Sensors for detecting and imaging of cancer metastasis |
US20230222313A1 (en) * | 2022-01-12 | 2023-07-13 | Dell Products L.P. | Polysaccharide archival storage |
Family Cites Families (129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4692435A (en) | 1978-11-06 | 1987-09-08 | Choay, S.A. | Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation |
SE449753B (en) | 1978-11-06 | 1987-05-18 | Choay Sa | MUCOPOLYSACCARIDE COMPOSITION WITH REGULATORY EFFECTS ON COAGULATION, MEDICINAL CONTAINING ITS SAME AND PROCEDURE FOR PREPARING THEREOF |
CA1136620A (en) | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
US4281108A (en) | 1980-01-28 | 1981-07-28 | Hepar Industries, Inc. | Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained |
US4443545A (en) | 1980-08-25 | 1984-04-17 | Massachusetts Institute Of Technology | Process for producing heparinase |
US4341869A (en) | 1980-08-25 | 1982-07-27 | Massachusetts Institute Of Technology | Process for producing heparinase |
US4373023A (en) | 1980-10-14 | 1983-02-08 | Massachusetts Institute Of Technology | Process for neutralizing heparin |
US4396762A (en) | 1981-08-24 | 1983-08-02 | Massachusetts Institute Of Technology | Heparinase derived anticoagulants |
DE3202894A1 (en) | 1982-01-29 | 1983-08-11 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Method for the determination of compounds containing tumour-associated glycoprotein, use of the method for cancer diagnosis and kit for use of the method |
US4551296A (en) * | 1982-03-19 | 1985-11-05 | Allied Corporation | Producing high tenacity, high modulus crystalline article such as fiber or film |
US4757056A (en) | 1984-03-05 | 1988-07-12 | Hepar Industries, Inc. | Method for tumor regression in rats, mice and hamsters using hexuronyl hexosaminoglycan-containing compositions |
US4679555A (en) | 1984-08-07 | 1987-07-14 | Key Pharmaceuticals, Inc. | Method and apparatus for intrapulmonary delivery of heparin |
US5106734A (en) | 1986-04-30 | 1992-04-21 | Novo Nordisk A/S | Process of using light absorption to control enzymatic depolymerization of heparin to produce low molecular weight heparin |
EP0245813B2 (en) | 1986-05-16 | 2000-03-22 | ITALFARMACO S.p.A. | EDTA-free heparins, heparin fractions and fragments, processes for their preparation and pharmaceutical compositions containing them |
US4784820A (en) | 1986-08-11 | 1988-11-15 | Allied-Signal Inc. | Preparation of solution of high molecular weight polymers |
US4942156A (en) | 1986-08-20 | 1990-07-17 | Hepar Industries, Inc. | Low molecular weight heparin derivatives having improved anti-Xa specificity |
US4745105A (en) | 1986-08-20 | 1988-05-17 | Griffin Charles C | Low molecular weight heparin derivatives with improved permeability |
US4830013A (en) | 1987-01-30 | 1989-05-16 | Minnesota Mining And Manufacturing Co. | Intravascular blood parameter measurement system |
FR2614026B1 (en) | 1987-04-16 | 1992-04-17 | Sanofi Sa | LOW MOLECULAR WEIGHT HEPARINS WITH REGULAR STRUCTURE, THEIR PREPARATION AND THEIR BIOLOGICAL APPLICATIONS |
SE8702254D0 (en) | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | NOVEL HEPARIN DERIVATIVES |
US5169772A (en) | 1988-06-06 | 1992-12-08 | Massachusetts Institute Of Technology | Large scale method for purification of high purity heparinase from flavobacterium heparinum |
IT1234508B (en) | 1988-06-10 | 1992-05-19 | Alfa Wassermann Spa | HEPARIN DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION |
US5204323B1 (en) | 1988-10-06 | 1995-07-18 | Ciba Geigy Corp | Hirudin antidotal compositions and methods |
GB8826448D0 (en) | 1988-11-11 | 1988-12-14 | Thrombosis Res Inst | Improvements in/relating to organic compounds |
US5776434A (en) | 1988-12-06 | 1998-07-07 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
CA1340966C (en) * | 1989-05-19 | 2000-04-18 | Thomas R. Covey | Method of protein analysis |
IT1237518B (en) | 1989-11-24 | 1993-06-08 | Renato Conti | SUPER-SULFATED HEPARINS |
GB8927546D0 (en) | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5152784A (en) | 1989-12-14 | 1992-10-06 | Regents Of The University Of Minnesota | Prosthetic devices coated with a polypeptide with type IV collagen activity |
FR2663639B1 (en) | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | LOW MOLECULAR WEIGHT POLYSACCHARIDE BLENDS PROCESS FOR PREPARATION AND USE. |
US5284558A (en) | 1990-07-27 | 1994-02-08 | University Of Iowa Research Foundation | Electrophoresis-based sequencing of oligosaccharides |
IT1245761B (en) | 1991-01-30 | 1994-10-14 | Alfa Wassermann Spa | PHARMACEUTICAL FORMULATIONS CONTAINING GLYCOSAMINOGLICANS ABSORBABLE ORALLY. |
JP3110064B2 (en) | 1991-03-06 | 2000-11-20 | 生化学工業株式会社 | Novel heparitinase, method for producing the same and bacteria producing the same |
US5262325A (en) | 1991-04-04 | 1993-11-16 | Ibex Technologies, Inc. | Method for the enzymatic neutralization of heparin |
SK120193A3 (en) | 1991-05-02 | 1994-07-06 | Yeda Res & Dev | Pharmaceutical composition for the prevention and/or treatment of pathological processes |
TR27248A (en) | 1991-06-13 | 1994-12-21 | Dow Italia | A method for preparing a polyurethane elastomer from a soft sectioned isocyanate end prepolymer. |
US5714376A (en) | 1991-10-23 | 1998-02-03 | Massachusetts Institute Of Technology | Heparinase gene from flavobacterium heparinum |
IT1254216B (en) | 1992-02-25 | 1995-09-14 | Opocrin Spa | POLYSACCHARIDIC DERIVATIVES OF HEPARIN, EPARAN SULPHATE, THEIR FRACTIONS AND FRAGMENTS, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US5453171A (en) | 1992-03-10 | 1995-09-26 | The Board Of Regents Of The University Of Michigan | Heparin-selective polymeric membrane electrode |
US5856928A (en) * | 1992-03-13 | 1999-01-05 | Yan; Johnson F. | Gene and protein representation, characterization and interpretation process |
GB9206291D0 (en) | 1992-03-23 | 1992-05-06 | Cancer Res Campaign Tech | Oligosaccharides having growth factor binding affinity |
US5389539A (en) | 1992-11-30 | 1995-02-14 | Massachusetts Institute Of Technology | Purification of heparinase I, II, and III from Flavobacterium heparinum |
US5696100A (en) | 1992-12-22 | 1997-12-09 | Glycomed Incorporated | Method for controlling O-desulfation of heparin and compositions produced thereby |
GB9306255D0 (en) | 1993-03-25 | 1993-05-19 | Cancer Res Campaign Tech | Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity |
FR2704861B1 (en) | 1993-05-07 | 1995-07-28 | Sanofi Elf | Purified heparin fractions, process for obtaining them and pharmaceutical compositions containing them. |
US5744155A (en) | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
WO1995013830A1 (en) | 1993-11-17 | 1995-05-26 | Massachusetts Institute Of Technology | Method for inhibiting angiogenesis using heparinase |
US6013628A (en) | 1994-02-28 | 2000-01-11 | Regents Of The University Of Minnesota | Method for treating conditions of the eye using polypeptides |
US5607859A (en) | 1994-03-28 | 1997-03-04 | Massachusetts Institute Of Technology | Methods and products for mass spectrometric molecular weight determination of polyionic analytes employing polyionic reagents |
US5658749A (en) | 1994-04-05 | 1997-08-19 | Corning Clinical Laboratories, Inc. | Method for processing mycobacteria |
US5753445A (en) | 1994-04-26 | 1998-05-19 | The Mount Sinai Medical Center Of The City University Of New York | Test for the detection of anti-heparin antibodies |
WO1995030424A1 (en) | 1994-05-06 | 1995-11-16 | Glycomed Incorporated | O-desulfated heparin derivatives, methods of making and uses thereof |
US5681733A (en) | 1994-06-10 | 1997-10-28 | Ibex Technologies | Nucleic acid sequences and expression systems for heparinase II and heparinase III derived from Flavobacterium heparinum |
US5619421A (en) | 1994-06-17 | 1997-04-08 | Massachusetts Institute Of Technology | Computer-implemented process and computer system for estimating the three-dimensional shape of a ring-shaped molecule and of a portion of a molecule containing a ring-shaped structure |
US5997863A (en) | 1994-07-08 | 1999-12-07 | Ibex Technologies R And D, Inc. | Attenuation of wound healing processes |
US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
FR2723847A1 (en) | 1994-08-29 | 1996-03-01 | Debiopharm Sa | HEPARIN - BASED ANTITHROMBOTIC AND NON - HEMORRHAGIC COMPOSITIONS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATIONS. |
US5687090A (en) | 1994-09-01 | 1997-11-11 | Aspen Technology, Inc. | Polymer component characterization method and process simulation apparatus |
EP0785774B1 (en) | 1994-10-12 | 2001-01-31 | Focal, Inc. | Targeted delivery via biodegradable polymers |
JP2927401B2 (en) * | 1994-12-28 | 1999-07-28 | 日本ビクター株式会社 | Helical scan type information recording device |
US5569366A (en) | 1995-01-27 | 1996-10-29 | Beckman Instruments, Inc. | Fluorescent labelled carbohydrates and their analysis |
US5618917A (en) | 1995-02-15 | 1997-04-08 | Arch Development Corporation | Methods and compositions for detecting and treating kidney diseases associated with adhesion of crystals to kidney cells |
US5763427A (en) | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5597811A (en) | 1995-04-10 | 1997-01-28 | Amerchol Corporation | Oxirane carboxylic acid derivatives of polyglucosamines |
DE69634013T2 (en) | 1995-05-26 | 2005-12-15 | SurModics, Inc., Eden Prairie | PROCESS AND IMPLANTABLE OBJECT FOR PROMOTING ENDOTHELIALIZATION |
US5824299A (en) | 1995-06-22 | 1998-10-20 | President & Fellows Of Harvard College | Modulation of endothelial cell proliferation with IP-10 |
US5770420A (en) * | 1995-09-08 | 1998-06-23 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
CA2235223A1 (en) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase i |
US5752019A (en) | 1995-12-22 | 1998-05-12 | International Business Machines Corporation | System and method for confirmationally-flexible molecular identification |
DE69724420T2 (en) | 1996-04-29 | 2004-06-09 | Quadrant Technologies Ltd. | METHOD FOR INHALING DRY POWDER |
US6228654B1 (en) | 1996-05-09 | 2001-05-08 | The Scripps Research Institute | Methods for structure analysis of oligosaccharides |
US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
AU727352B2 (en) | 1996-07-29 | 2000-12-14 | Paringenix, Inc. | Methods of treating asthma with o-desulfated heparin |
ES2317657T3 (en) | 1996-09-19 | 2009-04-16 | The Regents Of The University Of Michigan | POLYMERS CONTAINING POLYSACARIDS SUCH AS ALGINATES OR MODIFIED ALGINATES. |
US5767269A (en) | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
US5803726A (en) * | 1996-10-04 | 1998-09-08 | Bacon; David W. | Retractable, electric arc-ignited gas pilot for igniting flare stacks |
US5759767A (en) | 1996-10-11 | 1998-06-02 | Joseph R. Lakowicz | Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids |
US6642360B2 (en) * | 1997-12-03 | 2003-11-04 | Genentech, Inc. | Secreted polypeptides that stimulate release of proteoglycans from cartilage |
GB9708278D0 (en) | 1997-04-24 | 1997-06-18 | Danisco | Composition |
US5968822A (en) | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
US6190875B1 (en) | 1997-09-02 | 2001-02-20 | Insight Strategy & Marketing Ltd. | Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe |
US6268146B1 (en) | 1998-03-13 | 2001-07-31 | Promega Corporation | Analytical methods and materials for nucleic acid detection |
US6190522B1 (en) | 1998-04-24 | 2001-02-20 | Board Of Regents, The University Of Texas System | Analysis of carbohydrates derivatized with visible dye by high-resolution polyacrylamide gel electrophoresis |
AU4707899A (en) * | 1998-06-23 | 2000-01-10 | Pioneer Hi-Bred International, Inc. | Alteration of hemicellulose concentration in plants by rgp |
US5985576A (en) * | 1998-06-30 | 1999-11-16 | The United States Of America As Represented By The Secretary Of Agriculture | Species-specific genetic identification of Mycobacterium paratuberculosis |
US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
WO2000012726A2 (en) | 1998-08-27 | 2000-03-09 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase i and ii |
AU5585599A (en) | 1998-08-31 | 2000-03-21 | University Of Washington | Stable isotope metabolic labeling for analysis of biopolymers |
US6291439B1 (en) | 1998-09-02 | 2001-09-18 | Biomarin Pharmaceuticals | Methods for diagnosing atherosclerosis by measuring endogenous heparin and methods for treating atherosclerosis using heparin |
US6333051B1 (en) * | 1998-09-03 | 2001-12-25 | Supratek Pharma, Inc. | Nanogel networks and biological agent compositions thereof |
US6440705B1 (en) | 1998-10-01 | 2002-08-27 | Vincent P. Stanton, Jr. | Method for analyzing polynucleotides |
US6610484B1 (en) | 1999-01-26 | 2003-08-26 | Cytyc Health Corporation | Identifying material from a breast duct |
US6429302B1 (en) | 1999-02-02 | 2002-08-06 | Chiron Corporation | Polynucleotides related to pancreatic disease |
CA2370539C (en) * | 1999-04-23 | 2009-01-06 | Massachusetts Institute Of Technology | System and method for notating polymers |
JP3689842B2 (en) | 1999-05-28 | 2005-08-31 | 株式会社J−オイルミルズ | Monosaccharide analysis method for sugar composition |
CN1195909C (en) | 2000-02-16 | 2005-04-06 | 帝人株式会社 | Meta-form wholly aromatic polyamide fiber and process for producing same |
WO2001066772A2 (en) * | 2000-03-08 | 2001-09-13 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
DK1319183T3 (en) * | 2000-09-12 | 2009-05-18 | Massachusetts Inst Technology | Methods and products related to low molecular weight heparin |
CA2423469A1 (en) * | 2000-10-18 | 2002-04-25 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
IL155518A0 (en) | 2000-10-19 | 2003-11-23 | Target Discovery Inc | Mass defect labeling for the determination of oligomer sequences |
JP2005503120A (en) * | 2001-03-27 | 2005-02-03 | マサチューセッツ インスティテュート オブ テクノロジー | Methods and products for FGF dimerization |
AU2002312146A1 (en) | 2001-05-30 | 2002-12-09 | Triad Therapeutics, Inc. | Nuclear magnetic resonance-docking of compounds |
US6766817B2 (en) * | 2001-07-25 | 2004-07-27 | Tubarc Technologies, Llc | Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action |
CA2459040A1 (en) | 2001-09-14 | 2003-03-27 | Mimeon, Inc. | Methods of making glycolmolecules with enhanced activities and uses thereof |
US20040214228A9 (en) | 2001-09-14 | 2004-10-28 | Ganesh Venkataraman | Methods of evaluating glycomolecules for enhanced activities |
US7363168B2 (en) * | 2001-10-02 | 2008-04-22 | Stratagene California | Adaptive baseline algorithm for quantitative PCR |
WO2003078960A2 (en) | 2002-03-11 | 2003-09-25 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
US20040087543A1 (en) | 2002-04-25 | 2004-05-06 | Zachary Shriver | Methods and products for mucosal delivery |
WO2004069152A2 (en) * | 2002-05-03 | 2004-08-19 | Massachusetts Institute Of Technology | Δ4,5 glycuronidase and uses thereof |
CA2486456C (en) * | 2002-05-20 | 2012-07-17 | Massachusetts Institute Of Technology | Method for sequence determination using nmr |
DE60334220D1 (en) | 2002-06-03 | 2010-10-28 | Massachusetts Inst Technology | Rationally Constructed Lyases Derived from Chondroitinase B. |
US20040147033A1 (en) | 2002-12-20 | 2004-07-29 | Zachary Shriver | Glycan markers for diagnosing and monitoring disease |
JP4606712B2 (en) * | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | 2-O sulfatase compositions and related methods |
WO2005026720A1 (en) | 2003-09-04 | 2005-03-24 | Parivid Llc | Methods and apparatus for characterizing polymeric mixtures |
US7851223B2 (en) | 2004-02-27 | 2010-12-14 | Roar Holding Llc | Method to detect emphysema |
US7507570B2 (en) * | 2004-03-10 | 2009-03-24 | Massachusetts Institute Of Technology | Recombinant chondroitinase ABC I and uses thereof |
US20060057638A1 (en) * | 2004-04-15 | 2006-03-16 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
US20060127950A1 (en) * | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
WO2005110438A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
EP1768687A2 (en) * | 2004-06-29 | 2007-04-04 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
US20060154894A1 (en) * | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
US20070020243A1 (en) * | 2005-01-12 | 2007-01-25 | Massachusetts Institute Of Technology | Methods and compositions related to modulating the extracellular stem cell environment |
WO2006105315A2 (en) * | 2005-03-29 | 2006-10-05 | Massachusetts Institute Of Technology | Compositions and methods for regulating inflammatory responses |
US20090105463A1 (en) * | 2005-03-29 | 2009-04-23 | Massachusetts Institute Of Technology | Compositions of and Methods of Using Oversulfated Glycosaminoglycans |
AU2006262145B2 (en) * | 2005-06-22 | 2011-09-01 | Gen-Probe Incorporated | Method and algorithm for quantifying polynucleotides |
WO2007120478A2 (en) * | 2006-04-03 | 2007-10-25 | Massachusetts Institute Of Technology | Glycomic patterns for the detection of disease |
-
2000
- 2000-04-24 CA CA002370539A patent/CA2370539C/en not_active Expired - Lifetime
- 2000-04-24 JP JP2000614193A patent/JP4824170B2/en not_active Expired - Lifetime
- 2000-04-24 US US09/557,997 patent/US7412332B1/en not_active Expired - Lifetime
- 2000-04-24 US US09/558,137 patent/US6597996B1/en not_active Expired - Lifetime
- 2000-04-24 WO PCT/US2000/010990 patent/WO2000065521A2/en active Application Filing
- 2000-04-24 CA CA2643162A patent/CA2643162C/en not_active Expired - Lifetime
- 2000-04-24 EP EP00923599A patent/EP1190364A2/en not_active Withdrawn
-
2003
- 2003-01-31 US US10/356,349 patent/US7139666B2/en not_active Expired - Lifetime
-
2004
- 2004-01-16 US US10/760,133 patent/US7110889B2/en not_active Expired - Lifetime
- 2004-01-16 US US10/759,520 patent/US7117100B2/en not_active Expired - Lifetime
-
2006
- 2006-09-08 US US11/518,394 patent/US20070066769A1/en not_active Abandoned
-
2008
- 2008-06-04 US US12/133,334 patent/US20080301178A1/en not_active Abandoned
- 2008-10-29 US US12/260,992 patent/US20090119027A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030191587A1 (en) | 2003-10-09 |
WO2000065521A3 (en) | 2001-10-25 |
US20080301178A1 (en) | 2008-12-04 |
CA2643162A1 (en) | 2000-11-02 |
CA2370539C (en) | 2009-01-06 |
US20040204869A1 (en) | 2004-10-14 |
US7139666B2 (en) | 2006-11-21 |
US20040197933A1 (en) | 2004-10-07 |
JP2002543222A (en) | 2002-12-17 |
JP4824170B2 (en) | 2011-11-30 |
CA2643162C (en) | 2018-01-02 |
US7117100B2 (en) | 2006-10-03 |
US7412332B1 (en) | 2008-08-12 |
US6597996B1 (en) | 2003-07-22 |
US7110889B2 (en) | 2006-09-19 |
US20070066769A1 (en) | 2007-03-22 |
WO2000065521A2 (en) | 2000-11-02 |
US20090119027A1 (en) | 2009-05-07 |
EP1190364A2 (en) | 2002-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2370539A1 (en) | System and method for notating polymers | |
JP3059196B2 (en) | Code marking method for valuables and equipment | |
CN1242615C (en) | Digital watermarking for multimedia data | |
CA2285511A1 (en) | Improved polycarboxy/polyol fiberglass binder of low ph | |
EP0690375A3 (en) | Persistent object-mapping in an object-oriented environment | |
EP1698970A3 (en) | Method and system for encoding metadata | |
WO2001080088A8 (en) | Method of searching and producing matching color information | |
PT1012564E (en) | METHOD OF PRODUCTION OF HIGH DENSITY ARRANGEMENTS | |
EP1962209A3 (en) | Systems and methods for searching and storage of data | |
CA2273078A1 (en) | Use of nucleic acids bound to carrier macromolecules | |
WO2005057468A3 (en) | System and method for robust reversible data hiding and data recovery in the spatial domain | |
DE3484532D1 (en) | METHOD FOR CARRYING OUT CHEMICAL REACTIONS, ESPECIALLY FOR THE PRODUCTION OF PLASTICS WITH THE AID OF EXTRUDERS, AND SYSTEM FOR THAT. | |
CA2316190A1 (en) | Biodegradable shape memory polymers | |
WO2002067145A3 (en) | Information retrieval system | |
EP0239044A3 (en) | Method of preparing high strength and modulus poly (vinyl alcohol) fibers | |
WO2004015515A3 (en) | System and method for authentication | |
WO2004061600A3 (en) | Methods for managing a pool of multicast addresses and allocating addresses in a communications system | |
WO2002045323A3 (en) | Data relationship model | |
WO2004015629A3 (en) | Identification of digital data sequences | |
CA2298275A1 (en) | Method for processing network messages | |
CA2470158A1 (en) | Electronic ink processing | |
DE69726072D1 (en) | Latex with two grain sizes made of vinyl chloride polymers, process for their production and their uses | |
EP0834885A3 (en) | Method for producing soluble conductive polymers having acidic groups | |
DE59908671D1 (en) | METHOD FOR PRODUCING A POLYMERIC NETWORK | |
ATE263977T1 (en) | METHOD FOR SEISMIC DATA PROCESSING |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20200424 |