CA2372688A1 - Device and method for infusion of small molecule insulin mimetic materials - Google Patents

Device and method for infusion of small molecule insulin mimetic materials Download PDF

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Publication number
CA2372688A1
CA2372688A1 CA002372688A CA2372688A CA2372688A1 CA 2372688 A1 CA2372688 A1 CA 2372688A1 CA 002372688 A CA002372688 A CA 002372688A CA 2372688 A CA2372688 A CA 2372688A CA 2372688 A1 CA2372688 A1 CA 2372688A1
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CA
Canada
Prior art keywords
small molecule
insulin
mimetic material
insulin mimetic
driving mechanism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002372688A
Other languages
French (fr)
Other versions
CA2372688C (en
Inventor
William P. Van Antwerp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Minimed Inc
Original Assignee
Minimed, Inc.
William P. Van Antwerp
Medtronic Minimed, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minimed, Inc., William P. Van Antwerp, Medtronic Minimed, Inc. filed Critical Minimed, Inc.
Publication of CA2372688A1 publication Critical patent/CA2372688A1/en
Application granted granted Critical
Publication of CA2372688C publication Critical patent/CA2372688C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Abstract

A medication delivery device for delivering a small molecule insulin mimetic material to a body of an individual includes a housing, a reservoir and a controller. The housing contains a driving mechanism, and the reservoir is coupled to the driving mechanism in the housing for holding the small molecule insulin mimetic material to be infused into the body of the individual. The controller controls the driving mechanism to expel the small molecule insulin mimetic material from the reservoir into the body of the individual. Preferably, the medication delivery device is an infusion pump. In particular, the driving mechanism is a syringe type drive actuator, or a gas generator. The driving mechanism may also utilize iontophoresis or passive trans-dermal delivery. In addition, the driving mechanism is controlled to infuse the small molecule insulin mimetic material in a continuous, near-continuous, intermittent and pulsatile manner. The driving mechanism may also be controlled to deliver discrete, user settable boluses.
Preferably, the small molecule insulin mimetic material is L-783,281. Also, the small molecule insulin mimetic material may be an analog of L-783,281.
In addition, the small molecule insulin mimetic material may be infused with at least one additional component such as insulin, insulin analogs and insulin related peptides. Preferably, the small molecule insulin mimetic material binds to .beta. sub-units of an insulin receptor site. However, the small molecule insulin mimetic material may bind to .alpha. sub-units of an insulin receptor site. Alternatively, the small molecule insulin mimetic material is a trans-membrane insulin mimetic material that binds to at least one .beta.
sub-unit and at least one .alpha. sub-unit of an insulin receptor site.
CA002372688A 1999-05-21 2000-05-10 Device and method for infusion of small molecule insulin mimetic materials Expired - Fee Related CA2372688C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13527899P 1999-05-21 1999-05-21
US60/135,278 1999-05-21
US09/566,877 US6461331B1 (en) 1999-05-21 2000-05-08 Device and method for infusion of small molecule insulin mimetic materials
US09/566,877 2000-05-08
PCT/US2000/012744 WO2000071188A1 (en) 1999-05-21 2000-05-10 Device and method for infusion of small molecule insulin mimetic materials

Publications (2)

Publication Number Publication Date
CA2372688A1 true CA2372688A1 (en) 2000-11-30
CA2372688C CA2372688C (en) 2006-10-31

Family

ID=26833159

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002372688A Expired - Fee Related CA2372688C (en) 1999-05-21 2000-05-10 Device and method for infusion of small molecule insulin mimetic materials

Country Status (6)

Country Link
US (1) US6461331B1 (en)
EP (1) EP1181066A1 (en)
JP (1) JP2003500119A (en)
AU (1) AU4998500A (en)
CA (1) CA2372688C (en)
WO (1) WO2000071188A1 (en)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6554798B1 (en) * 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
JP4681795B2 (en) 2001-05-18 2011-05-11 デカ・プロダクツ・リミテッド・パートナーシップ Fluid pump infusion set
US8034026B2 (en) 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
US7278983B2 (en) 2002-07-24 2007-10-09 Medtronic Minimed, Inc. Physiological monitoring device for controlling a medication infusion device
US20040068230A1 (en) 2002-07-24 2004-04-08 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
WO2004009160A1 (en) 2002-07-24 2004-01-29 M 2 Medical A/S An infusion pump system, an infusion pump unit and an infusion pump
WO2004041330A2 (en) 2002-11-05 2004-05-21 M 2 Medical A/S A disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device
EP1583571B1 (en) 2002-12-23 2008-02-13 M2 Medical A/S Medical dispensing device for insulin
AU2003291963A1 (en) 2002-12-23 2004-07-14 M 2 Medical A/S Flexible piston rod
US7655618B2 (en) 2002-12-27 2010-02-02 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
NZ541365A (en) * 2002-12-27 2009-09-25 Diobex Inc Compositions and methods for the prevention and control of insulin-induced hypoglycemia
CA2523267C (en) 2003-04-23 2013-09-03 Biovalve Technologies, Inc. Hydraulically actuated pump for long duration medicament administration
IL157984A (en) 2003-09-17 2015-02-26 Dali Medical Devices Ltd Autoneedle
IL157981A (en) 2003-09-17 2014-01-30 Elcam Medical Agricultural Cooperative Ass Ltd Auto-injector
WO2005072794A2 (en) 2004-01-29 2005-08-11 M 2 Medical A/S Disposable medicine dispensing device
IL160891A0 (en) 2004-03-16 2004-08-31 Auto-mix needle
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
US7291107B2 (en) * 2004-08-26 2007-11-06 Roche Diagnostics Operations, Inc. Insulin bolus recommendation system
US7869851B2 (en) * 2004-12-23 2011-01-11 Roche Diagnostics Operations, Inc. System and method for determining insulin bolus quantities
WO2006105792A1 (en) 2005-04-06 2006-10-12 M 2 Medical A/S Method and device for dispensing liquid medicine by means of a reversible electrical motor
US8551046B2 (en) 2006-09-18 2013-10-08 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US7794427B2 (en) 2005-09-26 2010-09-14 Asante Solutions, Inc. Operating an infusion pump system
US8057436B2 (en) 2005-09-26 2011-11-15 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8409142B2 (en) 2005-09-26 2013-04-02 Asante Solutions, Inc. Operating an infusion pump system
US8105279B2 (en) 2005-09-26 2012-01-31 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
US7534226B2 (en) 2005-09-26 2009-05-19 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
US8852164B2 (en) 2006-02-09 2014-10-07 Deka Products Limited Partnership Method and system for shape-memory alloy wire control
US20070088442A1 (en) * 2005-10-14 2007-04-19 Microchips, Inc. Passive wear-indicating sensor for implantable prosthetic device
ATE439155T1 (en) 2005-11-08 2009-08-15 M2 Medical As INFUSION PUMP SYSTEM
EP3064236B1 (en) 2005-11-08 2020-02-05 Bigfoot Biomedical, Inc. Method and system for manual and autonomous control of an infusion pump
US11364335B2 (en) 2006-02-09 2022-06-21 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
DE602007013723D1 (en) 2006-02-09 2011-05-19 Deka Products Lp SYSTEMS FOR DISPENSING FLUIDS IN PATCH SIZE
US11478623B2 (en) 2006-02-09 2022-10-25 Deka Products Limited Partnership Infusion pump assembly
US11497846B2 (en) 2006-02-09 2022-11-15 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
CN103239773B (en) 2006-03-30 2015-08-26 瓦莱里塔斯公司 Multi-cartridge fluid delivery device
CN101489603A (en) * 2006-06-30 2009-07-22 诺沃-诺迪斯克有限公司 Perfusion device with compensation of medical infusion during wear-time
US8202267B2 (en) 2006-10-10 2012-06-19 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US7794426B2 (en) 2007-05-21 2010-09-14 Asante Solutions, Inc. Infusion pump system with contamination-resistant features
US7892199B2 (en) 2007-05-21 2011-02-22 Asante Solutions, Inc. Occlusion sensing for an infusion pump
US7981102B2 (en) 2007-05-21 2011-07-19 Asante Solutions, Inc. Removable controller for an infusion pump
US7833196B2 (en) 2007-05-21 2010-11-16 Asante Solutions, Inc. Illumination instrument for an infusion pump
WO2008154416A2 (en) * 2007-06-07 2008-12-18 Microchips, Inc. Electrochemical biosensors and arrays
WO2009032553A2 (en) * 2007-08-31 2009-03-12 Leon Dejournett Catheter and computerized system for intravenous blood chemistry monitoring
US7717903B2 (en) 2007-09-06 2010-05-18 M2 Group Holdings, Inc. Operating an infusion pump system
US7828528B2 (en) 2007-09-06 2010-11-09 Asante Solutions, Inc. Occlusion sensing system for infusion pumps
US7879026B2 (en) 2007-09-07 2011-02-01 Asante Solutions, Inc. Controlled adjustment of medicine dispensation from an infusion pump device
US7935105B2 (en) 2007-09-07 2011-05-03 Asante Solutions, Inc. Data storage for an infusion pump system
US8287514B2 (en) 2007-09-07 2012-10-16 Asante Solutions, Inc. Power management techniques for an infusion pump system
US7935076B2 (en) 2007-09-07 2011-05-03 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
US10188787B2 (en) 2007-12-31 2019-01-29 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US10080704B2 (en) 2007-12-31 2018-09-25 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US8881774B2 (en) 2007-12-31 2014-11-11 Deka Research & Development Corp. Apparatus, system and method for fluid delivery
US9456955B2 (en) 2007-12-31 2016-10-04 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US8900188B2 (en) 2007-12-31 2014-12-02 Deka Products Limited Partnership Split ring resonator antenna adapted for use in wirelessly controlled medical device
CA2919786C (en) 2007-12-31 2019-10-22 Deka Products Limited Partnership Infusion pump assembly
WO2009088956A2 (en) 2007-12-31 2009-07-16 Deka Products Limited Partnership Infusion pump assembly
USD612279S1 (en) 2008-01-18 2010-03-23 Lifescan Scotland Limited User interface in an analyte meter
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8708961B2 (en) 2008-01-28 2014-04-29 Medsolve Technologies, Inc. Apparatus for infusing liquid to a body
IL197532A0 (en) 2008-03-21 2009-12-24 Lifescan Scotland Ltd Analyte testing method and system
USD611853S1 (en) 2008-03-21 2010-03-16 Lifescan Scotland Limited Analyte test meter
USD615431S1 (en) 2008-03-21 2010-05-11 Lifescan Scotland Limited Analyte test meter
USD612275S1 (en) 2008-03-21 2010-03-23 Lifescan Scotland, Ltd. Analyte test meter
USD611151S1 (en) 2008-06-10 2010-03-02 Lifescan Scotland, Ltd. Test meter
USD611489S1 (en) 2008-07-25 2010-03-09 Lifescan, Inc. User interface display for a glucose meter
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
WO2010031059A2 (en) 2008-09-15 2010-03-18 Deka Products Limited Partnership Systems and methods for fluid delivery
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (en) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Solute concentration measurement device and related methods
USD611372S1 (en) 2008-09-19 2010-03-09 Lifescan Scotland Limited Analyte test meter
US8708376B2 (en) 2008-10-10 2014-04-29 Deka Products Limited Partnership Medium connector
US8262616B2 (en) 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US8016789B2 (en) 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US8267892B2 (en) 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
WO2011008966A2 (en) 2009-07-15 2011-01-20 Deka Products Limited Partnership Apparatus, systems and methods for an infusion pump assembly
WO2011014704A2 (en) 2009-07-30 2011-02-03 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
USD669165S1 (en) 2010-05-27 2012-10-16 Asante Solutions, Inc. Infusion pump
US8915879B2 (en) 2010-09-24 2014-12-23 Perqflo, Llc Infusion pumps
US9498573B2 (en) 2010-09-24 2016-11-22 Perqflo, Llc Infusion pumps
US9216249B2 (en) 2010-09-24 2015-12-22 Perqflo, Llc Infusion pumps
US9381300B2 (en) 2010-09-24 2016-07-05 Perqflo, Llc Infusion pumps
US8905972B2 (en) 2010-11-20 2014-12-09 Perqflo, Llc Infusion pumps
US8852152B2 (en) 2011-02-09 2014-10-07 Asante Solutions, Inc. Infusion pump systems and methods
US8454581B2 (en) 2011-03-16 2013-06-04 Asante Solutions, Inc. Infusion pump systems and methods
US8585657B2 (en) 2011-06-21 2013-11-19 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US9872982B2 (en) * 2012-01-10 2018-01-23 University of Pittsburgh—of the Commonwealth System of Higher Education Electroosmotic convection-enhanced delivery system
WO2013134519A2 (en) 2012-03-07 2013-09-12 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US8454557B1 (en) 2012-07-19 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
US8454562B1 (en) 2012-07-20 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
US9878096B2 (en) 2012-08-30 2018-01-30 Medtronic Minimed, Inc. Generation of target glucose values for a closed-loop operating mode of an insulin infusion system
US10496797B2 (en) 2012-08-30 2019-12-03 Medtronic Minimed, Inc. Blood glucose validation for a closed-loop operating mode of an insulin infusion system
US9662445B2 (en) 2012-08-30 2017-05-30 Medtronic Minimed, Inc. Regulating entry into a closed-loop operating mode of an insulin infusion system
US10130767B2 (en) 2012-08-30 2018-11-20 Medtronic Minimed, Inc. Sensor model supervisor for a closed-loop insulin infusion system
US9623179B2 (en) 2012-08-30 2017-04-18 Medtronic Minimed, Inc. Safeguarding techniques for a closed-loop insulin infusion system
US9849239B2 (en) 2012-08-30 2017-12-26 Medtronic Minimed, Inc. Generation and application of an insulin limit for a closed-loop operating mode of an insulin infusion system
US9364609B2 (en) 2012-08-30 2016-06-14 Medtronic Minimed, Inc. Insulin on board compensation for a closed-loop insulin infusion system
US9427523B2 (en) 2012-12-10 2016-08-30 Bigfoot Biomedical, Inc. Infusion pump system and method
US20140276536A1 (en) 2013-03-14 2014-09-18 Asante Solutions, Inc. Infusion Pump System and Methods
US9446186B2 (en) 2013-03-01 2016-09-20 Bigfoot Biomedical, Inc. Operating an infusion pump system
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
US9446187B2 (en) 2013-06-03 2016-09-20 Bigfoot Biomedical, Inc. Infusion pump system and method
EP3016629B1 (en) 2013-07-03 2023-12-20 DEKA Products Limited Partnership Apparatus and system for fluid delivery
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
US10569015B2 (en) 2013-12-02 2020-02-25 Bigfoot Biomedical, Inc. Infusion pump system and method
US9629901B2 (en) 2014-07-01 2017-04-25 Bigfoot Biomedical, Inc. Glucagon administration system and methods
US10137246B2 (en) 2014-08-06 2018-11-27 Bigfoot Biomedical, Inc. Infusion pump assembly and method
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
US10159786B2 (en) 2014-09-30 2018-12-25 Perqflo, Llc Hybrid ambulatory infusion pumps
EP3258989B1 (en) 2015-02-18 2020-01-01 Medtronic Minimed, Inc. Ambulatory infusion pump with static and dynamic seals
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
US10449294B1 (en) 2016-01-05 2019-10-22 Bigfoot Biomedical, Inc. Operating an infusion pump system
EP3374900A1 (en) 2016-01-05 2018-09-19 Bigfoot Biomedical, Inc. Operating multi-modal medicine delivery systems
EP3413954A1 (en) 2016-02-12 2018-12-19 Perqflo, LLC Ambulatory infusion pumps and assemblies for use with same
USD809134S1 (en) 2016-03-10 2018-01-30 Bigfoot Biomedical, Inc. Infusion pump assembly
WO2018064219A1 (en) 2016-09-27 2018-04-05 Bigfoot Biomedical, Inc. Personalizing preset meal sizes in insulin delivery system
AU2017376111B2 (en) 2016-12-12 2023-02-02 Bigfoot Biomedical, Inc. Alarms and alerts for medication delivery devices and related systems and methods
USD836769S1 (en) 2016-12-12 2018-12-25 Bigfoot Biomedical, Inc. Insulin delivery controller
USD839294S1 (en) 2017-06-16 2019-01-29 Bigfoot Biomedical, Inc. Display screen with graphical user interface for closed-loop medication delivery
US11260171B2 (en) 2017-07-04 2022-03-01 Medtronic Minimed, Inc. Ambulatory infusion pumps and assemblies for use with same
WO2019014594A1 (en) 2017-07-13 2019-01-17 Desborough Lane Multi-scale display of blood glucose information
WO2019209963A1 (en) 2018-04-24 2019-10-31 Deka Products Limited Partnership Apparatus and system for fluid delivery
US11174852B2 (en) 2018-07-20 2021-11-16 Becton, Dickinson And Company Reciprocating pump
US20220304580A1 (en) 2019-05-13 2022-09-29 Starkey Laboratories, Inc. Ear-worn devices for communication with medical devices

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4573994A (en) 1979-04-27 1986-03-04 The Johns Hopkins University Refillable medication infusion apparatus
US4562751A (en) 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4685903A (en) 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4678408A (en) 1984-01-06 1987-07-07 Pacesetter Infusion, Ltd. Solenoid drive apparatus for an external infusion pump
US5492534A (en) * 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5652221A (en) * 1994-11-07 1997-07-29 The University Of Virginia Patent Foundation Method of treating defective glucose metabolism using synthetic insulin substances
US5772635A (en) 1995-05-15 1998-06-30 Alaris Medical Systems, Inc. Automated infusion system with dose rate calculator
ZA9610374B (en) 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
US5785688A (en) * 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method
US5676648A (en) 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
US5860957A (en) * 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities

Also Published As

Publication number Publication date
AU4998500A (en) 2000-12-12
JP2003500119A (en) 2003-01-07
US6461331B1 (en) 2002-10-08
EP1181066A1 (en) 2002-02-27
CA2372688C (en) 2006-10-31
WO2000071188A1 (en) 2000-11-30

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